Disease models and research tools

The following gene manipulated mice are available on request. Please contact Dr. Yoichiro Iwakura.

A: available
B: may be delayed
C: only frozen embryos are available

Knockout mouse

  Genetic background**  
Strains 129*B6 C57BL/6J BALB/cA C3H/HeN NOD Reference note
DCIR (dendritic cell immunoreceptor):Clec4a2 C A A - - Nat Med 14:176-80(2008)  
Dectin-2:Clec4n C A A - - Immunity 32: 681-691 (2010)  
Dectin-1:Clec7a C A A - - Nat Immunol 8:39-49(2007)  
IFNγ:Ifng - A A C - J Immunol 159:1418-28(1997)  
IFNγ Receptor:Ifngr1 - C - - - Science 259:1742-5(1993) 1
IL-1α:Il1a - A A - - J Exp Med 187:1463-75 (1998)  
IL-1β:Il1b - A A - - J Exp Med 187:1463-75 (1998)  
IL-1α/β:Il1a/Il1b - A A - C J Exp Med 187:1463-75 (1998)  
IL-1 Receptor antagonist:Il1rn - A A - C J Exp Med 187:1463-75 (1998)  
IL-1F6:Il1f6 - C C - - -  
IL-4:Il4 - C C - - Nature 362: 245-8 (1993) 2
IL-6:Il6 - B B - - Nature 368: 339-42 (1994) 2
IL-17:Il17a C A A - C Immunity 17: 375-87 (2002)  
IL-17F:Il17f C A A - - Immunity 30: 108-19 (2009)  
IL-17A/F:
Il17a/Il17f
C A A - - Immunity 30: 108-19 (2009)  
TNFα:
Tnfa
- A A - - Lab Invest 77: 647-58 (1997) 3
CC chemokine receptor 8:Ccr8 - C A - - -  
CXC chemokine receptor 4:Cxcr4 - A C - - Arthritis Res Ther 12: R188 (2010)  
polymeric immunoglobulin receptor:Pigr - C - - - J Immunol 163: 5367-73 (1999) 5
Melanocortin 2 receptor:Mc2r - C - - - Proc Natl Acad Sci USA 103: 18205-10 (2007)  
βGlcNAcβ1,4-galactosyltransferase1:B4galt1 C - - - - EMBO J 16: 1850-7 (1997)  
Protein tyrosine phospatase recepter typeδ:Ptprd C C - - - EMBO J 19: 2775-85 (2000)  
docking protein 7: Dok7 C - - - - Science 312:1802-5 (2006) 6
Eph receptor A2:Epha2 C - - - - Mech Div 102: 95-102 (2001)  
guanine nucleotide binding protein (G protein), β1:Gnb1 C C - - - Dev Dyn 239:1089-101 (2010)  
EST gene 4933427D06Rik:4933427D06Rik C C - - - -  

transgenic mouse

  Genetic background**  
Strains 129*B6 C57BL/6J BALB/cA C3H/HeN NOD Reference note
Human T-cell Leukemia Virus type 1(pX) gene - C B C - Science 253: 1026-8 (1991)  
c-fms promoter/tax gene - - - C - J Immunol 162: 2956-63 (1999)  
Human Immunodeficiency Virus (RT-) gene - A - C - AIDS 6: 1069-75 (1992)  
CD4 promoter/vpr gene - - - C - Virology 285: 181-92 (2001)  
CD4 promoter/human CD4 gene - - - C - -  
metallothioneine promoter/Ifnb gene - - - C - EMBO J 7: 3757-62 (1988)  
SAP promoter/RANKL - C - - - J Bone Miner Metab 20: 337-44 (2002)
4
PGK promoter/neomycin phosphotransferase gene - - - C - -  
CD34 promoter/Cre recombinase gene - C - - - -  
CD19 promoter/Cre recombinase gene - C - - - -  

** mice were backcrossed more than 8 generations except for 129*B6 intercrossed mice

Additional permission from the following developers is required.
1: Dr. M Aguet
2: Dr. M Kopf
3: Dr. K Sekikawa
4: Snow Brand Milk Products Co. Ltd.
5: Yakult Central Institute for Microbiological Research
6: Dr. Y Yamanashi.