In order to secure the continuous use of CFRP, we aim to predict residual strength and lifetime quantitatively, assuming the thermodynamic entropy as the measure of microscopic damage and fatigue. Though CFRP becomes common material for transport vehicle, it has been difficult to estimate the lifetime because of complex response of composite materials and structure.　We apply “Entropy-damage”-involved viscoelastic-viscoplastic constitutive relationship to resin properties in CFRP, and then understand various time-dependent and multi-scale failures of CFRP through the comparison of experimental and numerical results. Such microscopic damages and degradation are validated by molecular simulation linked to the entropy damage model. This study will enable the simulation of failure under multiple loadings and fatigue for composite material.