OVERVIEW

Cell-based therapy, in which living cells are administered to patients to treat diseases, is attracting a big attention as a new modality in drug discovery. To optimize cellular medicines for disease treatment, Kusamori Laboratory (Kusamori Lab) is developing effective and safe cellular medicines based on cell engineering technology and drug delivery system technology and elucidating cell-related biological phenomena. In addition, we have expanded the scope of our research to mitochondria, which are one of cell organelles, and have begun development of new drug discovery modalities.

Target disease: Cancer, Diabetes, Sepsis, Liver failure, Anemia, etc.
Regeneration of tissues: Lymph node, Blood vessel, Neuron, Pancreatic islets, etc.

Research keywords: Cellular drugs/medicines, Mitochondria therapeutics, Regenerative therapy, Cell-based therapy, Gene therapy, Biopharmaceutics, DDS (drug delivery system), Cell engineering techniques, Stem cell, iPS cell, Exosome, Protein, Spheroids, Organoids

Cellular therapeutics

1. Development of mesenchymal stem cell-based drug delivery system
2. Development of function controllable cell-based gene therapy
3. Development of tissue-mimicking cell structure
4. Regenerative therapy using cell sheet and exosome

Mitochondria therapeutics

1. Development of mitochondria-introducing cells/cell sheets
2. Evaluation of mitochondrial function and its functionalization
3. Regulation of pharmacokinetics of mitochondria

Others

1. Development of smart antibody-producing cells
2. Evaluation of plant-derived nanoparticles page top