東京理科大学 基礎工学部 生物工学科
島田研究室（植物分子生物学研究室）

論文リスト

当研究室に関連した学術論文、著書、特許等を掲載しています。
過去の論文はナビゲーションリンクからご覧ください。

  1. Tomohiro Imamura, Ken-Taro Sekine, Tetsuro Yamashita, Hiroaki Kusano, Hiroaki Shimada. Production of recombinant thanatin in watery rice seeds that lack an accumulation of storage starch and proteins. J. Biotechnol. 219, 28-33 (2016) DOI: 10.1016/j.jbiotec.2015.12.006
  2. Noritoshi Inagaki, Keisuke Kinoshita, Takatoshi Kagawa, Ayumi Tanaka, Osamu Ueno, Hiroaki Shimada, Makoto Takano.Phytochrome B mediates the regulation of chlorophyll biosynthesis through transcriptional regulation of ChlH and GUN4 in rice seedlings. Plos One. (online journal) (2015) DOI: 10.1371/journal.pone.0135408
  3. Haruaki Yamazaki, Nobuo Suzui, Yong-Gen Yin, Naoki Kawachi, Satomi Ishii, Hiroaki Shimada, Shu Fujimaki. Live-imaging evaluation of the efficiency of elevated CO2 concentration in a closed cultivation system for the improvement of bioproduction in tomato fruits. Plant Biotechnol. 32, 31-37 (2014) DOI: 10.5511/plantbiotechnology. 14.1210a
  4. Hajime Ui, Mohammad Sameri, Mohanmadda Pourkheirandish, Men-Chi Chang, Hiroaki Shimada, Nils Stein, Takao Komatsuda, Hirokazu Handa. High-resolution genetic mapping and physical map constructions for the fertility restorerer Rfm1 locus in barley. Theor. Appl. Genet. 128, 283-290 (2014) DOI:10.1007/s00122-014-2428-2
  5. Hiromi Aoki, Hiroshi Teramura, Mikhail Schepetilnikov, Lyubov A Ryabova, Hiroaki Kusano, Hiroaki Shimada. Enhanced translation of the downstream ORF attributed to a long 5' untranslated region in the OsMac1 gene family members, OsMac2 and OsMac3. Plant Biotechnology 31, 221-228 (2014) DOI: 10.5511/plantbiotechnology.14.0512a
  6. Takamitsu Kurusu, Tomoko Koyano, Shigeru Hanamata, Takahiko Kubo, Yuhei Noguchi, Chikako Yagi, Noriko Nagata, Takashi Yamamoto, Takayuki Ohnishi, Yozo Okazaki, Nobutaka Kitahata, Daichi Ando, Masaya Ishikawa, Shinya Wada, Akio Miyao, Hirohiko Hirochika, Hiroaki Shimada, Amane Makino, Kazuki Saito, Hiroyuki Ishida, Tetsu Kinoshita, Nori Kurata, Kazuyuki Kuchitsu. OsATG7 is required for autophagy-dependent lipid metabolism in rice postmeiotic anther development. Autophagy 10, 878-888 (2014) on line published. http://dx.doi.org/10.4161/auto.28279
  7. Toshihiro Yoshihara, Nobuo Suzui, Satomi Ishii, Mayu Kitazaki, Haruaki Yamazaki, Kazuyoshi Kitazaki, Naoki Kawachi, Yong-Gen Yin, Sayuri Ito-Tanabata, Shin-nosuke Hashida, Kazuhiro Shoji, Hiroaki Shimada, Fumiyuki Goto, Shu Fujimaki. A kinetic analysis of cadmium accumulation in a Cd hyper-accumulator fern, Athryrium yokoscense and tobacco plants. Plant Cell Environ. 37, 1086-1096 (2013) online published. doi: 10.1111/pce.12217
  8. Hiroaki Kusano, Kao-Chih She, Hiroaki Shimada. Identification of rice FLOURY ENDOSPERM 2. (In:) Genomics I - Humans, Animals and Plants. #121, iConcept press (2013) ISBN: 978-1-477554-91-3
  9. Takemasa Koumoto, Hiroaki Shimada, Hiroaki Kusano, Kao-Chih She, Masao Iwamoto, Makoto Takano. Rice monoculm mutation moc2, which inhibits outgrowth of the seconde tillers, is ascribed to lack of a fructose-1,6-bisphosphatase. Plant Biotechnology 30, 47-56 (2013).
  10. Yong-Ik Kwon, Kiyomi Abe, Keishi Osakabe, Masaki Endo, Ayako Nishizawa-Yokoi, Hiroaki Saika, Hiroaki Shimada, Seiichi Toki. Over expression of either OsRecQ14 and/or OsExo1 enhances DSB-induced homologous recombination in rice. Plant Cell Physiol. 53, 2142-2152 (2012)
  11. Kao-Chih She, Mitsuhiro Yaeshima, Takemasa Koumoto, Mariko Ohnuma, Tomoko Hiromasa, Mio Hirai, Takuya Matsunaga, Ryouka Tashiro, Tadamasa Sasaki, Hiroaki Kusano, Hiroaki Shimada. High-temperature stress susceptibility of representative japonica rice cultivars derived from Norin-22: inadequate ATP supply during seed development may lead to severe damage. Plant Biotechnology 29, 465-471 (2012)
  12. Hiroshi Teramura, Yusuke Enomoto, Hiromi Aoki, Tadamasa Sasaki, Hiroaki Shimada. A long 5' UTR of the rice OsMac1 mRNA enabling the sufficient translation of the downstream ORF. Plant Biotechnol. 29, 43-49 (2012) .
  13. Hidefumi Hamasaki, Takeshi Yoshizumi, Naoki Takahashi, Mieko Higuchi, Takashi Kuromori, Yuko Imura, Hiroaki Shimada, Minami Matsui. SD3, an Arabidopsis thaliana homolog of TIM21, affects intracellular ATP levels and seedling development. Molecular Plant 5, 461-471 (2012) (online published Nov. 29, 2011)
  14. Shailesh Kumar, Takeshi Yoshizumi, Hiroaki Hongo, Arata Yoneda, Hiroko Hara, Hidehumi Hmasaki, Naoki Takahashi, Noriko Nagata, Hiroaki Shimada, Minami Matsui. Arabidopsis mitochondrial protein TIM50 affects hypocotyl cell elongation through intracellular ATP level. Plant Science 183, 212-217 (2012)
  15. Ken'ichiro Matsumoto, Kenjiro Morimoto, Aoi Gohda, Hiroaki Shimada, Seiichi Taguchi. Improved polyhydroxybutyrate (PHB) production in transgenic tobacco by enhancing translation efficiency of bacterial PHB biosynthetic genes. J. Biosci. Bioeng. 111, 485-488 (2011)
  16. Kao-Chih. She, Hiroaki Kusano, Kazuyoshi Koizumi, Hiromoto Yamakawa, Makoto Hakata, Tomohiro Imamura, Masato Fukuda, Natsuka Naito, Yumi Tsurumaki, Mitsuhiro Yaeshima, Tomohiko Tsuge, Ken'ichiro Matsumoto, Mari Kudoh, Eiko Itoh, Shoshi Kikuchi, Naoki Kishimoto, Junshi Yazaki, Tsuyu Ando, Masahiro Yano, Takashi Aoyama, Tadamasa Sasaki, Hikaru Satoh, Hiroaki Shimada. A novel factor FLOURY ENDOSPERM 2 is involved in regulation of rice grain size and starch quality. Plant Cell. online published (2010)
  17. Tadamasa Sasaki, Haruko Akutsu, Hiroaki Shimada, Shigetoshi Miura. A rice cytochrome p450 OsCYP84A that may interact with UV tolerance. Biosci. Biotechnol. Biochem., 74, 1045-1049 (2010)
  18. Kao-Chih She, Hiroaki Kusano, Mitsuhiro Yaeshima, Tadamasa Sasaki, Hikaru Satoh, Hiroaki Shimada: Redued rice grain production with ATP shortage during seed develoopment. Plant Biotechnol. 27, 67-73 (2010)
  19. Tomohiro Imamura. Michiko Yasuda, Hiroaki Kusano, Hideo Nakashita, Yuko Ohno, Takashi Kamakura, Seiichi Taguchi, Hiroaki Shimada: Acquired resistance to the rice blast in transgenic rice accumulating the antimicrobial peptide thanatin. Transgenic Res. 19, 415-424 (2010) (2009 online published)
  20. Hiroaki Shimada, Haruka Takeda, Akina Tsunoda, Tadamasa Sasaki. Regulatory mechanism on sucrose metabolism in rice endosperm by a specific protein kinase, SPK (April 13, 2009).Proc. Int. Plant Nutrition Colloquium XVI. paper 1117
  21. Yusuke Enomoto, Shin-nosuke Hashida, Kazuhiro Shoji, Hiroaki Shimada, Toshihiro Yoshihara, Fumiyuki Goto. Expression of iron uptake genes in roots are affected by long-distance signals both in non-graminaceous and in graminaceous plants (April 15, 2009). Proc. Int. Plant Nutrition Colloquium XVI. paper 1209
  22. Michiko Higuchi, Takeshi Yoshizumi, Tomoko Kuriyama, Hiroko Hara, Chika Akagi, Hiroaki Shimada, Minami Matusi: Simple construction of plant RNAi vectors using long oligonucleotides. J. Plant Res. 122, 477-482 (2009)
  23. Tomomi Shiga, Kazuhiro Shoji, Hiroaki Shimada, Shinnosuke Hashida, Fumiyuki Goto, Toshihiro Yoshihara: Effect of light quality on rosmarinic acid content and antioxidant activity of sweet basil, Ocimum basilicum L. Plant Biotechnol. 26, 255-259 (2009)
  24. Ken'ichiro Matsumoto, Takaaki Murata, Rina Nagao, Christopher T. Nomura, Satoshi Arai, Yuko Arai, Kazuma Takase, Hideo Nakashita, Seiichi Taguchi, Hiroaki Shimada: Production of short-chain-length/ medium-chain-length polyhydoroxyalkanoate (PHA) copolymer in the plastid of Arabidopsis thaliana using an engineered 3-ketoacyl-acyl carrier protein synthase III. Biomacromolecules (2009) 10, 686-690
  25. Tomoyuki Furukawa, Horoaki Shimada: The RAD2 family of nucleases in higher plants (review). Japan Agrculture Research Quaterly (JARQ), 43(2), 87-93 (2009)
  26. Tomohiro Imamura, Naoki Yamamoto, Atsuo Tamura, Shinji Murabayashi, Shigeki Hashimoto, Hiroaki Shimada, Seiichi Taguchi: NMR based structure-activity relationship analysis of an antimicrobial peptide, thanatin, engineered by site-specific chemical modification: activity imporovement and spectrum alteration. Biochem. Biophys Res Comm. 369, 609-615 (2008)
  27. Hiroaki Kusano, Christa Testerink, Joop E. Wermeer, Tomohiko Tsuge, Hiroaki Shimada, Atsuhiro Oka, Teun Munnik, Takashi Aoyama: The Arabidopsis phosphatidylinositol phosphate 5-kinase PIP5K3 is a key regulator for root hair tip growth. Plant Cell, 20, 367-380 (2008)
  28. Tomoyuki Furukawa, Tomohiro Imamura, Hiroko Kitamoto, Hiroaki Shimada: Rice exonuclease-1 homologue, OsEXO1, that interacts with DNA polyemarse λ and RPA subunit proteins, is involved in cell proliferation. Plant Mol. Biol., 66, 519-531 (2008)
  29. Yusuke Enomoto, Hirotaka Hodoshima, Hiroaki Shimada, Kazuhiro Shoji, Toshihiro Yoshihara, Fumiyuki Goto: Long-distance signals positively regulate the expression of iron uptake genes in tobacco roots. Planta, 227, 81-89 (2007)
  30. Tomohiro Imamura, Hiroaki Kusano, Yumiko Kajigaya, Masatoshi Ichikawa, Hiroaki Shimada: A rice dihydrosphingosine C4 hydrosylase (DSH1) gene, which is abundantly expressed in the stigmas, vascular cells and apical meristem my be involved in fertility. Plant Cell Physiol., 48, 1108-1120 (2007)
  31. Hirotaka Hodoshima, Yusuke Enomoto, Kazuhiro Shoji, Hiroaki Shimada, Fumiyuki Goto, Toshihiro Yoshihara: Differential regulation of cadmium-inducible expresion of iron-deficency-responsive genes in tobacco and barley. Physiologia Plantrum, 129, 622-634 (2007)
  32. Tomoyuki Furukawa, Masayuki Nisida, Takahiro Hada, Kouji Kuramochi, Fumio Sugawara, Susumu Kobayashi, Hiroshi Iijima, Hiroaki Shimada, Hiromi Yoshida, Yoshiyuki Mizushima: Inhibitory effect of sulfoquinovosyl diacylglycerol on prokaryotic DNA polymerase I activity and cell growth of Escherichia coli. Oleo Science, 56, 43-47 (2007)
  33. Tsutomu Furukawa, Masahiko Maekawa, Tomoyuki Oki, Ikuo Suda, Shigeru Iida, Hiroaki Shimada, Itsuro Takamure, Koh-ichi Kadowaki: The Rc and Rd genes are involved in proantocyanidin synthesis in rice pericarp. Plant J. 49, 91-102 (2006)
  34. Tomoyuki Furukawa, Norihiro Sakaguchi, Hiroaki Shimada: Two OsGASR genes, rice GAST homologue genes that are abundant in proliferating tissues, show different expression patterns in developing panicles. Genes Genet Syst. 81, 171-180 (2006)
  35. Fumiaki Hriose, Tomoko Shinomura, Takanari Tanabata, Hiroaki Shimada, Makoto Takano: Involvement of rice cryptochomes in de-etiolation responsess and flowering. Plant Cell Physiol. 47, 915-925 (2006)
  36. Norihiro Sakaguchi, Tomoyuki Furukawa, Hiroaki Shimada, Junji Hashimoto, Kengo Sakaguchi, Masaaki Umeda: Isolation and characterization of a rice cDNA encoding B1-type cyclin-dependent kinase. Plant BIotechnol. 23, 211-214 (2006)
  37. Sakiko Takahasi, Yuki Ogiyama, Hiroaki Kusano, Hiroaki Shimada, Makoto Kawamukai, Koh-ichi Kadowaki: Metabolic engineering of coenzyme Q by modification of isoprenoid side chain in plant. FEBS Lett. 580, 955-959 (2006)
  38. Ken'ichiro Matsumoto, Yuko Arai, Rina Nagao, Takaaki Murata, Kazuma Takase, Hideo Nakashita, Seiichi Taguchi, Hiroaki Shimada, Yoshiharu Doi: Synthesis of short-chain-length polyhydroxyalkanoate (PHA) copolymers in peroxisome of the trangenic Arabidopsis thaliana harboring the PHA synthase gene from Pseudomonas sp. 61-3. J Polymer & Environment, 14, 369-374 (2006)
  39. Ken'ichiro Matsumoto, Rino Nagao, Takaaki Murata, Yuko Arai, Tomoyasu Kichise, Hideo Nakashita, Seiichi Taguchi, Hiroaki Shimada, Yoshiharu Doi: Enhancement of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) production in the transgenic Arabidopsis thaliana by the in vitro ecolved highly active mutants of polyhydroxyalkanote (PHA) synthase from Aeromonas caviae. Biomacromolecules 6, 2126-2130 (2005)
  40. Sakiko Takahashi, Tsutomu Furukawa, Takayuki Asano, Yoshihumi Terajima, Hiroaki Shimada, Akira Sugimoto, Koh-ichi Kadowaki: Very close relationship of the chloroplast genomes among Saccharum species. Theor. Appl. Genet. 110, 1523-1529 (2005)
  41. Naoki Takahashi, Miki Nakazawa, Akie Ishikawa, Kumoko Suzuki, Mika Kawashima, Takanari Ichikawa, Takao Yokota, Hiroaki Shimada, Minami Matsui: shk1-D, a dwarf Arabidopsis mutant caused by activation of CYP72C1 gene, has altered brassinosteroid levels. Plant J. 42, 13-22 (2005)
  42. Hiroaki Kusano, Takayuki Asano, Hiroaki Shimada, Koh-ichi Kadowaki: Molecular characterization of ONAC300, a novel NAC gene specifically expressed at early stage of various developing tissue of rice. Mol. Genent. Genomics, 272, 616-626 (2005)
  43. Toshihiro Yoshihara, Kyoko Tsunokawa, Yoshiyuki Miyano, Yuki Arashima, Hirotaka Hodoshima, Kazuhiro Shoji, Hiroaki Shimada, Fumiyuki Goto: Induction of callus hyper-tolerant fern, Athytium yokoscense, and evaluation of the cadomium tolerance and acuumulation capacity. Plant Cell Report. 23, 579-585 (2005)
  44. Hiroaki Shimada, Hiroaki Koishihara, Yayoi Saito, Yuki Arashima, Tomoyuki Furukawa, Hiroaki Hayashi: A rice antisense SPK transformant that lacks the accumulation of seed storage substances shows no correlation between sucrose concentration in phloem sap and demand for carbon sources in the sink organs. Plant Cell Physiol. 45, 1105-1109 (2004)
  45. Takayuki Asano, Takahiko Tsuzuki, Sakiko Takahashi, Hiroaki Shimada, Koh-ichi Kadowaki: Complete nucleotide sequence of the sugarcane (Saccharum officinarum) chloroplast genome: a comparative analysis of four monocot chloroplast genomes. DNA Res. 11, 93-99 (2004)
  46. Tomoyuki Takase, Miki Nakazawa, Akie Ishikawa, Mika Kawashima, Takanari Ichikawa, Naoki Takahashi, Hiroaki Shimada, Katsuki Manabe, Minami Matsui: ydk1-D, an auxin-repsponsive GH3 mutant that is involved in hypocotyl and root elongation. Plant J. 37, 471-483 (2004)
  47. Naoki Takahashi, Hirofumi Kuroda, Takashi Kuromori, Takashi Hirayama, Motoaki Seki, Kazuo Shinozaki, Hiroaki Shimada, Minami Matsui: Expression and interaction analysis of Arabidopsis Skp1-related genes. Plant Cell Physiol. 45, 83-91 (2004)
  48. 小泉一愉、今村智弘、高野裕二、松江登久、島田浩章：小型密封容器（クールミル）を用いたイネ細胞の効率的破砕法。育種学研究 5, 53-57 (2003)
  49. T. Asano, T. Masumura, H. Kusano, S. Kikuchi, A. Kurita, H. Shimada, K. Kadowaki: Construction of a specialized cDNA library by laser microdissection: toward comprehensive analysis of the genes expressed in the rice phloem. Plant J. 32, 401-408 (2002)
  50. H. Kuroda, N. Takahashi, H. Shimada, M. Seki, K. Shinozaki, M. Matsui: Classification and expression analysis of Arabidopsis F-box-containing protein genes. Plant Cell Physiol. 43, 1073-1085 (2002)
  51. T. Asano, T. Okuda, N. Kubo, H. Shimada, K. Kadowaki: Rpp16 and Rpp17, from common origin, have different protein characteristics, but both genes are predominantly expressed in rice phloem. Plant Cell Physiol. 43, 668-674 (2002)
  52. T. Asano, N. Kunieda, Y. Omura, T. Kawasaki, M. Takano, M. Sato, H. Furuhashi, T. Mujin, F. Takaiwa, C. Wu, Y. Tada, T. Satozawa, M. Sakamoto, H. Shimada: Rice SPK, a calmodulin-like domain protein kinase, is required for storage product accumulation during seed development. Phosphorylation of sucrose synthase is a possible factor. Plant Cell 14, 619-628 (2002).
  53. A. Miura, S. Yonebayashi, K. Watanabe, T. Toyama, H. Shimada, T. Kakutani: Mobilization of transposons by a mutation abolishing full DNA methylation in Arabidopsis. Nature, 411, 212-214 (2001)
  54. T. Tuge, N. Inagaki, T. Yoshizumi, H. Shimada, T. Kawamoto, R. Matsuki, A. Tagiri, N. Yamamoto, M.Matsui: Phytochrome-mediated control of COP1 gene expression in rice plants. Mol. Genet. Genomics. 265, 43-50 (2001).

総説・著書

  1. 島田浩章「地球温暖化による稲作農業への影響とそれに対応する稲の分子育種」理大科学フォーラム　2011(1), 18-21 (2011)
  2. 地球環境テキストブック　環境科学。吉原利一編（分担執筆）2010年3月（オーム社）
  3. 植物ゲノム科学辞典。駒嶺穆（総編集）斎藤和季、田畑哲之、藤村達人、町田康則、三位正洋（編集）（分担執筆）（朝倉書店）2009年1月
  4. 島田浩章、今村智弘「組換え体植物を用いた高分子の生産」特集◇食と高分子。高分子　57（12）,　983-986 (2008)
  5. 島田浩章「植物で作る環境にやさしいプラスチックー組換え体植物による生分解性プラスチックの生産ー」ビオフィリア（Biophilia）4 （2）, 41-45 (2008)
  6. 島田浩章、松本謙一郎「組換え体植物による生分解性プラスチックの生産」バイオプロセス・ハンドブック：バイオケミカルエンジニアリングの基礎から有用物質生産・環境調和技術まで（分担執筆）（エヌ・ティー・エヌ）　2007年、pp.504-511
  7. 島田浩章、今村智弘。「分子農業で抗菌ペプチドをつくる」バイオニクス（Bionics）2, (6) 46-50 (2005)
  8. 今村智弘、島田浩章：抗菌ペプチドの生産（植物の力をバイオ産業へ）　バイオニクス　2 (6), 46-50 (2005 )
  9. 島田浩章：分子農業（組換え体植物を利用した物質生産）　理大科学フォーラム　234（12）16-22 (2003)
  10. 島田浩章：組換え体植物を利用した物質生産。--分子農業：食糧生産を目的としない新しい農業システム--、農業技術　58巻(5), 193-198（2003）　

主な特許・実用新案

  1. 「ＤＮＡ結合ドメイン組込み用ベクターおよびそのセット、融合タンパク質コーディングベクターおよびそのセットならびにその製造方法、デスティネーションベクター、植物細胞用発現ベクターおよびその製造方法、植物細胞用発現ベクター作製用キット、形質転換方法、ならびにゲノム編集方法」 特願2015-037195（2015.2.26）
  2. 「翻訳エンハンサー」 特願2014-102528（2014.5.16）PCT/JP2015/063648
  3. 「高温耐性植物及びそのスクリーニング方法」 特開2011-188744（2012.09.29公開）
  4. 「翻訳エンハンサー」 特許5598899号（2014.8.22)
  5. 「米アレルゲンタンパク質蓄積抑制剤およびアレルゲン低減化米」 特許第4941958号（2012.3.9)
  6. 「植物体の着色制御遺伝子、およびその利用」 特許5051742号（2012.08.03）
  7. 「組換え低アレルゲン植物及び低アレルゲン植物マーカー」 特許5252519号（2013.04.26）
  8. 「植物を用いたユビキノンー１０の製造方法」 特開2006-212019
  9. 「新規な抗菌性ペプチド、それを産生するための組換え体植物及び該抗菌性ペプチドの製造方法」 特開2006-281291
  10. 「flo2変異の形質が導入された低アレルゲン植物およびその作出方法」 特許3848183号（2006.09.01）
  11. 「凍結試料破砕用小型容器」実用新案　登録3086539号（2001.12.7）
  12. 「イネ師部における新規タンパク質およびその遺伝子」 特許3890402号（2006.12.15）
  13. 「ショ糖合成能力を増強したイネおよびその作成法」 特開平9-248084
  14. 「ADP-グルコースピロフォスフォリラーゼによるデンプン合成能力の強化」 特開平8-289789
  15. 「耐冷性イネおよびその作成方法」 特開平8-173167
  16. 「新規なイネ殿粉枝つけ酵素遺伝子」 特許3513192号（2004.01.16）
  17. 「可溶性のイネ殿粉合成酵素遺伝子およびその使用法」 特許3495749号（2003.11.21）
  18. 「イネ種子特異的プロティンキナーゼ遺伝子」 特開平6-153963
  19. 「枯草菌菌株による蛋白分泌の方法」 特許2857730号（1998.12.04）
  20. 「イネワキシイ配列およびそれを利用したイネ種子の胚乳成分の改良法」 特許3088438号（2000.07.14）
  21. 「禾本科植物の葉緑体DNA」 特許3124279号（2000.10.27）
  22. 「菌体外プロテアーゼ欠損変異株とこれを利用したタンパクの分泌生産法」 特許1798144号（1993.11.12）
  23. 「殺虫蛋白質産生枯草菌及びその生産法」 特許1966568号（1995.09.18）
  24. 「ヒト成長ホルモンの生産法」 特許2500312（1996.03.13）
  25. 「バチルス族細菌の菌体外分泌シグナルの部分を用いた枯草菌による蛋白の菌体外生産」 特許1928022号（1995.05.12）
  26. 「蛋白製造法」 特許2500311号（1996.03.13）
  27. 「蛋白の発現と分泌に関与する領域を含むDNA配列」 特許1888272号（1994.12.07）
  28. 「DNA塩基配列及びそのDNA塩基配列を含む組換え体プラスミドの創製法」 特許1917855号（1995.04.07）

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