研究業績

by aging_tus

学術論文

  1. PARIS/ZNF746 DNA-binding domain deficiency promotes adipose tissue hyp erplasia and hepatic lipid accumulation. Hachiya K, Mizunoe Y, Yang JJ, Uchida Y, Fukai H, Esashi T, Nozaki Y, Mizuno S, Takahashi S, Kobayashi M, Higami Y. Sci Rep, 15, 36095, 2025
  2. Co-overexpression of the caloric restriction-induced mitochondrial factors PGC-1a and MIPEP upregulates Phospho1 expression in adipocytes. Ishimatsu M, Taki K, Hayami A, Kato K, Nozaki Y, Mizunoe Y, Narita T, Mori R, Higami Y, Kobayashi M. FEBS Open Bio, 15, 1643–1657, 2025
  3. Caloric restriction alters NCOA2 splicing to regulate lipid metabolism in subcutaneous white adipose tissue. Mizunoe Y, Kumagai M, Fukai H, Hachiya K, Otani Y, Nozaki Y, Tezuka K, Kobayashi M, Haeno H, Saeki K, Murayama Y, Shimano H, Higami Y. Biochem Biophys Res Commun, 765, 151871, 2025
  4. Mipep deficiency in adipocytes impairs mitochondrial protein maturation and leads to systemic inflammation and metabolic dysfunctions. Nozaki Y, Kobayashi M, Fukuoh T, Ishimatsu M, Narita T, Taki K, Hirao Y, Ayabe S, Yokoyama M, Otani Y, Mizunoe Y, Matsumoto M, Ohno N, Kaifu T, Okazaki S, Goitsuka R, Nakagawa Y, Shimano H, Iwakura Y, Higami Y. Sci Rep, 15, 12839, 2025
  5. WW Domain-Containing E3 ubiquitin protein ligase 1 (WWP1) as a factor in obesity-related metabolic disorders: Emerging molecular mechanisms in metabolic tissues. Nozaki Y, Mizunoe Y, Kobayashi M, Higami Y. Int J Mol Sci, 26, 2025
  6. Depletion of WWP1 increases Adrb3 expression and lipolysis in white adipose tissue of obese mice. Nozaki Y, Ose Y, Ohmori C, Mizunoe Y, Kobayashi M, Saitoh A, Higami Y. Int J Mol Sci, 26, 2025
  7. Identification of a novel MIPEP splice variant with altered substrate-binding properties. Otani Y, Kawarai M, Kobayashi M, Nozaki Y, Uchida R, Tezuka K, Yokoyama M, Mizunoe Y, Narita T, Haeno H, Miyano K, Uezono Y, Higami Y. Biochem Biophys Rep, 44, 102329, 2025
  8. Establishment of DNA methylation during primate germ cell development. Kojima K, Li Y, Tomizawa S, Kohara M, Kuze Y, Sato T, Ebata T, Kubiura-Ichimaru M, Cao M, Hattori T, Maezawa S, Winge SB, Almstrup K, Nakaki R, Sato S, Miyagi Y, Daigo Y, Yoshioka T, Hasegawa Y, Kinoshita Y, Hyuga T, Moriya K, Kobayashi H, Baskin L, Sankai T, Watanabe T. Nat Commun, in press
  9. DAXX Directs Dual Modes of H3.4-to-H3.3 Histone Replacement in the Male Germline. Yeh Y, Hu M, Otsuka K, Alger BM, Nene SS, Wang H, Maezawa S, Namekawa SH. Genes Dev, in press
  10. Innate visual attraction before, during and after escape from adverse substrates in carpenter ants. Notomi Y, Dobata S, Kazawa T, Maezawa S, Namiki S, Kanzaki R, Haupt SS. J Exp Biol, 228, jeb250278, 2025
  11. CTCF-mediated 3D chromatin sets up the gene expression program in the male germline. Kitamura Y, Takahashi K, Maezawa S, Munakata Y, Sakashita A, Katz SP, Kaplan N, Namekawa SH. Nat Struct Mol Biol, 32, 1227-1240, 2025
  12.  ZBTB16/PLZF regulates juvenile spermatogonial stem cell development through an extensive transcription factor poising network. Yi C, Kitamura Y, Maezawa S, Namekawa SH, Cairns BR. Nat Struct Mol Biol, 32, 1213-1226, 2025
  13. Violet light photobiomodulation therapy for depression: A double-blind randomized crossover trial. , Noda Y, Taniguchi K, Takano M, Mimura Y, Yanagisawa N, Hayano M, Kitahata R, Ogawa Y, Mimura M, Tsubota K. J Affect Disord, 376, 325-332, 2025
  14. Lipid balance and chemoresistance in cancer cells, Kanemaru K, Nakamura Y. eLife, 15, e110231, 2026
  15. Phospholipase C d1 affects integrin-mediated cell adhesion and migration by altering available phosphatidylinositol 4,5-bisphosphate levels. Yoneda A, Fujinaka R, Tsuchiya N, Yaita S, Suzuki S, Kishi Y, Nakamura Y, Satow R, Fukami K. Exp Cell Res, 455, 114857, 2026
  16. Phosphatidylinositol-specific phospholipase C across biological kingdoms: domain organization, functions and regulation. Kanemaru K, Nakamura Y. J Biochem, 178, 305-313, 2025
  17. Self-reinforcing IL-1b signaling accelerates the development and recurrence of TCF3::HLF-positive B-ALL. Suzuki A, Shigehiro T, Hirakawa M, Hirano R, Tamai M, Akahane K, Okamoto K, Takayanagi H, Terashima Y, Ueha S, Kitami T, Takagi M, Keino D, Kato K, Kawaguchi H, Hino M, Yoshimura A, Inukai T, and Ikawa T. Blood, in press
  18. A single microRNA miR-195 rescues the arrested B cell development induced by EBF1 deficiency. Miyatake Y, Kamakura T, Ikawa T, Yanagiya R, Kotaki R, Kameda K, Koyama-Nasu R, Okuyama K, Hirano KI, Hosokawa H, Hozumi K, Ohtsuka M, Kishikawa T, Shibata C, Otsuka M, Maruyama R, Ando K, Kurosaki T, Kawamoto H, Kotani A. eLife, 13, RP101510, 2026
  19. Comprehensive molecular and functional analysis of NUTM1-rearranged leukemia. Nishimura K, Isobe T, Shigehiro T, Nomura M, Zang W, Xiao M, Liao W, Koike Y, Nishimura A, Sato-Otsubo A, Yamazaki H, Ito H, Okada S, Matsumoto N, Saika W, Zhang Y, Aoyama Y, Hasegawa C, Yamasaki T, Kubota Y, Oki K, Kiyokawa N, Nagae G, Yoshida K, Nannya Y, Ueno H, Fukuda S, Tatsuno K, Tsutsumi S, Shiozawa Y, Shiraishi Y, Chiba K, Tanaka H, Eguchi M, Arakawa Y, Koh K, Deguchi T, Tomizawa D, Miyamura T, Ishii E, Mizutani S, Miyano S, Aburatani H, Ogawa S, Takaori-Kondo A, Yokoyama A, Abdel-Wahab O, Ernst P, Takita J, Ikawa T, Takagi M, Inoue D. Blood, 147, 1395–1411, 2026
  20. Stage-specific roles of clonally expanded CD8+ T cells in regulating amyloid pathology in Alzheimer’s disease models. Ohyagi M, Ito M, Iizuka-Koga M, Mise-Omata S, Yoshimura A. Nat Commun, 16, 9458, 2025
  21. Germline variants and mosaic chromosomal alterations affect COVID-19 vaccine immunogenicity. Japan COVID-19 Task Force; Biobank Japan Project; Oda Y, Suzuki Y, Yoshimura A, Okada Y, Namkoong H. Cell Genom, 100783, 2025
  22. Generation of human induced pluripotent stem cell lines derived from Wolf-Hirschhorn syndrome patients with chromosomal 4p deletion. Shimizu T, Takami M, Matsuo-Takasaki M, Noguchi M, Nakamura Y, Hayata T, Hayashi Y. Hum Cell, 38, 164, 2025
  23. Low CTDNEP1 Expression Predicts Poor Prognosis and Is Associated With Immune Modulation in Pancreatic Cancer. Nii M, Hayata T. Cancer Genomics Proteomics, 23, 144-154, 2026
  24. Basal invasion of cancer cells driven by cell-cell interactions: An affirmative role of cell competition in cancer progression. Nakai K, Akter E, Kon S. Cancer Sci, 116, 2340–2346, 2025
  25. Tumor-Agnostic Circulating Tumor DNA Analysis as a Comprehensive Predictive Biomarker of Recurrence after Ablative Radiotherapy for Early-Stage Non-Small Cell Lung Cancer. Nakamura M, Kageyama SI, Hirata H, Ohira M, Sakai SA, Hakozaki Y, Hojo H, Fujisawa T, Yamashita R, Haeno H, Kanai A, Suzuki Y, Yamaguchi M, Tsuchihara K, Zenda S. Clin Lung Cancer, 26, 671-679.e2, 2025
  26. Clonal evolution of hematopoietic stem cells after myeloma targeting chemotherapy and autologous stem cell transplantation., Uryu H, Saeki K, Haeno H, Kapadia CD, Furudate K, Nangalia J, Chapman MS, Zhao L, Hsu JI, Zhao C, Chen S, Tanaka T, Li Z, Yang H, DiNardo C, Daver N, Pemmaraju N, Jain N, Ravandi F, Zhang J, Song X, Thompson E, Tang H, Little L, Gumbs C, Orlowski RZ, Qazilbash M, Bhalla K, Colla S, Kantarjian H, Shamanna RK, Ramos CB, Nakada D, Futreal PA, Shpall E, Goodell M, Garcia-Manero G, Takahashi K. Nat Genet, 57, 1695-1707, 2025
  27. Stable platelet production via the bypass pathway explains long-term hematopoietic stem cell reconstitution., Iwanami S, Sato T, Haeno H, Xu L, Imamura K, Ooehara J, Lan X, Nakauchi H, Iwami S, Yamamoto R, iScience, 28, 112547, 2025
  28. Development of a liquid chromatography–tandem mass spectrometry method for 4-aminobenzoic acid ethyl ester–derivatized glycosaminoglycans and its application to synovial fluid. Hirai K, Ishii T, Eom H, Takado R, Higashi K, Iwasaki Y, Ito R, Higashi N, Akiyama H. J Chromatogr Open, 9, 100324, 2026
  29. Antibody therapeutics with high affinity for FcγRs exacerbate anaphylaxis via FcγR-mediated capture by tumor-associated myeloid cells. Tang R, Aizemaiti A, Tamemoto Y, Kume R, Yasuda K, Sato K, Abo H, Tsuji K, Higashi K, Kiyoshi M, Hashii N, Ishii-Watabe A, Kawashima H, Hatakeyama H. J Immunother Cancer, 14, e013316, 2026
  30. Identification of Inhibitors for eIF5A2-Dependent Translation Elongation by Monitoring the Translational Efficiency of Polyproline Motif in Mitochondrial Fission Regulator 1. Suzuki M, Komeno M, Yasumura R, Miwa A, Enomoto M, Kotani H, Matsumoto K, Akimoto K, Takahashi C, Igarashi K, Higashi K. Biol Pharm Bull, 49, 355-363, 2026
  31. Structural Elucidation of Azo and Quinoneimine Products Formed in Diazonium-Based Color Reactions of Cannabinoids. Nishiguchi H, Nakamura K, Arai R, Hamajima R, Abe H, Ishida A, Tokeshi M, Higashi K, Saitoh A, Takahashi H. Molecules, 31, 796, 2026
  32. A Novel Chimeric Molecule of Heparanase and Ig-Fc Enables Histochemical and Cytochemical Detection of O-sulfated Heparan Sulfate. Shi J, Nakamura M, Baba R, Arakawa S, Yamaguchi A, Hariya T, Suzuki R, Inazuki Y, Takahashi K, Tsuiji M, Oku T, Komine M, Shimekake M, Higashi K, Nakamura M, Sasaki K, Nakajima M, Irimura T, Higashi N. Int J Mol Sci, 26, 11293, 2025
  33. Isolating and Determining the Structures of Colored Products from the Reactions of Cannabinoids with Fast Blue RR. Nakamura K, Nishiguchi H, Arai R, Hamajima R, Abe H, Ishida A, Tokeshi M, Higashi K, Saitoh A, Takahashi H. Molecules, 30, 3462, 2025
  34. Polyamines stimulate the protein synthesis of the initiation factor eIF5A2 participating in mRNA decoding distinct from eIF5A1. Suzuki M, Suzuki T, Nakano Y, Matsumoto K, Manaka H, Komeno M, Tamori S, Sato A, Dohmae N, Akimoto K, Miyazaki S, Suda T, Toida T, Kashiwagi K, Igarashi K, Higashi K. J Biol Chem, 301, 110453, 2025
  35. Cyclin-dependent kinase inhibitor 1A mediates mouse line- and fate-dependent cellular responses in Cx3cr1-Cre genetic tools. Yamasaki A, Shintaku H, Harada A, Maehara K, Tanaka K, Saeki M, Ito M, Konishi H, Tsuda M, Prinz M, Kishi Y, Ohkawa Y, Yamamoto S, Masuda T. Cell Rep 44, 116267, 2025
  36. LPLAT11/MBOAT7-driven phosphatidylinositol remodeling ensures radial glial cell integrity in developing neocortex. Ishino Y, Kishi Y, Iwama T, Kuwayama N, Arai H, Gotoh Y, Aoki J, Kono N. iScience, 29, 114248, 2025
  37. Age-associated transcriptomic and epigenetic alterations in mouse hippocampus. Bilgic M, Obata R, Panfil V-I, Zhu Z, Saeki M, Gotoh Y, Kishi Y. Aging Cell, 24, e70233, 2025
  38. In vivo transition in chromatin accessibility during differentiation of deep-layer excitatory neurons in the neocortex. Sakai S, Maeda Y, Saeki M, Konno D, Kawaji K, Matsuzaki F, Suzuki Y, Gotoh Y, Kishi Y. Development, 152, dev204564, 2025
  39. Mitochondrial complexity is regulated at ER-mitochondria contact sites via PDZD8-FKBP8 tethering. Nakamura K, Aoyama-Ishiwatari S, Nagao T, Paraan M, Obara C, Sakurai-Saito Y, Johnston J, Du Y, Suga S, Tsuboi M, Nakakido M, Tsumoto K, Kishi Y, Gotoh Y, Kwak C, Rhee H-W, Seo JK, Kosako H, Potter C, Carragher B, Lippincott-Schwartz J, Polleux F, Hirabayashi Y. Nat Commun, 16, 3401, 2025
  40. Structural insights into how DEK nucleosome binding facilitates H3K27 trimethylation in chromatin. Kujirai T, Echigoya K, Kishi Y, Saeki M, Ito T, Kato J, Negishi L, Kimura H, Masumoto H, Takizawa Y, Gotoh Y, Kurumizaka H. Nat Struct Mol Biol, 32, 1183-1192, 2025
  41. Propagation of neuronal micronuclei regulates microglial characteristics. Yano S, Asami N, Kishi Y, Takeda I, Kubotani H, Hattori Y, Kitazawa A, Hayashi K, Kubo K, Saeki M, Maeda C, Hiraki C, Teruya R, Taketomi T, Akiyama K, Okajima-Takahashi T, Sato B, Wake H, Gotoh Y, Nakajima K, Ichinohe T, Nagata T, Chiba T, Tsuruta F. Nat Neurosci, 28, 487-498, 2025
  42. Glucose, glutamine, lactic acid and α ketoglutarate restore metabolic disturbances and atrophic changes in energy deprived muscle cells. Ikeda M, Matsumoto M, Tamura M, Kobayashi M, Iida K. Mol Med Rep, 32, 197, 2025
  43. Cell observation and analysis with a three-dimensional optical wave field microscope. Matsumoto S, Itakura S, Minato J, Hashimoto M, Obana S, Kanai M, Kobayashi M, Nishikawa M, Kusamori K. Biosensors, 15, 515, 2025
  44. MOB1 deletion in murine mature adipocytes ameliorates obesity and diabetes. Nishio M, Yamaguchi K, Otani J, Yuguchi K, Kohno D, Sasaki T, Kitamura T, Shinohara M, Soga T, Kawamura K, Sasaki AT, Oshima M, Hikasa H, Woo M, Sasaki T, Nishina H, Nakao K, Maehama T, Suzuki A. Proc Natl Acad Sci USA, 122, e2424741122, 2025
  45. SLFN11-mediated tRNA regulation induces cell death by disrupting proteostasis in response to DNA-damaging agents. Iimori Y, Morita T, Masuda T, Kitajima S, Kono N, Kageyama S, Galipon J, Sasaki AT, Kanai A. Nucleic Acids Res, 53, gkaf789, 2025
  46. PI5P4K inhibitors: promising opportunities and challenges. Takeuchi K, Nagase L, Kageyama S, Kanoh H, Oshima M, Ogawa-Iio A, Ikeda Y, Fujii Y, Kondo S, Osaka N, Masuda T, Ishihara T, Nakamura Y, Hirota Y, Sasaki T, Senda T, Sasaki AT. FEBS J, 292, 4446-4476, 2025
  47. Polypharmacologic phosphoinositide modulation by FTY720 triggers endomembrane trafficking collapse and metabolic starvation in cancer cells. Kofuji S, Sumita K, Ikeda Y, Takahashi Y, Tabata S, Ito D, Hirota Y, Sasaki M, Kanoh H, Nakatsu F, Takeuchi K, Senda T, Davis MI, Shen M, Wakimoto H, Hirayama A, Soga T, Simeonov A, Sasaki AT. Biochem Biophys Res Commun, 815:153671, 2026
  48. Control of Golgi- V-ATPase through Sac1-dependent co-regulation of PI(4)P and cholesterol. Zhou X, van der Stoel MM, Kaptan S, Li H, Li S, Hölttä M, Vihinen H, Jokitalo E, Thiele C, Pietiläinen O, Morioka S, Sasaki J, Sasaki T, Vattulainen I, Ikonen E. Nat Commun, 16, 7808, 2025
  49. 100% Fish oil-based lipid emulsion inhibits hepatic stellate cell activation via suppression of the TGF-β1 autocrine signaling. Watanabe R, Morii M, Yamagata K, Ebihara T, Sasaki T, Mezaki Y, Mizuno M. Hum Cell, 38, 153, 2025
  50. Adrenal lipoma formation via PI(3,4,5)P3/AKT-dependent transdifferentiation of adrenocortical cells into adipocytes. Yanai S, Sasaki J, Lee-Okada HC, Takahashi F, Kikuchi Y, Morioka S, Yamamoto T, Yuguchi K, Oikawa M, Kajiho H, Baba T, Yokoyama C, Morohashi KI, Suzuki A, Yokomizo T, Sasaki T. Proc Natl Acad Sci USA, 122, e2510306122, 2025
  51. Cells adapt to extracellular acidic pH through TM9SF3-mediated PI(4,5)P2 flop. Sako K, Morimoto Y, Morioka S, Hasegawa J, Nakajima H, Fukumoto M, Nishida Y, Shintani Y, Sasaki J, Sasaki T, Kikuchi K, Mochizuki N. Nat Commun, 16, 8852, 2025
  52. Abrogation of aberrant glycolytic interactions eliminates senescent cells and alleviates aging-related dysfunctions. Mikawa T, Kameda M, Ikari S, Shibata E, Liu S, Miyagawa S, Ono K, Ito T, Yoshizawa A, Sugimoto M, Shibuya S, Shimizu T, Almunia J, Ogiso N, Revêchon G, Palazzo A, Bernard D, Kanda H, Soga T, Takubo K, Morioka S, Sasaki J, Sasaki T, Itamoto A, Fujii T, Seno H, Inagaki N, Kondoh H. Signal Transduct Target Ther, 10, 402, 2025
  53. Homocysteine thiolactone affects paraoxonase 1 activity via altered paraoxonase 1 distribution on high-density lipoprotein particles. Kawaguchi R, Miyakoshi T, Yoshimoto A, Hosoya S, Kugii Y, Sasaki T, Suzuki N, Ohkawa R. Biosci Rep, 46, BSR20253768, 2026
  54. PI3Kg Deficiency Suppresses Cutaneous Squamous Cell Carcinoma Formation by Modulating the Tumour Microenvironment Rather Than by Directly Regulating Keratinocyte Proliferation. Toyoshima A, Noguchi N, Suzuki T, Kuroki T, Kagaya M, Oda F, Kono M, Sasaki J, Sasaki T, Saeki H, Osada SI. Exp Dermatol, 35, e70219, 2026
  55. Circulating phospholipid species and internet addiction severity in Japanese adolescents: a pilot lipidomics study. Kawahara T, Tani Y, Nawa N, Morioka S, Kajiho H, Sasaki J, Sasaki T, Fujiwara T. Front Psychiatry, 17, 1751247, 2026
  56. Heme-Derived Iron Supply to Mitochondria via HMOX2 Ubiquitination at Mitochondria-ER Contact Sites. Oshio H, Shiiba I, Ito N, Okada N, Yamaguchi F, Ishikawa Y, Nagashima S, Fujikawa Y, Umezawa K, Miura Y, Shimizu M, Saito Y, Yamaguchi T, Inatome R, Yanagi S. Nat Cell Biol, in press
  57. Mitorubin, berberrubine-based compounds that improve mitochondrial function, exhibit cardioprotective effects against age-related cardiac dysfunction. Sato M, Tanabu D, Torigoe D, Kadomatsu T, Taniwaka K, Ogata Y, Shiiba I, Suzuki Y, Ito N, Inatome R, Tokuyama T, Takeiwa T, Inoue S, Kanai E, Hamano T, Hirata H, Kanamitsu K, Kusuhara H, Yokosuka A, Mimaki Y, Abe H, Oike Y, Yanagi S. npj Aging, 2026
  58. STIM1-Mitofusin2 interactions tether mitochondria and melanosome contacts that promote melanosome maturation. Shiiba I, Ishikawa Y, Oshio H, Ito N, Yamaguchi F, Nagashima S, Ando H, Umezawa K, Miura Y, Araiso Y, Nakamura K, Hirabayashi Y, Inatome R, Yanagi S. Nat. Commun, 2026
  59. Characterizing mitochondrial phenotypes and MERCS in aged human skeletal muscle myoblasts. Unten Y, Takafuji K, Masukagami Y, Shiiba I, Horiuchi K, Husnik F, Yanagi S, Tateishi N, Suzuki T, PLoS One, 2026
  60. Role of lipoylation in mitochondrial supercomplex formation during C2C12 cell differentiation. Oshio H, Shiiba I, Takeda A, Matsumoto S, Ishikawa Y, Nagashima S, Inatome R, Yanagi S. J Biochem, 2026
  61. Palmitic acid induces UCP1-independent mitochondrial depolarization specifically in brown adipose tissue. Ishikawa Y, Shiiba I, Kozakura E, Yabu H, Hirose S, Oshio H, Yamada KI, Okamatsu-Ogura Y, Inatome R, Yanagi S. J Biol Chem, 2026
  62. Aki D, Hayakawa T, Srirat T, Shichino S, Ito M, Saitoh SI, Mise-Omata S, Yoshimura A: The Nr4a family regulates intrahepatic Treg proliferation and liver fibrosis in MASLD models. J Clin Invest, 134. e175305, 2024 
  63. Hayabuchi H, Tokifuji Y, Takahashi H, Amagai M, Yoshimura A, Chikuma S: Disruption of post-thymic tolerance in skin-reactive TCR transgenic mice through the interaction of lymphopenia and intestinal microbiota. Int Immunol, 36:413-424, 2024 
  64. Hirata Y, Brems H, Van der Auweraer S, Ohyagi M, Iizuka M, Mise-Omata S, Ito M, Messiaen L, Mizuno S, Takahashi S, Legius E, Yoshimura A: Legius syndrome mutations in the Ras-regulator SPRED1 abolish its membrane localization and potentially cause neurodegeneration. J Biol Chem 300:107969, 2024 
  65. Iizuka-Koga M, Ito M, Yumoto N, Mise-Omata S, Hayakawa T, Komai K, Chikuma S, Takahashi S, Matsumoto I, Sumida T, Yoshimura A: Reconstruction of Sjögren’s syndrome-like sialadenitis by a defined disease specific gut-reactive single TCR and an autoantibody. Clin Immunol, 264:110258, 2024. 
  66. Ikeuchi M, Inoue M, Miyahara H, Sebastian WA, Miyazaki S, Takeno T, Kiyota K, Yano S, Shiraishi H, Shimizu N, Hanada R, Yoshimura A, Ihara K, Hanada T: A pH imbalance is linked to autophagic dysregulation of inner ear hair cells in Atp6v1ba-deficient zebrafish. Biochem Biophys Res Commun,  699:149551, 2024. 
  67. Jafarzadeh A, Jafarzadeh Z, Nemati M, Yoshimura A: The Interplay Between Helicobacter pylori and Suppressors of Cytokine Signaling (SOCS) Molecules in the Development of Gastric Cancer and Induction of Immune Response. Helicobacter, 29:e13105, 2024. 
  68. Lai S, Shiraishi H, Sebastian WA, Shimizu N, Umeda R, Ikeuchi M, Kiyota K, Takeno T, Miyazaki S, Yano S, Shimada T, Yoshimura A, Hanada R, Hanada T:  Effect of nonsense-mediated mRNA decay factor SMG9 deficiency on premature aging in zebrafish. Commun Biol, 7:654, 2024. 
  69. Lee J, Sasaki F, Koike E, Cho M, Lee Y, Dho SH, Lee J, Lee E, Toyohara E, Sunakawa M, Ishibashi M, Hung HH, Nishioka S, Komine R, Okura C, Shimizu M, Ikawa M, Yoshimura A, Morita R, Kim LK: Gelsolin alleviates rheumatoid arthritis by negatively regulating NLRP3 inflammasome activation. Cell Death Differ, 31:1679-1694, 2024. 
  70. Miyazaki S, Shimizu N, Miyahara H, Teranishi H, Umeda R, Yano S, Shimada T, Shiraishi H, Komiya K, Katoh A, Yoshimura A, Hanada R, Hanada T: DHCR7 links cholesterol synthesis with neuronal development and axonal integrity. Biochem Biophys Res Commun, 712-713:149932, 2024. 
  71. Nakagawara K, Ando M, Srirat T, Mise-Omata S, Hayakawa T, Ito M, Fukunaga K, Yoshimura A:　NR4A ablation improves mitochondrial fitness for long persistence in human CAR-T cells against solid tumors. J Immunother Cancer 12. e008665, 2024.
  72. Srirat T, Hayakawa T, Mise-Omata S, Nakagawara K, Ando M, Shichino S, Ito M, Yoshimura A:　NR4a1/2 deletion promotes accumulation of TCF1(+) stem-like precursors of exhausted CD8(+) T cells in the tumor microenvironment. Cell Rep, 43:113898, 2024.
  73. Takeuchi M, Nishio Y, Someya H, Sato T, Yoshimura A, Ito M, Harimoto K: Autoimmune uveitis attenuated in diabetic mice through imbalance of Th1/Th17 differentiation via suppression of AP-1 signaling pathway in Th cells. Front Immunol, 15:1347018, 2024
  74. Yoshifuji A, Toda M, Oyama E, Nakayama T, Mise-Omata S, Kikuchi K, Yoshizawa M, Kato N, Wakai H, Koibuchi K, Morimoto K, Uwamino Y, Namkoong H, Shibata A, Wakabayashi K, Fujino M, Komatsu M, Mochizuki N, Kondo N, Yoshimura A, Hasegawa N, Ryuzaki M: Cellular and humoral immune responses to COVID-19 booster vaccination in Japanese dialysis patients. Clin Exp Nephrol, 28:674-682, 2024.
  75. Aoyama Y, Yamazaki H, Nishimura K, Nomura M, Suzuki T, Zang W, Tatara Y, Shigehiro T, Ito H, Hayashi Y, Koike Y, Fukumoto M, Tanaka A, Zhang Y, Saika W, Kasai S, Sakamoto T, Kong Y, Minakuchi Y, Itoh K, Yamamoto M, Toyokuni S, Toyoda A, Ikawa T, Takaori-Kondo A, Inoue D. Selenoprotein-mediated redox regulation shapes the cell fate of HSCs and mature lineages. Blood. 145(11):1149-1163, 2025
  76. Miyatake Y, Ikawa T, Yanagiya R, Kotaki R, Kameda K, Koyama-Nasu R, Okuyama K, Hirano K, Hosokawa H, Hozumi K, Ohtsuka M, Kishikawa T, Shibata C, Otsuka M, Maruyama R, Ando K, Kurosaki T, Kawamoto H, Kotani A. A single microRNA miR-195 rescues the arrested B cell development induced by EBF1 deficiency. eLife. https://doi.org/10.7554/eLife.101510.1, 2024
  77. Uehata T, Yamada S, Ori D, Vandenbon A, Giladi A, Jelinski A, Murakawa Y, Watanabe H, Takeuchi K, Toratani K, Mino T, Kiryu H, Standley DM, Tsujimura T, Ikawa T, Kondoh G, Landthaler M, Kawamoto H, Rodewald HR, Amit I, Yamamoto R, Miyazaki M and Takeuchi O. Regulation of lymphoid-myeloid lineage bias through Regnase-1/3-mediated control of Nfkbiz. Blood. 143:243-257, 2024
  78. Shiiba I, Ito N, Oshio H, Ishikawa Y, Nagao T, Shimura H, Oh KW, Takasaki E, Yamaguchi F, Konagaya R, Kadowaki H, Nishitoh H, Tanzawa T, Nagashima S, Sugiura A, Fujikawa Y, Umezawa K, Tamura Y, Il Lee B, Hirabayashi Y, Okazaki Y, Sawa T, Inatome R, Yanagi S: ER-mitochondria contacts mediate lipid radical transfer via RMDN3/PTPIP51 phosphorylation to reduce mitochondrial oxidative stress. Nat Commun, 16(1):1508, 2025
  79. Tanabe M, Saito Y, Takasaki A, Nakano K, Yamamoto S, Suzuki C, Kawamura N, Hattori A, Oikawa M, Nagashima S, Yanagi S, Yamaguchi T, Fukuda T: Role of immature choroid plexus in the pathology of model mice and human iPSC-derived organoids with autism spectrum disorder. Cell Rep, 44(1):115133, 2025 
  80. Shimura H, Yamamoto S, Shiiba I, Oikawa M, Uchinomiya S, Ojida A, Yanagi S, Kadowaki H, Nishitoh H, Fukuda T, Nagashima S, Yamaguchi T: Etomoxir suppresses the expression of PPARγ2 and inhibits the thermogenic gene induction of brown adipocytes through pathways other than β-oxidation inhibition. J Biochem, 177(3):203–212, 2025 
  81. Ma W, Ahmad SAI, Hashimoto M, Khalilnezhad A, Kataoka M, Arima Y, Tanaka Y, Yanagi S, Umemoto T, Suda T: MITOL deficiency triggers hematopoietic stem cell apoptosis via ER stress response. EMBO J, 43(3):339–361, 2024
  82. Hirai K, Ishii T, Aijima A, Yokota N, Miyamoto Y, Higashi K, Iwasaki Y, Ito R, Higashi N, Akiyama H. Development of a method for simultaneous analysis of glycosaminoglycan disaccharides and evaluating the quality of chondroitin sulfate and hyaluronic acid in food raw materials. Food Chem. X, 25, 102239, 2025. 
  83. Nozaki Y, Suwa F, Furuya K, Komeno M, Hoshino S, Mizunoe Y, Higashi K, Kobayashi M, Higami Y. The effects of WWP1 overexpression on the golgi apparatus stress response and proteoglycan production in adipocytes. Sci. Rep., 14, 29004, 2024. 
  84. Ishii T, Hirai K, Higashi K, Aijima A, Yokota N, Toida T, Iwasaki Y, Ito R, Higashi N, Akiyama H. Novel simultaneous analysis of 18 types of glycosaminoglycan-derived disaccharides using 4-aminobenzoic acid ethyl ester derivatization by HPLC with fluorescence detection. Anal. Bioanal. Chem. 416, 6209-6221, 2024. 
  85. Shi J, Onuki Y, Kawanami F, Miyagawa N, Iwasaki F, Tsuda H, Takahashi K, Oku T, Suzuki M, Higashi K, Adachi H, Nishimura Y, Nakajima M, Irimura T, Higashi N. The uptake of heparanase into mast cells is regulated by its enzymatic activity to degrade heparan sulfate. Int. J. Mol. Sci., 25, 6281, 2024. 
  86. Ishii T, Aijima A, Yokota N, Hirai K, Higashi K, Iwasaki Y, Ito R, Higashi N, Akiyama H. Development of an analytical method for unsaturated disaccharides from heparan sulfate using dansylhydrazine derivatization and high-performance liquid chromatography with fluorescence detection. Biol. Pharm. Bull., 47, 1054-1057, 2024.
  87. Sampei C, Hayata T. Druggable genes for therapeutic targeting in PTH signaling for osteoporosis. Expert Opin Ther Targets. 2024 Dec;28(12):1027-1029. Review.
  88. Fukui T, Terashima A, Omata Y, Chijimatsu R, Okamoto K, Tsukasaki M, Fukuda Y, Hayata T, Saitoh A, Toda E, Takayanagi H, Tanaka S, Terashima Y, Saito T. Disulfiram ameliorates bone loss in ovariectomized mice by suppressing osteoclastogenesis. T J Bone Miner Metab. 2025 Mar;43(2):61-73. 
  89. Takagi D, Tsukamoto S, Nakade K, Shimizu T, Arai Y, Matsuo-Takasaki M, Noguchi M, Nakamura Y, Yumoto N, Kawada J, Hayata T, Hayashi Y. Generation of MBP-tdTomato reporter human induced pluripotent stem cell line for live myelin visualization. Stem Cell Res. 2024 Sep:79:103493. 
  90. Arai Y, Ito H, Shimizu T, Shimoda Y, Song D, Matsuo-Takasaki M, Hayata T, Hayashi Y. Patient-derived and gene-edited pluripotent stem cells lacking NPHP1 recapitulate juvenile nephronophthisis in abnormalities of primary cilia and renal cyst formation. Front Cell Dev Biol. 2024;12:1370723. 
  91. Shirakawa J, Ntege EH, Takemura M, Miyamoto S, Kawano T, Sampei C, Kawabata H, Nakamura H, Sunami H, Hayata T, Shimizu Y. Exploring SSEA3 as an emerging biomarker for assessing the regenerative potential of dental pulp-derived stem cells. Regen Ther. 2024 Jun;26:71-79. 
  92. Sampei C, Kato K, Arasaki Y, Kimura Y, Konno T, Otsuka K, Kohara Y, Noda M, Ezura Y, Hayata T. Gprc5a is a novel parathyroid hormone-inducible gene and negatively regulates osteoblast proliferation and differentiation. J Cell Physiol. 2024 Aug;239(8):e31297. 
  93. Konno T, Murachi H, Otsuka K, Kimura Y, Sampei C, Arasaki Y, Kohara Y, Hayata T. Ctdnep1 phosphatase is required for negative regulation of RANKL-induced osteoclast differentiation in RAW264.7 cells. Biochem Biophys Res Commun. 2024 Jul 30;719:150063.
  94. Arasaki Y, Hayata T. The RNA-binding protein Cpeb4 regulates splicing of the Id2 gene in osteoclast differentiation. J Cell Physiol. 2024 Apr;239(4):e31197. 
  95. Sato, S., Sakashita, M., Kagami, R., & Wada, N. Air-liquid interface culture for live analysis of zebrafish vertebral growth. (2025). microPublication biology, 10.17912/micropub.biology.001199. (2025).
  96. Koinuma, S., Miyaji, M., Akiyama, S., Ito, Y., Takemura, H., Wada, N., Igarashi, M., & Nakamura, T. TC10 on endosomes regulates the local balance between microtubule stability and dynamics through the PAK2-JNK pathway and promotes axon outgrowth. J. Cell Sci., 138(4), JCS263636 (2025).
  97. Otsuka K, Sakashita A, Maezawa S, Schultz RM, Namekawa SH. KRAB zinc-finger proteins regulate endogenous retroviruses to sculpt germline transcriptomes and genome evolution. Genome Res. 2025 Mar 12;35(3):417–31.　　
  98. Kitamura Y, Takahashi K, Maezawa S, Munakata Y, Sakashita A, Katz SP, Kaplan N, Namekawa SH. CTCF-mediated 3D chromatin sets up the gene expression program in the male germline. Nat Struct Mol Biol. 2025 Mar 3. doi: 10.1038/s41594-025-01482-z. Epub ahead of print.
  99. Yi C, Kitamura Y, Maezawa S, Namekawa SH, Cairns BR. ZBTB16/PLZF regulates juvenile spermatogonial stem cell development through an extensive transcription factor poising network. Nat Struct Mol Biol. 2025 Mar 3. doi: 10.1038/s41594-025-01509-5. Epub ahead of print.
  100. Yoneyama Y, Zhang RR, Maezawa M, Masaki H, Kimura M, Cai Y, Adam M, Parameswaran S, Mizuno N, Bhadury J, Maezawa S, Ochiai H, Nakauchi H, Potter SS, Weirauch MT, Takebe T. Intercellular mRNA transfer alters the human pluripotent stem cell state. Proc Natl Acad Sci U S A. 2025 Jan 28;122(4):e2413351122.
  101. Maezawa S, Yukawa M, Sakashita A, Barski A, Namekawa SH. Site-specific DNA demethylation during spermatogenesis presets the sites of nucleosome retention in mouse sperm. bioRxiv [Preprint]. 2025 Jan 11:2025.01.10.632457.
  102. Hayashi Y, Kaneko J, Ito-Matsuoka Y, Takehara A, Funakoshi M, Maezawa S, Shirane K, Furuya S, Matsui Y. Control of epigenomic landscape and development of fetal male germ cells through L-serine metabolism.. iScience. 2024 Aug 9;27(9):110702.
  103. Iguchi H, Katsuzawa T, Saruta C, Sadakata T, Kobayashi S, Sato Y, Sato A, Sano Y, Maezawa S, Shinoda Y, Furuichi T. Calcium-dependent activator protein for secretion 2 is involved in dopamine release in mouse midbrain neurons. Front Mol Neurosci. 2024 Jul 18;17:1444629.
  104. Nakajima M, Motouchi S, Tanaka N, Masaike T. Enzymes that catalyze cyclization of β-1,2-glucans, Applied Microbiology and Biotechnology, 109, 49, 2024
  105. Takikawa, M., Nakano, A., Krishnaraj, J., Tabata, Y., Watanabe, Y., Okabe, A., Sakaguchi, Y., Fujiki, R., Mochizuki, A., Tajima, T., Sada, A., Matsushita, S., Wakabayashi, Y., Araki, K., Kaneda, A., Ishikawa, F., Sadaie, M., Ohki, R., Extrinsic induction of apoptosis and tumor suppression via the p53-Reprimo-Hippo-YAP/TAZ-p73 pathway, Proc. Natl. Acad. Sci. USA, 122, e2413126122, 2025
  106. Kojima, Y., Fujieda, S., Zhou, L., Takikawa, M., Kuramochi, K., Furuya, T., Mizumoto, A., Kagaya, N., Kawahara, T., Shin-ya, K., Dan, S., Tomida, A., Ishikawa, F., Sadaie, M., Cytochrome P450 2J2 is required for the natural compound austocystin D to elicit cancer cell toxicity, Cancer Sci., 115, 3054-3066, 2024
  107. Kanemaru K, Nagasawa K, Kunugi Y, Tanaka A, Ikeoku S, Tai Y, Harada Y, Nakamura Y. Epidermal loss of Bcl6 exacerbates MC903-induced atopic dermatitis-like skin inflammation. Biochem Biophys Res Commun 705, 149745
  108. Kabasawa M, Furuta M, Ibayashi Y, Kanemaru K, Kohatsu H, Kuramochi F, Yamatoya K, Nakata K, Nakamura Y, Tomoshige S, Ohgane K, Furuyama Y, Takasawa R, Kobayashi S, Sugawara F, Ikekita M, Kuramochi K. Plakevulin A induces apoptosis and suppresses IL-6-induced STAT3 activation in HL60 cells. Bioorg Med Chem Lett. 110, 129886, 2024
  109. Watanabe M, Haeno H, Mimaki S, Tsuchihara K. Multistage carcinogenesis in occupational cholangiocarcinoma: the impact of clonal expansion and risk estimation. Genes Environ. 2024 Oct 24;46(1):21. doi: 10.1186/s41021-024-00315-7.2024
  110. Sase M, Sato T, Sato H, Miya F, Zhang S, Haeno H, Kajita M, Noguchi T, Mori Y, Ohteki T. Comparative analysis of tongue cancer organoids among patients identifies the heritable nature of minimal residual disease. Dev Cell. 2024 Nov 2:S1534-5807(24)00607-5. doi: 10.1016/j.devcel.2024.10.007. Online ahead of print.2024
  111. Sakai SA, Saeki K, Chi S, Hamaya Y, Du J, Nakamura M, Hojo H, Kojima T, Nakamura Y, Bando H, Kojima M, Suzuki A, Suzuki Y, Akimoto T, Tsuchihara K, Haeno H, Yamashita R, Kageyama SI. Mathematical modeling predicts optimal immune checkpoint inhibitor and radiotherapy combinations and timing of administration. Cancer Immunol Res. 2024 Dec 12. doi: 10.1158/2326-6066.CIR-24-0610. Online ahead of print.2024
  112. Uryu H, Saeki K, Haeno H, Kapadia CD, Furudate K, Nangalia J, Chapman MS, Zhao L, Hsu JI, Zhao C, Chen S, Tanaka T, Li Z, Yang H, DiNardo C, Daver N, Pemmaraju N, Jain N, Ravandi F, Zhang J, Song X, Thompson E, Tang H, Little L, Gumbs C, Orlowski RZ, Qazilbash M, Bhalla K, Colla S, Kantarjian H, Shamanna RK, Ramos CB, Nakada D, Futreal PA, Shpall E, Goodell M, Garcia-Manero G, Takahashi K. Clonal evolution of hematopoietic stem cells after myeloma targeting chemotherapy and autologous stem cell transplantation. Nat Genet Accepted.2025 
  113. Oikawa T, Hasegawa J, Handa H, Ohnishi N, Onodera Y, Hashimoto A, Sasaki J, Sasaki T, Ueda K, Sabe H: p53 ensures the normal behavior and modification of G1/S-specific histone H3.1 in the nucleus. Life Sci Alliance 7, e202402835, 2024 
  114. Kawai T, Morioka S, Miyata H, Andriani RT, Akter S, Toma G, Nakagawa T, Oyama Y, Iida-Norita R, Sasaki J, Watanabe M, Sakimura K, Ikawa M, Sasaki T, Okamura Y: The significance of electrical signals in maturing spermatozoa for phosphoinositide regulation through voltage-sensing phosphatase. Nature Commun. 15, 7289, 2024 
  115. Tsuji T, Hasegawa J, Sasaki T, Fujimoto T: Definition of phosphatidylinositol 4,5-bisphosphate distribution by freeze-fracture replica labeling. J Cell Biol. 224, e202311067, 2025 
  116. Ogawa Y, Tsuchiya I, Yanai S, Baba T, Morohashi KI, Sasaki T, Sasaki J, Terao M, Tsuji-Hosokawa A, Takada S: GATA4 binding to the Sox9 enhancer mXYSRa/Enh13 is critical for testis differentiation in mouse. Commun Biol. 8 (1):81. doi: 10.1038/s42003-025-07504-2, 2025 
  117. Wu JZ, Pemberton JG, Morioka S, Sasaki J, Bablani P, Sasaki T, Balla T, Grinstein S, Freeman SA: Sorting nexin 10 regulates lysosomal ionic homeostasis via ClC-7 by controlling PI(3,5)P2. J Cell Biol. 224, e202408174, 2025
  118. Nishio M, Yamaguchi K, Otani J, Yuguchi K, Kohno D, Sasaki T, Kitamura T, Shinohara M, Soga T, Kawamura K, Sasaki AT, Oshima M, Hikasa H, Woo M, Sasaki T, Nishina H, Nakao K, Maehama T, Suzuki A. Mob1 deletion in murine mature adipocytes ameliorates obesity and diabetes. Proc. Natl. Acad. Sci. USA. in press
  119. Kofuji S, Wolfe K, Sumita K, Kageyama S, Yoshino H, Hirota Y, Ogawa-Iio A, Kanoh H, Sasaki M, Kofuji K, Davis MI, Pragani R, Shen M, Boxer MB, Nakatsu F, Nigorikawa K, Sasaki T, Takeuchi K, Senda T, Kim SM, Sasaki AT. A high dose KRP203 induces cytoplasmic vacuoles associated with altered phosphoinositide segregation and endosome expansion. Biochem Biophys Res Commun, 718:149981, 2024 
  120. Takeuchi K, Nagase L, Kageyama S, Kanoh H, Oshima M, Ogawa-Iio A, Ikeda Y, Fujii Y, Kondo S, Osaka N, Masuda T, Ishihara T, Nakamura Y, Hirota Y, Sasaki T, Senda T, Sasaki AT. PI5P4K inhibitors: promising opportunities and challenges. FEBS J. 2025 Jan 19. doi: 10.1111/febs.17393. 
  121. Noda Y, Taniguchi K, Takano M, Mimura Y, Yanagisawa N, Hayano M, Kitahata R, Ogawa Y, Mimura M, Tsubota K. Violet light photobiomodulation therapy for depression: A double-blind randomized crossover trial. J Affect Disord. 2025 Feb 15;376:325-332.