Sato K, Miura K, Tamori S, Akimoto K, Identification of a Gene Expression Signature to Predict the Risk of Early Recurrence and the Degree of Immune Cell Infiltration in Triple-negative Breast Cancer, Cancer Genomics Proteomics 21,316-326(2024). doi: 10.21873/cgp.20450.
Matsuoka I, Kasai T, Onaga C, Ozaki A, Motomura H, Maemura Y, Tada Y, Mori H, Hara Y, Xiong Y, Sato K, Tamori S, Sasaki K, Ohno S, Akimoto K, Co‑expression of SLC20A1 and ALDH1A3 is associated with poor prognosis, and SLC20A1 is required for the survival of ALDH1‑positive pancreatic cancer stem cells, Oncol Lett. 28, 426 (2024).doi:10.3892/ol.2024.14558.
2023年度（6件）
Ozaki A, Matsuda A, Maemura Y, Tada Y, Kasai T, Nagashima Y, Onaga C, Hara Y, Kitabatake K, Tsukimoto M, Tamori S, Sasaki K, Ohno S, Akimoto K. Luminal B Breast Cancer Coexpressing p62 and ALDH1A3 Is Less Susceptible to Radiotherapy, Anticancer Res. 4, 37-47(2024).
Maeda-Minami A, Nishikawa T, Ishikawa H, Mutoh M, Makishima Y, Matsuyama Y, Akimoto K, Mano Y, Uemura H. Angiotensin II Receptor Blockers Cause Changes in Prostate-specific Antigen Levels: A Retrospective Cohort Study, Anticancer Res. 43, 5629-5636(2023).
Kasai T, Tamori S, Takasaki Y, Matsuoka I, Ozaki A, Matsuda C, Harada Y, Sasaki K, Ohno S, Akimoto K. High expression of PKCλ and ALDH1A3 indicates a poor prognosis, and PKCλ is required for the asymmetric cell division of ALDH1A3-positive cancer stem cells in PDAC. Biochem Biophys Res Commun. 2023 Aug 20;669:85-94. doi: 10.1016/j.bbrc.2023.05.086.
Okamoto T, Onaga C, Matsuoka I, Ozaki A, Matsuda C, Kasai T, Xiong Y, Harada Y, Sato T, Nakano Y, Mano Y, Miyazaki S, Ishiguro H, Sato K, Tamori S, Sasaki K, Ohno S, Akimoto K. High SLC20A1 Expression Indicates Poor Prognosis in Prostate Cancer. Cancer Diagn Progn. 2023 Jul 3;3(4):439-448. doi: 10.21873/cdp.10237.
Ayako Maeda-Minami, Tomoki Nishikawa, Hideki Ishikawa, Michihiro Mutoh, Kazunori Akimoto, Yutaka Matsuyama, Yasunari Mano* & Hiroji Uemura, Association of PSA variability with prostate cancer development using large-scale medical information data: a retrospective cohort study, Genes and Environment, 45:25, 2023.
Tai Y, Sakaida Y, Kawasaki R, Kanemaru K, Akimoto K, Brombacher F, Ogawa S, Nakamura Y, Harada Y. Foxp3 and Bcl6 deficiency synergistically induces spontaneous development of atopic dermatitis-like skin disease, Int Immunol. 2023 Sep 5;35(9):423-435. doi: 10.1093/intimm/dxad018.
2022年度（4件）
Yuyun, X, Motomura, H., Tamori, S., Ozaki, A., Onaga, C, Hara, Y., Sato, K., Tahata, K., Harada, Y., Sasaki, K., Yunwen, Z., Ohno, S., Akimoto, K. High expression of CD58 and ALDH1A3 predicts a poor prognosis in basal-like breast cancer, Anticancer Res., 42:5223-5232, (2022).
Ayaka Ozaki , Hitomi Motomura , Shoma Tamori, Chotaro Onaga , Yuka Nagashima , Maho Kotori , Chika Matsuda, Akari Matsuda, Nanako Mochizuki , Tsugumichi Sato , Yasushi Hara , Keiko Sato, Yohei Miyagi, Yoji Nagashima, Takehisa Hanawa , Yohsuke Harada, Yuyun Xiong , Kazunori Sasaki, Shigeo Ohno, Kazunori Akimoto, High Expression of p62 and ALDH1A3 Is Associated With Poor Prognosis in Luminal B Breast Cancer. Anticancer Res. 42(7):3299-3312. doi: 10.21873/anticanres.15818.
Chotaro Onaga , Shoma Tamori , Izumi Matsuoka, Ayaka Ozaki, Hitomi Motomura , Yuka Nagashima, Tsugumichi Sato, Keiko Sato, Kouji Tahata, Yuyun Xiong , Yoshio Nakano, Yasunari Mano, Satoru Miyazaki, Kazunori Sasaki , Shigeo Ohno, Kazunori Akimoto, High SLC20A1 Expression Is Associated With Poor Prognosis
for Radiotherapy of Estrogen Receptor-positive Breast Cancer. Cancer Diagn
Progn, 2(4):429-442, 2022, doi: 10.21873/cdp.10126.
Chotaro
Onaga, Shoma Tamori, Izumi Matsuoka, Ayaka Ozaki, Hitomi Motomura, Yuka
Nagashima, Tsugumichi Sato, Keiko Sato, Yuyun Xiong, Kazunori Sasaki, Shigeo
Ohno, Kazunori Akimoto, High expression of SLC20A1 is less effective for
endocrine therapy and predicts late recurrence in ER-positive breast cancer. PLoS
One. 17(5): e0268799, doi:
10.1371/journal.pone.0268799.
2021年度（5件）
Li-Ping Liu, Dong-Xu Zheng, Zheng-Fang Xu, Hu-Cheng Zhou, Yun-Cong
Wang, Hang Zhou, Jian-Yun Ge, Daisuke Sako, Mi Li, Kazunori Akimoto, Yu-Mei Li,
and Yun-Wen Zheng. Transcriptomic and Functional Evidence Show Similarities
between Human Amniotic Epithelial Stem Cells and Keratinocytes. Cells. 11(1):70,
2022, doi: 10.3390/cells11010070.
Sayaka Nagamoto, Miyuki Agawa, Emi Tsuchitani, Kazunori Akimoto,
Saki Kondo, and Yumi Kanegae. Short term but highly efficient Cas9
expression mediated by excisional system using adenovirus vector and Cre. Scientific
Reports 11(1): 24369, 2021, doi: 10.1038/s41598-021-03803-w
Yuji Kuramochi, Tomonari Awaya, Mami Matsuo-Takasaki, Miho Takami,
Yuri An, Jingyue Li, Yasuko Hemmi, Tamami Wakabayashi, Yutaka Arai, Jun Inoue,
Michiya Noguchi, Yukio Nakamura, Isao Asaka, Kazunori Akimoto, Megumu K. Saito,
Yohei Hayashi. Generation of two human induced pluripotent stem cell lines
derived from two X-linked adrenoleukodystrophy patients with ABCD1 mutations. Stem
Cell Research 53:102337, 2021, doi: 10.1016/j.scr.2021.102337.
Hitomi Motomura, Ayaka Ozaki, Shoma Tamori, Chotaro Onaga, Yuka
Nozaki, Yuko Waki, Ryoko Takasawa, Kazumi Yoshizawa, Yasunari Mano, Tsugumichi
Sato, Kazunori Sasaki, Hitoshi Ishiguro, Yohei Miyagi, Yoji Nagashima, Kouji
Yamamoto, Keiko Sato, Takehisa Hanawa, Sei-ichi Tanuma, Shigeo Ohno and Kazunori
Akimoto. Glyoxalase 1 and protein kinase Cλ as potential therapeutic targets
for late-stage breast cancer. Oncology Letters 22(1):547, 2021, doi: 10.3892/ol.2021.12808.
2020年度（4件）
Onaga C, Tamori S, Motomura H, Ozaki A,
Matsuda C, Matsuoka I, Fujita T, Nozaki Y, Hara Y, Kawano Y, Harada Y, Sato T,
Mano Y, Sato K, Akimoto K. High SLC20A1
expression is associated with poor prognoses in claudin-low and basal-like
breast cancers. Anticancer Res. 41(1): 43-54, 2021 doi: 10.21873/anticanres.14750.
Nozaki
Y, Motomura H, Tamori S, Kimura Y, Onaga C, Kanai S, Ishihara Y, Ozaki A, Hara
Y, Harada Y, Mano Y, Sato T, Sato K, Sasaki K, Ishiguro H, Ohno S, Akimoto K. High
PKCλ expression is required for ALDH1- positive cancer stem cell function and
indicates a poor clinical outcome in late-stage breast cancer patients. PLoS
One. 15(7): e0235747, 2020, doi: 10.1371/journal.pone.0235747.
Sato K, Tahata K, Akimoto K : Five Genes Associated With Survival
in Patients With Lower-grade Gliomas Were Identified by Information-theoretical
Analysis. Anticancer Res. 40(5): 2777-2875, 2020 doi: 10.21873/anticanres.14250.
Kobayashi M, Ishizaki Y, Owaki M, Matsumoto Y, Kakiyama Y, Hoshino
S, Tagawa R, Sudo Y, Okita N, Akimoto K, Higami Y. Nutlin-3a suppresses poly
(ADP-ribose) polymerase 1 by mechanisms different from conventional PARP1
suppressors in a human breast cancer cell line. Oncotarget 11(18): 1653-1655,
2020, doi: 10.18632/oncotarget.27581.
2019年度（3件）
Hitomi Motomura, Yuka Nozaki, Chotaro Onaga, Ayaka Ozaki, Shoma
Tamori, Taka-aki Shiina, Shotaro Kanai, Chihiro Ohira, Yasushi Hara, Yohsuke
Harada, Ryoko Takasawa, Takehisa Hanawa, Sei-Ichi Tanuma, Yasunari Mano,
Tsugumichi Sato, Keiko Sato and Kazunori Akimoto. High Expression of c-Met , PKCλ and ALDH1A3 Predicts a Poor
Prognosis in Late-stage Breast Cancer. Anticancer Res. 40(1):35-52, 2020, doi:10.21873/anticanres.13924.
Kinji Furuya, Yun-Wen Zheng, Daisuke Sako, Kenichi Iwasaki,
Dong-Xu Zheng, Jian-Yun Ge, Li-Ping Liu, Tomoaki Furuta, Kazunori Akimoto,
Hiroya Yagi, Hiromi Hamada, Hiroko Isoda, Tatsuya Oda and Nobuhiro Ohkohchi.
Enhanced hepatic differentiation in the subpopulation of human amniotic stem
cells under 3D multicellular microenvironment. World Journal of Stem Cells 11(9):705-721.
2019. doi: 10.4252/wjsc.v11.i9.705.
Aya Tokinaga-Uchiyama, Taichi Mizushima, Kazunori
Akimoto, Yoji Nagashima, Kazunori Sasaki, Masa-aki Nakaya, Kenichi
Ohashi, Kazumi Kubota, Yasuyo Maruyama, Hisamori Kato, Fumiki Hirahara, Etsuko
Miyagi, Shigeo Ohno, Mikiko Asai-Sato. Aberrant nuclear localization of aPKCλ/ι
is associated with poorer prognosis in uterine cervical cancer. Int. J. Gynecol. Pathol. 38(4):301-309, 2019,
doi: 10.1097/PGP.0000000000000539.
2018年度（4件）
Babita Shashni, Hidehiko Matsuura, Riku Saito, Takuma Hirata,
Shinya Ariyasu, Kenta Nomura, Hiroshi Takemura, Kazunori
Akimoto, Naoyuki Aikawa, Atsuo Yasumori and Shin Aoki. Simple and
Convenient Method for the Isolation, Culture, and Re-collection of Cancer Cells
from Blood by Using Glass-Bead Filters. ACS Biomaterials Science & Engineering 5(2):438-452, 2019, doi: 10.1021/acsbiomaterials.8b01335.
Junichi Baba, Mitomu Kioi, Kazunori
Akimoto, Yoji Nagashima, Masataka Taguri, Yoshiaki Inayama, Ichiro Aoki,
Shigeo Ohno, Kenji Mitsudo and Iwai Tohnai. Atypical Protein Kinase C λ/ι
Expression is Associated with Malignancy of Oral Squamous Cell Carcinoma. Anticancer Research 38(11):6291–6297, 2018, doi: 10.21873/anticanres.12985.
Shoma Tamori, Yuka Nozaki, Hitomi Motomura, Hiromi Nakane, Reika
Katayama, Chotaro Onaga, Eriko Kikuchi, Nami Shimada, Yuhei Suzuki, Mei Noike,
Yasushi Hara, Keiko Sato, Tsugumichi Sato, Kouji Yamamoto, Takehisa Hanawa,
Misa Imai, Ryo Abe, Atsushi Yoshimori, Ryoko Takasawa, Sei-Ichi Tanuma and Kazunori Akimoto. Glyoxalase
1 gene is highly expressed in basal-like human breast cancers and contributes to
survival of ALDH1-positive breast cancer stem cells. Oncotarget 9(92):36515-36529, 2018,
doi: 10.18632/oncotarget.26369.
Babita Shashni, Shinya Ariyasu, Reisa Takeda, Toshihiro Suzuki,
Shota Shiina, Kazunori Akimoto, Takuto Maeda, Naoyuki Aikawa,
Ryo Abe, Tomorhiro Osaki, Norihiko Itoh, and Shin Aoki. Size-based
Differentiation of Cancer and Normal Cells by a Particle Size Analyzer Assisted
by a Cell-recognition PC Software. Biological
and Pharmaceutical Bulletin 41(4):487-503, 2018, doi: 10.1248/bpb.b17-00776.
2017年度（2件）
Yuka Nozaki, Shoma Tamori, Masahiro Inada, Reika Katayama, Hiromi
Nakane, Osamu Minamishima, Yuka Onodera, Makoto Abe, Shota Shiina, Kei Tamura,
Daichi Kodama, Keiko Sato, Yasushi Hara, Ryo Abe, Ryoko Takasawa, Atsushi
Yoshimori, Nariyoshi Shinomiya, Sei-ichi Tanuma and Kazunori Akimoto. Correlation
between c-Met and ALDH1 contributes to the survival and tumor-sphere formation
of ALDH1 positive breast cancer stem cells and predicts poor clinical outcome
in breast cancer. Genes & Cancer, 8(7-8):628-639, 2017, doi: 10.18632/genesandcancer.148.
Keiko Sato and Kazunori Akimoto. Expression Levels of KMT2C and
SLC20A1 identified by information-theoretical analysis are powerful prognostic
biomarkers in ER-positive breast cancer. Clinical Breast Cancer
17(3):e135-e142, 2017, doi: 10.1016/j.clbc.2016.11.005.
2015年度（4件）
Sasaki K, Kakuwa T, Akimoto K, Koga H, Ohno S. Regulation of
epithelial cell polarity by PAR-3 depends on Girdin transcription and
Girdin-Gαi3 signaling. J Cell Sci. 128(13):2244-58. 2015, doi:
10.1242/jcs.160879.
Osada SI, Minematsu N, Oda F, Akimoto K, Kawana S, Ohno S. Atypical Protein Kinase C Isoform, aPKCλ, Is Essential for
Maintaining Hair Follicle Stem Cell Quiescence. J Invest Dermatol.
135(11):2584-2592. 2015, doi: 10.1038/jid.2015.222.
Metz PJ, Lopez J, Kim SH, Akimoto K, Ohno S, Chang JT.
Regulation of Asymmetric Division by Atypical Protein Kinase C Influences Early
Specification of CD8(+) T Lymphocyte Fates. Sci Rep. 6:19182. 2016, doi:
10.1038/srep19182.
Mizushima T, Asai-Sato M, Akimoto K, Nagashima Y, Taguri M,
Sasaki K, Nakaya MA, Asano R, Tokinaga A, Kiyono T, Hirahara F, Ohno S, Miyagi
E. Aberrant Expression of the Cell Polarity Regulator aPKCλ/ι is Associated
With Disease Progression in Cervical Intraepithelial Neoplasia (CIN): A
Possible Marker for Predicting CIN Prognosis. Int J Gynecol Pathol. 35(2):106-17.
2016, doi: 10.1097/PGP.0000000000000228.
2014年度（3件）
Ichikawa Y, Nagashima Y, Morioka K, Akimoto K, Kojima Y,
Ishikawa T, Goto A, Kobayashi N, Watanabe K, Ota M, Fujii S, Kawamata M,
Takagawa R, Kunizaki C, Takahashi H, Nakajima A, Maeda S, Shimada H, Inayama Y,
Ohno S, Endo I. Colorectal laterally spreading tumors show characteristic
expression of cell polarity factors, including atypical protein kinase C λ/ι,
E-cadherin, β-catenin and basement membrane component. Oncol Lett.
8(3):977-984. 2014, doi: 10.3892/ol.2014.2271.
Okayama A, Miyagi Y, Oshita F, Nishi M, Nakamura Y, Nagashima
Y, Akimoto K, Ryo A, Hirano H. Proteomic analysis of proteins related to
prognosis of lung adenocarcinoma. J Proteome Res. 13(11):4686-94. 2014,
doi: 10.1021/pr4012969.
Metz PJ, Arsenio J, Kakaradov B, Kim SH, Remedios KA, Oakley
K, Akimoto K, Ohno S, Yeo GW, Chang JT. Regulation
of asymmetric division and CD8+ T lymphocyte fate specification by protein
kinase Cζ and protein kinase Cλ/ι. J Immunol. 194(5):2249-59. 2015, doi:
10.4049/jimmunol.1401652.
2013年度（4件）
Yamanaka T, Tosaki A, Kurosawa M, Akimoto K, Hirose T, Ohno
S, Hattori N, Nukina N. Loss of aPKCλ in differentiated neurons disrupts the
polarity complex but does not induce obvious neuronal loss or disorientation in
mouse brains. PLoS One. 8(12):e84036. 2013, doi:
10.1371/journal.pone.0084036. eCollection 2013.
Hirate Y, Hirahara S, Inoue K, Suzuki A, Alarcon VB, Akimoto
K, Hirai T, Hara T, Adachi M, Chida K, Ohno S, Marikawa Y, Nakao K, Shimono A,
Sasaki H. Polarity-dependent
distribution of angiomotin localizes Hippo signaling in preimplantation
embryos. Curr Biol. 23(13):1181-94. 2013, doi:
10.1016/j.cub.2013.05.014. Epub 2013 Jun 20.
Kato
S, Akimoto K, Nagashima Y, Ishiguro H, Kubota K, Kobayashi N, Hosono K,
Watanabe S, Sekino Y, Sato T, Sasaki K, Nakaigawa N, Kubota Y, Inayama Y, Endo
I, Ohno S, Maeda S, Nakajima A. aPKCλ/ι
is a beneficial prognostic marker for pancreatic neoplasms. Pancreatology,
13(4):360-8. 2013, doi: 10.1016/j.pan.2013.05.006.
Suzuki M, Yamanoi A, Machino Y, Kobayashi E, Fukuchi K, Tsukimoto
M, Kojima S, Kohroki J, Akimoto K, Masuho Y. Cleavage of the interchain
disulfide bonds in rituximab increases its affinity for FcγRIIIA. Biochem
Biophys Res Commun. 436(3):519-24. 2013, doi: 10.1016/j.bbrc.2013.05.137.
2012年度（2件）
Yoshihama Y, Izumisawa Y, Akimoto K, Satoh Y, Mizushima T,
Satoh K, Chida K, Takagawa R, Akiyama H, Ichikawa Y, Kunisaki C, Inayama Y,
Endo I, Nagashima Y, Ohno S. High
expression of KIBRA in low atypical protein kinase C-expressing gastric cancer
correlates with lymphatic invasion and poor prognosis, Cancer Sci.
104(2):259-65. 2013, doi: 10.1111/cas.12066.
Yoshihama Y, Izumisawa Y, Akimoto K(corresponding author), Satoh
Y, Mizushima T, Satoh K, Chida K, Takagawa R, Akiyama H, Ichikawa Y, Kunisaki
C, Inayama Y, Endo I, Nagashima Y, Ohno S. KIBRA-aPKC Connection: High
expression of KIBRA in High Invasion and Poor Prognosis. Overexpression of the
aPKC-binding region of KIBRA affects tight junction formation in epithelial
cells. Cancer Sci. 104(2):1-1, 2013. doi: 10.1111/CAS.12069.
学会発表
2024年度（口頭発表1件）
Identification of a Gene Expression Signature to Predict the Risk of Early Recurrence and the Degree of Immune Cell Infiltration in Triple-negative Breast Cancer, Keiko Sato, Kentaro Miura, Shoma Tamori, Kazunori Akimoto, QBIC Small Workshop on Bio-information, Noda campus, Tokyo University of Science, 2024年4月,（口頭発表）国際会議
2023年度（口頭発表・招待・特別1件、口頭発表4件、ポスター発表8件）
Mutual information-based screening identifies gene signature for late recurrence in luminal A breast cancer, Shoma Tamori, Keiko Sato, Kazunori Sasaki, Shigeo Ohno, Kazunori Akimoto, The 10th International Postgraduate Conference on Pharmaceutical Sciences 2024, TUS, Noda, Japan, 2024年3月, (口頭発表)招待・特別, 国際会議
Identification of prognostic genes related to nuclear localized aPKCλ/ι in cervical squamous cell carcinoma, Ryosuke Chiwaki, Kazunori Sasaki, Taichi Mizushima, Kazunori Akimoto, Shigeo Ohno, The 10th International Postgraduate Conference on Pharmaceutical Sciences 2024, TUS, Noda, Japan, 2024年3月,（ポスター発表）国際会議
Analysis of PKCλ-dependent expression of glycolysis related molecules in triple-negative breast cancer, Yuna Tada, Ayaka Ozaki, Akari Matsuda, Yuki Maemura, Masaki Ishii, Shoma Tamori, Kazunori Sasaki, Shigeo Ohno and Kazunori Akimoto, The 10th International Postgraduate Conference on Pharmaceutical Sciences 2024, TUS, Noda, Japan, 2024年3月,（ポスター発表）国際会議
Screening of natural compounds regulating in vitro tumor-sphere formation of ALDH1 positive cancer stem cells, Haruka Mori, Shoma Tamori, Hideyuki Muramatsu, Masayuki Igarashi, Kazunori Sasaki, Shigeo Ohno, Kazunori Akimoto, The 10th International Postgraduate Conference on Pharmaceutical Sciences 2024, TUS, Noda, Japan, 2024年3月,（ポスター発表）国際会議
Analysis of the acquisition mechanism of cancerous heterogeneity generating by asymmetric cell division of cancer stem cells, Takahiro Kasai, Shoma Tamori, Yuta Takasaki, Kazunori Sasaki, Shigeo Ohno, Kazunori Akimoto, The 10th International Postgraduate Conference on Pharmaceutical Sciences 2024, TUS, Noda, Japan, 2024年3月,（口頭発表）国際会議★The best oral presentation award受賞
PKCλ involves to the regulation for asymmetric cell division of pancreatic cancer stem cells, Takahiro Kasai, Shoma Tamori, Yuta Takasaki, Kazunori Sasaki, Shigeo Ohno, Kazunori Akimoto, The 41st Sapporo International Cancer Symposium Cancer Organoids: Domain Expansion, Tokyo, 2023年10月（ポスター発表）国際会議.
PKCλ involves to the regulation for asymmetric cell division of pancreatic cancer stem cells、Takahiro Kasai, Shoma Tamori, Yuta Takasaki, Kazunori Sasaki, Shigeo Ohno, Kazunori Akimoto、第82回日本癌学会学術総会、横浜市、2023年 9月（ポスター発表）
High expression of CD58 and ALDH1A3 predicts a poor prognosis in basal-like breast cancer, Y Xiong, H Motomura, S Tamori, A Ozaki, C Onaga, Y Hara, K Sato, K Tahata, Y Harada, K Sasaki, Y Zheng, S Ohno, K Akimoto, ISSCR 2023 Annual Meeting, Boston, 2023年6月，（口頭発表）国際会議
NEW APPROACH FOR BREAST CANCER
STRATIFICATION BASED ON CANCER GENOMICS DB, Kazunori Akimoto, The 9th
International Postgraduate Conference on Pharmaceutical Sciences 2022,
Malaysia, IMU, 2022年6月．（口頭発表）基調講演
High expression of p62 and ALDH1A3 is
associated with poor prognosis in luminal B breast cancer, Ayaka Ozaki, Shoma
Tamori, Kazunori Akimoto, The 9th International Postgraduate Conference on
Pharmaceutical Sciences 2022, Malaysia, IMU, 2022年6月．（口頭発表）
High expression of SLC20A1 is less
effective for endocrine therapy and predicts late recurrence in ER-positive
breast cancer, Chotaro Oaga, Shoma Tamori, Kazunori Akimoto, The 9th
International Postgraduate Conference on Pharmaceutical Sciences 2022, Malaysia,
IMU, 2022年6月. （口頭発表）★The best oral presentation award受賞
p62とALDH1A3遺伝子共高発現Luminal B型乳癌は予後不良である High p62 and
ALDH1A3 expressions are associated with poorprognosis in Luminal B breast
cancer, 尾崎 綾栞、多森
翔馬、本村 瞳、翁長 朝太郎、長島 佑夏、小鳥 真歩、松田 あかり、望月菜々子、佐々木 和教、大野 茂男、秋本 和憲, 日本薬学会第142年会, 名古屋, 2022年3月．（口頭発表）
がんゲノミクスデータ解析を起点とした無機リン酸共輸送体SLC20A1のALDH1陽性膵臓がん幹細胞における役割解析 Analysis of the role
of SLC20A1 in ALDH1 positive pancreatic cancer stem cells based on cancer
genomics data, 松岡 泉、翁長 朝太郎、多森 翔馬、石井 雅貴、佐藤 圭子、佐々木 和教、大野 茂男、秋本 和憲, 日本薬学会第142年会, 名古屋, 2022年3月. （口頭発表）
がんゲノミクスデータ解析によるProtein Kinase C ζ（PKCζ）の乳がん幹細胞における役割の解析 Analysis of the role
of Protein Kinase C ζ(PKCζ) in ALDH1 positivebreast cancer stem cells based on
cancer genomics data, 長島 佑夏、多森 翔馬、本村 瞳、尾﨑 綾栞、翁長 朝太郎、佐々木 和教、大野 茂男、秋本 和憲, 日本薬学会第142年会, 名古屋, 2022年3月．（口頭発表）
Design and Synthesis of Optically Pure
Triscyclometalated Iridium(III) Complex-Peptide Hybrids for the Use in
Biological and Material Sciences, Azusa Kanbe, Kenta Yokoi Seiya Nakagawa,
Tomohiro Tanaka, Hitomi Motomura, Kazunori Akimoto and Shin Aoki, Azusa Kanbe,
Kenta Yokoi Seiya Nakagawa, Tomohiro Tanaka, Hitomi Motomura, Kazunori Akimoto
and Shin Aoki, Online (Honolulu), 2021年12月．（ポスター発表）
Glyoxalase 1 and protein kinase Cλ as
potential therapeutic targets for late-stage breast cancer, 本村 瞳、尾崎 綾栞、多森 翔馬、野崎 優香、高澤 涼子、佐々木 和教、石黒 斉、宮城 洋平、長嶋 洋治、田沼
靖一、大野 茂男、秋本 和憲, 第80回日本癌学会学術総会, 横浜 パシフィコ横浜, 2021年9月. （ポスター発表）
High PKCλ expression is required for
asymmetric cell division of ALDH1-positive cancer stem cells and indicates poor
clinical outcome in late-stage breast cancer patients, Tamori S., Nozaki Y.,
Motomura H., Onaga C., Ozaki A., Sasaki K., Ohno S., Akimoto K. International
Research Network Initiative (IRNI) & International Postgraduate Conference
on Pharmaceutical Sciences (IPoPS) 2021, Malaysia (Zoom webinar), 2021年9月．（口頭発表）
High SLC20A1 expression is associated with
poor prognosis in claudin-low and basal-like breast cancers, Onaga C., Tamori
S., Motomura H., Ozaki A., Matsuda C., Matsuoka I., Fujita T., Nozaki Y., Hara
Y., Kawano Y., Harada Y., Sato T., Mano Y., Sato K., Akimoto K. International
Research Network Initiative (IRNI) & International Postgraduate Conference
on Pharmaceutical Sciences (IPoPS) 2021, Malaysia, 2021年9月.（口頭発表）
High p62 and ALDH1A3 expressions are
associated with poor prognosis in luminal B breast cancer, Ozaki A., Motomura
H., Tamori S., Onaga C., Matsuda C., Matsuda A., Mochizuki N., Sasaki K., Ohno
S., Akimoto K., International Research Network Initiative (IRNI) &
International Postgraduate Conference on Pharmaceutical Sciences (IPoPS) 2021, Malaysia,
2021年9月.（口頭発表）
Glyoxalase 1 and protein kinase Cl as
potential therapeutic targets for late-stage breast cancer, Motomura
H., Ozaki A., Tamori S., Onaga C., Nozaki Y., Akimoto K., International
Research Network Initiative (IRNI) & International Postgraduate Conference
on Pharmaceutical Sciences (IPoPS) 2021, Malaysia, 2021年9月.（口頭発表）
Glyoxalase 1 and protein kinase Cλ as
potential therapeutic targets for late-stage breast cancer, Hitomi
Motomura-Shiina, Ayaka Ozaki, Shoma Tamori, Chotaro Onaga, Yuka Nozaki and
Kazunori Akimoto, 7TH EDITION - WEBINAR ON BREAST CANCER, WEBINAR, 2021年7月. （口頭発表）
2020年度（口頭発表7件,ポスター発表1件）
PKCλ高発現はALDH1A3陽性乳癌幹細胞の非対称分裂能に関与する High PKCλ
expression is required for asymmetric cell division of ALDH1A3-positive breast
cancer stem cell, 多森 翔馬、野崎 優香、本村 瞳、翁長 朝太郎、尾﨑 綾栞、佐々木 和教、大野 茂男、秋本 和憲, 第141回 日本薬学会年会, 広島 オンライン開催, 2021年3月.（口頭発表）
TNBC型乳癌においてPKCλとGATA4のタンパク質発現は逆相関し、PKCλタンパク質高発現かつGATA4タンパク質低発現患者は予後不良である Inverse correlation between PKCλ and GATA4 at protein level
indicates poorer clinical outcomes in TNBC patients, 尾崎 綾栞、多森 翔馬、今岡 宏太朗、山口
淳三、樋上 賀一、秋本 和憲, 第141回 日本薬学会年会, 広島 オンライン開催, 2021年3月.（口頭発表）★優秀口頭発表賞
Claudin-low型、Basal-like型乳がんにおけるSLC20A1高発現は乳がん患者の予後不良に関与する High SLC20A1 Expression is Associated with Poor Prognoses in
Claudin-low and Basal-like Breast Cancers, 翁長 朝太郎、多森 翔馬、本村 瞳、尾﨑 綾栞、松田 千佳、松岡
泉、藤田 拓真、野崎 優香、原 泰志、河野 洋平、原田 陽介、佐藤 嗣道、真野 泰成、佐藤 圭子、秋本 和憲, 第141回 日本薬学会年会, 広島 オンライン開催, 2021年3月.（口頭発表）
ステージIII-IV乳癌におけるGLO 1 - PKCλ共発現患者は予後不良である Correlation
between Glyoxalase 1 and Protein kinase C λ is predictive of poor clinical
outcomes in late-stage breast cancer, 本村 瞳、尾﨑 綾栞、多森 翔馬、翁長 朝太郎、野崎 優香、和氣 由布子、高澤
涼子、吉澤 一巳、真野 泰成、佐藤 嗣道、佐々木 和教、石黒 斉、宮城 洋平、長嶋 洋治、山本 紘司、佐藤 圭子、花輪 剛久、田沼 靖一、大野 茂男、秋本 和憲, 第141回 日本薬学会年会, 広島 オンライン開催, 2021年3月.（口頭発表）
Correlation between Glyoxalase 1 and PKCλ
is predictive of poor clinical outcomes in late-stage breast cancer ステージIII-IV乳癌におけるGLO 1 - PKCλ共発現患者は予後不良である, 本村 瞳、尾崎 綾栞、多森
翔馬、野崎 優香、高澤 涼子、佐々木 和教、石黒 斉、宮城 洋平、長嶋 洋治、田沼 靖一、大野 茂男、秋本 和憲, 第79回日本癌学会学術総会, 広島,
2020年10月（ポスター発表）.
がんゲノムデータベースを用いた様々ながん種におけるSLC20A1遺伝子の予後予測因子としての可能性の検討High expression of SLC20A1 gene indicates poor prognoses in various
cancer types, 翁長朝太郎、多森翔馬、本村瞳、藤田拓真、真野泰成、佐藤嗣道、田畑耕治、佐藤圭子、秋本和憲, 日本薬学会 第140年会, 京都, 2020年3月.（ポスター発表）
High Expression of c-Met, PKCλ and ALDH1A3
Predicts a Poor Prognosis in Late-stage Breast Cancer, Hitomi Motomura, Yuka
Nozaki, Chotaro Onaga, Ayaka Ozaki, Shoma Tamori, Taka-aki Shiina, Shotaro
Kanai, Chihiro Ohira, Yasushi Hara, Yohsuke Harada, Ryoko Takasawa, Takehisa
Hanawa, Sei-ichi Tanuma, Yasunari Mano, Tsugumichi Sato, Keiko Sato, Kazunori
Akimoto, 7th International Postgraduate Conference on Pharmaceutical Sciences
(iPoPs2020), Noda, Chiba, Japan, 2020年2月.（ポスター発表）
High PKCλ expression is required for
ALDH1-positive cancer stem cell function and indicates a poor clinical outcome
in late-stage breast cancer patients, Yuka Nozaki, Hitomi Motomura, Shoma
Tamori, Yumiko Kimura, Chotaro Onaga, Shotaro Kanai, Yuka Ishihara, Ayaka
Ozaki, Yasushi Hara, Yohsuke Harada, Yasunari Mano, Tsugumichi Sato, Keiko
Sato, Kazunori Sasaki, Hitoshi Ishiguro, Shigeo Ohno, Kazunori Akimoto, 7th
International Postgraduate Conference on Pharmaceutical Sciences (iPoPs2020), Noda,
Chiba, Japan, 2020年2月.（ポスター発表）
High expression of SLC20A1 gene indicates
poor prognoses among various cancer types, Chotaro Onaga, Shoma Tamori, Hitomi
Motomura, Takuma Fujita, Yasunari Mano, TsugumichiSato, Kouji Tahata, Keiko
Sato, Kazunori Akimoto, 7th International Postgraduate Conference on
Pharmaceutical Sciences (iPoPs2020), Noda, Chiba, Japan, 2020年2月.（ポスター発表）
GLO1 gene is highly expressed in basal-like
human breast cancers and contributes to survival of ALDH1-positive CSCs 解糖系代謝酵素GLO1はBasal-like型乳癌において高発現し、ALDH1 陽性乳癌幹細胞の生存に関与する, Shoma Tamori, Yuka
Nozaki, Hitomi Motomura, Chotaro Onaga, Ryo Abe, Ryoko Takasawa, Sei-ichi
Tanuma, Kazunori Akimoto, 第78回日本癌学会学術総会 The 78th Annual Meeting of the Japanese Cancer Association, 京都, 2019年9月.（ポスター発表）
Correlation between GLO 1 and PKCl
contributes to prediction for poor clinical outcome at late stage of breast
cancer ステージIII-IV乳癌におけるGLO 1 - PKCl共発現患者は予後不良である, Hitomi Motomura,
Ayaka Ozaki, Shoma Tamori, Yuka Nozaki, Ryoko Takasawa, Kazunori Sasaki,
Hitoshi Isiguro, Yohei Miyagi, Yoji Nagashima, Sei-ichi Tanuma, Shigeo Ohno,
Kazunori Akimoto, 第78回日本癌学会学術総会
The 78th Annual Meeting of the Japanese Cancer Association, 京都, 2019年9月.（ポスター発表）
ALDH1陽性乳癌幹細胞におけるPKCλ依存的な解糖系制御機構の解析 Analysis of PKCλ
dependent glycolytic regulation in ALDH1 positive breast cancer stem cells, 野崎優香、本村瞳、多森翔馬、翁長朝太郎、金井章太郎、佐藤圭子、原泰志、安部良、川上隆雄、大野茂男、秋本和憲, 第92回日本生化学会, 神奈川, 2019年9月. （ポスター発表）
Development of New Methods for the
Detection, Isolation, Growth, and Re-collection of Cancer Cells in Blood Based
on Size-discrimination of Cancer Cells and Mormal Cell, Shin Aoki, Babita
Shashni, Shinya Ariyasu, Hiroshi Takemura, Kazunori Akimoto, Naoyuki Aikawa,
Ken-ichiro Iwasaki, Takayuki Nakanishi, Atsuo Yasumori, Tomohiro Osaki,
Norihiko ItohInternational Conference on Cancer Research (e-ICCR2019), London
and website (Video presentation), 2019年6月. （ポスター発表）
Development of New Methods for Cancer
Theranostics in Interdisciplinary Collaboration of Tokyo University of Science,
Shin Aoki, Babita Shashni, Kazunori Akimoto, Masanori Hayase, Hiroshi Takemura,
Atsuo Yasumori, Naoyki Aikawa, Masato Kubo, and Masahiro Motosuke, International
Symposium of Tokyo University of Science, Translational Research (TR) Center, Tokyo,
Tokyo University of Science, 2018年10月.（口頭発表）招待
aPKCλ associates with prostate cancer
development by increasing cytokine expression, Hitoshi Ishiguro, Kazunori
Akimoto, Masahiro Yao and Hiroji Uemura, 第７７回日本癌学会学術総会, 大阪 大阪国際会議場, 2018年9月.（ポスター発表）
The role of atypical protein kinase C
(aPKC) in glycolysis of breast cancer stem cells, Kazunori Akimoto, 6th
International Postgraduate Conference on Pharmaceutical Sciences 2018
(ipops2018), International Medical University, Kuala Lumpur, 2018年8月.（口頭発表）招待
CORRELATION BETWEEN c-MET AND ALDH1
CONTRIBUTES TO THE SURVIVAL OF ALDH1 POSITIVE CSCs IN BREAST CANCER, Y. Nozaki,
S. Tamori, K. Sato, Y. Hara, R. Abe, R. Takasawa, A. Yoshimori, N. Shinomiya,
S. Tanuma, K. Akimoto, 6th International Postgraduate Conference on
Pharmaceutical Sciences 2018 (ipops2018), International Medical University,
Kuala Lumpur, 2018年8月. (口頭発表)
CORRELATION BETWEEN c-MET AND ALDH1
CONTRIBUTES TO THE SURVIVAL OF ALDH1 POSITIVE CSCs IN BREAST CANCER, Y. Nozaki,
S. Tamori, K. Sato, Y. Hara, R. Abe, R. Takasawa, A. Yoshimori, N. Shinomiya,
S. Tanuma, K. Akimoto, 6th International Postgraduate Conference on
Pharmaceutical Sciences 2018 (ipops2018), International Medical University,
Kuala Lumpur, 2018年8月. (ポスター発表)
HIGH EXPRESSION OF GLO I GENE IN HUMAN
BASAL-LIKE BREAST CANCER CONTRIBUTES TO THE SURVIVAL OF ALDH1 POSITIVE CSCs, S.
Tamori, Y. Nozaki, H. Motomura, K. Sato, T. Sato, Y. Hara, R. Abe, K. Yamamoto,
M. Imai, A. Yoshimori, R. Takasawa, S. Tanuma, K. Akimoto, 6th International
Postgraduate Conference on Pharmaceutical Sciences 2018 (ipops2018), International
Medical University, Kuala Lumpur, 2018年8月. （口頭発表）
HIGH EXPRESSION OF GLO I GENE IN HUMAN
BASAL-LIKE BREAST CANCER CONTRIBUTES TO THE SURVIVAL OF ALDH1 POSITIVE CSCs, S.
Tamori, Y. Nozaki, H. Motomura, K. Sato, T. Sato, Y. Hara, R. Abe, K. Yamamoto,
M. Imai, A. Yoshimori, R. Takasawa, S. Tanuma, K. Akimoto, 6th International
Postgraduate Conference on Pharmaceutical Sciences 2018 (ipops2018), International
Medical University, Kuala Lumpur, 2018年8月. （ポスター発表）
CO-EXPRESSION OF PKCλ AND GLOI CORRELATES
WITH POOR CLINICAL OUTCOME IN BREAST CANCER, H. Motomura, S. Tamori, Y. Nozaki,
R. Katayama, Y. Waki, R. Takasawa, S. Tanuma, Y. Mano, Y. Miyagi, Y. Nagashima,
M. Imai, K. Yamamoto, K. Sato, K. Akimoto, 6th International Postgraduate
Conference on Pharmaceutical Sciences 2018 (ipops2018), International Medical
University, Kuala Lumpur, 2018年8月. （口頭発表）
CO-EXPRESSION OF PKCλ AND GLOI CORRELATES
WITH POOR CLINICAL OUTCOME IN BREAST CANCER, H. Motomura, S. Tamori, Y. Nozaki,
R. Katayama, Y. Waki, R. Takasawa, S. Tanuma, Y. Mano, Y. Miyagi, Y. Nagashima,
M. Imai, K. Yamamoto, K. Sato, K. Akimoto, 6th International Postgraduate
Conference on Pharmaceutical Sciences 2018 (ipops2018), International Medical
University, Kuala Lumpur, 2018年8月. (ポスター発表)
Co-expression of PKCλ and GLOI correlates
with poor clinical outcome in breast cancer, Hitomi MOTOMURA,Shoma TAMORI, Yuka
NOZAKI, Ryoko TAKASAWA, Sei-ichi TANUMA, Yohei MIYAGI, Yoji NAGASHIMA, Koji
YAMAMOTO, Keiko SATO, Kazunori AKIMOTO, 第４１回日本基礎老化学会大会
第９回東京理科大学総合研究院トランスレーショナルリサーチセンターシンポジウム, 東京理科大学葛飾キャンパス図書館ホール 葛飾、東京, 2018年6月.（ポスター発表）
High expression of GLO I gene in human
basal-like breast cancer contributes to the survival of ALDH1 positive CSCs, Shoma
TAMORI, Yuka NOZAKI, Hitomi MOTOMURA, Keiko SATO, Tsugumichi SATO, Kouji
YAMAMOTO, Ryo ABE, Ryoko TAKASAWA, Sei-ichi TANUMA, Kazunori AKIMOTO, 第４１回日本基礎老化学会大会 第９回東京理科大学総合研究院トランスレーショナルリサーチセンターシンポジウム, 東京理科大学葛飾キャンパス図書館ホール 葛飾、東京, 2018年6月. （ポスター発表）
Correlation between c-Met and ALDH1
contributes to the survival of ALDH1 positive CSCs in breast cancer, Yuka
NOZAKI, Shoma TAMORI, Keiko SATO, Yasushi HARA, Ryo ABE, Ryoko TAKASAWA,
Atsushi YOSHIMORI, Nariyoshi SHINOMIYA, Sei-ichi TANUMA and Kazunori AKIMOTO, 第４１回日本基礎老化学会大会 第９回東京理科大学総合研究院トランスレーショナルリサーチセンターシンポジウム, 東京理科大学葛飾キャンパス図書館ホール 葛飾、東京, 2018年6月. （ポスター発表）
Size- and Software- Based Differentiation
of Normal and Cancer Cells, Babita Shashni, Shota Shiina, Kazunori Akimoto,
Takuto Maeda, Naoyuki Aikawa, Ryo Abe, Tomohiro Osaki, Norihiko Itoh, and Shin
Aoki, つくば医工連携フォーラム2018, つくば
産業技術総合研究所, 2018年2月. （口頭発表）
Development of Convenient and Easy Methods
for Detection and Capture of Abnormal Cells in Blood, Babita Shashni, Shota
Shiina, Kazunori Akimoto, Takuto Maeda, Naoyuki Aikawa, Takuma Hirata, Atsuo
Yasumori, Ryo Abe, Tomohiro Osaki, Norihiko Itoh, and Shin Aoki, 東京理科大学・日本医科大学第4回合同シンポジウム, 新宿区 東京理科大学森戸記念館, 2017年12月. （ポスター発表）
Basic Research of New Drug Development to
Target Cancer Stem Cell: The role of atypical protein kinase C (aPKC) in
glycolysis of breast cancer stem cells, Kazunori Akimoto, 創薬フロンティア （筑波大学大学院講義）, 筑波大学 つくば市, 2017年10月、（口頭発表）招待
Correlation between c-Met and ALDH1
contributes to the survival and tumor-sphere formation of ALDH1 positive breast
cancer stem cells and predicts poor clinical outcome in breast cancer, 野崎優香、多森翔馬、稲田将大、片山鈴花、中根裕美、南島治、小野寺祐佳、阿部真実、椎名將太、田村渓、小玉大地、佐藤圭子、原泰志、安部良、髙澤涼子、吉森篤史、四ノ宮成祥、田沼靖一、秋本和憲, 第61回日本薬学会関東支部大会, 東京都（慶應義塾大学（元共立大キャンパス）), 2017年9月.（口頭発表）
Correlation between c-Met and ALDH1
contributes to the survival and tumor-sphere formation of ALDH1 positive breast
cancer stem cells and predicts poor clinical outcome in breast cancer, 野崎優香、多森翔馬、稲田将大、片山鈴花、中根裕美、南島治、 小野寺祐佳、阿部真実、椎名將太、田村渓、小玉大地、佐藤圭子、原泰志、安部良、髙澤涼子、吉森篤史、四ノ宮成祥、田沼靖一、秋本和憲, 第61回日本薬学会関東支部大会, 東京都（慶應義塾大学（元共立大キャンパス）), 2017年9月.（口頭発表）
Convenient Methods for Detection and
Capture of Circulating Tumor Cells, Shin Aoki, Babita Shashni, Hidehiko
Matsuura, Kenta Nomura, Takuto Maeda, Shota Shiina, Kazunori Akimoto, Hiroshi
Takemura, Atsuo Yasumori, Naoyuki Aikawa, Tomohiro Ohsaki, and Norihiko Itoh, 9th
AFMC International Medicinal and Chemical Symposium (AIMEC2017), Melbourne,
Australia, 2017年7月．（口頭発表）
An Information-theoretical Approach to
Identify Biomarkers in Estrogen Receptor-positive Breast Cancer, Keiko Sato,
Kazunori Akimoto, BIT's 6th Annual International Symposium of Drug Delivery
Systems-2017, Prague, Czech Republic, 2017年7月. （口頭発表）招待
The role of atypical protein kinase C
(aPKC) in glycolysis of breast cancer stem cells, Kazunori Akimoto, The 3rd
Annual UHCC-TUS Symposium, Sullivan Conference Center, University of Hawaii
Cancer Center, Honolulu, Hawaii, USA, 2017年5月. （口頭発表）招待
Application of a Particle Size Anlayzer for
Size-based Differentiation of Normal and Cancer Cells, Babita Shashni, Shinya
Ariyasu, Reisa Takeda, Toshihiro Suzuki, Shota Shiina, Kazunori Akimoto, Takuto
Maeda, Naoyuki Aikawa, Ryo Abe, Tomohiro Osaki, Norihiko Itoh, and Shin Aoki, 5th
International Postgraduate Conference on Pharmaceutical Sciences 2017
(iPoPS2017), Puncak Alam, Malaysia, 2017年5月. （口頭発表）招待
Aberrant expression of atypical protein
kinase C λ associates with prostate cancer development, 石黒斉、秋本和憲、長嶋洋治、矢尾正祐、上村博司, 第75回日本癌学会学術総会, 横浜 (パシフィコ横浜), 2016年10月．(ポスター発表)
Development of Convenient Methods in
Detection and Separation of Circulating Tumor Cells (CTCs) and CTC Clusters, Babita
Shashni, Hidehiko Matsuura, Kenta Nomura, Takuto Maeda, Kazunori Akimoto,
Masanori Hayase, Hiroshi Takemura, Atsuo Yasumori, Naoyuki Aikawa, Shin Aoki, 第60回日本薬学会関東支部大会, 東京（東京大学本郷キャンパス）, 2016年9月．（口頭発表）
乳がん幹細胞の解糖系代謝におけるatypical protein
kinase C (aPKC)の役割, 秋本和憲, がんプロ研究シンポジウム, 東京 葛飾, 2016年7月．（口頭発表）招待
The role of atypical protein kinase C
(aPKC) in glycolysis of breast cancer stem cell, Kazunori Akimoto, International
Symposium of Tokyo University of Science, Translational Research (TR) Center, Katsushika,
Tokyo, 2016年6月．（口頭発表）招待
2015年度（口頭発表・招待３件,口頭発表4件,ポスター発表15件）
乳癌ALDH1陽性癌幹細胞におけるatypical protein kinase C(aPKC)依存的な解糖系代謝制御機構の役割, 片山鈴花、中根裕美、稲田将大、小野寺佑佳、神保美穂、原泰志、安部良、今井美沙、田沼靖一、大野茂男、川上隆雄、秋本和憲, 日本薬学会 第１３６年会（横浜）, 横浜 パシフィコ横浜, 2016年3月．（口頭発表）
ヒト乳癌におけるAtypical protein kinase C
(aPKC)λ/ιと糖代謝機構との関連, 本村瞳、片山鈴花、多森翔馬、松村将史、柳川拓哉、和氣由布子、高澤涼子、田沼靖一、宮城洋平、長嶋洋治、秋本和憲, 日本薬学会 第１３６年会（横浜）, 横浜 パシフィコ横浜, 2016年3月．（口頭発表）
乳癌幹細胞の解糖系代謝におけるatypical protein
kinase C (aPKC)の役割, 秋本和憲, 日本薬学会 第１３６年会（横浜）, 横浜 パシフィコ横浜, 2016年3月．（口頭発表）招待
Atypical protein kinase C (aPKC) 依存的な乳癌ALDH1陽性癌幹細胞の生存メカニズムの解析, 野崎優香、稲田将大、片山鈴花、中根裕美、二俣沙央里、松村将史、小野寺佑佳、原泰志、安部良、今井美沙、田沼靖一、秋本和憲, 日本薬学会 第１３６年会（横浜）, 横浜 パシフィコ横浜, 2016年3月．(ポスター発表)
Characterization of role of atypical
protein kinase C (aPKC) in in vitro model of CTC cluster, Shota SHIINA, Hitomi
MOTOMURA, Babita SHASHNI, Masanori HAYASE, Shin AOKI, Kazunori AKIMOTO, 4th
international Postgraduate Conference on Pharmaceutical Sciences (iPoPS2016), Chiba,
Japan Tokyo University of Science, 2016年2月．(ポスター発表)
Regulation of the expression of atypical
protein kinase C by autophagy in cancer cells, Shoma TAMORI, Osamu MINAMISHIMA,
Masashi MATSUMURA, Yuka NOZAKI, Hiromi NAKANE, Ken TACHIBANA, Yuhei MIZUNOE,
Yoshikazu HIGAMI, Kazunori AKIMOTO, 4th international Postgraduate Conference
on Pharmaceutical Sciences (iPoPS2016), Chiba, Japan Tokyo University of
Science, 2016年2月．(ポスター発表)
Correlation between the expression levels
of aPKCλ/ι and GLOI in breast cancer, Hitomi MOTOMURA, Reika KATAYAMA, Shoma
TAMORI, Masashi MATSUMURA, Takuya YANAGAWA, Yuko WAKI, Ryoko TAKASAWA, Sei-ichi
TANUMA, Yohei MIYAGI, Yoji NAGASHIMA, Misa IMAI, Keiko SATO, Kazunori AKIMOTO, 4th
international Postgraduate Conference on Pharmaceutical Sciences (iPoPS2016),
Chiba, Japan Tokyo University of Science, 2016年2月．(ポスター発表) ★Poster
Presentation Award受賞
The Role of Atypical Protein Kinase C
(aPKC) in Glycolysis of Breast Cancer Stem Cell, Kazunori Akimoto, 4th
international Postgraduate Conference on Pharmaceutical Sciences (iPoPS2016),
Chiba, Japan Tokyo University of Science, 2016年2月．（口頭発表）招待
Survival dependency of ALDH1 positive
breast cancer stem cells(CSCs) on atypical protein kinase C (aPKC), Yuka
NOZAKI, Masahiro INADA, Reika KATAYAMA, Hiromi NAKANE, Shoma TAMORI, Yuka
ONODERA, Saori FUTAMATA,Yuhei MIZUNOE, Yasushi HARA, Ryo ABE, Misa IMAI,
Sei-ichi TANUMA, Yoshikazu HIGAMI, Kazunori AKIMOTO, 4th international
Postgraduate Conference on Pharmaceutical Sciences (iPoPS2016), Chiba, Japan
Tokyo University of Science, 2016年2月．(ポスター発表)
リン酸化プロテオミクスを用いた乳癌ALDH1high細胞におけるAtypical Protein Kinase C (aPKC)の機能解析 Phosphoproteomics to examine the role of atypical protein kinase C
in ALDHhigh cells from breast cancer cell line, 片山鈴花、中根裕美、稲田将大、小野寺佑佳、神保美穂、原泰志、田沼靖一、大野茂男、川上隆雄、秋本和憲, BMB2015 第38回日本分子生物学会年会、第88回日本生化学会大会 合同大会, 神戸市 神戸国際展示場, 2015年12月．(ポスター発表)
乳癌ALDH1high細胞における解糖系代謝酵素Glyoxalase I (GLO I)の役割解析 Analysis of
Glyoxalase I (GLO I) of ALDH1high cells in breast cancer cell lines, 中根裕美、片山鈴花、本村瞳、南島治、椎名將太、松村将史、稲田将大、菊池恵梨子、嶋田奈実、原泰志、安部良、吉森篤史、田沼靖一、高澤涼子、秋本和憲, BMB2015 第38回日本分子生物学会年会、第88回日本生化学会大会 合同大会, 神戸市 神戸国際展示場, 2015年12月．(ポスター発表)
がん特異的代謝におけるGlyoxalase I阻害による代謝シフトの解析 Analysis of metabolic shift caused by Glyoxalase I inhibitior in
cancer specific metabolism, 菊地恵梨子、嶋田奈美、秋本和憲、田沼靖一、高澤涼子, BMB2015
第38回日本分子生物学会年会、第88回日本生化学会大会
合同大会, 神戸市 神戸国際展示場, 2015年12月．(ポスター発表)
アポトーシスにおけるGSK-3β限定分解の分子機構の解明 Elucidation of molecular mechanism of GSK-3beta limited proteolysis
in apoptosis, 西岡 隼哉, 衛藤 慎一, 藤川
誠, 秋本 和憲, 高澤 涼子, 田沼 靖一, 第86回日本生化学大会, 横浜 パシフィコ横浜, 2013年9月．（ポスター発表）
Depletion of aPKClambda in mouse
differentiated neurons disrupts the polarity protein complex but does not
induce cell degeneration or brain structual disorganization, Yamanaka T.,
Tosaki, A., Kurosawa M., Akimoto K., Hirose T., Ohno S., Hattori N., and Nukina
N. 包括脳ネットワーク夏のワークショップ, 名古屋 名古屋国際会議場, 2013年8月．（ポスター発表）
細胞極性制御因子atypical protein kinase Cιの過剰発現および核局在は子宮頸癌の予後不良因子である, 水島大一, 秋本和憲, 長嶋洋治，最上多恵，佐藤美紀子，宮城悦子，亀田陽一，中山裕樹，稲山嘉明，青木一郎，大野茂男，大橋健一，平原史樹, 第１２回日本婦人科がん分子標的研究会学術集会, 奈良, 2013年7月．（口頭発表）
The role of aPKC in cancer progression, Hitoshi
Ishiguro, Kazunori Akimoto, 18th international Charles Heidelberger Symposium
on Cancer Research, Stadthaus Ulm (Ulm, GER), 2012年6月．（口頭発表）
Takahiro Kasai (葛西 隆広), The best oral presentation award, Analysis of the acquisition mechanism of cancerous heterogeneity generating by asymmetric cell division of cancer stem cells, 10th International Postgraduate Conference on Pharmaceutical Sciences 2024, 2024年3月7日
Chotaro Onaga (翁長 朝太郎), The best oral presentation
award, High expression of SLC 20A1 is less effective for endocrine therapy and
predicts late recurrence in ER-positive breast cancer, 9th International
Postgraduate Conference on Pharmaceutical Sciences, 2022年7月4日
Hitomi Motomura（本村瞳）, Poster Presentation Award, Correlation
between the expression levels of aPKCλ/ι and GLOI in breast cancer, 4th
International Postgraduate Conference on Pharmaceutical Sciences, 2016年2月28日
本村瞳, 第59回日本薬学会関東支部大会 優秀ポスター賞, ヒト乳癌におけるAtypical protein kinase C
(aPKC)λ/ιと糖代謝機構との関連, 日本薬学会関東支部,
2015年9月12日