草森研究室 東京理科大学 薬学部 細胞創薬学

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ACHIEVEMENTS

原著論文

英文

  1. Yukitake Yosioka, Syunsuke Yamamoto, Kosuke Kusamori, Miyu Nakayama, Hisashi Fujita, Akihiko Goto, Shinji Iwasaki, Tetsuya Nagata, Shoko Itakura, Hiroyuki Kusuhara, Takanori Yokota, Hideki Hirabayashi, Makiya Nishikawa.
    Pharmacokinetics and protein binding of cholesterol-conjugated heteroduplex oligonucleotide.
    Journal of Controlled Release 380, 787-799 (2025). （詳細）
  2. Naohiro Oshima, Kosuke Kusamori, Ryo Takasaki, Noriyasu Hada, Makiya Nishikawa.
    Baicalin-induced hepatocyte toxicity: The critical role of multidrug resistance-associated protein 2.
    Integrative Medicine Discovery 9, e25001 (2025). （詳細）
  3. Jian Jin, Kosuke Kusamori, Takumi Tanifuji, Yoshifumi Yamagata, Shoko Itakura, Makiya Nishikawa.
    Biocompatible DNA hydrogel composed of minimized Takumi-shaped DNA nanostructure exhibits sustained retention after in vivo administration.
    Journal of Controlled Release 377, 704-715 (2024). （詳細）
  4. Naohiro Oshima, Kosuke Kusamori, Moe Takeda, Ryo Takasaki, Makiya Nishikawa, Noriyasu Hada.
    Removal of Ginger from shosaikoto can reduce hepatocyte toxicity.
    Traditional & Kampo Medicine 2024, 1-7 (2024). （詳細）
  5. Kaushik Pal, Swati Singh, Shoko Itakura, Masahiro Hashimoto, Kosuke Kusamori, Makiya Nishikawa.
    Reactive oxygen species augmented polydopamine-chlorin e6 nanosystem for enhanced chemo/photothermal/photodynamic therapy: A synergistic trimodal combination approach in vitro & in vivo.
    International Journal of Biological Macromolecules 283, 137236 (2024). （詳細）
  6. Reza Taghizadeh-Tabarsi, Shiva Akbari-Birgani, Mehrnaz Amjadi, Soheila Mohammadi, Nasser Nikfarjam, Kosuke Kusamori.
    Aptamer-guided graphene oxide quantum dots for targeted suicide gene therapy in an organoid model of luminal breast cancer.
    Scientific Reports 14, 24104 (2024). （詳細）
  7. Mengmeng Tan, Natsuki Makiguchi, Kosuke Kusamori, Shoko Itakura, Yuki Takahashi, Yoshinobu Takakura, Makiya Nishikawa.
    Tuning CpG motif position in nanostructured DNA for efficient immune stimulation.
    Biotechnology Journal 19, e2300308 (2024). （詳細）
  8. Naohiro Oshima, Kosuke Kusamori, Ryo Takasaki, Moe Takeda, Yuri Katsurada, Kazuki Okoshi, Makiya Nishikawa, Noriyasu Hada.
    Scutellaria Root extract-induced hepatocytotoxicity can be controlled by regulating its baicalin content.
    Journal of Natural Medicines     78, 978-984 (2024) （詳細）
  9. Daisuke Sasaki, Hinako Suzuki, Kosuke Kusamori, Shoko Itakura, Hiroaki Todo, Makiya Nishikawa.
    Development of rice bran-derived nanoparticles with excellent anti-cancer activity and their application for peritoneal dissemination.
    Journal of Nanobiotechnology     22, 114 (2024). （詳細）
  10. Yukiya Takayama, Kosuke Kusamori, Yuri Katsurada, Shu Obana, Shoko Itakura, Makiya Nishikawa.
    Efficient delivery of mesenchymal stem/stromal cells to injured liver by surface PEGylation.
    Stem Cell Research and Therapy     14, 216 (2023). （詳細）
  11. Ryota Suzuki, Kosuke Kusamori, Kodai Takamura, Yuma Miyakawa, Shu Obana, Shoko Itakura, Makiya Nishikawa.
    Optimal preparation protocol of cell-encapsulating alginate capsules for long-term cell-based therapy.
    Applied Sciences 13, 6676 (2023).
  12. Yuta Otsuka, Daisuke Sasaki, Kosuke Kusamori, Makiya Nishikawa, Besim Ben-Nissan.
    Investigation of the crystallinity change after the addition of magnesium hydroxides into the calcium phosphate during mechanochemical synthesis; an FTIR spectroscopy, XRD analysis, chemometrics and cell culture.
    Journal of the Australian Ceramic Society     (2023).
  13. Takumi Tanifuji, Moeka Nishimura, Kosuke Kusamori, Makiya Nishikawa.
    Intradermal delivery of Cryj1 loaded in CpG DNA hydrogel for inhibiting allergic reactions in mice.
    Journal of Controlled Release 354, 429-438 (2023) (詳細）
  14. Daisuke Sasaki, Kosuke Kusamori, Makiya Nishikawa.
    Delivery of corn-derived nanoparticles with anticancer activity to tumor tissues by modification with polyethylene glycol for cancer therapy.
    Pharmaceutical Research 40, 917-926 (2023) (詳細)
  15. Kodai Koyanagi, Kosuke Kusamori, Makiya Nishikawa, Satoshi Konishi.
    In situ evaluation of cellular spheroid stiffness by pinching device composed of piezoactuator and strain gauge.
    IEEJ Transactions on Electrical and Electronic Engineering 18, 1226-1228 (2023).
  16. Mari Tsujimura, Kosuke Kusamori, Kodai Takamura, Temmei Ito, Takatoshi Kaya, Kazunori Shimizu, Satoshi Konishi, Makiya Nishikawa.
    Quality evaluation of cell spheroids for transplantation by monitoring oxygen consumption using an on-chip electrochemical device.
    Biotechnology Reports 36, e00766 (2022). (詳細)
  17. Yoshihiko Shimazawa, Kosuke Kusamori, Mari Tsujimura, Asuka Shimomura, Ryo Takasaki, Yukiya Takayama, Kazunori Shimizu, Satoshi Konishi, Makiya Nishikawa.
    Intravenous injection of mesenchymal stem cell spheroids improves the pulmonary delivery and prolongs in vivo survival.
    Biotechnology Journal 17, e2100137 (2022). （詳細）
  18. Makoto Nagaoka, Wenqing Liao, Kosuke Kusamori, Makiya Nishikawa.
    Targeted delivery of immunostimulatory CpG oligodeoxynucleotides to antigen-presenting cells in draining lymph nodes by stearic acid modification and nanostructurization.
    International Journal of Molecular Sciences 23, 1350 (2022). （詳細）
  19. Daisuke Sasaki, Kosuke Kusamori, Yukiya Takayama, Shoko Itakura, Hiroaki Todo, Makiya Nishikawa.
    Development of nanoparticles derived from corn as mass producible bionanoparticles with anticancer activity.
    Scientific Reports 11, 22818 (2021). （詳細）
  20. Keisuke Umemura, Shozo Ohtsuki, Makoto Nagaoka, Kosuke Kusamori, Takao Inoue, Yuki Takahashi, Yoshinobu Takakura, Makiya Nishikawa.
    Critical contribution of macrophage scavenger receptor 1 to the uptake of nanostructured DNA by immune cells.
    Nanomedicine 34, 102386 (2021). （詳細）
  21. Yuki Araie, Shozo Ohtsuki, Soyoung Park, Makoto Nagaoka, Keisuke Umemura, Hiroshi Sugiyama, Kosuke Kusamori, Yuki Takahashi, Yoshinobu Takakura, Makiya Nishikawa.
    Combined use of chemically modified nucleobases and nanostructured DNA for enhanced immunostimulatory activity of CpG oligodeoxynucleotide.
    Bioorganic & Medicinal Chemistry 29, 115864 (2021). （詳細）
  22. Yukiya Takayama, Kosuke Kusamori, Chihiro Tsukimori, Yosuke Shimizu, Mika Hayashi, Ikumi Kiyama, Hidemasa Katsumi, Toshiyasu Sakane, Akira Yamamoto, Makiya Nishikawa.
    Anticancer drug-loaded mesenchymal stem cells for targeted cancer therapy.
    Journal of Controlled Release 329, 1090-1101 (2021). （詳細）
  23. Wenqing Liao, Mengmeng Tan, Kosuke Kusamori, Yoshinobu Takakura, Makiya Nishikawa.
    Construction of monomeric and dimeric G-quadruplex structured CpG oligodeoxynucleotides for enhanced uptake and activation in TLR9-positive macrophages.
    Nucleic Acid Therapeutics 30, 299-311 (2020). （詳細）
  24. Wenqing Liao, Sakiko Akahira, Rintaro Iwata Hara, Takeshi Wada, Kosuke Kusamori, Yoshinobu Takakura, Makiya Nishikawa.
    Enhanced immunostimulatory activity of CpG oligodeoxynucleotide by the combination of mannose modification and incorporation into nanostructured DNA.
    Biological and Pharmaceutical Bulletin 43, 1188-1195 (2020). （詳細）
  25. Louvy Lynn Punzalan, Lulu Jiang, Di Mao, Amarjyoti Das Mahapatra, Shinichi Sato, Yasushi Takemoto, Mari Tsujimura, Kosuke Kusamori, Makiya Nishikawa, Lu Zhou, Motonari Uesugi.
    Chemoproteomic profiling of a pharmacophore-focused chemical library.
    Cell Chemical Biology 27, 708-718 (2020). （詳細）
  26. Naoya Seino, Emi Omori, Kosuke Kusamori, Shin’ichi Miyamoto, Yuto Nagasaki, Kyohei Higashi, Yutaka Yamase, Makiya Nishikawa.
    Application of sodium alginate hydrogel for clear preoperative endoscopic marking using India ink.
    Polymer Journal 52, 977-983 (2020).
  27. Zhaoma Shu, Azumi Ota, Yukiya Takayama, Yuri Katsurada, Kosuke Kusamori, Naoko Abe, Kosuke Nakamoto, Fumiaki Tomoike, Seiichi Tada, Yoshihiro Ito, Makiya Nishikawa, Yasuaki Kimura, Hiroshi Abe.
    Intracellular delivery of antisense DNA and siRNA with amino groups masked with disulfide units.
    Chemical and Pharmaceutical Bulletin 68, 129-132 (2020). （詳細）
  28. Mengmeng Tan, Natsuki Takahashi, Shota Fujii, Kazuo Sakurai, Kosuke Kusamori, Yuki Takahashi, Yoshinobu Takakura, Makiya Nishikawa.
    Analysis of tertiary structural features of branched DNA nanostructures with partially common sequences using small-angle X-ray scattering.
    ACS Applied Bio Materials 3(1), 308-314 (2020). （詳細）
  29. Mari Tsujimura, Kosuke Kusamori, Hidemasa Katsumi, Toshiyasu Sakane, Akira Yamamoto, Makiya Nishikawa.
    Cell-based interferon gene therapy using proliferation-controllable, interferon-releasing mesenchymal stem cells.
    Scientific Reports 9, 18869 (2019). （詳細）
  30. Mari Tsujimura, Kosuke Kusamori, Makiya Nishikawa.
    Rapid regulation of human mesenchymal stem cell proliferation using inducible caspase-9 suicide gene for safe cell-based therapy.
    International Journal of Molecular Sciences 20, E5759 (2019). （詳細）
  31. Tammam Alama, Kosuke Kusamori, Masaki Morishita, Hidemasa Katsumi, Toshiyasu Sakane, Akira Yamamoto.
    Mechanistic studies on the absorption-enhancing effects of SLG-30 on the intestinal absorption of poorly absorbed hydrophilic drugs in rats.
    Pharmaceutics 11(4), 170 (2019). （詳細）
  32. Ippei Takashima, Kosuke Kusamori, Thi Hue Vu, Tetsuya Ogawa, Yuya Mizukami, Megumi Takashima, Yosuke Katsuda, Shin-ichi Sato, Hiroki Kurata, Makiya Nishikawa, Motonari Uesugi.
    Multi-functionalization of cells with a self-assembling molecule to enhance cell engraftment.
    ACS Chemical Biology 14(4), 775-783 (2019). （詳細）
  33. Shunsuke Kimura, Akiko Kiriyama, Erika Nishimura, Shiori Sakata, Daisuke Inoue, Tomoyuki Furubayashi, Reiko Yutani, Akiko Tanaka, Kosuke Kusamori, Hidemasa Katsumi, Katsumi Iga, Akira Yamamoto, Toshiyasu Sakane.
    Novel strategy for the systemic delivery of furosemide based on a new drug transport mechanism.
    Biological and Pharmaceutical Bulletin 41(12), 1769-1777 (2018). （詳細）
  34. Kasirawat Sawangrat, Shugo Yamashita, Akiko Tanaka, Masaki Morishita, Kosuke Kusamori, Hidemasa Katsumi, Toshiyasu Sakane, Akira Yamamoto.
    Modulation of intestinal transport and absorption of topotecan, a BCRP substrate by various pharmaceutical excipients and their inhibitory mechanisms of BCRP transporter.
    Journal of Pharmaceutical Sciences 108(3), 1315-1325 (2018). （詳細）
  35. Yuka Umeki, Masaaki Saito, Kosuke Kusamori, Mari Tsujimura, Moeka Nishimura, Yuki Takahashi, Yoshinobu Takakura, Makiya Nishikawa.
    Combined encapsulation of a tumor antigen and immune cells using a self-assembling immunostimulatory DNA hydrogel to enhance antigen-specific tumor immunity.
    Journal of Controlled Release 288, 189-198 (2018). （詳細）
  36. Kasirawat Sawangrat, Masaki Morishita, Kosuke Kusamori, Hidemasa Katsumi, Toshiyasu Sakane, Akira Yamamoto.
    Effects of various pharmaceutical excipients on the intestinal transport and absorption of sulfasalazine, a typical substrate of BCRP transporter.
    Journal of Pharmaceutical Sciences 107, 2946-2956 (2018). （詳細）
  37. Kenjiro Matsumoto, Hiroki Kawanaka, Masatoshi Hori, Kosuke Kusamori, Daichi Utsumi, Takuya Tsukahara, Kikuko Amagase, Syunji Horie, Akira Yamamoto, Hiroshi Ozaki, Yasuo Mori, and Shinichi Kato.
    Role of transient receptor potential melastatin 2 in surgical inflammation and dysmotility in a mouse model of post-operative ileus.
    American Journal of Physiology-Gastrointestinal and Liver Physiology 315, G104-G116 (2018). （詳細）
  38. Mari Tsujimura, Kosuke Kusamori, Chihiro Oda, Airi Miyazaki, Hidemasa Katsumi, Toshiyasu Sakane, Makiya Nishikawa, Akira Yamamoto.
    Regulation of proliferation and functioning of transplanted cells by using herpes simplex virus thymidine kinase gene in mice.
    Journal of Controlled Release 275, 78-84 (2018). （詳細）
  39. Akiko Tanaka, Tomoyuki Furubayashi, Mari Arai, Daisuke Inoue, Shunsuke Kimura, Akiko Kiriyama, Kosuke Kusamori, Hidemasa Katsumi, Reiko Yutani, Toshiyasu Sakane, and Akira Yamamoto.
    Delivery of oxytocin to the brain for the treatment of autism spectrum disorder by nasal application.
    Molecular Pharmaceutics 15, 1105-1111 (2018). （詳細）
  40. Yutaro Tanaka, Makiya Nishikawa, Yuya Mizukami, Kosuke Kusamori, Yuka Ogino, Shunsuke Nishimura, Kazunori Shimizu, Satoshi Konishi, Yuki Takahashi, Yoshinobu Takakura.
    Control of polarization and tumoricidal activity of macrophages by multicellular spheroid formation.
    Journal of Controlled Release 270, 177-183 (2018). （詳細）
  41. Shunsuke Kimura, Akiko Kiriyama, Kaeko Araki, Mai Yoshizumi, Masakazu Enomura, Daisuke Inoue, Tomoyuki Furubayashi, Reiko Yutani, Reiko Teraoka, Akiko Tanaka, Kosuke Kusamori, Hidemasa Katsumi, Akira Yamamoto, Katsumi Iga, Toshiyasu Sakane.
    Novel strategy for improving the bioavailability of curcumin based on a new membrane transport mechanism that directly involves solid particles.
    European Journal of Pharmaceutics and Biopharmaceutics 122, 1-5 (2018). （詳細）
  42. Xinpeng Li, Sachiyo Uehara, Kasirawat Sawangrat, Masaki Morishita, Kosuke Kusamori, Hidemasa Katsumi, Toshiyasu Sakane, Akira Yamamoto.
    Improvement of intestinal absorption of curcumin by cyclodextrins and the mechanisms underlying absorption enhancement.
    International Journal of Pharmaceutics 535, 340-349 (2018). （詳細）
  43. Yukiya Takayama, Kosuke Kusamori, Mika Hayashi, Noriko Tanabe, Satoru Matsuura, Mari Tsujimura, Hidemasa Katsumi, Toshiyasu Sakane, Makiya Nishikawa, Akira Yamamoto.
    Long-term drug modification to the surface of mesenchymal stem cells by the avidin-biotin complex method.
    Scientific Reports 7, 16953 (2017). （詳細）
  44. Xinpeng Li, Ami Kawamura, Yusuke Sato, Masaki Morishita, Kosuke Kusamori, Hidemasa Katsumi, Toshiyasu Sakane, Akira Yamamoto.
    Improvement of the solubility and intestinal absorption of curcumin by N-acyl taurates and elucidation of the absorption-enhancing mechanisms.
    Biological and Pharmaceutical Bulletin 40, 2175-2182 (2017). （詳細）
  45. Shugo Yamashita, Hidemasa Katsumi, Nozomi Hibino, Yugo Isobe, Yumiko Yagi, Kosuke Kusamori, Toshiyasu Sakane, Akira Yamamoto.
    Development of PEGylated carboxylic acid-modified polyamidoamine dendrimers as bone-targeting carriers for the treatment of bone diseases.
    Journal of Controlled Release     262, 10-17 (2017). （詳細）
  46. Tomoko Nishikawa, Yutaro Tanaka, Makiya Nishikawa, Kosuke Kusamori, Narumi Mizuno, Yuya Mizukami, Yuka Ogino, Kazunori Shimizu, Satoshi Konishi, Yuki Takahashi, Yoshinobu Takakura.
    Using size-controlled multicellular spheroids of murine adenocarcinoma cells efficiently establish pulmonary tumors in mice.
    Biotechnology Journal 12, 1600513 (2017). （詳細）
  47. Tomoko Nishikawa, Yutaro Tanaka, Makiya Nishikawa, Yuka Ogino, Kosuke Kusamori, Narumi Mizuno, Yuya Mizukami, Kazunori Shimizu, Satoshi Konishi, Yuki Takahashi, Yoshinobu Takakura.
    Optimization of albumin secretion and metabolic activity of cytochrome P450 1A1 of human hepatoblastoma HepG2 cells in multicellular spheroids by controlling spheroid size.
    Biological and Pharmaceutical Bulletin     40, 334-338 (2017). （詳細）
  48. Akiko Tanaka, Tomoyuki Furubayashi, Enomura Yuki, Hori Tomoki, Shimomura Rina, Maeda Chiaki, Shunsuke Kimura, Daisuke Inoue, Kosuke Kusamori, Hidemasa Katsumi, Toshiyasu Sakane, Akira Yamamoto.
    Nasal Drug Absorption from Powder Formulations: Effect of Fluid Volume Changes on the Mucosal Surface.
    Biological and Pharmaceutical Bulletin     40, 212-219 (2017). （詳細）
  49. Akiko Tanaka, Tomoyuki Furubayashi, Manami Tomisaki, Mayuko, Kawakami, Shunsuke Kimura, Daisuke Inoue, Kosuke Kusamori, Hidemasa, Katsumi, Toshiyasu Sakane, Akira Yamamoto.
    Nasal drug absorption from powder formulations: The effect of three types of hydroxypropyl cellulose (HPC).
    European Journal of Pharmaceutical Sciences     96, 284-289 (2017). （詳細）
  50. Masashi Adachi, Yuta Hinatsu, Kosuke Kusamori, Hidemasa Katsumi, Toshiyasu Sakane, Manabu Nakatani, Koichi Wada, Akira Yamamoto.
    Effects of manufacturing methods on dissolution and absorption of ketoconazole in the presence of organic acid as a pH modifier.
    AAPS PharmSciTech 18, 1203-1212 (2017). （詳細）
  51. Tammam Alama, Hiroko Katayama, Sachiko Hirai, Shizuka Ono, Ayumi Kajiyama, Kosuke Kusamori, Hidemasa Katsumi, Toshiyasu Sakane, Akira Yamamoto.
    Enhanced oral delivery of alendronate by sucrose fatty acids esters in rats and their absorption-enhancing mechanisms.
    International Journal of Pharmaceutics 515, 476-489 (2016). （詳細）
  52. Yuka Nakaya, Mayu Takaya, Yuta Hinatsu, Tammam Alama, Kosuke Kusamori, Hidemasa Katsumi, Toshiyasu Sakane, Akira Yamamoto.
    Enhanced oral delivery of bisphosphonate by novel absorption enhancers: improvement of intestinal absorption of alendronate by N-acyl amino acids and N-acyl taurates and their absorption-enhancing mechanisms.
    Journal of Pharmaceutical Sciences     105, 3680-3690 (2016). （詳細）
  53. Wanting Zhao, Tammam Alama, Kosuke Kusamori, Hidemasa Katsumi, Toshiyasu Sakane, Akira Yamamoto.
    Effects of 2 polyoxyethylene alkyl ethers on the function of intestinal P-glycoprotein and their inhibitory mechanisms.
    Journal of Pharmaceutical Sciences     105, 3668-3679 (2016). （詳細）
  54. Wanting Zhao, Sachiyo Uehera, Keiichiro Tanaka, Shuhei Tadokoro, Kosuke Kusamori, Hidemasa Katsumi, Toshiyasu Sakane, Akira Yamamoto.
    Effects of polyoxyethylene alkyl ethers on the intestinal transport and absorption of rhodamine 123: a P-glycoprotein substrate by in vitro and in vivo studies.
    Journal of Pharmaceutical Sciences     105, 1526-1534 (2016). （詳細）
  55. Dan Wu, Hidemasa Katsumi, Ying-shu Quan, Fumio Kamiyama, Kosuke Kusamori, Toshiyasu Sakane, Akira Yamamoto.
    Permeation of sumatriptan succinate across human skin using multiple types of self-dissolving microneedle arrays fabricated from sodium hyaluronate.
    Journal of Drug Targeting     24, 752-758 (2016). （詳細）
  56. Kosuke Kusamori, Hidemasa Katsumi, Ryota Sakai, Rie Hayashi, Yuka Hirai, Yutaro Tanaka, Kaori Hitomi, Ying-shu Quan, Fumio Kamiyama, Keigo Yamada, Shun-ichiro Sumida, Kazumasa Kishi, Katsuhiko Hashiba, Toshiyasu Sakane, Akira Yamamoto.
    Development of a drug-coated microneedle array and its application for transdermal delivery of interferon alpha.
    Biofabrication     8, 015006 (2016). （詳細）
  57. Tammam Alama, Kosuke Kusamori, Hidemasa Katsumi, Toshiyasu Sakane, Akira Yamamoto.
    Absorption-enhancing effects of gemini surfactant on the intestinal absorption of poorly absorbed hydrophilic drugs including peptide and protein drugs in rats.
    International Journal of Pharmaceutics     499, 58-66 (2016). （詳細）
  58. Shunsuke Kimura, Sachiha Kasatani, Megumi Tanaka, Kaeko Araki, Masakazu Enomura, Kei Moriyama, Daisuke Inoue, Tomoyuki Furubayashi, Akiko Tanaka, Kosuke Kusamori, Hidemasa Katsumi, Toshiyasu Sakane, Akira Yamamoto.
    Importance of the direct contact of amorphous solid particles with the surface of monolayers for the transepithelial permeation of curcumin.
    Molecular Pharmaceutics 13, 493-499 (2016). （詳細）
  59. Shu Liu, Dan Wu, Ying-shu Quan, Fumio Kamiyama, Kosuke Kusamori, Hidemasa Katsumi, Toshiyasu Sakane, Akira Yamamoto.
    Improvement of transdermal delivery of exendin-4 using novel tip-loaded microneedle arrays fabricated from hyaluronic acid.
    Molecular Pharmaceutics     13, 272-279 (2016). （詳細）
  60. Kosuke Kusamori, Makiya Nishikawa, Narumi Mizuno, Tomoko Nishikawa, Akira Masuzawa, Yutaro Tanaka, Yuya Mizukami, Kazunori Shimizu, Satoshi Konishi, Yuki Takahashi, Yoshinobu Takakura.
    Increased insulin secretion from insulin-secreting cells by construction of mixed multicellular spheroids.
    Pharmaceutical Research     33, 247-256 (2016). （詳細）
  61. Masashi Adachi, Yuta Hinatsu, Kosuke Kusamori, Hidemasa Katsumi, Toshiyasu Sakane, Manabu Nakatani, Koichi Wada, Akira Yamamoto.
    Improved dissolution and absorption of ketoconazole in the presence of organic acids as pH-modifiers.
    European Journal of Pharmaceutical Sciences 76, 225-230 (2015). （詳細）
  62. Dan Wu, Ying-shu Quan, Fumio Kamiyama, Kosuke Kusamori, Hidemasa Katsumi, Toshiyasu Sakane, Akira Yamamoto.
    Improvement of transdermal delivery of sumatriptan succinate using a novel self-dissolving microneedle array fabricated from sodium hyaluronate in rats.
    Biological and Pharmaceutical Bulletin     38, 365-373 (2015). （詳細）
  63. Kosuke Kusamori, Makiya Nishikawa, Narumi Mizuno, Tomoko Nishikawa, Akira Masuzawa, Kazunori Shimizu, Satoshi Konishi, Yuki Takahashi, Yoshinobu Takakura.
    Transplantation of insulin-secreting multicellular spheroids for the treatment of type 1 diabetes in mice.
    Journal of Controlled Release 173, 119-124 (2014). （詳細）
  64. Heidie L. Frisco-Cabanos, Mizuki Watanabe, Naoki Okumura, Kosuke Kusamori, Naohiro Takemoto, Junichiro Takaya, Shin-ichi Sato, Sayumi Yamazoe, Yoshinobu Takakura, Shigeru Kinoshita, Makiya Nishikawa, Noriko Koizumi, Motonari Uesugi.
    Synthetic molecules that protect cells from anoikis and their use in cell transplantation.
    Angewandte Chemie International Edition 53, 11208-11213 (2014). （詳細）
  65. Hidemasa Katsumi, Kentaro Fukui, Kanako Sato, Shoko Maruyama, Shugo Yamashita, Erika Mizumoto, Kosuke Kusamori, Munetaka Oyama, Masataka Sano, Toshiyasu Sakane, Akira Yamamoto.
    Pharmacokinetics and preventive effects of platinum nanoparticles as reactive oxygen species scavengers on hepatic ischemia/reperfusion injury in mice.
    Metallomics     6, 1050-1056 (2014). （詳細）
  66. Hidemasa Katsumi, Makiya Nishikawa, Kazushi Nishiyama, Rikiya Hirosaki, Narumi Nagamine, Haruka Okamoto, Hironori Mizuguchi, Kosuke Kusamori, Hiroyuki Yasui, Fumiyoshi Yamashita, Mitsuru Hashida, Toshiyasu Sakane, Akira Yamamoto.
    Development of PEGylated serum albumin with multiple reduced thiols as a long-circulating scavenger of reactive oxygen species for the treatment of fulminant hepatic failure in mice.
    Free Radical Biology and Medicine     69, 318-323 (2014). （詳細）
  67. Shu Liu, Mei-na Jin, Ying-shu Quan, Fumio Kamiyama, Kosuke Kusamori, Hidemasa Katsumi, Toshiyasu Sakane, Akira Yamamoto.
    Transdermal delivery of relatively high molecular weight drugs using novel self-dissolving microneedle arrays fabricated from hyaluronic acid and their characteristics and safety after application to the skin.
    European Journal of Pharmaceutics and Biopharmaceutics 86, 267-276 (2014). （詳細）
  68. Naohiro Takemoto, Tetsuya Suehara, Heidie L. Frisco, Shin-ichi Sato, Takuhito Sezaki, Kosuke Kusamori, Yoshinori Kawazoe, Sun Min Park, Sayumi Yamazoe, Yoshiyuki Mizuhata, Rintaro Inoue, Gavin J. Miller, Steen U. Hansen, Gordon C. Jayson, John M. Gardiner, Toshiji Kanaya, Norihiro Tokitoh, Kazumitsu Ueda, Yoshinobu Takakura, Noriyuki Kioka, Makiya Nishikawa, Motonari Uesugi.
    Small molecule-induced clustering of heparan sulfate promotes cell adhesion.
    Journal of the American Chemical Society     135, 11032-11039 (2013). （詳細）
  69. Kazunori Shimizu, Kosuke Kusamori, Makiya Nishikawa, Narumi Mizuno, Tomoko Nishikawa, Akira Masuzawa, Shingo Katano, Yuki Takahashi, Yoshinobu Takakura, Satoshi Konishi.
    Poly (N-isopropylacrylamide) coated microwell arrays for construction and recovery of multicellular spheroids.
    Journal of Biosciences and Bioengineering     115, 695-699 (2013). （詳細）
  70. Mai Ikemura, Makiya Nishikawa, Kosuke Kusamori, Miho Fukuoka, Fumiyoshi Yamashita, Mitsuru Hashida.
    Pivotal role of oxidative stress in tumor metastasis under diabetic conditions in mice.
    Journal of Controlled Release     170, 191-197 (2013). （詳細）
  71. Hidemasa Katsumi, Shu Liu, Yutaro Tanaka, Kaori Hitomi, Rie Hayashi, Yuka Hirai, Kosuke Kusamori, Ying-shu Quan, Fumio Kamiyama, Toshiyasu Sakane, Akira Yamamoto.
    Development of a novel self-dissolving microneedle array of alendronate, a nitrogen-containing bisphosphonate: Evaluation of transdermal absorption, safety, and pharmacological effects after application in rats.
    Journal of Pharmaceutical Sciences     101, 3230-3238 (2012). （詳細）
  72. Hidemasa Katsumi, Maria Nakatani, Jun-ichi Sano, Mari Abe, Kosuke Kusamori, Maki Kurihara, Rika Shiota, Miki Takashima, Takuya Fujita, Toshiyasu Sakane, Toru Hibi, AkiraYamamoto.
    Absorption and safety of alendronate, a nitrogen-containing bisphosphonate, after intrapulmonary administration in rats.
    International Journal of Pharmaceutics 400, 124-130 (2010). （詳細）
  73. Kosuke Kusamori, Hidemasa Katsumi, Mari Abe, Asuka Ueda, Ryota Sakai, Rie Hayashi, Yuka Hirai, Ying-shu Quan, Fumio Kamiyama, Toshiyasu Sakane, Akira Yamamoto.
    Development of a novel transdermal patch of alendronate, a nitrogen-containing bisphosphonate, for the treatment of osteoporosis.
    Journal of Bone and Mineral Research     25, 2582-2591 (2010). （詳細）

和文

  1. 村橋睦了、大山康博、大西秀哉、高崎 凌、草森浩輔、西川元也.
    膵癌に対する線維化抑制ペプチドとT細胞輸注療法併用免疫療法の開発.
    JRAI Report     9, 13-18 (2022).

総説

英文

  1. Lanwen Gao, Fansu Meng, Zhenjiang Yang, Markel Lafuente-Merchan, Laura Merino Fernández, Ye Cao, Kosuke Kusamori, Makiya Nishikawa, Shoko Itakura, Junqian Chen, Xiaoxun Huang, Dongfang Ouyang, Oliver Riester, Hans-Peter Deigner, Haibiao Lai, Jose Luis Pedraz, Murugan Ramalingam, Yu Cai.
    Nano-drug delivery system for the treatment of multidrug-resistant breast cancer: Current status and future perspectives.
    Biomedicine & Pharmacotherapy 179, 117327 (2024). （詳細）
  2. Yukiya Takayama, Kosuke Kusamori, Makiya Nishikawa.
    Mesenchymal stem/stromal cells as next-generation drug delivery vehicles for cancer therapeutics.
    Expert Opinion on Drug Delivery 5, 1-16 (2021).
  3. Kosuke Kusamori.
    Development of advanced cell-based therapy by regulating cell-cell interactions.
    Biological and Pharmaceutical Bulletin 44, 1029-1036 (2021).
  4. Makiya Nishikawa, Mengmeng Tan, Wenqing Liao, Kosuke Kusamori.
    Nanostructured DNA for the delivery of therapeutic agents.
    Advanced Drug Delivery Reviews 147, 29-36 (2019).
  5. Yukiya Takayama, Kosuke Kusamori, Makiya Nishikawa.
    Click chemistry as a tool for cell engineering and drug delivery.
    Molecules     24(1), 172 (2019).
  6. Kosuke Kusamori, Yukiya Takayama, Makiya Nishikawa.
    Stable surface modification of mesenchymal stem cells using the avidin-biotin complex technique.
    Current Protocols in Stem Cell Biology 47, e66 (2018).

和文

  1. 金井　舞、西川元也、草森浩輔. “標的細胞へのミトコンドリア導入技術“ 医学のあゆみ 291, 459-464 (2024)（詳細）
  2. 草森浩輔. “細胞間の情報伝達を担う多様な細胞間物質輸送” 科学フォーラム 4, 30-35 (2024).
  3. 草森浩輔、西川元也. “DDS技術を搭載した細胞医薬” Drug Delivery System 38-1, 31-41 (2023).
  4. 西川元也、吉岡志剛、長岡　誠、草森浩輔. “核酸医薬品開発における体内動態とDDS” Drug Delivery System 36-1, 40-50 (2021).
  5. 二神　岳、草森浩輔、西川元也. “エクソソームを含む細胞外小胞の体内動態” オレオサイエンス 21(2), 55-61 (2021).
  6. 西川元也、草森浩輔. “がん治療における核酸免疫アジュバントの高機能化および標的指向化” Drug Delivery System 34-1 (2019).
  7. 山本 昌、勝見英正、草森浩輔、坂根稔康. “ヒアルロン酸を素材とする溶解型マイクロニードルを利用した糖尿病治療薬の経皮吸収性の改善” Japanese Journal of Pharmaceutical and Diabetes 6, 29-33 (2017).
  8. 勝見英正、権 英淑、神山文男、草森浩輔、坂根稔康、山本 昌. ”マイクロニードルを用いたペプチド・タンパク性医薬品の次世代型経皮吸収製剤の開発” YAKUGAKU ZASSHI 134, 63-67 (2014).
  9. 山本 昌、勝見英正、草森浩輔、坂根稔康. “難吸収性薬物の消化管吸収性に及ぼす各種ショ糖脂肪酸エステルの影響” YAKUGAKU ZASSHI 134, 47-53 (2014).
  10. 草森浩輔、西川元也、高橋有己、高倉喜信. “細胞スフェロイド化技術の開発と細胞治療への応用” Drug Delivery System 28, 45-53 (2013).
  11. 勝見英正、草森浩輔、坂根稔康、山本昌. “骨粗鬆症治療薬ビスホスホネートの新規DDS開発と治療への応用” YAKUGAKU ZASSHI 130, 1129-1133 (2010).

その他

著書

  1. 編著：栄田敏之、西川元也. 執筆者：草森浩輔等:　実践薬物速度論 第２版、京都廣川書店 (2023).
  2. 草森浩輔、西川元也、高橋有己、山本　昌、高倉喜信:　第4章　核酸医薬品・遺伝子治療への応用を目的としたDDSの開発　10節　細胞治療へのDDS技術の応用. DDS先端技術の製剤への応用開発、pp. 233-241、技術情報協会 (2017).
  3. 草森浩輔、山本 昌:　第7章　経皮吸収技術を利用した開発事例　第6節 アルツハイマー治療用経皮吸収型製剤. 経皮吸収型製剤開発における基礎と実務への応用、pp. 195-204、情報機構 (2015).

広報・その他

  1. 草森浩輔: 解説. 用語解説「Ex vivo遺伝子治療」Drug Delivery System 38-1, 74 (2023).
  2. 草森浩輔: 解説．2022年のノーベル化学賞を受賞した「クリックケミストリー」の技術開発について解説, 日経サイエンス12月号 P19, 2022.10.25 （https://www.nikkei-science.com/page/magazine/202212.html）
  3. 草森浩輔: 解説．2022年のノーベル化学賞を受賞した「クリックケミストリー」の技術開発について解説, 朝日新聞デジタル, 2022.10.18 『朝日新聞』2022年10月18日 朝刊 電子版 （https://www.asahi.com/articles/DA3S15448137.html?iref=pc_ss_date_article）
  4. 佐々木大輔、草森浩輔、西川元也. 理科大プレスリリース：食用トウモロコシから、がん細胞増殖抑制効果のあるナノ粒子を作製～安価で大量に作製できる治療薬として、がん治療などへの応用に期待～（2022年2月14日）.
    日本語版：https://www.tus.ac.jp/today/archive/20220214_5834.html
    "Amazing" Nanoparticles from Maize: A Potent and Economical Anti-Cancer Therapeutic
    英語版：https://www.tus.ac.jp/en/mediarelations/archive/20220214_5834.html
    EurekAlert: https://www.eurekalert.org/news-releases/943324
    LinkedIn: https://www.linkedin.com/feed/update/urn:li:activity:6898931474607726592
  5. 髙山幸也、草森浩輔、西川元也. 理科大プレスリリース：間葉系幹細胞が腫瘍組織に集積する性質を利用した、新規がん標的治療法を開発〜細胞移植によるドラッグデリバリーシステムの開発〜（2020年12月16日）.
    日本語版：https://www.tus.ac.jp/today/archive/20201215_1057.html
    動画：https://www.youtube.com/user/ridaiweb
    英語版：https://www.tus.ac.jp/en/mediarelati ons/archive/20201216_0123.html
    メディア版：https://www.tus.ac.jp/mediarelations/
  6. 草森浩輔: 奨励賞受賞研究“細胞間相互作用制御に基づいた次世代型細胞治療法の開発”薬事日報 第12432号, 2021年3月19日号p19 (2021).
  7. 草森浩輔、濱野展人: シンポジウムの概要“海外研究留学経験を活かして国際共同研究を展開する方策を考える”薬事日報 第12286号, 2020年3月18日号p13 (2020).
  8. 草森浩輔: 日本経済産業新聞　2017年3月28日「幹細胞　壁を超えて－上」.

学会発表

2023

  1. 草森浩輔、西川元也.間葉系幹細胞の効率的な肝送達による肝疾患治療効果の増強．第39回日本DDS学会学術集会（千葉）, 2023.7.29.（招待講演）
  2. 草森浩輔、西川元也. 細胞医薬品の臨床応用に向けた課題を克服する細胞機能化技術. 日本薬剤学会第38年会（名古屋）, 2023. 5.16.（招待講演）
  3. 草森浩輔、西川元也. 間葉系幹細胞を利用した 核酸デリバリーシステムの開発. 東京理科大学 研究推進機構 総合研究院（RIST）核酸創薬研究部門 第7回シンポジウム（東京）, 2023. 2.25.（招待講演）

2022

  1. 草森浩輔、西川元也: DDS技術を応用した間葉系幹細胞を基盤とする疾患治療法の開発. 東京理科大学 研究推進機構 総合研究院（RIST）東京理科大学薬学部DDSシンポジウム2022（東京）, 2022.12.8.（招待講演）
  2. Kosuke Kusamori, Yukiya Takayama, Makiya Nishikawa: Cell-Based Tumor-Targeted Therapy by Cell Surface Engineering. ICPAC Kota Kinabalu 2022（マレーシア、オンライン）, 2022.11.25.（招待講演）
  3. 草森浩輔、西川元也: 細胞工学技術を応用した間葉系幹細胞を基盤とする細胞医薬の開発. 日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会2022（静岡）, 2022.11.6.（招待講演）
  4. 草森浩輔、西川元也: 細胞を利用したがん標的治療法の開発. 第165回日本獣医学会学術集会（神奈川）, 2022.9.6.（オンライン開催）（招待講演）
  5. 草森浩輔、西川元也: 細胞を利用した薬物送達システムの開発. 遺伝子・デリバリー研究会 第21回シンポジウム、第20回夏期セミナー（東京）, 2022.8.26.（招待講演）
  6. 草森浩輔: DDS技術を基盤とした革新的細胞医薬の開発. 第38回日本DDS学会学術集会（岡山）, 2022.6.30.（オンライン開催）（招待講演）
  7. 草森浩輔: 細胞の高度機能化による有効かつ安全な細胞医薬の開発. 日本薬剤学会第37年会 （京都）, 2022.5.28.（オンライン開催）（招待講演）
  8. 草森浩輔、髙山幸也、西川元也. 間葉系幹細胞表面へのポリエチレングリコール修飾による肺塞栓の回避. 第21回日本再生医療学会総会（オンライン発表）, 2022. 3.

2021

  1. 草森浩輔、西川元也: オルガノイドサイズ依存的なヒト iPS 細胞由来膵島オルガノイドの分化誘導. 東京理科大学薬学部DDSシンポジウム2021（千葉）, 2021.12.18（オンライン開催）（招待講演）
  2. Kosuke Kusamori, Mari Tsujimura, Makiya Nishikawa. Cell suicide-based functional control of genetically modified cells for cell-based gene therapy. Tissue Engineering and Regenerative Medicine International Society (TERMIS) 6th World Congress (Online, Oral presentation), 2021.11.
  3. 草森浩輔、栗林雅之、桑原謙介、髙山幸也、西川元也. 細胞カプセル化と冷蔵保存培地による細胞簡易輸送法の開発. 日本薬剤学会第36年会（オンライン発表）, 2021.5.
  4. 草森浩輔: 細胞間相互作用制御に基づいた次世代型細胞治療法の開発. 日本薬学会第141年会（広島）, 2021.3.28.（オンライン開催）（招待講演）

2020

  1. 草森浩輔、西川元也: 間葉系幹細胞の表面機能化と疾患治療への応用. 東京理科大学薬学部DDSシンポジウム2020（千葉）, 2020.12.19.（オンライン開催）（招待講演）
  2. 草森浩輔、西川元也: 多機能型ワクチンアジュバント開発を指向したナノ構造化免疫刺激性核酸の立体構造設計と最適化. 第69回高分子討論会（盛岡）, 2020.9.17.（オンライン開催）（招待講演）
  3. Kosuke Kusamori: Expansion of the international collaborative research through the short-term overseas research -Looking back my research life in Cincinnati-. 日本薬学会第140年会（京都）, 2020.3.28.（要旨掲載）（招待講演）
  4. Kosuke Kusamori, Philip Lewis, Makiya Nishikawa, James M. Wells: Size regulation of pancreas organoids for the manipulation of their differentiation and fate. iPoPS2020, Noda, 2020.2.29.（要旨掲載）（招待講演）
  5. 草森浩輔: 核酸の高次構造化による効率的な免疫細胞活性化システムの開発. 核酸創薬研究部門第2回シンポジウム/研究交流会（東京）, 2020.1.25.（招待講演）

2019

  1. 草森浩輔：細胞を利用した疾患治療システムの開発．第5回東京慈恵会医科大学・東京理科大学合同シンポジウム（東京）, 2019.10.5.（招待講演）
  2. 草森浩輔、西川元也: スフェロイド作製、培養法と応用～３次元培養・組織化を行うにあたって必要な知識、ポイントと実際の3次元培養モデルの作製方法. 「スフェロイド作製、培養法と応用」セミナー（東京）, 2019.2.28.（招待講演）

2018

  1. Kosuke Kusamori, Makiya Nishikawa: Improving Functioning of Insulin-secreting Cells by Multicellular Spheroid Formation. Tissue Engineering and Regenerative Medicine International Society (TERMIS) World Congress 2018 (Kyoto, Japan), 2018.9.
  2. 草森浩輔、西川元也: オンデマンド機能制御可能な細胞介在型遺伝子治療システムの開発. 第7回超異分野学会本大会（東京）, 2018.3.3.（招待講演）

2017

  1. 草森浩輔: 移植細胞の生体内制御による安全性の高い細胞移植治療. 日本薬物動態学会第32年会（東京）, 2017.11.29.（招待講演）

アワード

  1. 尾花　柊. 独立行政法人日本学術振興会. 特別研究員DC1、2024年9月内定.
  2. 伊藤 悠也. 第29回創剤フォーラム若手研究会 最優秀発表賞. 「アポトーシスした間葉系幹細胞の抗炎症作用の評価」、2024年9月.（詳細）
  3. 尾花　柊. 第40回日本DDS学会学術集会 優秀発表賞.「リンパ管網内蔵組織移植により形成された リンパ節様組織の機能評価」、2024年7月.（詳細）
  4. 尾花　柊. 国立研究開発法人科学技術振興機構. 次世代研究者挑戦的研究プログラム採択事業（SPRING）「2024年度イノベーティブ博士人材育成のための共創力強化プロジェクト」、2024年5月内定（辞退）.
  5. 尾花　柊. 日本薬剤学会第39年会学生主催シンポジウムSNPEE2024優秀発表者賞. 「遠心力を利用して作製したリンパ管網内蔵組織移植によるリンパ節の再生」、2024年5月.（詳細）
  6. 尾花　柊. 日本薬剤学会第39年会永井財団大学院学生スカラシップ. 「遠心力を利用して作製したリンパ管網内蔵組織移植によるリンパ節の再生」、2024年5月.（詳細）
  7. 草森浩輔. 第3回細胞シート工学イノベーションフォーラム ポスター奨励賞「ミトコンドリアを豊富に含む間葉系幹細胞シートの開発」、2023年12月.
  8. 草森浩輔. 第14回日本DDS学会奨励賞（実用化・臨床研究）（日本DDS学会）「DDS技術を基盤とした革新的細胞医薬の開発」、2022年6月.
  9. 草森浩輔. 2022年度日本薬剤学会奨励賞（公益社団法人 日本薬剤学会）「細胞の高度機能化による有効かつ安全な細胞医薬の開発」、2022年5月.
  10. 草森浩輔. 2021年度学校法人東京理科大学優秀研究者奨励賞（学校法人東京理科大学）、2022年3月.
  11. 草森浩輔. 2021年度日本薬学会奨励賞（公益社団法人 日本薬学会）「細胞間相互作用制御に基づいた次世代型細胞治療法の開発」、2021年3月.
  12. 草森浩輔. 第36回リバネス研究費池田理化再生医療研究奨励賞（本賞）（株式会社リバネス／株式会社池田理化）、「細胞増殖制御を介した機能調節可能な遺伝子治療法の開発」、2017年10月．
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