学術論文・著作
PUBLICATIONs

原著論文　　総説　　総説（和文）　　翻訳　　その他
原著論文　　総説　　総説（和文）
翻訳　　その他

原著論文

Takikawa, M., Nakano, A., Krishnaraj, J., Tabata, Y., Watanabe, Y., Okabe, A., Sakaguchi, Y., Fujiki, R., Mochizuki, A., Tajima, T., Sada, A., Matsushita, S., Wakabayashi, Y., Araki, K., Kaneda, A., Ishikawa, F., Sadaie, M., and Ohki, R.
Extrinsic induction of apoptosis and tumor suppression via the p53-Reprimo-Hippo-YAP/TAZ-p73 pathway.
Proc. Natl. Acad. Sci. USA 122, e2413126122 (2025)
[プレスリリース
; ニュースnews
]

 

Kojima, Y., Fujieda, S., Zhou, L., Takikawa, M., Kuramochi, K., Furuya, T., Mizumoto, A., Kagaya, N., Kawahara, T., Shin-ya, K., Dan, S., Tomida, A., Ishikawa, F., and Sadaie, M. 
Cytochrome P450 2J2 is required for the natural compound austocystin D to elicit cancer cell toxicity.
Cancer Sci. 115, 3054-3066 (2024)
[プレスリリース
; press release
; ニュースnews
]

 

Mizumoto, A., Yokoyama, Y., Miyoshi, T., Takikawa, M., Ishikawa, F., and Sadaie, M. 
DHX36 maintains genomic integrity by unwinding G-quadruplexes.
Genes Cells 28, 694-708 (2023)
[received enough views to be a Top Viewed Article in Genes Cells 
 ]

 

Kato, Y.*, Inoue, T.*, Furuyama Y., Ohgane,K., Sadaie, M., and Kuramochi, K. 
Deoxygenation of tertiary and secondary alcohols with sodium borohydride, trimethylsilyl chloride, and potassium iodide in acetonitrile.
Tetrahedron Lett. 86, 153519 (2021)
*equal contribution
 
Cairney, C. J., Godwin, L. S., Bilsland, A. E., Burns, S., Stevenson, K. H., McGarry, L., Revie, J., Moore, J. D., Wiggins, C. M., Collinson, R. S., Mudd, C., Tsonou, E., Sadaie, M., Bennett, D. C., Narita, M., Torrance, C. J., Keith, W. N.
A 'synthetic-sickness' screen for senescence re-engagement targets in mutant cancer backgrounds.
PLoS Genet. 13, e1006942 (2017)
 
Furubayashi, T., Motohashi, K., Wakao, K., Matsuda, T., Kii, I., Hosoya, T., Hayashi, N., Sadaie, M., Ishikawa, F., Matsushita, M., and Fujiyoshi, S.
Three-dimensional localization of an individual fluorescent molecule with angstrom precision.
J. Am. Chem. Soc. 139, 8990-8994 (2017)
 
 
Sadaie, M., Dillon, C., Narita, M., Young, A. R. J., Cairney, C. J., Godwin, L. S., Torrance, C. J., Bennett, D. C., Keith, W. N., and Narita, M.
Cell-based screen for altered nuclear phenotypes reveals senescence progression in polyploid cells after Aurora kinase B inhibition.
Mol. Biol. Cell 26, 2971-2985 (2015)
 
[highlighted in: Silence the uncontrolled cancer cells’ growth by controlling cellular senescence. Atlas of Science (2016)
]
 
Bilsland, A. E., Pugliese, A., Liu, Y., Revie, J., Burns, S., McCormick, C., Cairney, C. J., Bower, J., Drysdale, M., Narita, M., Sadaie, M., and Keith, W. N.
Identification of a selective G1-phase benzimidazolone inhibitor by a senescence-targeted virtual screen using artificial neural networks.
Neoplasia 17, 687-756 (2015)
 
Sadaie, M.*, Salama, R.*, Carroll, T., Tomimatsu, K., Chandra, T., Young, A. R., Narita, M., Pérez-Mancera, P. A., Bennett, D. C., Chong, H., Kimura, H., and Narita, M.
Redistribution of the Lamin B1 genomic binding profile affects rearrangement of heterochromatic domains and SAHF formation during senescence.
Genes Dev. 27, 1800-1808 (2013)
*equal contribution
 
Shirai, A.*, Sadaie, M.*, Shinmyozu, K., and Nakayama, J.
Methylation of ribosomal protein L42 regulates ribosomal function and stress-adapted cell growth.
J. Biol. Chem. 285, 22448-22460 (2010)
*equal contribution
 
Young, A. R.*, Narita, M.*, Ferreira, M., Kirschner, K., Sadaie, M., Darot, J. F., Tavaré, S., Arakawa, S., Shimizu, S., Watt, F. M., and Narita, M.
Autophagy mediates the mitotic senescence transition.
Genes Dev. 23, 798-803 (2009)
*equal contribution
 
Shimada, A., Dohke, K., Sadaie, M., Shinmyozu, K., Nakayama, J., Urano, T., and Murakami, Y.
Phosphorylation of Swi6/HP1 regulates transcriptional gene silencing at heterochromatin.
Genes Dev. 23, 18-23 (2009)
 
Sadaie, M., Kawaguchi, R., Ohtani, Y., Arisaka, F., Tanaka, K., Shirahige, K., and Nakayama, J.
Balance between distinct HP1 proteins controls heterochromatin assembly in fission yeast.
Mol. Cell Biol. 28, 6973-6988 (2008)
 
Sadaie, M., Shinmyozu, K., and Nakayama, J.
A conserved SET-domain methyltransferase, Set11, modifies ribosomal protein Rpl12 in fission yeast.
J. Biol. Chem. 283, 7185-7195 (2008)
 
Kanoh, J., Sadaie, M., Urano, T., and Ishikawa, F.
Telomere-binding protein Taz1 establishes Swi6 heterochromatin independently of RNAi at telomeres.
Curr. Biol. 15, 1808-1819 (2005)
 
Sadaie, M., Iida, T., Urano, T., and Nakayama, J.
A chromodomain protein, Chp1, is required for the establishment of heterochromatin in fission yeast.
EMBO J. 23, 3825-3835 (2004)
 
Sadaie, M., Naito, T., and Ishikawa, F.
Stable inheritance of telomere chromatin structure and function in the absence of telomeric repeats.
Genes Dev. 17, 2271-2282 (2003)
 
[highlighted in: Telomere stutters superfluous. Nature 425, 253 (2003)
]
 
Miyoshi, T., Sadaie, M., Kanoh, J., and Ishikawa, F.
Telomeric DNA ends are essential for the localization of Ku at telomeres in fission yeast.
J. Biol. Chem. 278, 1924-1931 (2003)
 
Kobayashi, T., Sadaie, M., Ohnishi, M., Wang, H., Ikeda, S., Hanada, M., Yanagawa, Y., Nakajima, T., and Tamura, S. 
Isoform-specific phosphorylation of fission yeast type 2C protein phosphatase. 
Biochem. Biophys. Res. Commun. 251, 296-300 (1998)

総説

Salama, R.*, Sadaie, M.*, Hoare, M.*, and Narita, M.
Cellular senescence and its effector programs.
Genes Dev. 28, 99-114 (2014)
 *equal contribution

総説（和文）

定家真人  細胞老化. 皮膚科 7, 84-90 (2025)  
 
定家真人  がん細胞の無限増殖を保証するテロメア維持機構の解明と征圧. 科学フォーラム 433, 8-11 (2023)  LinkIcon 
 
定家真人  がんを理解する〜後編〜. I/O 7月号, 102-103 (2020) 
 
定家真人  がんを理解する〜前編〜. I/O 6月号, 102-103 (2020) 
 
定家真人, 石川冬木 合成致死を利用したがん治療. 日本臨牀 72（増刊2）, 84-89 (2014) 
 
定家真人, 成田匡志 細胞老化における核とクロマチンの動態. 実験医学 31（増刊）, 148-154 (2013) 
 
定家真人, 成田匡志 老化. 牛島俊和, 眞貝洋一（編）エピジェネティクスキーワード事典, 羊土社, 東京. 160-168 (2013) 
 
定家真人, 成田匡志 細胞老化・個体老化における核構造と遺伝子発現の調節. 実験医学 27（増刊）, 2774-2778 (2009) 
 
定家真人, 成田匡志 細胞老化におけるクロマチン構造変換のダイナミズム. 蛋白質核酸酵素 54（増刊）, 508-513 (2009) 
 
定家真人, 中山潤一 ヒストンのメチル化修飾と高次クロマチン構造の形成機構.  蛋白質核酸酵素 52, 739-746 (2007) 
 
定家真人, 石川冬木 テロメアと染色体の維持機構. 竹安邦夫, 米田悦啓（編）細胞核のダイナミクス, シュプリンガー・フェアラーク東京, 東京. 159-168 (2004)
 
定家真人, 中山潤一 ヘテロクロマチン化の分子機構. 実験医学 21（増刊）, 1478-1484 (2003)

翻訳

定家真人 DNA損傷応答としての癌遺伝子誘導型生細胞老化. 細胞工学 27, 865-869 (2008) (Calabrese, V., and Ferbeyre, G. Oncogene-induced senescence as a DNA damage response.)

その他

学生インタビュー1, 佐藤成美（著） 生命科学部, なるにはBOOKS 大学学部調べ, ぺりかん社, 東京. 78-81 (2025)