Takahashi, Y., Sato, K., Wada, T. Preparation of boranophosphate DNA via the boranophosphotriester method and synthesis of P-modified DNAs from boranophosphate DNA via an acyl phosphite intermediate. Current Protocols in press.
Ikeda, Y., Yamashita, N., Ito, N., Minamikawa, N., Okamura, H., Yashiro, T., Hachisu, M., Aida, M., Yamada, R., Nagata, K., Nishiyama, C. Immunostimulatory effects of Hyndrickxia coaglans SANK70258. Biosci. Biotechnol. Biochem.89: 622-632 (2025).
Oishi, K., Nakano, N., Ota, M., Inage, E., Izawa, K., Kaitani, A., Ando, T., Hara, M., Ohtsuka, Y., Nishiyama, C., Ogawa, H., Kitaura, J., Okumura, K., Shimizu, T. MHC class II-expressing mucosal mast cells promote intestinal mast cell hyperplasia in a mouse model of food allergy. Allergy80: 2297-2309 (2025).
Takahashi, M., Nagata, K., Watanuki, Y., Yamaguchi, M., Ishii, K., Harada, T., Minamikawa, N., Katagiri, M., Zhao, W., Ito, N., Yashiro, T., Nishiyama, C. Kaempferol exerts anti-inflammatory effects by accelerating Treg development via Aryl hydrocarbon receptor-mediated and PU.1/IRF4-dependent transactivation of the Aldh1a2/Raldh2 gene in dendritic cells. Allergy80:896-900 (2025).
Tojima, R., Nagata, K., Ito, N., Ishii, K., Arai, T., Ito, T., Kasakura, K., Nishiyama, C. Roles of C/EBPa, GATA2, TGF-b signaling, and epigenetic regulation in the expression of basophil-specific protease genes. FEBS Lett. 599:777-786 (2025).
Hamada, M., Yoshida, S. Conditional fluorescent changes of azaylides with fluorescent chromophores, Chem. Lett. 54: upaf033 (2025)
Hoshi, Y., Tabata, S., Yoshida, S. Synthesis of α-arylacetophenone derivatives by Grignard reactions and transformations of arynes via C–C bond cleavage. Chem. Commun. 61: 3752 (2025).
Kawada, M., Tabata, S., Hoshi, Y., Yoshida, S. Thioxanthone Synthesis from Thioureas through Double Aryne Insertion into a Carbon=Sulfur Double Bond. Org. Lett. 27: 827 (2025).
Tanaka, T., Tabata, S., Nakamura, K., Hazama, Y., Sakata, Y., Hosoya, T., Yoshida, S. Synthesis of Multisubstituted Naphthalenes through Consecutive Aryne Reactions. Bull. Chem. Soc. Jpn. 98: uoaf001 (2025).
Yasuda, T., Orimoto, G., Yoshida, S. Three-step click assembly using trivalent platforms bearing azido, ethynyl, and fluorosulfonyl groups. Chem. Commun. 61: 2333 (2025).
Hirose, K., Nitto, R., Yokota, S., Kawano, Y., Yamatoya, K., Tabuchi, A., Suzuki, Y., Hanawa, T. Preparing and Characterizing of Xyloglucan Films Containing Tea Extract for Oral Mucositis. ACS Omega 10, 390–399 (2025).
Yoshioka, Y., Yamamoto, S., Kusamori, K., Nakayama, M., Fujita, H., Goto. A., Iwasaki, S., Nagata, T., Itakura, S., Kusuhara, H., Yokota, T., Hirabayashi, H., Nishikawa, M. Pharmacokinetics and protein binding of cholesterol-conjugated heteroduplex oligonucleotide. J. Control. Release 380: 787-799 (2025).
Jin, J., Kusamori, K., Tanifuji, T., Yamagata, Y., Itakura, S., Nishikawa, M. Biocompatible DNA hydrogel composed of minimized Takumi-shaped DNA nanostructure exhibits sustained retention after in vivo administration. J. Control. Release 377: 704-715 (2025). 東京理科大学プレスリリース https://www.tus.ac.jp/today/archive/20250213_0214.html
Kakuta, K., Sakamoto, T., Sato, H., Sato, K., Wada, T. Stereocontrolled Synthesis and NMR Analysis of PB/PO Chimeric Oligonucleotides. R. Soc. Open Sci. in press (2025).
Akita, T. Curative Treatment for COPD Based on Differentiation Induction by Synthetic Retinoid Am80 and Development of Inhalation Powder. YAKUGAKU ZASSHI 145: 1-6 (2025).
Nozaki, Y., Mizunoe, Y., Kobayashi, M., Higami, Y. WW Domain-Containing E3 UbiquitinProtein Ligase 1 (WWP1) as a Factor in Obesity-Related Metabolic Disorders:Emerging Molecular Mechanisms in Metabolic Tissues. Int. J. Mol.Sci., 26(18): 9172 (2025).
Ishimatsu, M., Taki, K., Hayami, A., Kato, K., Nozaki, Y., Mizunoe, Y., Narita, T., Mori, R., Higami, Y., Kobayashi, M. Co-overexpressionof the caloric restriction-induced mitochondrial factors PGC-1α and MIPEPupregulates Phospho1 expression in adipocytes. FEBS Open Bio,15(10): 1643–1657 (2025).
Mizunoe, Y., Kumagai,M., Fukai, H., Hachiya, K., Otani, Y., Nozaki, Y., Tezuka, K.,Kobayashi, M., Haeno, H., Saeki, K., Murayama, Y.,Shimano, H., Higami, Y. Caloricrestriction alters NCOA2 splicing to regulate lipid metabolism in subcutaneouswhite adipose tissue.Biochem. Biophys. Res. Commun., 765: 151871 (2025).
Nozaki, Y., Ose, Y., Ohmori, C., Mizunoe, Y.,Kobayashi, M., Saitoh, A., Higami,Y. Depletion of WWP1 Increases Adrb3 Expression and Lipolysis in WhiteAdipose Tissue of Obese Mice. Int. J. Mol. Sci., 26(9):4219 (2025).
Nozaki, Y., Kobayashi,M., Fukuoh, T., Ishimatsu,M., Narita, T., Taki, K., Hirao, Y., Ayabe, S.,Yokoyama, M., Otani, Y., Mizunoe, Y.,Matsumoto, M., Ohno, N., Kaifu, T., Okazaki, S., Goitsuka,R., Nakagawa, Y., Shimano, H., Iwakura, Y., Higami,Y. Mipep deficiency in adipocytes impairsmitochondrial protein maturation and leads to systemic inflammation andmetabolic dysfunctions. Sci. Rep., 15(1): 12839 (2025).
Ishii, K.,Nagata, K., Yamashita, N., Yamazaki, Y., Akimoto, Y., Zhao, W, Inoue, M., Ito,N., Kasakura, K., Nishiyama, C. PU.1 and TGF-b signalingactivate the cell-surface expression of CD103 in mast cells and dendriticcells: opposite roles of GATA2 in the expression of mucosal mast cell genes. FEBSJ., in press.
Nagata, K., Kasakura, K., Ishii, K., Ito, N., Hara, M., Nakano, N.,Okumura, K. Nishiyama, C. The role of GATA2 in the expression of thesoluble decoy receptor ST2/IL1RL1 in human and mouse mast cell. Allergol. Int., in press.
Saito, J.,Yamatani, A., Kojima, Y., Nakakuni, M., Nakano, K., Hirose, K., Nakamura, H., Hanawa,T., and Akabane, M. Stability and Dissolution Behavior Changes After DrugCompounding for Pediatric Cardiovascular Pharmacotherapy. Pharmaceutics,17:535-550(2025).
Okutsu, H., Takahashi, Y., Shiraishi, T., Kashio, U., Sato, K., Wada, T. Synthesis ofP-Modified Chimeric Oligonucleotides via ChemoselectiveCondensation of Nucleoside 3′-H-Phosphonothioate.J. Org. Chem. ;90: 12346–12358 (2025).
Takahashi, Y., Kato, I., Sato, K. Wada,T. Solution-Phase Synthesis of Boranophosphateand Boranophosphate/Phosphorothioate/PhosphateChimeric Oligonucleotides via the H-BoranophosphonateMethod. J. Org. Chem. ;90: 8966-8985 (2025).
Nakamura, N., Kakuta,K., Sato, K., Wada, T. Stereoselective Synthesis of NucleotideAnalog Prodrugs (Protides) via an OxazaphospholidineMethod. J. Org. Chem. ;90: 6434-6442 (2025).
Prevention ofSerious Adverse Drug Reactions and Economic Effects Through Community Pharmacists’ Inquiries, Home Care, and MedicationFollow-up: From The Japanese NationwidePharmacy Collaboration Survey in 2023”, Shu Sekiya, ReiTanaka, Hisashi Iijima,Yoshio Nakano, Satoru Miyazaki, Atsushi Toyomi, Hajime Hashiba, Masanori Nagatsu, Yoshiaki Shikamura, Yakugaku Zasshi,145:707-722, (2025).
Pain-stimulated ultrasoundvocalizations and their impact on painresponse in mice”, SatokaKasai, Saki Ukai, Junpei Kuroda, Tsugumi Yamauchi, Daisuke Yamada, Akiyoshi Saitoh, Satoshi Iriyama, MasashiSuzuki, Kazuki Arita, Yoshio Nakano,Satoru Miyazaki, Kazumi Yoshizawa,PLoS One,20: e0324730, (2025).
Polyamines stimulatethe protein synthesis of theinitiation factor eIF5A2 participatingin mRNA decoding distinct from eIF5A1”, Suzuki M, Suzuki T, NakanoY, Matsumoto K, Manaka H, KomenoM, Tamori S, Sato A, Dohmae N, Akimoto K, Miyazaki S, Suda T, Toida T, Kashiwagi K, Igarashi K,Higashi K, J. Biol. Chem.,301: 110453, (2025).
Ohira, K., Numata,K., Yoshida, S. Synthesis ofPartially Reduced Biaryls from ThiopheneS,S-Dioxides and Styrenes, Bull. Chem. Soc. Jpn., 98: uoaf052 (2025).
Hiromasa, S., Hamada, M., Orimoto, G., Yoshida, S. Sequentialassembly via Michael addition of 2-(triazolyl)acrylates, Bull. Chem. Soc. Jpn., 98:uoaf061 (2025).
Meng, F., Wang, P., Yang, L.,Yan, J., Giri, A. K., Lee, J., Kusamori, K., Nishikawa, M., Itakura,S., Gu, H., Li, Q., Chen, Z., Yang, Z., Li, D., Cai, Y. Construction ofpH-responsive albumin nanoparticles loaded with baicalin and evaluation oftheir anti-breast cancer activity. Int. J. Biol. Macromol.,322: 146937 (2025).
Hashimoto, M., Itakura,S., Kusamori, K., Yajima, K., Mitsuhashi, S., Hayashi, S., Todo, H.,Nishikawa, M. Therapeutic potential of rose hip-derived nanoparticlesfor psoriatic skin inflammation. ACS Biomater. Sci. Eng., 11:5938-5951 (2025).
Matsumoto, S.,Itakura, S., Minato, J., Hashimoto, M., Obana, S., Kanai, M., Kobayashi,M., Nishikawa, M., Kusamori, K. Cell Observation and Analysiswith a Three-Dimensional Optical Wave Field Microscope. Biosensors,15: 515 (2025).
Itakura, S., Kusamori, K., Nishikawa,M. 非哺乳類由来細胞外小胞の機能とDDSへの応用. 膜, 50: 174-179 (2025).
Li, Q., Meng, F., Yang,L., Díaz García, A. M., Parkhats, M., Lee, J., Kusamori, K., Nishikawa,M., Gu, H., Li, Q., Williams, G. R., Yang, Z., Cai, Y. MetabolicReprogramming of Tumors: Induced Immunosuppression and Therapeutic Prospects ofNanoscale Drug Delivery Systems. Mol. Pharm.,22: 5193-5211. (2025).
Mizutani, A., Kondo, M., Itakura,S., Takamura, H., Hoshino, Y., Nishikawa, M., Kadota, I., Kusamori,K., Tanaka, K. Redox-potential-controlled intermolecular [2 + 2]cycloaddition of styrenes for the regio- and diastereoselective synthesis ofmultisubstituted halogenocyclobutanes. Bull. Chem. Soc. Jpn., 98:uoaf044 (2025).
Li, Q., Meng, F., Xie,M., Nishikawa, M., Kusamori, K., Giri, AK., Yang, L., Li, Qi.,Gu, H., Chen, Z., Yang, Z., Qin, J., Cai, Yu. Folate-targeted pH-sensitivealbumin nanoparticles loaded with Baicalin enhance tamoxifen efficacy andovercome drug resistance in estrogen receptor alpha-positive breast cancer. Int.J. Biol. Macromol., 318: 145-155 (2025).
Jin, J., Kusamori, K.,Yamagata, Y., Itakura, S., Nishikawa, M. Induction of sustainedantibody responses by subcutaneous administration of immunostimulatoryTakumi-shaped CpG DNA hydrogel loaded with Japanese cedar pollen antigen Cryj1in mice. J. Drug Deliv. Sci. Technol., 109: 107011 (2025).
Oshima, N., Kusamori,K., Takasaki, R., Hada, N., Nishikawa, M. Baicalin-inducedhepatocyte toxicity: The critical role of multidrug resistance-associatedprotein 2. Integr. Med. Discov., 9: e25001 (2025).
Narita, I., Todo, H.,Fujiwara, C., Teramae, H., Oshizaka, T., Itakura, S., Komatsu, S.,Takayama, K., Sugibayashi, K. In silico model to predict dermal absorption ofchemicals in finite dose conditions, J. Toxicol. Sci., 50:171-186 (2025).
Tamori S,Matsuda C, Kasai T, Ohno S, Sasaki K, ;Akimoto K. Asymmetric celldivision of ALDH1-positive cancer stem cells generates glycolytic metabolicallydiverse cell populations, Sci Rep. 15(1):13932 (2025).
Zeng Q, TamoriS, Harada T, Application of Graph Attention Network for Breast Cancer Dataand Explanation of Prediction Basis, IEEE Access,13:99183-99191(2025).
Suzuki M, Suzuki T, Nakano Y, Matsumoto K,Manaka H, Komeno M,Tamori S, Sato A, Dohmae N, ;Akimoto K, Miyazaki S, Suda T, Toida T, Kashiwagi K, Igarashi K, Higashi K. Polyaminesstimulate the protein synthesis of the translation initiation factor eIF5A2,participating in mRNA decoding, distinct from eIF5A1, J Biol Chem.301(8):110453(2025). Online ahead of print.
Nagashima Y, Sasaki K, ChiwakiR, Ishii H, Nohata K, MaemuraY, Kasai T, Ozaki A, Tamori S, Ohno S, ;AkimotoK. High Expression of ;PKCζ ;And ;CTNNBIP1 ;IsAssociated With Poor Prognosis in Luminal B BreastCancer, Cancer Genomics Proteomics. ;22(4):538-556(2025).
Nagashima Y, Sasaki K, NohataK, Chiwaki R, Maemura Y,Kasai T, Ozaki A, Tamori S, OhnoS, ;Akimoto K. High Expression of PKCζand ALDH1A3 Is Associated With Poor Prognosisin Luminal B Breast Cance, Anticancer Res.,45(10):4357-4372(2025).
Maemura Y, Ozaki A, ChiwakiR, Enomoto M, Tada Y, Nagashima Y, Ishii H, Nohata K,Kasai T, Okiyama R, Harada Y, TamoriS, Ohno S, Sasaki K, Akimoto K, High p62and ALDH1A3reduce the effectiveness ofendocrine therapy in luminal B breast cancer, CancerDiagn. Progn.(2025) in press.
Nohata k, Enomoto M, Ishiyama A, Nagashima y, Okiyama R, Kasai T, TamoriS, Harada Y, Ohno S, Sasaki K, Akimoto K,PKCζ, CTNNBIP1 and ALDH1A3 expression in luminal B breastcancer indicates decreased hormone therapyeffectiveness, Cancer Diagn. Progn. (2025)in press.
Yosioka,Y., Yamamoto, S., Kusamori, K.,Nakayama, M., Fujita, H., Goto, A., Iwasaki, S., Nagata, T., Itakura, S., Kusuhara, H., Yokota, T., Hirabayashi, H., Nishikawa, M.Pharmacokinetics and protein binding of cholesterol-conjugated heteroduplexoligonucleotide. J. Control. Release. 380: 787-799 (2025).
Jin, J., Kusamori, K., Tanifuji, T., Yamagata, Y., Itakura, S., Nishikawa,M. Biocompatible DNA hydrogel composed of minimized Takumi-shaped DNAnanostructure exhibits sustained retention after in vivo administration. J.Control. Release., 377: 704-715 (2025).
2024
Takasawa, S., Kimura, K., Miyanaga, M., Uemura, T., Hachisu, M., Miyagawa, S., Ramadan, A., Sukegawa, S., Kobayashi, M., Kimura, S., Matsui, K., Shiroishi, M., Terashita, K., Nishiyama, C., Yashiro, T., Nagata, K., Higami, Y., Arimura, G. The powerful potential of amino acid menthol esters for anti-inflammatory and anti-obesity therapies. Immunology173:76-92 (2024).
Ando, M., Nagata, K., Takeshita, R., Ito, N., Noguchi, S., Minamikawa, N., Kodama, N., Yamamoto, A., Yashiro, T., Hachisu, M., Ichihara, G., Kishino, S., Yamamoto, M., Ogawa, J., Nishiyama, C. The gut lactic acid bacteria metabolite, 10-oxo-cis-6,trans-11-octadecadienoic acid, suppresses inflammatory bowel disease in mice by modulating the NRF2 pathway and GPCR-signaling. Front. Immunol.15:1374425 (2024).
Mizobuchi, S., Hirose, K., Ishii, N., Kawano, Y., Hanawa, T. Preparation and characterization of the ground mixture of rebamipide commercial tablets and Hydroxypropyl Cellulose-SSL by ball-milling: Application to the dispersoid of mouthwash suspension. Eur. J. Pharm. Biopharm. 206:114584 (2024).
Nakamura, K., Suzuki, M., Yoshida, S. Synthesis of Thiaphenanthridinones from Sulfinate Esters and 2-Borylanilines. Org. Lett. 26: 9676 (2024).
Yamamoto, C., Numata, K., Suzuki, M., Yoshida, S. Regioselective pyridazine synthesis from tetrazines and alkynyl sulfides. Org. Chem. Front. 11: 6159 (2024).
Pal, K., Singh S., Itakura, S., Hashimoto M., Kusamori, K., Nishikawa, M. Reactive oxygen species augmented polydopamine-chlorin e6 nanosystem for enhanced hemo/photothermal/photodynamic therapy: A synergistic trimodal combination approach in vitro and in vivo. Int. J. Biol. Macromol. 283: 137236 (2024).
Gao, L., Meng, F., Yang, Z., Merchan, M.L., Fernández, L.M., Cao, Y., Kusamori, K., Nishikawa, M., Itakura, S., Chen, J., Huang, X., Ouyang, D., Riester, O., Deigner, H.P., Lai, H., Pedraz, J.L., Ramalingam, M., Cai, Y. Nano-drug delivery system for the treatment of multidrug-resistant breast cancer: Current status and future perspectives. Biomed. Pharmacother. 179:117327 (2024).
Yoshida, Y., Aoki, M., Nagase, K., Marubashi, K., Kojima, H., Itakura, S., Komarsu, S., Sugibayashi, K., Todo, H. Plasmid DNA delivery into the skin via electroporation with a depot-type electrode. Pharmaceutics 16:1219 (2024).
Torigoe, H., Nakayama, S., Shiraishi, T., Sato, K., Hara, R. I., Wada, T. Development of cationic oligodiaminogalactoses specifically binding to duplex RNA, but not to duplex DNA. Thermochimica Acta 738: 179789 (2024).
Yang, Y., Nakayama, K., Okada, S., Sato, K., Wada, T., Sakaguchi, Y., Murayama, A., Suzuki, T., Sakurai, M. ICLAMP: a novel technique to explore adenosine deamination via inosine chemical labeling and affinity molecular purification. FEBS Lett. 598: 1080-1093 (2024).
Nozaki, Y., Suwa, F., Furuya, K., Komeno, M., Hoshino, S., Mizunoe, Y., Higashi, K., Kobayashi, M., Higami, Y. The effects of WWP1 overexpression on the golgi apparatus stress response and proteoglycan production in adipocytes. Scientific Reports. 14(1): 29004-29004 (2024).
Oshima, N., Kusamori, K., Takasaki, R., Takeda, M., Katsurada, Y., Nose, T., Okoshi, K., Nishikawa, M., Hada, N. Scutellaria Root extract-induced hepatocytotoxicity can be controlled by regulating its baicalin content. J. Nat. Med. 78: 978-984 (2024).
Kawato, K., Sato, K., Wada, T. α-Selective Solid-Phase Synthesis of Glycosyl Phosphate Repeating Structure via the Phosphoramidite Method. Chem. Eur. J. e202401226 (2024).
Matsuoka I, Kasai T, Onaga C, Ozaki A, Motomura H, Maemura Y, Tada Y, Mori H, Hara Y, Xiong Y, Sato K, Tamori S, Sasaki K, Ohno S, Akimoto K, Co‑expression of SLC20A1 and ALDH1A3 is associated with poor prognosis, and SLC20A1 is required for the survival of ALDH1‑positive pancreatic cancer stem cells, Oncol Lett. 2024 Jul 5;28(3):426. doi: 10.3892/ol.2024.14558. eCollection 2024 Sep.
Imai, S., Fukano, Y., Niwayama, Y., Tamura, N., Miyoshi, M., Fukuhara, K., Kodaira, H., Iwazaki, N., Yamanaka, Y., Miyazawa, N., Takakusa, H., Kadotsuji, K., Goto, A., Shimada, S., Yoshida, T., Obika, S., Nishikawa, M. Inoue, T. Survey and Consideration for Evaluation of Tissue Distribution and Plasma/Serum Protein Binding of Approved Oligonucleotide Therapeutics. 医薬品医療機器レギュラトリーサイエンス 55(3):208-209 (2024).
Tan, M., Makiguchi, N., Kusamori, K., Itakura, S., Takahashi, Y., Takakura, Y., Nishikawa, M. Tuning CpG motif position in nanostructured DNA for efficient immune stimulation. Biotechnology Journal 19(4):e2300308 (2024).
Sasaki, D., Suzuki, H., Kusamori, K., Itakura, S., Todo, H., Nishikawa, M. Development of rice bran -derived nanoparticles with excellent anti-cancer activity and their application for peritoneal dissemination. Journal of Nanobiotechnology 22:114 (2024).
Akita, T., Shimamura, M., Tezuka, A., Takagi, M., Yamashita, C., GLP-1 derivatives with functional sequences transit and migrate through trigeminal neurons. European Journal of Pharmaceutics and Biopharmaceutics 195: 114176 (2024).
Orimoto, G., Yoshida, S., Iterative click reactions using trivalent platforms for sequential molecular assembly, Chemical Communication, 60: 4545 (2024).
Tabata, S., Yoshida, S., Bromothiolation of Arynes for the Synthesis of 2-Bromobenzenethiol Equivalents, Organic Letters, 26: 3816 (2024).
Kobayashi, A., Tabata, S., Yoshida, S., Highly substituted benzo[b]furan synthesis through substituent migration, Chemical Communication, 60: 4545 (2024). A. Kobayashi, S. Tabata, S. Yoshida*
Kumagai, Y., Kobayashi, A., Nakamura, K., Yoshida, S., Facile Synthesis of Dibenzothiophene S-Oxides from Sulfinate Esters, Chemical Communication, 60: 1611 (2024).
Kanemaru, K., Nagasawa, K., Kunugi, Y., Tanaka, A., Tai, Y., Harada, Y., Nakamura, Y. Epidermal loss of Bcl6 exacerbates MC903-induced atopic dermatitis-like skin inflammation. Biochem. Biophys. Res. Commun. 705:149745 (2024).
Nagata, K., Ando, D., Ashikari, T., Ito, K., Miura, R., Fujigaki, I., Goto, Y., Ando, M., Ito, N., Kawazoe, H., Iizuka, Y., Inoue, M., Yashiro, T., Hachisu, M., Kasakura, K., Nishiyama, C. Butyrate, valerate, and niacin ameliorate anaphylaxis by suppressing IgE-dependent mast cell activation: Roles of GPR109A, PGE2, and epigenetic regulation. J. Immunol. 212:771-784 (2024).