核酸創薬研究部門 - 東京理科大学 研究推進機構総合研究院

研究業績

2021年の業績

  1. Kobayashi, M., Yasukawa, H., Arikawa, T., Deguchi, Y., Mizushima, N., Sakurai, M., Onishi, S., Tagawa, R., Sudo, Y., Okita, N., Higashi, K., Higami, Y. Trehalose induces SQSTM1/p62 expression and enhances lysosomal activity and antioxidative capacity in adipocytes. FEBS Open Bio. 11(1):185-194 (2021).
  2. Motomura, H., Ozaki, A., Tamori,S., Onaga, C., Nozaki, Y., Waki, Y., Takasawa, R., Yoshizawa, K., Mano, Y., Sato, T., Hanawa, T., Sato, K., Miyagi, Y., Nagashima, Y., Yamamoto, K., Sasaki, K., Ishiguro, H., Tanuma, S., Ohno, S., Akimoto, K. Glyoxalase 1 and protein kinase Cλ as potential therapeutic targets for late-stage breast cancer, Oncology letters. In press.
  3. Onaga, C., Tamori, S., Motomura, H., Ozaki, A., Matsuda, C., Matsuoka, I., Fujita, T., Nozaki, Y., Hara, Y., Kawano, Y., Harada, Sato, T., Mano, Y., Sato, K., Akimoto, K. High SLC20A1 expression is associated with poor prognoses in claudin-low and basal-like breast cancers, Anticancer Res. 41: 43-54 (2021).
  4. Shiromoto, Y.*, Sakurai, M.* (*Equal contribution as a 1st author), Minakuchi, M.*, Ariyoshi, K., and Nishikura, K. ADAR1 RNA editing enzyme regulates R-loop formation and genome stability at telomeres in cancer cells. Nat. Commun. 2021 Mar 12;12(1):1654. (2021).
  5. Yang, Y., Okada, S., and Sakurai, M+(Corresponding Author). Adenosine-to-inosine RNA editing in neurological development and disease. RNA Biology. Jan. 6:1-15 (2021).
  6. Mai, N., N., S., Otsuka, Y., Goto, S., Kawano, Y., Hanawa, T., Effects of polymer molecular weight on curcumin amorphous solid dispersion; at-line monitoring system based on attenuated total reflectance mid-infrared and near-infrared spectroscopy, Journal of Drug Delivery Science and Technology, 61: 102278 (2021).

2020年の業績

  1. Itagaki, K., Sasada, M., Miyazaki, S., Iyoda, T., Imaizumi, T., Haga, M., Kuga, A., Inomata, H., Kondo, Y., Osada, S., Kodama, H., Higami, Y., Fukai, F. Exposure of the cryptic de-adhesive site FNIII14 in fibronectin molecule and its binding to membrane-type eEF1A induce migration and invasion of cancer cells via β1-integrin inactivation. Am. J. Cancer Res. 10:3990-4004 (2020).
  2. Zhao, J., Nishiumi, S., Tagawa, R., Yano, Y., Inoue, J., Hoshi, N., Yoshida, M., Kodama, Y. Adrenic acid induces oxidative stress in hepatocytes. Biochem. Biophys. Res. Commun. 532:620-625 (2020).
  3. Yamashita, K., Tagawa, R., Higami, Y., Tokunaga, E. Noninvasive and Safe Cell Viability Assay for Breast Cancer MCF-7 Cells Using Natural Food Pigment. Biology (Basel). 9:227 (2020).
  4. Tomonaga, O., Kobayashi, M., Tagawa, R., Higami, Y. The Effects of Teneligliptin on Lipid Profile: A Prospective Study for Comparison of Biomarkers Before and After a Meal, J. Endocrinol. Metab. 10:79-88 (2020).
  5. Kobayashi, M., Uta, S., Otsubo, M., Deguchi, Y., Tagawa, R., Mizunoe, Y., Nakagawa, Y., Shimano, H., Higami, Y. Srebp-1c/Fgf21/Pgc-1α Axis Regulated by Leptin Signaling in Adipocytes-Possible Mechanism of Caloric Restriction-Associated Metabolic Remodeling of White Adipose Tissue. Nutrients. 12:2054 (2020).
  6. Miyano, K., Ohbuchi, K., Sudo, Y., Minami, K., Yokoyama, T., Yamamoto, M., Uzu, M., Nonaka, M., Shiraishi, S., Murata, H., Higami, Y., Uezono, Y. A novel method for evaluating activity of transient receptor potential channels using a cellular dielectric spectroscopy. J. Pharmacol. Sci. 143:320-324 (2020).
  7. Nakane, Y., Kemmochi, Y., Ogawa, N., Sasase, T., Ohta, T., Higami, Y., Fukai, F. Hyperglycemia contributes to the development of Leydig cell hyperplasia in male Spontaneously Diabetic Torii rats. J. Toxicol. Pathol. 33:121-129 (2020).
  8. Kobayashi, M., Ishizaki, Y., Owaki, M., Matsumoto, Y., Kakiyama, Y., Hoshino, S., Tagawa, R., Sudo, Y., Okita, N., Akimoto, K., Higami, Y. Nutlin-3a suppresses poly (ADP-ribose) polymerase 1 by mechanisms different from conventional PARP1 suppressors in a human breast cancer cell line. Oncotarget. 11:1653-1665 (2020).
  9. Koinuma, S., Negishi, R., Nomura, R., Sato, K., Kojima, T., Segi-Nishida, E., Goitsuka, R., Iwakura, Y., Wada, N., Koriyama, Y., Kiryu-Seo, S., Kiyama, H., Nakamura, T. TC10, a Rho family GTPase, is required for efficient axon regeneration in a neuron-autonomous manner. J. Neurochem. doi: 10.1111/jnc.15235 (2020).
  10. Potaczek, D.P., Przytulska-Szczerbik, A., Bazan-Socha, S., Jurczyszyn, A., Okumura, K., Nishiyama, C., Undas, A., and Wypasek, E. Elements of immunoglobulin E network associate with aortic valve area in patients with acquired aortic stenosis. Biomedicines, 9:23 (2020).
  11. Shiromoto, Y*., Sakurai, M., Qu, H., Kossenkov, A.V. , and Nishikura, K. Processing of Alu small RNAs by DICER/ADAR1 complexes and their RNAi targets. RNA. 26: 1801-1814 (2020).
  12. Kishima, H., Kawano, Y., Nakamura, K., Kabasawa, Y., Tabata, Y., Furuya, J., Hanawa, T., Application of a Gelatin Nonwoven Fabric as a Novel Oral Care Product, Jpn. J. Dental Equipment, 25: 41-46 (2020).
  13. Kawano Y.i, Jordan, O., Hanawa, T., Borchard, G., Patrulea, V., Are Antimicrobial Peptide Dendrimers an Escape from ESKAPE?, Adv. Wound Care, 9: 378-95(2020).
  14. Goto, K., Sato, T., Shikamura, Y., Nomura, K., Negishi, K., Hanawa, T., Examining the association between the “My Pharmacist” model and the service quality of community pharmacies, Research Social Administrative Pharmacy,16: 958-966 (2020).
  15. Kawano Y., Chen, S., Hanawa, T., Adsorption of a Poorly Water-Soluble Drug onto Porous Calcium Silicate by the Sealed Heating Method, Int. J. Pharm. 587:119637 (2020).
  16. Otsuka. Y., Utsunomiya, Y., Umeda D., Yonemochi E., Kawano, Y., Hanawa, T., Effect of Polymers and Storage Relative Humidity on Amorphous Rebamipide and Its Solid Dispersion Transformation: Multiple Spectra Chemometrics of Powder X-Ray Diffraction and Near-Infrared Spectroscopy, Pharmaceuticals, 13: 147-165(2020).
  17. Teshima R., Kawano, Y., Hanawa, T., Kikiuchi, A, Preparation and evaluation of physicochemical properties of novel alkaline calcium alginate hydrogels with carbonated water, Polymers for Advanced Technologies, 31: 3032-3038(2020).
  18. Yoshizawa, K., Arai, N., Suzuki, Y., Fujita, A., Takahashi, Y., Kawano, Y., Hanawa, T., Synergistic Antinociceptive Activity of Tramadol/Acetaminophen Combination Mediated by μ-Opioid Receptors, Biol. Pharm. Bull., 43: 1128-1134 (2020).
  19. Hirose, K., Kawano, Y., Shigeno, N., Mizutani, Y., Onishi, H., Hanawa, T., Preliminary Investigation of the Usability Characteristics Required for Wound Management Products by Semi-Structural Interview of Medical Staff, Pharmacy, 8:152 (2020).
  20. Kawano, Y., Utsunomiya, Y., Yokoyama, F., Ishii, N., Hanawa, T., Preparation and Evaluation of Rebamipide Colloidal Nanoparticles Obtained by Cogrinding in Ternary Ground Mixtures, Colloids and Interfaces, 4: 1-20 (2020).
  21. Goto, K., Kawachi, F., Nakano, S., Yoshimura, K., Negishi, K., Hanawa, T., Mizukami, K., An Evaluation of Community Pharmacistsʼ Knowledge and Experience Regarding Dementia with Lewy Bodies: A Cross-Sectional Study in Japan, Japanese Journal of Drug Informatics, 22: 153-161(2020).
  22. Mai, N., N., S.,, Otsuka, Y., Kawano, Y., Hanawa, T., Preparation and Characterization of Solid Dispersions Composed of Curcumin, Hydroxypropyl Cellulose and/or Sodium Dodecyl Sulfate by Grinding with Vibrational Ball Milling, Pharmaceuticals, 13: 383 (2020).
  23. Mai, N.N.S., Nakai, R., Kawano, Y., Hanawa, T., Enhancing the Solubility of Curcumin Using a Solid Dispersion System with Hydroxypropyl-β-Cyclodextrin Prepared by Grinding, Freeze-Drying, and Common Solvent Evaporation Methods, Pharmacy, 8: 203(2020).
  24. Kemmochi, A., Tamura, T., Shimizu, Y., Owada, Y., Ozawa, Y., Oda, T., Kawano, Y., Hanawa, T., Ohkohchi, N. A novel hydrogel sheet prevents postoperative pancreatic fistula in a rat model Journal of Hepato-Biliary-Pancreatic Sciences, 28: 192-201 (2020).
  25. Satoh, M., Shiraishi, T., Sekikawa, K., Motohashi, M., Tanaka, H., Kawano, Y., Hanawa, T., Healing Effects of Rebamipide on Acetic Acid-Induces Oral Stomatitis in 5-Fluorouracil-Treated and -Untreated Golden Syrian Hamsters, Pharmacometrics, 99: 65-70 (2020).
  26. Shu, Z., Ota, A., Takayama, Y., Katsurada, Y., Kusamori, K., Abe, N., Nakamoto, K., Tomoike, F., Tada, S., Ito, Y., Nishikawa, M., Kimura, Y., Abe, H. Intracellular delivery of atisense DNA and siRNA with amino groups masked with disulfide units. Chem. Pharm. Bull. 68, 129-132 (2020).
  27. Seino, N., Omori, E., Kusamori, K., Miyamoto, S., Nagasaki, Y., Higashi, K., Yamase, Y., Nishikawa, M. Application of a sodium alginate hydrogel for clear preoperative endoscopic marking using India ink. Polym. J. 52, 977-983 (2020).
  28. Punzalan, L. L., Jiang, L., Mao, D., Mahapatra, A., D., Sato, S., Takemoto, Y., Tsujimura, M., Kusamori, K., Nishikawa, M., Zhou, L., Uesugi, M. Chemoproteomic profiling of a pharmacophore-focused chemical library. Cell. Chem. Biol. 27, 708-718.e10 (2020).
  29. Liao, W., Akahira, S., Hara, R. I. Wada, T., Kusamori, K., Takakura, Y., Nishikawa, M. Enhanced Immunostimulatory Activity of CpG Oligonucleotide by the Combination of Mannose Modification and Incorporation into Nanostructured DNA. Biol. Pharm. Bull. 43:11881-1195 (2020).
  30. Irie, A., Sato, K., Hara, R. I., Wada, T., Shibasaki, F. An artificial cationic oligosaccharide combined with phosphorothioate linkages strongly improves siRNA stability. Sci. Rep. 10:14845(2020)
  31. Hara, R. I., Yoshino, R., Nukaga, Y., Maeda, Y., Sato, K., Wada, T. Synthesis and properties of DNA oligomers containing stereopure phosphorothioate linkages and C-5 modified deoxyuridine derivatives. RSC Adv. 10, 34006-34013 (2020)
  32. Mizukami, Y., Moriya, A., Takahashi, Y., Shimizu, K., Konishi, S., Takakura, Y., Nishikawa, M. Incorporation of gelatin microspheres into HepG2 human hepatocyte spheroids for functional improvement through improved oxygen supply to spheroid core. Biol. Pharm. Bull. 43, 1220-1225 (2020).
  33. Liao, W., Tan, M., Kusamori, K., Takakura, Y., Nishikawa M. Construction of monomeric and dimeric G-Quadruplex-structured cytosine-phosphate-guanine oligodeoxynucleotides for enhanced uptake and activation in Toll-like receptor 9-positive macrophages. Nucleic Acid Ther. in press.
  34. Liu, W., Takahashi, Y., Morishita, M., Nishikawa, M., Takakura Y. Development of CD40L-modified tumor small extracellular vesicles for the effective induction of anti-tumor immune response. Nanomedicine 15, 1641-1652 (2020).
  35. Maezawa, T., Ohtsuki, S., Hidaka, K., Sugiyama, H., Endo, M., Takahashi, Y., Takakura, Y., Nishikawa, M. DNA density-dependent uptake of DNA origami-based two-or three-dimensional nanostructures by immune cells. Nanoscale 12, 14818-14824 (2020).
  36. Mohri, K., Hayashia, E., Nishinoa, M., Matsushita, N., Tanishita, S., Nishikawa, M., Sakuma, S. Polypod-like structured guanine-rich oligonucleotide aptamer as a selective and cytotoxic nanostructured DNA to cancer cells. J. Drug Target. in press.
  37. Sakurai, M., Okada, S., Ueda, H., and Yang, Y. Discovering A-to-I RNA Editing Through Chemical Methodology "ICE-seq". Methods Mol. Biol. 2181:113-148 (2020)
  38. Shiromoto, Y., Sakurai, M., Qu, H., Kossenkov, A.V. , and Nishikura, K. Processing of Alu small RNAs by DICER/ADAR1 complexes and their RNAi targets. RNA. in press & online (2020)
  39. Yang, Y., Okada, S., and Sakurai, M. Adenosine-to-inosine RNA editing in neurological development and disease. RNA Biology. in press (2020)
  40. Shiromoto, Y.*, Sakurai, M.*, Minakuchi, M.*, Ariyoshi, K., and Nishikura, K. ADAR1 RNA editing enzyme regulates R-loop formation and genome stability at telomeres. Nat. Commun. Revising (2020)
    *; Equal contribution as a 1st author.
  41. Yashiro, T., Yura, S., Tobita, A., Toyoda, Y., Kasakura, K., and Nishiyama, C. Pterostilbene reduces colonic inflammation by suppressing dendritic cell activation and promoting regulatory T cell development. FASEB J. 34:14810-14819 (2020).
  42. Potaczek, D.P., Przytulska-Szczerbik, A., Bazan-Socha, S., Nastalek, M., Wojas-Pelc, A., Okumura, K., Nishiyama, C., Jurczyszyn, A., Undas, A., and Wypasek, E. Interaction between functional polymorphisms in FCER1A and TLR2 and the severity of atopic dermatitis. Human Immunol. 81:709-713 (2020).
  43. Inaba, K.*, Yashiro, T.*, Hiroki, I., Watanabe, R., Kasakura, K., and Nishiyama, C. Dual roles of PU.1 in the expression of PD-L2: Direct transactivation with IRF4 and indirect epigenetic regulation. J. Immunol. 205:822-829. (2020).
    *; Equal contribution as a 1st author
  44. Hagiwara, S., Nagata, K., Kasakura, K., Sakata, F., Kishino, S., Ogawa, J., Yashiro, T., and Nishiyama, C. The anti-inflammatory effect of the gut lactic acid bacteria-generated metabolite 10-oxo-cis-6,trans-11-octadecadienoic acid on monocytes. Biochem. Biophys. Res. Commun. 530:342-347 (2020).
  45. Yashiro, T., Takeuchi, H., Kasakura, K., and Nishiyama, C. PU.1 regulates Ccr7 gene expression by binding to its promoter in naïve CD4+ T cells. FEBS Open Bio. 10:1115-1121 (2020).
  46. Uemura, T., Hachisu, M., Desaki, Y., Ito, A., Hoshino, R., Sano, Y., Nozawa, A., Mujiono, K., Galis, I., Yoshida, A., Nemoto, K., Miura, S., Nishiyama, M., Nishiyama, C., Horito, S., Sawasaki, T., and Arimura, G. Soy and Arabidopsis receptor-like kinases respond to polysaccharide signals from Spodoptera species and mediate hervivore resistance. Commun. Biol. 3: 224 (2020).
  47. Nagata, K., Kasakura, K., Miura, R., Yashiro, T., and Nishiyama, C. Suppressive role of PPARgannma in the IgE-dependent activation of mast cells. Int. Immunol. 32:143-15 (2020).
  48. Tan, M., Takahashi, N., Fujii, S., Sakurai, K., Kusamori, K., Takahashi, Y., Takakura, Y., Nishikawa, M. Analysis of tertiary structural features of branched DNA nanostructures with partially common sequences using small-angle X-ray scattering. ACS App. Bio Mater. in press.
  49. Komura, F., Okuzumi, K., Takahashi, Y., Takakura, Y., Nishikawa, M. Development of RNA/DNA hydrogel targeting Toll-like receptor 7/8 for sustained RNA release and potent immune activation. Molecules 25, E728 (2020).
  50. Motomura, H., Nozaki, Y., Onaga, Chotaro., Ozakli,A., Tamori, S.homa T., Shiina, T., Kanai, S., Ohira, C., Hara, Y., Harada,Y., Takasawa, R., Hanawa, T., Tanuma, S., Mano, Y., Sato, T., Sato, K., Akimoto, K., High Expression of c-Met , PKCλ and ALDH1A3 Predicts a Poor Prognosis in Late-stage Breast Cancer, ANTICANCER RESEARCH, 40, (1), 35-52(2020).
  51. Sato, K., Tahata, K., Akimoto, K. Five genes associated with survival in patients with lower -grade gliomas were identified by information-theoretical analysis, Anticancer Res. 40: 2777-2785 (2020).
  52. Nozaki, Y., Motomura, H., Tamori, S., Kimura, Y., Onaga, C., Kanai, S., Ishihara, Y., Ozaki, A., Hara, Y., Harada, Y., Mano, Y., Sato, T., Sato, K., Sasaki, K., Ishiguro, H., Ohno, S., Akimoto, K. High PKCλ expression is required for ALDH1-positive cancer stem cell function and indicates a poor clinical outcome in late-stage breast cancer patients, PLOS ONE 15: e0235747 (2020).
  53. Ishii, A., Kusakabe, K., Kato, N., Sasaki, S., Tsujikawa, K., Wada, T. Studies on the phase I metabolites of the new designer drug 1-(2,3-dihydro-1H-inden-5-yl)-2- (pyrrolidine-1-yl)butan-1-one (5-PPDI) in human urine, Forensic Sci Int. 310: 110214 (2020).
  54. 佐藤一樹和田猛,ボラノホスフェート核酸の効率的な合成法の開発,J. Org. Synth. Chem. Jpn. 78(5):421-434 (2020).
  55. Shu, Z., Ota, A., Takayama, Y., Katsurada, Y., Kusamori, K., Abe, N., Nakamoto, K., Tomoike, F., Tada, S., Ito, Y., Nishikawa, M., Kimura, Y., Abe, H. Intracellular delivery of atisense DNA and siRNA with amino groups masked with disulfide units. Chem. Pharm. Bull. 68: 129-132 (2020).
  56. Tan, M., Takahashi, N., Fujii, S., Sakurai, K. Kusamori, K. Takahashi, Y., Takakura, Y., Nishikawa, M. Analysis of tertiary structural features of branched DNA nanostructures with partially common sequences using small-angle X-ray scattering. ACS Appl. Bio Mater. 3: 308-314 (2020).
  57. Seino, N., Omori, E., Kusamori, K. Miyamoto, S., Nagasaki, Y., Higashi, K., Yamase, Y., Nishikawa, M. Application of a sodium alginate hydrogel for clear preoperative endoscopic marking using India ink. Polym. J. in press (2020)
  58. Funai, T., Aotani, M., Kiriu, R., Nakamura, J., Miyazaki, Y., Nakagawa, O., Wada, S., Torigoe, H., Ono, A., Urata, H. Silver(I)-Ion-Mediated Cytosine- Containing Base Pairs: Metal Ion Specificity for Duplex Stabilization and Susceptibility toward DNA Polymerases, ChembioChem 21(4): 517-522 (2020).
  59. Matsuno, Y., Atsumi, Y., Alauddin, M., Rana, M. M., Fujimori, H., Hyodo, M., Shimizu, A., Ikuta, T., Tani, H., Torigoe, H., Nakatsu, Y., Tsuzuki, T., Komai, M., Shirakawa, H., Yoshioka, K. Resveratrol and Its Related Polyphenols Contribute to the Maintenance of Genome Stability, Sci. Rep. 10(1): 5388 (2020).
  60. Takahashi, R, Higami, Y. Multidisciplinary Approach to Aging: Future Trends. Yakugaku Zasshi 140(3): 377-378 (2020)
  61. Hoshino, S., Kobayashi, M., Tagawa, R., Konno, R., Abe, T., Furuya, K., Miura, K., Wakasawa, H., Okita, N., Sudo, Y., Mizunoe, Y., Nakagawa, Y., Nakamura, T., Kawabe, H., Higami, Y. WWP1 knockout in mice exacerbates obesity-related phenotypes in white adipose tissue but improves whole-body glucose metabolism. FEBS Open Bio. 10(3): 06-315 (2020).
  62. Kurokawa, Y., Fujii, G., Tomono, S., Miyamoto, S., Hamoya, T., Takahashi, M., Narita, T., Komiya, M., Kobayashi, M., Higami, Y. Mutoh, M. The Radical Scavenger NZ-419 Suppresses Intestinal Polyp Development in Apc-Mutant Mice. J. Clin. Med. 9(1): 270 (2020).
  63. Mizunoe, Y., Kobayashi, M., Hoshino, S., Tagawa, R., Itagawa, R., Hoshino, A., Okita, N., Sudo, Y., Nakagawa, Y., Shimano, H. Higami, Y. Cathepsin B overexpression induces degradation of perilipin 1 to cause lipid metabolism dysfunction in adipocytes. Sci. Rep. 10(1): 634 (2020).
  64. Miyano K, Eto M, Hitomi S, Matsumoto T, Hasegawa S, Hirano A, Nagabuchi K, Asai N, Uzu M, Nonaka M, Omiya Y, Kaneko A, Ono K, Fujii H, Higami Y, Kono T, Uezono Y. The Japanese herbal medicine Hangeshashinto enhances oral keratinocyte migration to facilitate healing of chemotherapy-induced oral ulcerative mucositis.  Sci. Rep. 10(1): 625 (2020).
  65. Miyano, K., Ohshima, K., Suzuki, N., Furuya, S., Yoshida, Y., Nonaka, M., Higami, Y., Yoshizawa, K., Fujii, H., Uezono, Y. Japanese Herbal Medicine Ninjinyoeito Mediates Its Orexigenic Properties Partially by Activating Orexin 1 Receptors. Front. Nutr. 7: 5 (2020).
  66. Kobayashi, M., Higami, Y. Metabolic Alteration in Aging Process: Metabolic Remodeling in White Adipose Tissue by Caloric Restriction. Yakugaku Zasshi 140(3): 383-389 (2020).
  67. Takeda, W., Nishina, T.*, Deguchi, Y., Kawauchi, M., Mikami, T., Yagita, H., Nishiyama, C. Nakano, H. Stromal fibroblasts produce interleukin 11 in the colon of TNBS-treated mice. Toho J. Med. in press (2020).
  68. Shindo, R., Katagiri, T., Komazawa-Sakon, S., Ohmuraya, M., Takeda, W., Nakagawa, Y., Nakagata, N., Sakuma, T., Yamamoto, T., Nishiyama, C., Nishina, T., Yamazaki, S., Kameda, H., Nakano, H. Regenerating islet-derived protein (Reg)3beta plays a crucial role in attenuation of ileitis and colitis in mice. Biochem. Biophys. Rep. in press (2020).
  69. Kasakura, K., Nagata, K., Miura, R., Iida, M., Nakaya, H., Okada, H., Arai, T., Arai, T., Kawakami, Y., Kawakami, T., Yashiro, T., Nishiyama, C. Cooperative regulation of the mucosal mast cell-specific protease genes Mcpt1 and Mcpt2 by GATA and Smad transcription factors. J. Immunol. 204: 1641-1649 (2020).
  70. Kondo, Y., Miyazaki, S. Gene Expression Level and Gene Set Enrichment Analysis of Host Genes, J. Data Mining Genomics & Proteomics 11(1): 1-4 (2020).

2019年の業績

  1. Arima Y, Liu W, Takahashi Y, Nishikawa M., Takakura Y. Effects of localization of antigen proteins in antigen-loaded exosomes on efficiency of antigen presentation. Mol. Pharm. in press.
  2. Yashiro, T.*, Sakata, F.*, Sekimoto, T.*, Shirai, T., Hasebe, F., Matsuda, K., Kurosawa, S., Suzuki, S., Nagata, K., Kasakura, K., Nishiyama, M., Nishiyama, C. Immunosuppressive effect of a non-proteinogenic amino acid from Streptomyce through inhibiting allogeneic T cell proliferation. Biosci. Biotechnol. Biochem., in press.
    *; contribute equal first authors.
  3. Takashima, I., Kusamori, K., Hakariya, H., Takashima, M., Vu, T.H., Mizukami, Y., Noda, N., Takayama, Y., Katsuda, Y., Sato, S.I., Takakura, Y., Nishikawa, M., Uesugi, M. Multi-functionalization of Cells with a Self-assembling Molecule to Enhance Cell Engraftment. ACS Chem Biol. in press.
  4. Sugiyama, A., Yamada, M., Furuie, H., Goto, L., Saitoh, A., Nagase, H., Oka, J-I., Yamada, M, Systemic administration of the delta opioid receptor agonist KNT-127 facilitates extinction of fear memory in rats, Journal of Pharmacological Sciences, in press.
  5. Sasaki-Hamada, S., Nakamura, Y., Koizumi, K., Nabeta, R., Oka, J-I., Pharmacological evidence for the relationship between the NMDA receptor and nitric oxide pathway and the antidepressant-like effects of glucagon-like peptide-2 in the mouse forced-swim test, Behavioural Brain Research, 364:162-166 (2019).
  6. Yashiro, T., Nakano, S., Nomura, K., Uchida, Y., Kasakura, K., Nishiyama, C. PU.1 is a critical transcription factor for Ccl22 gene expression in dendritic cells and macrophages. Sci. Rep. in press.
  7. Takayama Y, Kusamori K, Nishikawa M. Click Chemistry as a Tool for Cell Engineering and Drug Delivery. Molecules.24(1):e172. (2019)
  8. 河野弥生, 花輪剛久: 医療ニーズに基づく新規臨床製剤の開発, YAKUGAKU ZASSHI,130(10),1275-1280(2019).
  9. 百賢二、金崎祐哉、河野弥生花輪剛久: 臨床製剤の市販化を目指した橋渡し研究―臨床製剤データベースの構築と有用性評価―, YAKUGAKU ZASSHI,139(10),1293-1296(2019).
  10. Nishikawa, M., Tan, M., Liao, W., Kusamori, K. Nanostructured DNA for the delivery of therapeutic agents. Adv. Drug Deliv. Rev. 147, 29-36 (2019).
  11. Komura, F., Takahashi, Y., Inoue, T., Takakura, Y., Nishikawa, M. Development of a nanostructured RNA/DNA assembly as an adjuvant targeting Toll-like receptor 7/8. Nucleic Acid Ther. 29, 335-342 (2019).
  12. Matsumoto, A., Takahashi, Y., Ariizumi, R., Nishikawa, M., Takakura, Y. Development of DNA-anchored assembly of small extracellular vesicle for efficient antigen delivery to antigen presenting cells. Biomaterials 225, 119518 (2019).
  13. Ohtsuki, S., Shiba, Y., Maezawa, T., Hidaka, K., Sugiyama, H., Endo, M., Takahashi, Y., Takakura, Y., Nishikawa, M. Folding of single-stranded circular DNA into rigid rectangular DNA accelerates its cellular uptake. Nanoscale 11, 23416-23422 (2019).
  14. Piao, X., Miura, R., Miyake, S., Komazawa-Sakon, S., Koike, M., Shindo, R., Takeda, J., Hasegawa, A., Abe, R., Nishiyama, C., Mikami, R., Yagita, H., Uchida, Y., and Nakano, H. Blockade of TNFR1-dependent and –independent cell death is crucial for normal epidermal differentiation. J. Allergy Clin. Immunol. 143:213-228.e10 (2019).
  15. Yashiro, T., Nakano, S., Nomura, K., Uchida, Y., Kasakura, K., and Nishiyama, C. A transcription factor PU.1 is critical for Ccl22 gene expression in dendritic cells and macrophages. Sci. Rep. 9:1161 (2019).
  16. Yashiro, T., Sakata, F., Sekimoto, T., Shirai, T., Hasebe, F., Matsuda, K., Kurosawa, S., Suzuki, S., Nagata, K., Kasakura, K., Nishiyama, M., and Nishiyama, C. Immunosuppressive effect of a non-proteinogenic amino acid from Streptomyces through inhibiting allogeneic T cell proliferation. Biosci. Biotechnol. Biochem. 83:1111-1116 (2019).
  17. Yashiro, T., Takeuchi, H., Nakamura, S., Tanabe, A., Hara, M., Uchida, K., Okumura, K., Kasakura, K., and Nishiyama, C. PU.1 plays a pivotal role in dendritic cell migration from the periphery to secondary lymphoid organs via regulating CCR7 expression. FASEB J. 33:11481-11491 (2019).
  18. Ito, T., Egusa, C., Maeda, T., Numata, T., Nakano, N., Nishiyama, C., and Tsuboi, R. Stem cell factor suppressed IL-33-induced MHC class II expression in murine bone marrow-derived mast cells. Allergol. Int. 68:254-257 (2019).
  19. Hara, R. I., Saito, T., Kogure, T., Hamamura, Y., Uchiyama, N., Nukaga, Y., Iwamoto, N., Wada, T. Stereocontrolled synthesis of boranophosphate DNA by an oxazaphospholidine approach and evaluation of its properties. J. Org. Chem. 84, 7971–7938 (2019).
  20. 和田猛, リン原子の立体化学を厳密に制御したリン原子修飾核酸医薬の開発, 日本核酸医薬学会誌, 23: 4-11 (2019).
  21. Yoshioka, K.,Kunieda, T., Asami, Y., Guo, H., Miyata, H., Yoshida-Tanaka, K., Sujino, Y., Piao, W., Kuwahara, H., Nishina, K., Hara, R. I., Nagata, T., Wada, T., Obika, S., Yokota, T. Highly efficient silencing of microRNA by heteroduplex oligonucleotides. Nucleic Acids Res. 47, 7321–7332 (2019).
  22. 和田猛, 化学構造式から見たアカデミック・ディテーリング, YAKUGAKU ZASSHI, 139, 1101–1105 (2019).
  23. Sato, K., Imai, H., Shuto, T., Hara, R. I., Wada, T. Solid-phase synthesis of phosphate/boranophosphate chimeric DNAs using the H-phosphate–H-boranophosphonate method. J. Org. Chem. 84: 15032–15041 (2019).
  24. Mizunoe, Y., Kobayashi, M., Tagawa, R., Nakagawa, Y., Shimano, H., Higami, Y. Association between Lysosomal Dysfunction and Obesity-Related Pathology: A Key Knowledge to Prevent Metabolic Syndrome. Int. J. Mol. Sci. 20(15): 3688 (2019).
  25. Miyano, K., Shiraishi, S., Minami, K., Sudo, Y., Suzuki, M., Yokoyama, T., Terawaki, K., Nonaka, M., Murata, H., Higami, Y., Uezono, Y. Carboplatin Enhances the Activity of Human Transient Receptor Potential Ankyrin 1 through the Cyclic AMP-Protein Kinase A-A-Kinase Anchoring Protein (AKAP) Pathways. Int. J. Mol. Sci. 20(13): 3271 (2019).
  26. Hashimoto, Y., Tsuchiya, T., Doi, R., Matsumoto, K., Higami, Y., Kobayashi, E., Nagayasu, T. Alteration of the extracellular matrix and alpha-gal antigens in the rat lung scaffold reseeded using human vascular and adipogenic stromal cells. J. Tissue Eng. Regen. Med. 13(11): 2067-2076 (2019).
  27. Otsuka, K., Sasada, M., Hirano, Y. U., Nohara, Y., Iyoda, T., Higami, Y., Kodama, H., Fukai, F. Acyclic Retinoid Combined With Tenascin-C-derived Peptide Reduces the Malignant Phenotype of Neuroblastoma Cells Through N-Myc Degradation. Anticancer Res. 39(7): 3487-3492 (2019).
  28. Torres, O., Yamada, A., Rigby, N. M., Hanawa, T., Kawano, Y. Gellan gum: A new member in the dysphagia thickener family, Biotribology 17: 8-18 (2019).
  29. Hanawa, T., Kawano, Y. Preparation and characterization of hydrogels by electron beam cross-linking, Proceedings of International Conference on Nuclear Capacity building, Education, Research and Applications, (2019).
  30. Tokinaga-Uchiyama, A., Mizushima, T., Akimoto, K. Nagashima, Y., Sasaki, K., Nakaya, M., Ohashi, K., Kubota, K., Maruyama, Y., Kato, H., Hirahara, F., Miyagi, E., Ohno, S., Asai-Sato, M. Aberrant nuclear localization of aPKCλ/ι is associated with poorer prognosis in uterine cervical cancer, Int. J. Gynecol. Pathol.. 38: 301-309 (2019).
  31. Furuya, K., Zheng, Y.-W. Sako, D., Iwasaki, K., Zheng, D.-X., Ge, J.-Y., Liu, L.-P., Furuta, T., Akimoto, K., Yagi, H., Hamada, H., Isoda, H., Oda, T., Ohkohchi, N. Enhanced hepatic differentiation in the subpopulation of human amniotic stem cells under 3D multicellular microenvironment, World J. Stem Cells 11: 705-721 (2019).
  32. iscovering RNA editing by chemical methods Sakurai, M., Okada, S., Ueda, H., Y. Yang. Methods Mol. Biol. in press (2019).
  33. 櫻井雅之「もう一つの遺伝子 ”編集” ~哺乳動物が備える核酸塩基の編集機構」
    MSD メディカル・サイエンス・ダイジェスト (ニューサイエンス社) 45: 576-577 (2019).

2018年の業績

  1. Tokinaga-Uchiyama, A., Mizushima, T., Akimoto, K., Nagashima, Y., Sasaki, K., Nakaya, M., Ohashi, K., Kubota, K., Maruyama, Y., Kato, H., Hirahara, F., Miyagi, E., Ohno, S., Asai-Sato, M. Aberrant nuclear localization of aPKCλ/ι is associated with poorer prognosis in uterine cervical cancer International Journal of Gynecological Pathology in press.
  2. Tamori, S., Nozaki, Y., Motomura, H., Nakane, H., Katayama, R., Onaga, C., Kikuchi, E., Shimada, N., Suzuki, Y., Noike, M., Hara, Y., Sato, K., Sato, T., Yamamoto, K., Hanawa, T., Imai, M., Abe, R., Yoshimori, A., Takasawa, R., Tanuma, S., and Akimoto, K. Glyoxalase 1 gene is highly expressed in basal-like human breast cancers and contributes to survival of ALDH1-positive breast cancer stem cells Oncotarget, 9: 36515–36529 (2018).
  3. Baba, J., Kioi, M., Akimoto, K., Nagashima, Y., Taguri, M., Inayama, Y., Aoki, I., Ohno, S., Mitsudo, K., and Tohnai, I. Atypical Protein Kinase C λ/ι Expression is Associated with Malignancy of Oral Squamous Cell Carcinoma Anticancer Research, 38: 6291–6297 (2018).
  4. 岡淳一郎, ペプチド薬の中枢機能障害改善作用と経鼻投与による中枢移行法の開発, YAKUGAKU ZASSHI, in press.
  5. Ishikawa, S., Iijima, K., Sasaki, K., Kawabe, M., Otsuka, H. Improvement of Hepatic Functions by Spheroids Coculture with Fibroblasts in 3D Silica Nonwoven Fabrics. J. Nanosci. Nanotechnol., in press.
  6. 山田光彦, 赤木希衣, 山田美佐,斎藤顕宜,岡淳一郎, 恐怖記憶の処理過程を制御する新規薬物療法の開発, 日本生物学的精神医学会誌, 29:60-63(2018).
  7. Saitoh, A., Soda, A., Kayashima, S., Yoshizawa, K., Oka, J-I., Nagase, H., Yamada, M, A delta opioid receptor agonist, KNT-127, in the prelimbic medial prefrontal cortex attenuates glial glutamate transporter blocker-induced anxiety-like behavior in mice. Journal of Pharmacological Sciences, 138:176-183 (2018).
  8. Iijima, K., Ishikawa, S., Sasaki, K., Hashizume, M., Kawabe, M., Otsuka, H. Osteogenic Differentiation of Bone Marrow-Derived Mesenchymal Stem Cells in Three-Dimensional Silica Nonwoven Fabrics. ACS Omega., 3:10180−10187 (2018).
  9. Ishikawa, S., Iijima, K., Sasaki,, K. Hashizume, M., Kawabe, M., Otsuka, H. Cartilage Differentiation of Bone Marrow-Derived Mesenchymal Stem Cells in Three-Dimensional Silica Nonwoven Fabrics. Appl. Sci., 8,1398 (2018).
  10. Sudo, Y., Otsuka, H., Miyakawa, R., Goto, A., Kashiwase, Y., Terawaki, K., Miyano, K., Hirao, Y., Taki, K., Tagawa, R., Kobayashi, M., Okita, N., Uezono, Y., Higami, Y. Differential Metabolic Responses to Adipose Atrophy Associated with Cancer Cachexia and Caloric Restriction in Rats and the Effect of Rikkunshito in Cancer Cachexia
    Int. J. Mol. Sci. 19(12). pii: E3852. doi: 10.3390/ijms19123852. (2018).
  11. Kobayashi, M., Hoshino, S., Abe, T., Okita, N., Tagawa, R., Nagai, W., Konno, R., Suzuki, Y., Furuya, K., Ishikawa, N., Okado, H., Oku, M., Iwamoto, M., Miura, Y., Sudo, Y., Higami, Y. Identification of WWP1 as an obesity-associated E3 ubiquitin ligase with a protective role against oxidative stress in adipocytes. Biochem. Biophys. Res. Commun. 508:117-122 (2019).
  12. Umeki, Y., Saito, M., Kusamori, K., Tsujimura, M., Nishimura, M., Takahashi, Y., Takakura, Y., Nishikawa, M. Combined encapsulation of a tumor antigen and immune cellsusing a self-assembling immunostimulatory DNA hydrogel to enhance antigen-specific tumor immunity. J. Control Release. 288:189-198 (2018).
  13. Kobayashi, M., Fujii, N., Narita, T., Higami, Y. SREBP-1c-Dependent Metabolic Remodeling of White Adipose Tissue by Caloric Restriction. Int. J. Mol. Sci. 19(11). pii: E3335. doi: 10.3390/ijms19113335. Review. (2018).
  14. Charoenviriyakul, C., Takahashi, Y., Nishikawa, M., Takakura, Y. Preservation of exosomes at room temperature using lyophilization. Int. J. Pharm. 553(1-2):1-7. (2018)
  15. Yashiro, T.*, Yamaguchi, M.*, Watanuki, Y., Kasakura, K., Nishiyama, C. The transcription factors PU.1 and IRF4 determine dendritic cell-specific expression of RALDH2. J. Immunol. in press.
    *; contribute equal first authors.
  16. Terawaki, K., Kashiwase, Y., Uzu, M., Nonaka, M., Sawada, Y., Miyano, K., Higami, Y., Yanagihara, K., Yamamoto, M., Uezono, Y. Leukemia inhibitory factor via the Toll-like receptor 5 signaling pathway involves aggravation of cachexia induced by human gastric cancer-derived 85As2 cells in rats. Oncotarget. 9:34748-34764 (2018).
  17. Hoshino, S., Kobayashi, M., Higami, Y. Mechanisms of the anti-aging and prolongevity effects of caloric restriction: evidence from studies of genetically modified animals. Aging 10:2243-2251 (2018).
  18. Ito, T., Egusa, C., Maeda, T., Numata, T. Nakano, N., Nishiyama, C., Tsuboi, R. Stem cell factor suppressed IL-33-induced MHC class II expression in murine bone marrow-derived mast cells. Allergol. Int. in press.
  19. Kusamori, K., Takayama, Y., Nishikawa, M. Stable Surface Modification of Mesenchymal Stem Cells Using the Avidin-Biotin Complex Technique. Curr. Protoc. Stem Cell Biol. 47(1):e66(2018)
  20. Mizukami, Y., Takahashi, Y., Shimizu, K., Konishi, S., Takakura, Y., Nishikawa, M. Regulation of the distribution of cells in mixed multicellular spheroids by altering their migration direction. Tissue Eng. A in press.
  21. Nomura, D., Saito, M., Takahashi, Y., Takahashi, Y., Takakura, Y., Nishikawa, M. Development of orally-deliverable DNA hydrogel by microemulsification and chitosan coating. Int. J. Pharm. 547:556-562 (2018).
  22. Sugiyama, A., Yamada, M., Saitoh, A., Nagase, H., Oka, J-I., Yamada, M., Administration of a delta opioid receptor agonist KNT-127 to the basolateral amygdala has potent anxiolytic-like effects in rats, Psychopharmacology, 235:2947-2955 (2018).
  23. Iwai,T., Obara, K., Ito, C., Furukawa H., Oka, J-I., Hydroxyobutustyrene protects neuronal cells from chemical hypoxia-induced cell death, Journal of Natural Medicines, 72:915-921 (2018).
  24. Ohno, H., Matsuzaka, T., Tang, N., Sharma, R., Motomura, K., Shimura, T., Satoh, A., Han, S.I., Takeuchi, Y., Aita, Y., Iwasaki, H., Yatoh, S., Suzuki, H., Sekiya, M., Nakagawa, Y., Sone, H., Yahagi, N., Yamada, N., Higami, Y., Shimano, H.
    Transgenic Mice Overexpressing SREBP-1a in Male ob/ob Mice Exhibit Lipodystrophy and Exacerbate Insulin Resistance.
    Endocrinology. 159:2308-2323 (2018).
  25. Oda, A., Tezuka, T., Ueno, Y., Hosoda, S., Amemiya, Y., Notsu, C., Kasahara, T., Nishiyama, C., Goitsuka, R. Niche-induced extramedullary hematopoiesis in the spleen is regulated by the transcription factor Tlx1.
    Sci. Rep. 8:8308 (2018).
  26. Charoenviriyakul, C., Takahashi, Y., Morishita, M., Nishikawa, M., Takakura, Y. Role of Extracellular Vesicle Surface Proteins in the Pharmacokinetics of Extracellular Vesicles. Mol. Pharm. 15:1073-1080 (2018).
  27. Fujiwara, H., Ohtake, H., Oka, J-I., Matsumoto, K., Kimura, K., Endogenous acetylcholine regulates neuronal and astrocytic vascular endothelial growth factor expression levels via different acetylcholine receptor mechanisms, Neurochemistry International, 118:42-51 (2018).
  28. Sasaki-Hamada, S., Narusawa, K., Nakamura, R., Ishibashi, H., Oka, J-I., Effects of centrally administered glucagon-like peptide-2 on blood pressure and barosensitive neurons in spontaneously hypertensive rats, Neuropeptides, 69:66-75 (2018).
  29. Matsushita, J., Okamura, K., Nakabayashi, K., Suzuki, T., Horibe, Y., Kawai, T., Sakurai, T., Yamashita, S., Higami, Y., Ichihara, G., Hata, K., Nohara, K.
    The DNA methylation profile of liver tumors in C3H mice and identification of differentially methylated regions involved in the regulation of tumorigenic genes.
    BMC Cancer. 18:317 (2018).
  30. Hamana, H., Takahashi, Y., Tanioka, A., Nishikawa, M., Takakura, Y. Safe and effective interferon-beta gene therapy for the treatment of multiple sclerosis by regulating biological activity through the design of interferon-beta-galectin-9 fusion proteins. Int. J. Pharm. 536:310-317 (2018).
  31. Uemura, T.*, Yashiro, T.*, Oda, R.*, Shioya, N., Nakajima, T., Hashisu, M., Kobayashi, S., Nishiyama, C., Arimura, G. Intestinal anti-inflammatory activity of Perillaldehyde. J. Agric. Food Chem. in press.
    *; contribute equal first authors.
  32. Kaneko, H., Kobayashi, M., Mizunoe, Y., Yoshida, M., Yasukawa, H., Hoshino, S., Itagawa, R., Furuichi, T., Okita, N., Sudo, Y., Imae, M., Higami, Y. Taurine is an amino acid with the ability to activate autophagy in adipocytes. Amino Acids in press.
  33. Piao, X.*, Miura, R.*, Miyake, S., Komazawa-Sakon, S., Koike, M., Shindo, R., Takeda, J., Hasegawa, A., Abe, R., Nishiyama, C., Mikami, R., Yagita, H., Uchida, Y., Nakano, H. Blockade of TNFR1-dependent and –independent cell death is crucial for normal epidermal differentiation. J. Allergy Clin. Immunol. in press. *; contribute equal first authors.
  34. Araie, Y., Takahashi, Y., Takahashi, Y., Takakura, Y., Nishikawa, M. Enhanced activity of immunosuppressive oligodeoxynucleotides by incorporating them into hexapod-like nanostructured DNA. Biol Pharm Bull in press.
  35. Tsujimura, M., Kusamori, K., Oda, C., Miyazaki, A., Katsumi, H., Sakane, T., Nishikawa, M., Yamamoto, A. Regulation of proliferation and functioning of transplanted cells by using herpes simplex virus thymidine kinase gene in mice. J Control Release 275:78-84 (2018).
  36. Tanaka, Y., Nishikawa, M., Mizukami, Y., Kusamori, K., Ogino, Y., Nishimura, S., Shimizu, K., Konishi, S., Takahashi, Y., Takakura, Y. Control of polarization and tumoricidal activity of macrophages by multicellular spheroid formation. J Control Release 270:177-183 (2018).
  37. Takahashi, Y., Araie, Y., Nomura, D., Takahashi, Y., Sano, K., Saji, H., Takakura, Y., Nishikawa, M. Construction of nanostructured DNA harbouring phosphorodiamidate morpholino oligonucleotide for controlled tissue distribution in mice. J Drug Target 26: 373-381 (2018).
  38. Oda, Y.*, Kasakura, K.*, Fujigaki, I., Kageyama, A., Okumura, K., Ogawa, H., Yashiro, T., Nishiyama, C. The effect of PU.1 knockdown on gene expression and function of mast cells. Sci. Rep. in press.
    *; contribute equal first authors.
  39. Narita, N., Kobayashi, M., Itakura, K., Itagawa, R., Kabaya, R., Sudo, Y., Okita, N., Higami, Y. Differential response to caloric restriction of retroperitoneal, epididymal, and subcutaneous adipose tissue depots in rats, Exp. Gerontol. in press.
  40. Takebe T, Sakamoto K, Higami Y, Harada Y. A novel mouse model for tracking the fate of CXCR5-expressing T cells. Biochem Biophys Res Commun. 495:1642-1647 (2018).
  41. Akagi, K., Yamada, M., Saitoh, A., Oka, J-I., Yamada, M., Post-reexposure administration of riluzole attenuates the reconsolidation of conditioned fear memory in rats, Neuropharmacology, 131: 1-10 (2018).
  42. Sasaki-Hamada, S., Funane, T., Nakao, Y., Sasaki, R., Nagai, M., Ueta, U., Yoshizawa, K., Horiguchi, M., Yamashita, C., Oka, J-I., Intranasal administration of neuromedin U derivatives containing cell-penetrating peptides and a penetration-accelerating sequence induced memory improvements in mice, Peptides, 99:241-246 (2018).
  43. Saitoh, A., Suzuki, S., Soda, A., Ohashi, M., Yamada, M., Oka, J-I., Nagase, H., Yamada, M., The delta opioid receptor agonist KNT-127 in the prelimbic medial prefrontal cortex attenuates veratrine-induced anxiety-like behaviors in mice, Behavioural Brain Research, 336:77-84 (2018).
  44. Sugiyama, A., Yamada, M., Saitoh, A., Oka, J-I., Yamada, M., Administration of riluzole into the basolateral amygdala facilitates the extinction of fear memory in rats, Behavioural Brain Research, 336:8-14 (2018).

2017年の業績

  1. Nishikawa, T., Tanaka, Y., Kusamori, K., Mizuno, N., Mizukami, Y., Ogino, Y., Shimizu, K., Konishi, S., Takahashi, Y., Takakura, Y., Nishikawa, M. Using size-controlled multicellular spheroids of murine adenocarcinoma cells to efficiently establish pulmonary tumors in mice. Biotechnol J in press.
  2. Takahashi, Y., Maezawa, T., Araie, Y., Takahashi, Y., Takakura, Y., Nishikawa, M. In vitro and in vivo stimulation of Toll-like receptor 9 by CpG oligodeoxynucleotides incorporated into polypod-like DNA nanostructures. J Pharm Sci 106: 2457-2462 (2017).
  3. Umeki, Y., Saito, M., Takahashi, Y., Takakura, Y., Nishikawa, M. Retardation of antigen release from DNA hydrogel using cholesterol-modified DNA for increased antigen-specific immune response. Adv Healthc Mater 6: 1700355 (2017).
  4. Ohtsuki, S., Takahashi, Y., Inoue, T., Takakura, Y., Nishikawa, M. Reconstruction of Toll-like receptor 9-mediated responses in HEK-Blue hTLR9 cells by transfection of human macrophage scavenger receptor 1 gene. Sci Rep 7: 13661 (2017).
  5. Mohri, K., Nagata, K., Ohtsuki, S., Toyama, S., Nonomura, M., Takahashi, Y., Takakura, Y., Nishikawa, M., Sakuma, S. Elucidation of the mechanism of increased activity of immunostimulatory DNA by the formation of polypod-like structure. Pharm Res 34: 2362-2370 (2017).
  6. Yata, T., Takahashi, Y., Tan, M., Nakatsuji, H., Ohtsuki, S., Murakami, T., Imahori, H., Umeki, Y., Shiomi, T., Takakura, Y., Nishikawa, M. DNA nanotechnology-based composite-type gold nanoparticle-immunostimulatory DNA hydrogel for tumor photothermal immunotherapy. Biomaterials 146: 136-145 (2017).
  7. Takayama, Y., Kusamori, K., Hayashi, M., Tanabe, N., Matsuura, S., Tsujimura, M., Katsumi, H., Sakane, T., Nishikawa, M., Yamamoto, A. Long-term drug modification to the surface of mesenchymal stem cells by the avidin-biotin complex method. Sci Rep 7: 16953 (2017).
  8. Kobayashi M, Takeda K, Narita T, Nagai K, Okita N, Sudo Y, Miura Y, Tsumoto H, Nakagawa Y, Shimano H, Higami Y. Mitochondrial intermediate peptidase is a novel regulator of sirtuin-3 activation by caloric restriction. FEBS Lett. 591:4067-4073 (2017).
  9. Kobayashi, M., Higami, Y. A novel caloric restriction mediator, Aging (Albany NY) 9:2012-2013 (2017).
  10. Sasaki-Hamada, S., Suzuki, A., Sanai, E., Matsumoto, K., Oka, J-I., Neuroprotection by chotosan, a Kampo formula, against glutamate excitotoxicity involves the inhibition of GluN2B-, but not GluN2A-containing NMDA receptor-mediated responses in primary cultured cortical neurons, Journal of Pharmacological Sciences, 135:134-137 (2017).
  11. Mizunoe, Y., Kobayashi, M., Sudo, Y., Watanabe S, Yasukawa H, Natori D, Hoshino A, Negishi A, Okita, N., Komatsu, M., Higami, Y., Trehalose protects against oxidative stress by regulating the Keap1–Nrf2 and autophagy pathways, Redox Biology, 15:115-124 (2017).
  12. Nagaoka, M.*, Yashiro, T.*, Uchida, Y., Ando, T., Hara, M., Arai, H., Ogawa, H., Kasakura, K., and Nishiyama, C. The nuclear orphan receptor NR4A3 is involved in the function of dendritic cells. J. Immunol. 199:2958-2967 (2017).
    *; contribute equal first authors.
  13. Nozaki, Y., Tamori, S., Inada, M., Katayama, R., Nakane, H., Minamishima, O., Onodera, Y., Abe, M., Shiina, S., Tamura, K., Kodama, D., Sato, K., Hara, Y., Abe, R., Takasawa, R., Yoshimori, A., Shinomiya, N., Tanuma, S., Akimoto, K. Correlation between c-Met and ALDH1 contributes to the survival and tumor-sphere formation of ALDH1 positive breast cancer stem cells and predicts poor clinical outcome in breast cancer. Genes & Cancer, in press.
  14. Sugiyama, A., Saitoh, A., Yamada, M., Oka, J-I., Yamada, M., Administration of riluzole into the basolateral amygdala has an anxiolytic-like effect and enhances recognition memory in the rat, Behavioural Brain Research, 327:98-102 (2017).
  15. Saitoh, A., Akagi, K., Oka, J-I., Yamada, M., Post-reexposure administration of D-cycloserine facilitates reconsolidation of contextual conditioned fear memory in rats, Journal of Neural Transmission, 124:583-587 (2017).
  16. Umazume, A., Kezuka, T., Matsuda, R., Usui, Y., Takahashi, H., Yamanaka, N., Yashiro, T., Nishiyama, C., Goto, H. Role of PU.1 expression as an inflammatory marker in experimental autoimmune uveoretinitis. Ocular Immunology and Inflammation, in press
  17. Terawaki, K., Kashiwase, Y., Sawada, Y., Hashimoto, H., Yoshimura, M., Ohbuchi, K., Sudo, Y., Suzuki, M., Miyano, K., Shiraishi, S., Higami, Y., Yanagihara, K., Hattori, T., Kase, Y., Ueta, Y., Uezono, Y. Development of ghrelin resistance in a cancer cachexia rat model using human gastric cancer-derived 85As2 cells and the palliative effects of the Kampo medicine rikkunshito on the model. PLoS One, 12(3):e0173113. (2017).
  18. Hara, R. I., Maeda, Y., Sakamoto, T., Wada, T. Double-stranded RNA-binding artificial cationic oligosaccharides stabilizing siRNAs with a low N/P ratio Organic & Biomolecular Chemistry 15:1710-1717 (2017).
  19. Yashiro, T.*, Kasakura, K.*, Oda, Y., Kitamura, N., Inoue, A., Nakamura, S., Yokoyama, H., Fukuyama, K., Hara, M., Ogawa, H., Okumura, K., Nishiyama, M., Nishiyama, C. The hematopoietic cell-specific transcription factor PU.1 is critical for expression of CD11c. Int. Immunol., 29:87-94 (2017). *; contribute equal first authors.
  20. Matsukuma, D., Sanbai, T., Otsuka, H. UCST-type Phase Transition driven by Protein-derived Polypeptide Employing Gelatin and Chitosan, Polym. Adv. Technol., 28:1636–1641 (2017).
  21. Fujii, N.*, Narita, T.*, Okita, N.*, Kobayashi, M., Furuta, Y., Chujo, Y., Sakai, M., Yamada, A., Takeda, K., Konishi, T., Sudo, Y., Shimokawa, I., Higami, Y. Sterol Regulatory Element-Binding Protein-1c Orchestrates Metabolic Remodeling of White Adipose Tissue by Caloric Restriction. Aging Cell, 16:508-517 (2017).
    *; contribute equal first authors.
  22. Sasaki-Hamada, S., Suzuki, A., Ueda, Y., Matsumoto, K., Oka, J-I., Serotonergic and dopaminergic systems are implicated in the antidepressant-like effects of chotosan, a Kampo formula, in mice, Journal of Pharmacological Sciences, 133:64-70 (2017).
  23. Kawano, Y., Ishii, N., Shimizu, Y., Hanawa, T. Development and Characterization of a Suspension Containing Nanoparticulated Rebamipide for a Mouth Wash for Stomatitis. J. Pharm Sci Tech, Japan, in press.
  24. Sato, K., Akimoto, K. Expression Levels of KMT2C and SLC20A1 Identified by Information-theoretical Analysis Are Powerful Prognostic Biomarkers in Estrogen Receptor-positive Breast Cancer, Clinical Breast Cancer, in press.
  25. Honjo, A., Nakano, N., Yamazaki, S., Hara, M., Uchida, K., Kitaura, J., Nishiyama, C., Yagita, H., Ohtsuka, Y., Ogawa, H., Okumura, K., and Shimizu, T.
    Pharmacological inhibition of Notch signaling suppresses food antigen-induced mucosal mast cell hyperplasia.
    J. Allergy Clin. Immunol. 139:987-996 (2017). 
  26. Miyajima, A., Hirota, T., Tashiro, M., Noguchi, W., Kawano, Y., Hanawa, T., Kigure, A., Anata, T., Yamamoto, Y., Yuasa, N., Koshino, M., Shiraishi, Y., Yuzawa, K., Akagi, K., Yoshimasu, T., Makigami, K., Komoda, M. Pharmacokinetics of ivermectin applied topically by whole-body bathing method in healthy volunteers. J. Dermatol. in press.
  27. Sasaki-Hamada, S., Nakamura, R., Nakao, Y., Akimoto, T., Sanai, E., Nagai, M., Horiguchi, M., Yamashita, C., Oka, J-I., Antidepressant-like effects exerted by the intranasal administration of a glucagon-like peptide-2 derivative containing cell-penetrating peptides and a penetration-accelerating sequence in mice, Peptides 87:64-70 (2017).
  28. Iyoda, T., Nagamine, Y., Nakane, Y., Tokita, Y., Hayashi, R., Kodama, H., Fukai, F. Coadministration of the FNIII14 Peptide Synergistically Augments the Anti-Cancer Activity of Chemotherapeutic Drugs by Activating Pro-Apoptotic Bim. PLoS One 11:eo162525 (2017).
  29. Suzuki, H., Sasada, M., Ito, Y., Watanabe, H., Okada, Y., Ishibashi, K., Iyoda, T,, Yanaka, A. and Fukai, F. The Promoting Effect of the Extracellular Matrix peptide TNIIIA2 Derived from Tenascin-C in Colon Cancer Cell Infiltration. Int. Mol. Sci. 18: 181 (2017).
  30. Okita, N., Higami, Y., Fukai, F., Kobayashi, M., Mitarai, M., Sekiya, T., Sasaki, T. Modified Western blotting for insulin and other diabetes-associated peptide hormones. Sci. Rep. 7:6949 (2017).
  31. Yoshizawa, K., Okumura, A., Nakashima, K., Sato, T. Higashi, T. Role of allopregnanolone biosynthesis in acute stress-induced anxiety-like behaviors in mice. Synapse, in press.
  32. Mizunoe, Y., Sudo, Y., Okita, N., Hiraoka, H., Mikami, K., Narahara, T., Negishi, A., Yoshida, M., Higashibata, R., Watanabe, S., Kaneko, H., Natori, D., Furuichi, T., Yasukawa, H., Kobayashi, M., Higami, Y. Involvement of lysosomal dysfunction in autophagosome accumulation and early pathologies in adipose tissue of obese mice. Autophagy, 13:642-653 (2017).

2016年の業績

  1. Sato, K., Wada, T. One-pot conversion reactions of glycosyl boranophosphates into glycosyl phosphate derivatives via acyl phosphite intermediates Organic & Biomolecular Chemistry 14:11092-11095 (2016).
  2. Nukaga, Y., Oka, N., Wada, T. Stereocontrolled Solid-Phase Synthesis of Phosphate/Phosphorothioate (PO/PS) Chimeric Oligodeoxyribonucleotides on an Automated Synthesizer Using an Oxazaphospholidine-Phosphoramidite Method Journal of Organic Chemistry 81:2753-2762 (2016)
  3. Kawano, Y., Imamura, A., Nakamura, T., Akaishi, M., Satoh, M., Hanawa, T. Development and characterization of oral spray for stomatitis containing irsogladine maleate. Chem. Pharm. Bull. 64:1659-1665 (2016).
  4. Satoh, M., Kamada, A., Saito, M., Akaishi, M., Imamura, A., Kawano, Y., Hanawa, T. Healing Effects of Irsogladine Maleate on Acetic Acid- induced Oral Stomatitis in 5-Fluorouracil-treated and -untreated Syrian Golden Hamsters. Research & Reviews in Pharmacy and Pharmaceutical Sciences, 5:18-22 (2016).
  5. Yashiro, T., Hara, M., Ogawa, H., Okumura, K., Nishiyama, C. Critical role of transcription factor PU.1 in the function of the OX40L/TNFSF4 promoter in dendritic cells. Sci. Rep. 6:34825 (2016).
  6. Nakao, Y., Horiguchi, M., Nakamura, R., Sasaki-Hamada, S., Ozawa, C., Funane, T., Ozawa, R., Oka, J-I., Yamashita, C. LARETH-25 and β-CD improve central transitivity and central pharmacological effect of the GLP-2 peptide. International Journal of Pharmaceutics, 515:37-45 (2016).
  7. Iijima, M., Ulkoski, D. Sakuma, S., Matsukuma, D., Nishiyama, N., Otsuka, H., Scholz, C. Synthesis of PEGylated poly(amino acid) pentablock copolymers and their self-assembly. Polym. Int. 65: 1132?1141 (2016).
  8. Sasaki-Hamada, S., Hoshi, M., Niwa, Y., Ueda, Y., Kokaji, A., Kamisuki, S., Kuramochi, K., Sugawara, F., Oka, J-I. Neoechinulin A induced memory improvements and antidepressant-like effects in mice. Progress in Neuro-Psychopharmacology & Biological Psychiatry 71:155-161 (2016).
  9. Suzuki, S., Saitoh, A., Ohashi, M., Yamada, M., Oka, J-I., Yamada, M. The infralimbic and prelimbic medial prefrontal cortices have differential functions in the expression of anxiety-like behaviors in mice. Behavioural. Brain Research 304:120-124 (2016).
  10. 岡淳一郎、松本欣三、濱田幸恵、釣藤散の脳機能障害改善作用、日本薬理学雑誌 147, 157-160 (2016).
  11. Nagasawa, H., Hamada, C., Wakabayashi, M., Nakagawa, Y., Nomura, S., Kohno, Y. Time to spontaneous ductus arteriosus closure in full-term neonates. Open Heart 3:e000413 (2016).
  12. Sato, H., Hirakawa, A., Hamada, C. An adaptive dose-finding method using a change-point model for molecularly targeted agents in phase I trials. Stat Med. 35:4093-109 (2016).
  13. Hamada, C., Yamada, Y., Azuma, M., Nishikawa, K., Gotoh, M., Bando, H., Sugimoto, N., Nishina, T., Amagai, K., Chin, K., Niwa, Y., Tsuji, A., Imamura, H., Tsuda, M., Yasui, H., Fujii, H., Yamaguchi, K., Yasui, H., Hironaka, S., Shimada, K., Miwa, H., Hyodo, I. Meta-analysis supporting noninferiority of oxaliplatin plus S-1 to cisplatin plus S-1 in first-line treatment of advanced gastric cancer (G-SOX study): indirect comparison with S-1 alone. Int J Clin Oncol. 21:668-75 (2016).
  14. Bando, H., Yamada, Y., Tanabe, S., Nishikawa, K., Gotoh, M., Sugimoto, N., Nishina, T., Amagai, K., Chin, K., Niwa, Y., Tsuji, A., Imamura, H., Tsuda, M., Yasui, H., Fujii, H., Yamaguchi, K., Yasui, H., Hironaka, S., Shimada, K., Miwa, H., Hamada, C., Hyodo, I. Efficacy and safety of S-1 and oxaliplatin combination therapy in elderly patients withadvanced gastric cancer. Gastric Cancer 19:919-26 (2016).
  15. Miura, R., Kasakura, K., Nakano, N., Hara, M., Maeda, K., Okumura, K., Ogawa, H., Yashiro, T., Nishiyama, C. Role of PU.1 in MHC class II expression via CIITA transcription in plasmacytoid dendritic cells. PLoS One 11:e0154094 (2016).
  16. Ishii, N., Kawano, Y., Suzuki, M., Komoda, M., Makino, K., Hanawa, T. Effects of camostat mesilate gargle on stomatitis caused by molecular target therapy: a case report. Jpn. J. Pharm. Palliat. Care Sci. 9, 87-91 (2016).
  17. Miyajima, A., Hirota, T., Sugioka, A., Fukuzawa, M., Sekine, Y., Yamamoto, Y., Yoshimasu, T., Kigure, A., Anata, T., Noguchi, W., Akagi, K., Komoda, M. Effect of high-fat meal intake on the pharmacokinetic profile of ivermectin in Japanese patients with scabies, J. Dermatol., 43, 1030-1036 (2016).
  18. 飯嶋久志、宇野弘展、大澄朋香、幸田真純、雑賀匡史、大木健史、大塚淳一、木村聡子、近藤忠、椎名雄一、長澤宏之、牧山泰士、青山隆夫、小嶋文良、小茂田昌代、日高慎二、柳川忠二、石井伊都子、棗則明、水野茂:薬局における調剤方法の相違と問題点. 千葉県薬誌. 62 (2), 77-81 (2016).
  19. 布施春奈、大西優香里、松井布美、杉山奈律子、小茂田昌代:タモキシフェンのCYP阻害作用に関連する相互作用情報. 医薬情報学. 18(2), 64-71 (2016).
  20. 中谷友美, 池谷有紀子, 荒井里実, 坂田将貴, 高橋あずさ, 阿波裕輔, 黄栄吉, 小峰千鶴, 藤掛直樹, 石井直子, 藤井清貴, 小茂田昌代: ジスチグミン臭化物錠適正使用プロトコール導入効果―薬学的介入に対する薬剤師と患者の意識調査―. 医薬情報学. 18(2), 95-105 (2016).
  21. 小茂田昌代: 患者安全に向けた更なる変化を―職種共通ノンテクニカル・スキル―, 日本医薬品安全性学会会誌 2: 17-25 (2016).

2015年の業績

  1. Okita, N., Tsuchiya, T., Fukushima, M., Itakura, K., Yuguchi, K., Narita, T., Hashizume, Y., Sudo, Y., Chiba, T., Shimokawa, I., Higami, Y., Chronological analysis of caloric restriction-induced alteration of fatty acid biosynthesis in white adipose tissue of rats. Exp. Gerontol. 63:59-66 (2015).
  2. Mizunuma, T., Iyoda, T., Fukai, F., Cell adhesion-mediated drug resistance (CAM-DR) in acute myelogenous leukemia cells and its abrogation by the antiadhesive peptide FNIII14. Peptide Science 2014, 261-264 (2015).
  3. Iyoda, T., Kazama, M., Takeda, K., Fukai, F., Role of the tenascin-C-derived peptide TNIIIA2 in the formation of atherosclerotic foam cell. Peptide Science 2014, 61-64 (2015).
  4. Yashiro, T., Kubo, M., Ogawa, H., Okumura, K., Nishiyama, C. PU.1 suppresses Th2 cytokine expression via silencing of GATA3 transcription in dendritic cells. PLoS One 10.e0137699 (2015).
  5. Yamazaki, S., Nakano, N., Honjo, A., Hara, M., Maeda, K., Nishiyama, C., Kitamura, J., Ohtsuka, Y., Okumura, K., Ogawa, H., Shimizu, T. The transcription factor Ehf is involved in TGF-β-induced suppression of FcεRI and c-Kit expression and FεcRI-mediated activation of mast cells. J. Immunol. 195, 3427-3435 (2015).
  6. Ito, T., Egusa, C., Maeda, T., Numata, T., Nakano, N., Nishiyama, C., Tsuboi, R., IL-33 promotes MHC class II expression in murine mast cells. Immun. Inflamm. Dis. 3, 196-208 (2015).
  7. Ishiyama, K., Yashiro, T., Nakano, N., Kasakura, K., Miura, R., Hara, M., Kawai, F., Maeda, K., Tamura, N., Okumura, K., Ogawa, H., Takasaki, Y., Nishiyama, C., Involvement of PU.1 in NFATc1 promoter function in osteoclast development. Allergol. Int. 64, 241-247 (2015).
  8. Nakano, N., Nishiyama, C., Yagita, H., Hara, M., Motomura, Y., Kubo, M., Okumura, K., Ogawa, H., Notch signaling enhances FcεRI-mediated cytokine production by mast cells through direct and indirect mechanisms. J. Immunol. 194, 4535-4544 (2015).
  9. Metz, P. J., Arsenio, J., Kakaradov, B., Kim, S. H., Remedios, K. A., Oakley, K., Akimoto, K., Ohno, S., Yeo, G. W., Chang, J. T., Regulation of Asymmetric Division and CD8+ T Lymphocyte Fate Specification by PKCζ and PKCλ/ι. J. Immunol. 194, 2249-2259 (2015).
  10. Iwata, R., Nakayama, F., Hirochi, S., Sato, K., Piao,W., Nishina, K., Yokota, T., Wada, T., Synthesis and properties of vitamin E analog-conjugated neomycin for delivery of RNAi drugs to liver cells. Bioorg. Med. Chem. Lett. 25 (4), 815-819 (2015).
  11. Nishina, T., Numata, J., Nishina,K., Yoshida-Tanaka, K., Nitta, K., Piao, W., Iwata, R., Ito, S., Kuwahara, H., Wada, T., Mizusawa, H., Yokota, T., Chimeric Antisense Oligonucleotide Conjugated to α-Tocopherol. Mol. Ther. Nucleic Acids 4, e220 (2015).
  12. Nukaga, Y., Takemura, T., Iwamoto, N., Okad, N., Wada, T., Enhancement of affinity of 2'-O-Me-oligonucleotides for complementary RNA by incorporating a stereoregulated boranophosphate backbone. RSC Adv. 5, 2392-2395 (2015).
  13. Otsuka, H., Muramatsu, Y., Matsukuma, D., Gold Nanorod Functionalized with Self-assembled Glycopolymers for Ultrasensitive Detection of Proteins. Chem. Lett. 44(2), 132-134 (2015).
  14. Matsukuma, D., Otsuka, H., Thermo-responsive Reversible Phase-transition of Alginate Based Semi-IPN Gel through Self-assembly of Interpenetrated Elastin-Like Polypeptide. Chem. Lett. 44(1), 26-28 (2015).
  15. Goto K., Shinozaki I., Ishihara T., Kaiho F., Hanawa T.,Evaluation of Community Pharmacist Training on Patients'Non-Verbal Communication. Jpn. J. Pharm. Health Care Sci., 41, 66-79(2015).
  16. Sasaki-Hamada S., Yuri, Y., Hoshi, M., Oka, J-I. Immunohistochemical determination of the site of antidepressant-like effects of glucagon-like peptide-2 in ACTH-treated mice. Neuroscience 294, 156-165 (2015).
  17. Sasaki-Hamada, S., Hojo, Y., Koyama, H., Otsuka, H., Oka, J-I. Changes in hippocampal synaptic functions and protein expression in monosodium glutamate-treated obese mice during development of glucose intolerance. Eur. J. Neurosci. 41, 1393-1401 (2015).
  18. Sugiyama, A., Saitoh, A., Inagaki, M., Oka, J-I., Yamada, M. Systemic administration of riluzole enhances recognition memory and facilitates extinction of fear memory in rats. Neuropharmacology 97, 322-328 (2015).
  19. Yamada, M., Saitoh, A., Ohashi, M., Suzuki, S., Oka, J-I., Yamada, M. Induction of c-Fos immunoreactivity in the amygdala of mice expressing anxiety-like behavior after local perfusion of veratrine in the prelimbic medial prefrontal cortex. J. Neural Transm. 122, 1203-1207 (2015).
  20. Saitoh, A., Makino, Y., Hashimoto, T., Yamada, M., Goto, L., Sugiyama, A., Ohashi, M., Tsukagoshi, M., Oka, J-I., Yamada, M. The voltage-gated sodium channel activator veratrine induces anxiogenic-like behaviors in rats. Behav. Brain Res. 292, 316-322 (2015).
  21. Niu, Y., Li, F., Inada, C., Tanaka, K., Watanabe, S., Fujiwara, H., Sasaki-Hamada, S., Oka, J-I., Matsumoto, K., Chemical profiling with HPLC-FTMS of exogenous and endogenous chemicals susceptible to the administration of chotosan in an animal model of type 2 diabetes-induced dementia. J. Pharmaceut. Biomed. Anal. 104, 21-30 (2015).
  22. Ohashi, M., Saitoh, A., Yamada, M., Oka, J-I., Yamada, M., Riluzole in the prelimbic medial prefrontal cortex attenuated veratrine-induced anxiety-like behaviors in mice. Psychopharmacol. 232, 391-398 (2015).
  23. Iwai, T., Jin, K., Ohnuki, T., Sasaki-Hamada, S., Nakamura, M., Saitoh, A., Sugiyama, A., Ikeda, M., Tanabe, M., Oka, J-I., Glucagon-like peptide-2-induced memory improvement and anxiolytic effects in mice. Neuropeptides 49, 7-14 (2015).
  24. Yamada, M., Tsukagoshi, M., Hashimoto, T., Oka, J-I., Saitoh, A., Yamada, M., Lysophosphatidic acid induces anxiety-like behavior via its receptors in mice. J. Neural Transm. 122, 487-494 (2015).
  25. Kato, M., Sasaki, M., Ueyama, Y., Koga, A., Sano, A., Higashi, T., Santa, T., Comparison of the Migration Behavior of the Polyethylene Glycol- and the Silica-Based Nanoparticles Using Micellar Electrokinetic Chromatography. J. Sep. Sci. 38, 468-474 (2015).
  26. Miyajima, A., Komoda, M., Akagi, K., Yuzawa, K., Yoshimasu, T., Yamamoto, Y., Hirota, T., Experimental study of pharmacokinetics of external, whole body bathing application of ivermectin. J. Dermatol. 42(1), 87-89(2015).
  27. 石井則久、 浅井俊弥、 朝比奈 昭彦、 石河 晃、 今村 英一、 加藤豊範、 金澤 伸雄、久保田 由美子、 黒須 一見、 幸野 健、 小茂田昌代、 関根 万里、 田中 勝、 谷口 裕子、 常深 祐一郎、 夏秋優、 廣田 孝司、 牧上 久仁子、 松田 知子、 吉住 順子、 四津里英、 和田 康夫:疥癬診療ガイドライン(第3版). 日本皮膚科学会雑誌 125(11): 2023―2048,(2015).
  28. Kakurai, Y., Hirakawa, A., and Hamada, C., A Dose-Finding Method Based on Multiple Dosing in Two-Agent Combination Phase I Trials. J. Biopharm. Stat. [Epub ahead of print] PubMed PMID: 25369852.(2015).
  29. Kubota, K., Kamijima, Y., Sato, T., Ooba, N., Koide, D., Iizuka, H., and Nakagawa, H., Epidemiology of psoriasis and palmoplantar pustulosis: a nationwide study using the Japanese national claims database. BMJ Open 5, e006450 (2015).
  30. 中村修也、 小茂田昌代、 藤森進、 赤倉貴子: 講義形式の違いが学生満足度に及ぼす影響とその要因に関する調査・分析, 電子情報通信学会技術研究報告 = IEICE technical report : 信学技報, 東京, 電子情報通信学会 115(223), 7-12 (2015).

2014年の業績

  1. Terawaki, K., Sawada, Y., Kashiwase, Y., Hashimoto, H., Yoshimura, M., Suzuki, M., Miyano, K., Sudo, Y., Shiraishi, S., Higami, Y., Yanagihara, K., Kase, Y., Ueta, Y., Uezono, Y., New cancer cachexia rat model generated by implantation of a peritoneal dissemination-derived human stomach cancer cell line. Am. J. Physiol. Endocrinol. Metab. 306(4), E373-87 (2014).
  2. Okita, N., Ishikawa, N., Mizunoe, Y., Oku, M., Nagai, W., Suzuki, Y., Matsushima, S., Mikami, K., Okado, H., Sasaki, T., Higami, Y., Inhibitory effect of p53 on mitochondrial content and function during adipogenesis. Biochem. Biophys. Res. Commun. 446(1), 91-97 (2014).
  3. Hatachi, G., Tsuchiya, T., Miyazaki, T., Matsumoto, K., Yamasaki, N., Okita, N., Nanashima, A., Higami, Y., Nagayasu, T., The poly(adenosine diphosphate-ribose) polymerase inhibitor PJ34 reduces pulmonary ischemia-reperfusion injury in rats. Transplantation. 98(6), 618-624 (2014).
  4. Miyano, K., Sudo, Y., Yokoyama, A., Hisaoka-Nakashima, K., Morioka, N., Takebayashi, M., Nakata, Y., Higami, Y., Uezono, Y., History of the G protein-coupled receptor (GPCR) assays from traditional to a state-of-the-art biosensor assay. J. Pharmacol. Sci. 126(4), 302-9 (2014).
  5. Tanaka, R., Seki, Y., Saito, Y., Kamiya, S., Fujita, M., Okutsu, H., Iyoda, T., Takai, T., Owaki, T., Yajima, H., Taira, J., Hayashi, R., Kodama, H., Matsunaga, T., and Fukai, F., Tenascin-C-derived peptide TNIIIA2 highly enhances cell survival and platelet-derived growth factor (PDGF)-dependent cell proliferation through potentiated and sustained activation of integrin a5b1. J. Biol. Chem. 289(25), 17699-17708 (2014).
  6. Iyoda, T., Takada, M., Fukatsu, K., Kumokoshi, S., Fujisawa, T., Shimada, T.,Shimokawa, N., Matsunaga, T., Makino, K., Doi, N., Terada, H., and Fukai, F., A novel mechanism underlying the basic defensive response of macrophages against Mycobacterium infection. J. Immnunol. 192(9), 4254-4262 (2014).
  7. Yoshida, A., Tomita, T., Fujimura, T., Nishiyama, C., Kuzuyama, T., Nishiyama, M., Structure insight into amino group-carrier protein-mediated lysine biosynthesis: crystal structure of the LysZ-LysW complex from Thermus thermophilus. J. Biol. Chem. 290, 435-447 (2014).
  8. Kasakura, K., Takahashi, K., Ito, T., Hosono, A., Nunomura, S., Ra, C., Momose, Y., Ito, K., Nishiyama, C., Kaminogawa, S., C/EBPα controls functions of mast cells. FEBS Lett. 588, 4645-4653 (2014).
  9. Kasakura, K., Takahashi, K., Ito, T., Hosono, A., Momose, Y., Ito, K., Nishiyama, C., Kaminogawa, S., Commensal bacteria directly suppress in vitro degranulation of mast cells in a MyD88-independent manner. Biosci. Biotechnol. Biochem. 78, 1669-1676 (2014).
  10. Inage, E., Kasakura, K., Yashiro, T., Suzuki, R., Baba, Y., Nakano, N., Hara, M., Tanabe, A., Oboki, K., Matsumoto, K., Saito, H., Niyonsaba, F., Ohtsuka, Y., Ogawa, H., Okumura, K., Shimizu, T., Nishiyama, C., Critical roles for PU.1, GATA1 and GATA2 in the expression of human FcεRI on mast cells: PU.1 and GATA1 transactivate FCER1A, and GATA2 transactivates FCER1A and MS4A2. J. Immunol. 192, 3936-3946 (2014).
  11. Nakamura, Y., Nakano, N., Ishimaru, K., Hara, M., Ikegami, T., Tahara, Y., Katoh, R., Ogawa, H., Okumura, K., Shibata, S., Nishiyama, C., Nakao, A., Circadian regulation of allergic reaction by the mast cell clock. J. Allergy Clin. Immunol. 133, 568-575 (2014).
  12. Schendzielorz, G., Dippong, M., Grunberger, A., Kohlheyer, D., Yoshida, A., Binder, S., Nishiyama, C., Nishiyama, M., Bott, M., Eggeling, L., Taking control over control: Use of product sensing in single cells to remove flux control at key enzymes in biosynthesis pathways. ACS Synth. Biol. 3, 21-29 (2014).
  13. Ichikawa, Y., Nagashima, Y., Morioka, K., Akimoto, K., Kojima, Y., Ishikawa, T., Goto, A., Kobayashi, N., Watanabe, K., Ota, M., Fujii, S., Kawamata, M., Takagawa, R., Kunizaki, C., Takahashi, H., Nakajima, A., Maeda, S., Shimada, H., Inayama, Y., Ohno, S., Endo, I., Colorectal laterally spreading tumors show characteristic expression of cell polarity factors, including atypical protein kinase C λ/ι, E-cadherin, β-catenin and basement membrane component. Oncol. Lett. 8, 977-984 (2014).
  14. Okayama, A., Miyagi, Y., Oshita, F., Nishi, M., Nakamura, Y., Nagashima, Y., Akimoto, K., Ryo, A., Hirano, H.,Proteomic analysis of proteins related to prognosis of lung adenocarcinoma. J. Proteosome Res. 13, 4686-4694 (2014).
  15. Otsuka, H., Matsukuma, D., Sanbai, T., and Ikenaga, Y., Self-Assembly of Poly(ethylene glycol)-block-Polypyridine Copolymer into Micelles and at Silica Surface: Effect of molecular architecture on Silica Dispersion. Colloid Polym. Sci., 292, 291?300 (2014). (DOI 10.1007:s00396-013-3062-2)
  16. Matsukuma, D., Maejima, Y, Ikenaga, Y., Sanbai, T., Ueno, K., and Otsuka, H., Amphiphilic Copolymer of Poly(ethylene glycol)-block-Polypyridine; Synthesis, Physicochemical Characterization, and Adsorption onto Silica Nanoparticle. J. Nanosci. Nanotechnol., 14(9), 6774-6780 (2014).
  17. Kutsuzawa, K., Suzuki, T., Kishimoto, H., Murakami, A., Azuma, T., Abe, R., Otsuka, H. Highly Robust Protein Production by Coculture of CHO Spheroids Layered on Feeder Cells in Serum-Free Medium. Colloid Polym. Sci., 292, 839-848 (2014). (DOI: 10.1007:s00396-013-3093-8)
  18. Otsuka, H., Sasaki, K., Okimura, S., Nagamura, M., Watanabe, R., Kawabe, M., Contribution of Fibroblasts Cultured on 3D Silica Nonwoven Fabrics to the Co-cultured Hepatocytes Function. Chem. Lett., 43, 343?345 (2014).
  19. Otsuka, H., Hagiwara, T., Yamamoto, S., Carbohydrate-Based Amphiphilic Diblock Copolymers With Pyridine for the Sensitive Detection of Protein Binding. J. Nanosci. Nanotechnol. 14(9), 6764-6773 (2014).
  20. Kuriyama, M., Haruta, K., Dairaku, T., Kawamura, T., Kikkawa, S., Inamoto, K., Tsukamoto, H., Kondo, Y., Torigoe, H., Okamoto, I., Ono, A., Morita, E. H., Tanaka, Y., Hg2+-Trapping Beads: Hg2+-Specific Recognition through Thymine-Hg(II)-Thymine Base Pairing. Chem. Pharm. Bull. 62(7), 709-712 (2014).
  21. 前田拓也、津久井宏行、梅原伸大、岩朝静子、杉浦唯久、早川美奈子、河野弥生、山崎健二、酪酸菌製剤によるwarfarin作用減弱が疑われた1例、胸部外科、67、505-507(2014).
  22. Iwai, T., Sawabe, T., Tanimitsu, K., Suzuki, M., Sasaki-Hamada, S., Oka, J-I., Glucagon-like peptide-1 protects synaptic and learning functions from neuroinflammation in rodents. J. Neurosci. Res. 92, 446-454 (2014).
  23. Sasaki-Hamada, S., Tamaki, K., Otsuka, H., Ueno, T., Sacai, H., Niu, Y., Matsumoto, K., Oka, J-I., Chotosan, a Kampo formula, ameliorates hippocampal LTD and cognitive deficits in juvenile-onset diabetes rats. J. Pharmacol. Sci. 124, 192-200 (2014).
  24. Sugiyama, A., Nagase, H., Oka, J-I., Yamada, M., Saitoh, A., DOR2-selective but not DOR1-selective antagonist abolishes anxiolytic-like effects of the d opioid receptor agonist KNT-127. Neuropharmacol. 79, 314-320 (2014).
  25. Sacai1, H., Sasaki-Hamada1, S., Sugiyama, A., Saitoh, A., Mori, K., Yamada, M., Oka, J-I., The impairment in spatial learning and hippocampal LTD through the PKA pathway in juvenile-onset diabetes rats are rescued by modulating NMDA receptor function. Neurosci. Res. 81-82, 55-63 (2014). 1These authors contributed equally to this work.
  26. Saitoh, A., Ohashi, M., Suzuki, S., Tsukagoshi, M., Sugiyama, A., Yamada, M., Oka, J-I., Inagaki, M., Yamada, M., Activation of the prelimbic medial prefrontal cortex induces anxiety-like behaviors via N-methyl-D-aspartate receptor-mediated glutamatergic neurotransmission in mice. J. Neurosci. Res. 92, 1044-1053 (2014).
  27. Ogawa, S., Tadokoro, H., Sato, M., Higashi, T., Enantioselective Determination of Ibuprofen in Saliva by Liquid Chromatography/Tandem Mass Spectrometry with Chiral Electrospray Ionization-Enhancing and Stable Isotope-Coded Derivatization. J. Pharm. Biomed. Anal. 98, 387-392 (2014).
  28. Higashi, T., Goto, A., Morohashi, M., Ogawa, S., Komatsu, K., Sugiura, T., Fukuoka, T., and Mitamura, K., Development and Validation of a Method for Determination of Plasma 25-Hydroxyvitamin D3 3-Sulfate Using Liquid Chromatography/Tandem Mass Spectrometry. J. Chromatogr. B 969, 230-234 (2014).
  29. Ogawa, S., Ooki, S., Shinoda, K., Higashi, T., Analysis of Urinary Vitamin D3 Metabolites by Liquid Chromatography/Tandem Mass Spectrometry with ESI-Enhancing and Stable Isotope-Coded Derivatization. Anal. Bioanal. Chem. 406, 6647-6654 (2014).
  30. Saito, M., Sugiyama, N., Komoda, M., Faculty Development of Oncology Expects. Juntendo Medical Journal. 60(3), 220-223(2014).
  31. 天津怜、 齋藤隼、 大登剛、 吉澤一巳、 杉山奈津子、 齋藤光江、 小茂田昌代、 外来臨床薬剤師支援システムの開発-乳がん治療における薬学的管理の質の向上を目指して-. 医薬品情報学. 16(3), 17-22(2014).
  32. 森田茜、 栗田知沙、 池谷有紀子、 中谷友美、 黄栄吉、 中村達也、 大澄朋香、 小茂田昌代、 取り間違い発見ツール普及活動報告-患者の健康被害発生前に気付くために-. 医療の質・安全学会誌. 9(3), 216-224(2014).
  33. Shikamura, Y., Kikuchi, Y., Takahashi, J., Negishi, K., Komoda, M., Mochizuki, M., Terada, H., Medical Economic Research on Pharmaceutical Inquiries Made by Hospital Pharmacists about Prescriptions for Inpatients. 医薬品情報学. 16(2), 41-52(2014).
  34. 金永進、 酒巻智美、 湯浅奈絵、 吉増孝嗣、 宮嶋篤志、 廣田孝司、 小茂田昌代、経鼻チューブを使用した経管投与がストロメクトールR錠の投与量に及ぼす影響. 医療薬学. 40(9), 515-521(2014).
  35. 篠原紘子、 深田祐羽妃、 鈴木信世、 杉山奈津子、 内呂拓実、 齊藤光江、 小茂田昌代、 東京理科大学とヒューストン大学の薬学部授業時間比較. 千葉県薬剤師雑誌. 60(10), 3-11 (2014).
  36. Abe, K., Itoyama, Y., Sobue, G., Tsuji, S., Aoki, M., Doyu, M., Hamada, C., Kondo, K., Yoneoka, T., Akimoto, M., Yoshino, H., Edaravone ALS Study Group. Confirmatory double-blind, parallel-group, placebo-controlled study of efficacy and safety of edaravone (MCI-186) in amyotrophic lateral sclerosis patients. Amyotroph. Lateral Scler. Frontotemporal Degener. 15(7-8), 610-7(2014).
  37. Asano, J., Hirakawa, A., Hamada, C., Assessing the prediction accuracy of cure in the Cox proportional hazards cure model: an application to breast cancer data. Pharm. Stat. 13(6), 357-63(2014).
  38. Uchiyama, S., Shinohara, Y., Katayama, Y., Yamaguchi, T., Handa, S., Matsuoka, K., Ohashi, Y., Tanahashi, N., Yamamoto, H., Genka, C., Kitagawa, Y., Kusuoka, H., Nishimaru, K., Tsushima, M., Koretsune, Y., Sawada, T., Hamada, C., Benefit of cilostazol in patients with high risk of bleeding: subanalysis of cilostazol stroke prevention study 2. Cerebrovasc. Dis. 37(4), 296-303(2014).
  39. Tsuchiya, T., Sadahiro, S., Sasaki, K., Kondo, K., Katsumata, K., Nishimura, G., Kakeji, Y., Baba, H., Morita, T., Koda, K., Sato, S., Matsuoka, J., Yamaguchi, Y., Usuki, H., Hamada, C., Kodaira, S., Saji, S., Safety analysis of two different regimens of uracil-tegafur plus leucovorin as adjuvant chemotherapy for high-risk stage II and III colon cancer in a phase III trial comparing 6 with 18 months of treatment: JFMC33-0502 trial. Cancer Chemother. Pharmacol. 73(6), 1253-61(2014).
  40. Asakawa, T., Hirakawa, A., Hamada, C., Bayesian model averaging continual reassessment method for bivariate binary efficacy and toxicity outcomes in phase I oncology trials. J. Biopharm. Stat. 24(2), 310-25(2014).
  41. Nakamura, M., Nanto, S., Hirayama, A., Takayama, T., Nishikawa, M., Kimura, K., Morita, S., Aizawa, T., Asano, R., Matsumaru, Y., Hamada, C., Isshiki, T, OPERA Steering Committee and Investigators. Optimal duration of dual antiplatelet therapy following treatment with the endeavor zotarolimus-eluting stent in real-world Japanese patients with coronary artery disease (OPERA): study design and rationale. Catheter. Cardiovasc. Interv. 84(3), 368-74(2014).
  42. Ishihara, M., Asakura, M., Kimura, K., Nakao, K., Hamada, C., Hirayama, A., Trial design and rationale of TY-51924 as a novel Na+/H+ exchanger inhibitor in patients with ST-elevation acute myocardial infarction undergoing percutaneous coronary intervention. J. Cardiol. 63(1), 82-7 (2014).
  43. 矢田真城、浜田知久馬、有効性と毒性を指標としたCRMの中止基準に関する研究. 臨床薬理. 45-1, 3-10 (2014).
  44. 矢田真城、浜田知久馬、代替性評価指標を利用したCRMの性能評価に関する研究. 臨床薬理. 45-5, 179-186 (2014).
  45. Ooba, N., Sato, T., Wakana, A., Orii, T., Kitamura, M., Kokan, A., Kurata, H., Shimodozono, Y., Matsui, K., Yoshida, H., Yamaguchi, T., Kageyama, S., Kubota, K., A Prospective Stratified Case-Cohort Study on Statins and Multiple Adverse Events in Japan. PLoS One 9, e96919 (2014).
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