Kanemaru, K., Nagasawa, K., Kunugi, Y., Tanaka, A., Tai, Y., Harada, Y., Nakamura, Y. Epidermal loss of Bcl6 exacerbates MC903-induced atopic dermatitis-like skin inflammation. Biochem. Biophys. Res. Commun. 705:149745 (2024).
Nagata, K., Ando, D., Ashikari, T., Ito, K., Miura, R., Fujigaki, I., Goto, Y., Ando, M., Ito, N., Kawazoe, H., Iizuka, Y., Inoue, M., Yashiro, T., Hachisu, M., Kasakura, K., Nishiyama, C. Butyrate, valerate, and niacin ameliorate anaphylaxis by suppressing IgE-dependent mast cell activation: Roles of GPR109A, PGE2, and epigenetic regulation. J. Immunol. 212:771-784 (2024).
2023年の業績
Tsurusaki, T., Sato, K., Wada, T., "Internucleotidic bond formation using H-phosphonamidate derivatives and acidic activators", RSC Adv. 13:31674–31686 (2023).
Yamamoto, Y., Nakano, Y., Murae, M., Shimizu, Y., Sakai, S., Ogawa, M., Mizukami, T., Inoue, T., Onodera, T., Takahashi, Y., Wakita, T., Fukasawa, M., Miyazaki, S., Noguchi, K., Direct Inhibition of SARS-CoV-2 Spike Protein by Peracetic Acid. Int. J. Mol. Sci., 24:20 (2023).
Tachó-Piñot, R., Stamper, C.T., King, J.I., Matei-Rascu, V., Richardson, E., Li, Z., Roberts, L.B., Bassett, J.W., Melo-Gonzalez, F., Fiancette, R., Lin, I.H., Dent, A., Harada, Y., Finlay, C., Mjösberg, J., Withers, D.R., Hepworth, M.R. Bcl6 is a subset-defining transcription factor of lymphoid tissue inducer-like ILC3. Cell Rep. 42:113425 (2023).
Kakuta, K., Kasahara, R., Sato, K., Wada, T., “Solid-phase synthesis ofoligodeoxynucleotides using nucleobase N-unprotected oxazaphospholidinederivatives bearing a long alkyl chain” Org. Biomol. Chem. 21, 7580–7592 (2023).
Tsurusaki, T., Sato, K., Imai, H., Hirai, K., Takahashi, D., Wada, T., "Convergentsynthesis of phosphorodiamidate morpholino oligonucleotides (PMOs) by the H-phosphonateapproach" Sci. Rep. 13, 12576(2023).
Takahashi, Y., Kakuta, K., Namioka, Y., Igarashi, A., Sakamoto, T., Hara, R. I., Sato, K., Wada, T., "Synthesis of P-Modified DNA fromBoranophosphate DNA as a Precursor via Acyl Phosphite Intermediates" J. Org. Chem. 88, 10617–10631 (2023).
"Analysisof Acetylated Hyaluronic Acid in Moisturizing Lotion and Milk Lotion by HPLCwith Fluorescence Detection" Shimekake, M., Komeno, M., Taguchi, M., Katsumoto, S., Tanda, Y., Sato, K., Wada, T., Toida, T., Higashi, K., Chem. Pharm. Bull. 71, 616–619 (2023).
Sato, K., Nukaga, Y., Wada, T., "Solid-phase synthesis and properties of stereocontrolled boranophosphate/phosphate and phosphorothioate/phosphate chimeric oligouridylates" R. Soc. Open Sci. 10, 230095 (2023).
"Solid-PhaseSynthesis of Glycosyl Phosphate Repeating Units via Glycosyl Boranophosphatesas Stable Intermediates" Sato, K., Muramoto, K., Hagio, T., Hara, R. I., Wada, T.,Org. Lett. 25, 3927–3931 (2023).
"Fucosylatedheparan sulfate from the midgut gland of Patinopecten yessoensis" Onishi, S.; Shionoya, K.; Sato, K.; Mubuchi, A.; Maruyama, S.; Nakajima, T.; Komeno, M.; Miyata, S.; Yoshizawa, K.; Wada, T.; Linhardt, R. J.; Toida, T.; Higashi, K. Carbohydr. Polym. 313, 120847 (2023).
"Developmentof a quick preparation method for the analysis of 11-nor-9-carboxy-Δ9-tetrahydrocannabinolin human urine by phenylboronic-acid solid-phase extraction" Ishii, A., Sato, K., Kusakabe, K., Kato, N., Wada, T.,J. Pharm. Biomed. Anal., 234, 115556 (2023).
Otsuka, K., Sasaki, D., Kusamori, K., Nishikawa, M. Ben-Nissan, B. Investigation of the crystallinity change after the addition of magnesiumhydroxides into the calcium phosphate during mechanochemical synthesis; an FTIRspectroscopy, XRD analysis, chemometrics and cell culture. Journal of theAustralian Ceramic Societyin press (2023).
Takayama, Y., Kusamori, K., Katsurada, Y., Obana, S., Itakura, S., Nishikawa, M.Efficient delivery of mesenchymal stem/stromal cells to injured liver bysurface PEGylation. Stem Cell Research and Therapy 14: 216(2023).
Suzuki, R., Kusamori, K., Takamura, K., Miyakawa, Y., Obana, S., Itakura, S., Nishikawa, M. Optimal Preparation Protocol of Cell-Encapsulating Alginate Capsules forLong-Term Cell-Based Therapy. Applied Sciences 13(11):6676(2023).
Koyanagi, K., Kusamori, K., Nishikawa, M. Konishi, K. In situ evaluation of cellularspheroid stiffness by pinching device composed of piezoactuator and straingauge. IEEJ Transactions on Electrical and Electronic Engineering18(7):1226-1228 (2023).
Tanifuji, T., Nishimura, M., Kusamori, K., Nishikawa, M. Intradermal delivery of Cryj1 loadedin CpG DNA hydrogel for inhibiting allergic reactions in mice. Journal ofControlled Release 354: 429-438 (2023).
Takakusa, H., Iwazaki, N., Nishikawa, M., Yoshida, T., Obika, S., Inoue T. Drug metabolismand pharmacokinetics of antisense oligonucleotide therapeutics: typicalprofiles, evaluation approaches, and points to consider compared with small. NucleicAcid Therapeutics 33-1 (2023).
Akita, T#,*., Miyamoto, K.#, Yamashita, C*., Efficiency of a Lyophilizate for Dry Powder Inhalation System for Drug Deliveryof Ghrelin in Monkeys. Drug Delivery Letters, (2023) inpress. #These authors contributed equally to this work.
Tanino, R., Tsubata, Y*., Hotta, T., Okimoto, T., Amano, Y., Takechi, M., Tanaka, T., Akita, T., Nagase, M., Yamashita, C., Wada, K., and Isobe, T., Characterization ofa spontaneous mouse model of mild, accelerated aging via ECM degradation inemphysematous lungs. Scientific reports,13(1):10740(2023)
Akita, T*., Oda, K., Narukawa, S., Morita, Y., Tange, K., Nakai, Y., Yamashita, C*., Intracellular Drug Delivery Processof Am80-Encapsulated Lipid Nanoparticles Aiming for Alveolar Regeneration. Pharmaceuticals,16(6):838(2023)
山下親正,「新しい概念に基づいた神経回路を活かした Nose-to-Brain システムの開発」, Drug Delivery System,Vol.38,No2,P134-145(2023)
Tai, Y., Sakaida, Y., Kawasaki, R., Kanemaru, K., Akimoto, K., Brombacher, F., Ogawa, S., Nakamura, Y., Harada, Y., Foxp3 and Bcl6 deficiency synergistically induces spontaneous development ofatopic dermatitis-like skin disease. Int. Immunol. 35:423-435(2023).
Okamoto, T., Onaga, C., Matsuoka, I., Ozaki, A., Matsuda, C., Kasai, T., Xiong, Y., Harada, Y., Sato, T., Nakano, Y., Mano, Y., Miyazaki, S., Ishiguro, H., Sato, K., Tamori, S., Sasaki, K., Ohno, S., Akimoto, K., High SLC20A1 Expression Indicates Poor Prognosis inProstate Cancer. Cancer Diagn. Progn. 3:439-448 (2023).
Kasai, T., Tamori, S., Takasaki, Y., Matsuoka, I., Ozaki, A., Matsuda, C., Harada, Y., Sasaki, K., Ohno, S., Akimoto, K., High expression of PKCλ and ALDH1A3 indicates a poor prognosis, andPKCλ is required for the asymmetric cell division of ALDH1A3-positive cancerstem cells in PDAC. Biochem. Biophys. Res. Commun.669:85-94 (2023).
Zhu, F., McMonigle, R.J., Schroeder, A.R., Xia, X., Figge, D., Greer, B.D., González-Avalos, E., Sialer, D.O., Wang, Y.H., Chandler, K.M., Getzler, A.J., Brown, E.R., Xiao, C., Kutsch, O., Harada, Y., Pipkin, M.E., Hu, H., Spatiotemporal resolution of germinal center Tfhcell differentiation and divergence from central memory CD4+ Tcell fate. Nat. Commun. 14:3611 (2023).
Koshida, K., Ito, M., Yakabe, K., Takahashi, Y., Tai, Y., Akasako, R., Kimizuka, T., Takano, S., Sakamoto, N., Haniuda, K., Ogawa, S., Kimura, S., Kim, Y.G., Hase, K., Harada, Y., Dysfunctionof Foxp3+ Regulatory T Cells Induces Dysbiosis of Gut Microbiota via AberrantBinding of Immunoglobulins to Microbes in the Intestinal Lumen. Int. J. Mol. Sci. 24:8549 (2023).
Namioka, R., Suzuki, M., Yoshida, S., Synthesis of1,2,3-triazoles using Grignard reactions through the protection of azides.Front. Chem., in press. (DOI: 10.3389/fchem.2023.1237878)
Numata, K., Tabata, S., Kobayashi, A., Yoshida, S., Multisubstituted naphthalene synthesis from 4-hydroxy-2-pyrones and o-silylaryltriflates. New. J. Chem., 47: 18762-18768 (2023).
Nakamura, K., Kumagai, Y., Kobayashi, A., Suzuki, M., Yoshida, S., Facile synthesis of sulfinate esters from aryl iodides via directoxidation of thioesters. Org. Biomol. Chem., 21: 6886–6891 (2023).
Shiraishi, T., Sato, K., Hara, R. I., Wada, T.,“Properties of artificial cationic oligodiaminosaccharides and oligopeptides that bind to A-type oligonucleotide duplexes”Nucleosides Nucleotides Nucleic Acid., 43, 619-636(2023).
Tsurusaki, T., Sato, K., Wada, T., "Development of a new synthetic method for oligodeoxynucleotides using 3ʹ-H-phosphonamidate derivatives" Org. Biomol. Chem., 21, 2486-2492 (2023).
Nozaki, Y., Kobayashi, M., Wakasawa, H., Hoshino, S., Suwa, F., Ose, Y., Tagawa, R., Higami, Y. Systemic depletion of WWP1 improves insulin sensitivity and lowers triglyceride content in the liver of obese mice. FEBS Open bio. in press (2023).
Tanifuji, T., Nishimura, M., Kusamori, K., Nishikawa, M. Intradermal delivery of Cryj1 loaded in CpG DNA hydrogel for inhibiting allergic reactions in mice. Journal of Controlled Release 354: 429-438 (2023).
Takakusa, H., Iwazaki, N., Nishikawa, M., Yoshida, T., Obika, S., Inoue T. Drug metabolism and pharmacokinetics of antisense oligonucleotide therapeutics: typical profiles, evaluation approaches, and points to consider compared with small. Nucleic Acid Therapeutics 33-1 (2023).
Sasaki, D., Kusamori, K., Nishikawa M. Delivery of corn-derived nanoparticles with anticancer activity to tumor tissues by modification with polyethylene glycol for cancer therapy. Pharmaceutical Research 40(4):917-926 (2023).
Hamada, S., Yoshida, S., Synthesis of Fluorenones and Xanthones through Intramolecular C–F Arylation. Bull. Chem. Soc. Jpn., 96: 401–405 (2023).
Yoshida, S., C−F Transformations of Benzotrifluorides by the Activation of ortho‐Hydrosilyl Group. Chem. Rec., 23, e202200308 (2023).
Tabata, S., Minoshima, M., Kobayashi, A., Hosoya, T., Yoshida, S., Migrative Thioamination of Aryne Intermediates Generated from o-Iodoaryl Triflates. Synlett, 34: 1259–1264 (2023).
Kobayashi, A., Matsuzawa, T., Hosoya, T., Yoshida, S. Synthesis of benzo[b]furans from alkynyl sulfoxides and phenols by the interrupted Pummerer reaction. RSC Adv., 13: 839–843 (2023).
Nagata, K., Araumi, S., Ando, D., Ito, N., Ando, M., Ikeda, Y., Takahashi, M., Noguchi, S., Yasuda, Y., Nakano, N., Ando, T., Hara, M., Yashiro, T., Hachisu, M., Nishiyama, C. Kaempferol suppresses the activation of mast cells by modulating the expression of FceRI and SHIP1. Int. J. Mol. Sci. 24:5997. (2023).
Kodama, N., Okada, H., Hachisu, M., Ando, M., Ito, N., Nagata, K., Katagiri, M., Yasuda, Y., Hiroki, I., Yashiro, T., Ichihara, G., Yamamoto, M., Nishiyama, C. A rose flavor compound activating the NRF2 pathway in dendritic cells ameliorates contact hypersensitivity in mice. Front. Nutr. 10:1081263. (2023).
2022年の業績
Kobayashi, M., Nezu, Y., Itoh, M., Uchida, R., Arikawa, T., Otsubo, M., Nozaki, Y., Tagawa, R., Fujishima. Y., Maeda, N., Shimomura, I., Higami, Y. Individual evaluation of aging- and caloric restriction-related changes to distinct multimeric complexes of circulating adiponectin by immunoblotting. Experimental Gerontology, 164: 111821 (2022).
Akita, T., Morita, Y., Kawai, T., Oda, K., Tange, K., Nakai, Y., Yamashita, C., Am80-Encapsulated Lipid Nanoparticles, Developed with the Aim of Achieving Alveolar Regeneration, Have an Improvement Effect on Pulmonary Emphysema. Pharmaceutics,15(1):37 (2022).
Akita, T., Oda, Y., Kimura, R., Nagai, M., Tezuka, A., Shimamura, M., Washizu, K., Oka, J., Yamashita, C., Involvement of trigeminal axons in nose-to-brain delivery of glucagon-like peptide-2 derivative, Journal of Controlled Release, 351, 573-580 (2022).
Yamagishi, R., Kamachi, F., Nakamura, M., Yamazaki, S., Kamiya, T., Takasugi, M., Cheng, Y., Nonaka, Y., Yukawa-Muto, Y., Thuy, L.T.T., Harada, Y., Arai, T., Loo, T.M., Yoshimoto, S., Ando, T., Nakajima, M., Taguchi, H., Ishikawa, T., Akiba, H., Miyake, S., Kubo, M., Iwakura, Y., Fukuda, S., Chen, W.Y., Kawada, N., Rudensky, A., Nakae, S., Hara, E., Ohtani, N., Gasdermin D-mediated release of IL-33 from senescent hepatic stellate cells promotes obesity-associated hepatocellular carcinoma. Sci. Immunol. 2022 7:eabl7209 (2022).
Yamamoto, C., Suzuki, M. Yoshida, S.. Pyridazine Synthesis from 1,2,4,5-Tetrazines and Alkynes in 1,1,1,3,3,3-Hexafluoro-2-propanol through the Inverse Electron Demand Diels–Alder Reaction. Bull. Chem. Soc. Jpn., 95: 1741–1746 (2022). (BCSJ award article)
Shiraishi, T., Sato, K., Hara, R. I., Wada, T., Synthesis and properties of oligodiaminogalactoses that bind to A-type oligonucleotide duplexes. Org. Biomol. Chem., 20, 8243-8258 (2022).
Sato, K., Chiba, A., Shiraishi, T., Ogawa, Y., Hara, R. I., Wada, T., Solid-phase synthesis of N-trichloroacetyl mannosamine 1-phosphate repeating units mimicking capsular polysaccharide derived from Neisseria meningitidis serotype A. Carbohydr. Res., 518: 108585 (2022).
Ishii, A., Sato, K., Kusakabe, K., Kato, N., Wada, T., Identification and Quantitative Analysis of 2-Fluoro Methamphetamine and its Metabolites in Human Urine. J. Anal. Toxicol., in press (2022).
Yuyun, X, Motomura, H., Tamori, S., Ozaki, A., Onaga, C, Hara, Y., Sato, K., Tahata, K., Harada, Y., Sasaki, K., Yunwen, Z., Ohno, S., Akimoto, K., High expression of CD58 and ALDH1A3 predicts a poor prognosis in basal-like breast cancer. Anticancer Res., 42: 5223-5232 (2022).
Ozaki, A., Motomura, H., Tamori, S., Onaga, C., Nagashima, Y., Kotori, M., Matsuda, C., Matsuda, A., Mochizuki, N., Sato, T., Hara, Y., Sato, K., Miyagi, Y., Nagashima, Y., Hanawa, T., Harada, Y., Yuyun, X., Sasaki, K., Ohno, S., Akimoto, K., High Expression of p62 and ALDH1A3 Is Associated With Poor Prognosis in Luminal B Breast Cancer. Anticancer Res., 42: 3299–3312 (2022).
Onaga, C., Tamori, S., Matsuoka, I., Ozaki, A., Motomura, H. Nagashima, Y., Sato, T., Sato, K., Tahata, K., Yuyun, X., Nakano, Y., Mano, Y., Miyazaki, S., Sasaki, K., Ohno, S., Akimoto, K., High SLC20A1 Expression Is Associated With Poor Prognosis for Radiotherapy of Estrogen Receptor-positive Breast Cancer. Cancer Diagn. Prognosis., 2: 429–442 (2022).
Onaga, C., Tamori, S., Matsuoka, I., Ozaki, A., Motomura, H. Nagashima, Y., Sato, T., Sato, K., Yuyun, X., Sasaki, K., Ohno, S., Akimoto, K., High expression of SLC20A1 is less effective for endocrine therapy and predicts late recurrence in ER-positive breast cancer. PLoS One, 17: e0268799 (2022).
Tsujimura, M., Kusamori, K., Takamura, K., Ito, T., Kaya, T., Shimizu, K., Konishi, S., Nishikawa, M., Quality evaluation of cell spheroids for transplantation by monitoring oxygen consumption using an on-chip electrochemical device. Biotechnol. Rep., 36: e00766 (2022).
Ashikari, T., Hachisu, M., Nagata, K., Ando, D., Iizuka, Y., Ito, N., Ito, K., Ikeda, Y., Matsubara, H., Yashiro, T., Kasakura, K., Nishiyama, C., Salichylaldehyde suppresses IgE-mediated activation of mast cells and ameliorates anaphylaxis in mice. Int. J. Mol. Sci., 23: 8826 (2022).
Semba, M., Takamatsu, S., Komazawa-Sakon, S., Miyoshi, S., Nishiyama, C., Nakano, H., Moriwaki, K., Proscillaridin A sensitizes human colon cancer cells to TRAIL-induced cell death. Int. J. Mol. Sci., 23: 6973 (2022).
Shionoya, K., Suzuki, T., Takada M., Sato, K., Onishi, S., Dohmae, N., Nishino, K., Wada, T., Linhardt, R. J., Toida, T., Higashi, K., Comprehensive analysis of chondroitin sulfate and aggrecan in the head cartilage of bony fishes: Identification of proteoglycans in the head cartilage of sturgeon. Int. J. Biol. Macromol., 208: 333–342 (2022).
Takahashi, Y., Sato, K., Wada, T., Solid-Phase Synthesis of Boranophosphate/Phosphorothioate/Phosphate Chimeric Oligonucleotides and Their Potential as Antisense Oligonucleotides. J. Org. Chem., 87: 3895–3909 (2022).
Liu, L. P., Zheng, D. X., Xu, Z. F., Zhou, H.C., Wang, Y. C., Zhou, H., Ge, J. Y., Sako, D., Li, M., Akimoto, K., Li, Y. M., Zheng, Y. W., Transcriptomic and Functional Evidence Show Similarities between Human Amniotic Epithelial Stem Cells and Keratinocytes. Cells, 11(1): 70 (2022).
Tagawa, R., Kobayashi, M., Sakurai, M., Yoshida, M., Kaneko, H., Mizunoe, Y., Nozaki, Y., Okita, N., Sudo, Y., Higami, Y., Long-term dietary taurine lowers plasma levels of cholesterol and bile acids. Int. J. Mol. Sci., 23(3): 1793 (2022).
Miyano, K., Ikehata, M., Ohshima, K., Yoshida, Y., Nose, Y., Yoshihara, S.I., Oki, K., Shiraishi, S., Uzu, M., Nonaka, M., Higami, Y., Uezono, Y., Intravenous administration of human mesenchymal stem cells derived from adipose tissue and umbilical cord improves neuropathic pain via suppression of neuronal damage and anti-inflammatory actions in rats. PLoS One, 17(2): e0262892 (2022).
Inamasu, E., Tsuchiya, T., Yamauchi, M., Nishi, K., Matsuda, K., Sugawara, F., Sakaguchi, K., Mori, R., Matsumoto, K., Miyazaki, T., Hatachi, G., Doi, R., Watanabe, H., Tomoshige, K., Matsuda, N., Higami, Y., Shimokawa, I., Nakashima, M., Nagayasu, T., Anticancer agent α-sulfoquinovosyl-acylpropanediol enhances the radiosensitivity of human malignant mesothelioma in nude mouse models. J. Radiat. Res., 63(1): 19–29 (2022).
Mamada, H., Kemmochi, A., Tamura, T., Shimizu, Y., Owada, Y., Ozawa, Y., Hisakura, K., Oda, T., Ohkohchi, N., Kawano, Y., Hanawa, T., Development and evaluation of novel hydrogel for preventing postoperative pancreatic fistula. Polym. Adv. Technol., 33(1): 125–136 (2022).
Endo, A., Nemoto, A., Hanawa, K., Ishikawa, T., Koshiisi, M., Maebayashi, Y., Hasebe, Y., Naito, A., Kobayashi, Y., Isobe, K., Kawano, Y., Hanawa, T., Index for the appropriate vancomycin dosing in premature neonates and infants. Pediatr. Int., 64(1): e14905 (2022).
Ito, N., Sakata, F., Hachisu, M., Nagata, K., Ito, T., Nomura, K., Nagaoka, M., Inaba, K., Hara, M., Nakano, N., Nakajima, T., Yashiro, T., Nishiyama, C., The Ccl17 gene encoding TARC is synergistically transactivated by PU.1 and IRF4 driven by the mammalian common promoter in dendritic cells. Allergy, 77:1054–1059 (2022).
Shimizu, K., Suzuki, H., Uemura, T., Nozawa, A., Desaki, Y., Hoshino, R., Yoshida, A., Abe, H., Nishiyama, M., Nishiyama, C., Sawasaki, T., Arimura, G. I., Immune gene activation by NPR and TGA transcriptional regulators in the model monocot Brachypodium distachyon. Plant J., in press.
2021年の業績
Matsuda, H., Yoshida, E., Shinoda, T., Sato, K., Hara, R. I., Wada, T., Solution-phase synthesis of oligodeoxyribonucleotides using the H-phosphonate method with N-unprotected 5'-phosphite monomers. RSC Adv., 11: 38094–38107 (2021).
Matsuda, H., Ito, H., Nukaga, Y., Uehara, S., Sato, K., Hara, R. I., Wada, T., Solid-phase synthesis oh oligouridine boranophosphates using the H-boranophosphonate method with 2'-O-(2-cyanoethoxymethyl) protection. Tetrahedron Lett., 87: 153526 (2021).
Nagamoto, S., Agawa, M., Tsuchitani, E., Akimoto, K., Kondo, S., Kanegae, Y. Short term but highly efficient Cas9 expression mediated by excisional system using adenovirus vector and Cre. Sci. Rep., 11: 24369 (2021).
Mizunoe, Y., Kobayashi, M., Saito, H., Goto, A., Migitaka, R., Miura, K., Okita, N., Sudo, Y., Tagawa, R., Yoshida, M., Umemori, A., Nakagawa, Y., Shimano, H., Higami, Y. Prolonged caloric restriction ameliorates age-related atrophy in slow and fast muscle fibers of rat soleus muscle. Exp. Gerontol., 154: 111519 (2021).
Miyano, K., Yoshida, Y., Hirayama, S., Takahashi, H., Ono, H., Meguro, Y., Manabe, S., Komatsu, A., Nonaka, M., Mizuguchi, T., Fujii, H., Higami, Y., Narita, M., Uezono, Y., Oxytocin Is a Positive Allosteric Modulator of κ-Opioid Receptors but Not δ-Opioid Receptors in the G Protein Signaling Pathway. Cells, 10(10): 2651 (2021).
Fujita, M., Sasada, M., Eguchi, M., Iyoda, T., Okuyama, S., Osawa, T., Tsuzuranuki, K., Sakamoto, M., Hagihara, Y., Matsumura, M., Osada, S., Kodama, H., Higami, Y., Fukai, F., Induction of cellular senescence in fibroblasts through β1-integrin activation by tenascin-C-derived peptide and its protumor effect. Am. J. Cancer Res., 11(9): 4364–4379 (2021).
Kobayashi, M., Deguchi, Y., Nozaki, Y., Higami, Y. Contribution of PGC-1α to obesity- and caloric restriction-related physiological changes in white adipose tissue. Int. J. Mol. Sci., 22(11): 6025 (2021).
Kobayashi, M., Nezu, Y., Tagawa, R., Higami, Y. Mitochondrial unfolded protein responses in white adipose tissue: lipoatrophy, whole-body metabolism and lifespan. Int. J. Mol. Sci., 22(6): 2854 (2021).
Saito, J., Hanawa, T., Matsumoto, T., Yoshikawa, N., Harada, T., Iwahashi, K., Nakamura, H., Yamatani, A., Stability of clonidine hydrochloride in an oral powder form compounded for pediatric patients in Japan. J. Pharm. Health Care Sci., 7: 31 (2021).
Ishii, N., Mizobuchi, S., Kawano, Y., Hanawa, T., Preparation and Evaluation of a Powdered Rebamipide Mouthwash as In-Hospital Formulation: Considering Dispersion before Use in Patients. Pharmaceutics, 13(18): 1848 (2021).
Nakano, N., Saida, K., Hara, M., Izawa, K., Ando, T., Kaitani, A., Kasakura, K., Yashiro, T., Nishiyama, C., +D17:D28Ogawa, H., Kitaura, J. Okumura, K., Mucosal mast cell-specific gene expression is promoted by interdependent action of Notch and TGF-beta signaling. J. Immunol., 207(12): 3098-3106 (2021).
Kobayashi, M., Yasukawa, H., Arikawa, T., Deguchi, Y., Mizushima, N., Sakurai, M., Onishi, S., Tagawa, R., Sudo, Y., Okita, N., Higashi, K., Higami, Y. Trehalose induces SQSTM1/p62 expression and enhances lysosomal activity and antioxidative capacity in adipocytes. FEBS Open Bio.11(1):185-194 (2021).
Onaga, C., Tamori, S., Motomura, H., Ozaki, A., Matsuda, C., Matsuoka, I., Fujita, T., Nozaki, Y., Hara, Y., Kawano, Y., Harada, Sato, T., Mano, Y., Sato, K., Akimoto, K. High SLC20A1 expression is associated with poor prognoses in claudin-low and basal-like breast cancers, Anticancer Res. 41: 43-54 (2021).
Shiromoto, Y.*, Sakurai, M.* (*Equal contribution as a 1st author), Minakuchi, M.*, Ariyoshi, K., and Nishikura, K. ADAR1 RNA editing enzyme regulates R-loop formation and genome stability at telomeres in cancer cells. Nat. Commun. 2021 Mar 12;12(1):1654. (2021).
Yang, Y., Okada, S., and Sakurai, M+(Corresponding Author). Adenosine-to-inosine RNA editing in neurological development and disease. RNA Biol., 18(7): 999-1013 (2021). RNA Biol., 18(7): 999-1013 (2021).
Mai, N., N., S., Otsuka, Y., Goto, S., Kawano, Y., Hanawa, T., Effects of polymer molecular weight on curcumin amorphous solid dispersion; at-line monitoring system based on attenuated total reflectance mid-infrared and near-infrared spectroscopy, J. Drug Delivery Sci. Technol., 61: 102278 (2021).
Hara, R. I., Sato, K.,Wada, T., 糖-1-リン酸繰り返し構造およびその化学修飾アナログの合成, 有機合成化学協会誌 79: 558-569 (2021).
Suzuki, A., Takagi, K., Sato, K.,Wada, T., Synthesis of thioamides from thiocarboxylic acids using phosphonium-type condensing reagents, Tetrahedron Lett., 75: 153179 (2021).
Sato, K., Hagio, T., Sano, M., Muramoto, K., Yaoita, A., Noro, M., Hara, R. I., Wada, T., Solid-Phase Stereocontrolled Synthesis of Oligomeric P-Modified Glycosyl Phosphate Derivatives Using the Oxasaphospholidine Method, ACS Omega, 6: 20026-20041 (2021).
Hara, R. I., Wada, T., Inhibition of off-target cleavage by RNase H using an artificial cationic oligosaccharide, Org. Biomol. Chem., 19: 8675-6870 (2021).
Nagata, T., Dwyer, C. A., Yoshida, K. T., Ihara, K., Ohyagi, M., Kaburagi, M., Miyata, H., Ebihara, S., Yoshioka, K., Ishii, T., Miyata, K., Miyata, K., Powers, B., Igari, T., Yamamoto, S., Arimura, N., Hirabayashi, H., Uchihara, T., Hara, R. I., Wada, T., Bennett, F. C., Seth, P. P., Rigo, F., Yokota, T., Cholesterol-functionalized DNA/RNA heteroduplexes cross the blood-brain barrier and knock down genes in the rodent CNS, Nat. Biotechnol.,39: 1529–1536 (2021)
Kusamori, K., Development of advanced cell-based therapy by regulating cell-cell interactions. Biol. Pharm. Bull., 44: 1029–1036 (2021).
Takayama, Y., Kusamori, K., Nishikawa, M., Mesenchymal stem/stromal cells as next-generation drug delivery vehicles for cancer therapeutics.Expert Opin. Drug Delivery, 18(11): 1627–1642 (2021).
Mizukami, Y., Takahashi, Y., Shimizu, K., Konishi, S., Takakura, Y., Nishikawa, M., Calcium peroxide-containing polydimethylsiloxane-based microwells for inhibiting cell death in multicellular spheroids through improved oxygen supply. Biol. Pharm. Bull., 44: 1458–1464 (2021).
Shimazawa, S., Kusamori, K., Tsujimura, M., Shimomura, A., Takasaki, R., Takayama, Y., Shimizu, K., Konishi, S., Nishikawa, M., Intravenous injection of mesenchymal stem cell spheroids improves the pulmonary delivery and prolongs in vivo survival. Biotechnol. J., 17(1): e2100137 (2021).
Sasaki, D., Kusamori, K., Takayama, Y., Itakura, S., Todo, H., Nishikawa, M., Development of nanoparticles derived from corn as mass producible bionanoparticles with anticancer activity. Sci. Rep., 11: 22818 (2021).
Takahashi, H., Aoyama, T., Saitoh, A., Shimada, S., Suzuki, T., Takasawa, R., Nishikawa, M., Mano, Y., Komoda, M., Academic detailing exercise course in RIKADAI: Toward the integration of basic and clinical science. J. Asian Assoc. Sch. Pharm., 10: 35–39 (2021).
Araie, Y., Ohtsuki, S., Park, S., Nagaoka, M., Umemura, K., Sugiyama, H., Kusamori, K., Takahashi, Y., Takakura, Y., Nishikawa, M., Combined use of chemically modified nucleobases and nanostructured DNA for enhanced immunostimulatory activity of CpG oligodeoxynucleotide, Bioorg. Med. Chem., 29: 115864 (2021).
Umemura, K., Ohtsuki, S., Nagaoka, M., Kusamori, K., Inoue, T., Takahashi, Y., Takakura, Y., Nishikawa, M., Critical contribution of macrophage scavenger receptor 1 to the uptake of nanostructured DNA by immune cells. Nanomedicine 34: 102386 (2021).
Motomura, H., Tamori, S., Yatani, M., Namiki, A., Onaga, C., Ozaki, A., Takasawa, R., Mano, Y., Sato, T., Hara, Sato, K., Yuyun, X., Harada, Y., Hanawa, T., Tanuma, S., Sasaki, K., Ohno, S., Akimoto, K. GLO 1 and PKCλ regulate ALDH1-positive breast cancer stem cell survival, Anticancer Res., in press, (2021).
Kuramochi, Y., Awaya, T., Matsuo-Takasaki, M., Takami, M., An, Y., Li, J., Hemmi, Y., Wakabayashi, T., Arai, Y., Inoue, J., Noguchi, M., Nakamura, Y., Asaka, I., Akimoto, K., Saito, K., M., Hayashi, Y. Generation of two human induced pluripotent stem cell lines derived from two X-linked adrenoleukodystrophy patients with ABCD1 mutations. Stem Cell Res., 53: 102337 (2021).
Motomura, H., Tamori, S., Yatani, M., Namiki, A., Onaga, C., Ozaki, A., Takasawa, R., Mano, Y., Sato, T., Hara, Sato, K., Yuyun, X., Harada, Y., Hanawa, T., Tanuma, S., Sasaki, K., Ohno, S., Akimoto, K. GLO 1 and PKCλ regulate ALDH1-positive breast cancer stem cell survival, Anticancer Res., 41(12): 5959–5971 (2021).
Kawano, Y., Patrulea, V., Sublet, E., Borchard, G., Iyoda, T., Kageyama, R., Morita, A., Seino, S., Yoshida, H., Jordan, O., Hanawa, T. Wound healing promotion by hyaluronic acid: Effect of molecular weight on gene expression and in vivo wound closure, Pharmaceuticals, 14(4): 301 (2021).
Kawano, Y., Shimizu, Y., Hanawa, T. Testing a Benchtop Wet-Milling Method for Preparing Nanoparticles and Suspensions as Hospital Formulations, Pharmaceutics, 13(4): 482 (2021).
Kawano, Y., Chen, S., Hanawa, T. Solubility Enhancement of Ibuprofen by Adsorption onto Spherical Porous Calcium Silicate, Pharmaceutics, 13(6): 767 (2021).
Ishikawa, S., Iijima, K., Matsukuma, D., Iijima, M., Osawa S., Otsuka, H., An interpenetrating polymer network hydrogel with biodegradability through controlling self-assembling peptide behavior with hydrolyzable cross-linking networks, Mater. Today Adv., 9: 100131 (2021).
Osawa, S., Kitanishi, K., Kiuchi, M., Shimonaka, M., Otsuka, H., Accelerated Redox Reaction of Hydrogen Peroxide by Employing Locally Concentrated State of Copper Catalysts on Polymer Chain, Macromol. Rapid Commun., 42(16): 2100274, (2021).
Nagata, K., Nagase, H., Okuzumi, A., Nishiyama, C. Delta opioid receptor agonists ameliorate colonic inflammation by modulating immune responses, Front. Immunol., 12: 730706 (2021).
Nagata, K., Nishiyama, C. IL-10 in mast cell-mediated immune responses: anti-inflammatory and proinflammatory roles, Int. J. Mol. Sci. 22(9): 4972 (2021).
Nishina, T., Deguchi, Y., Ohshima, D., Takeda, W., Ohtsuka, M., Shichino, S., Ueha, S., Yamazaki, S., Kawauchi, M., Nakamura, E., Nishiyama, C., Kojima, Y., Adachi-Akahane, S., Hasegawa, N., Nakayama, M., Oshima, M., Yagita, H., Shibuya, K., Mikami, T., Inohara, N., Matsushima, K., Tada, N., Nakano, H. Interleukin-11-expressing fibroblasts have a unique gene signature correlated with poor prognosis of colorectal cancer, Nat. Commun., 12: 2281 (2021).
Yashiro, T., Yamamoto, M., Araumi, S., Hara, M., Yogo, K., Uchida, K., Kasakura, K., Nishiyama, C. PU.1 and IRF8 modulate activation of NLRP3 inflammasome via regulating its expression in human macrophages. Front. Immunol., 12: 649572 (2021).
2020年の業績
Itagaki, K., Sasada, M., Miyazaki, S., Iyoda, T., Imaizumi, T., Haga, M., Kuga, A., Inomata, H., Kondo, Y., Osada, S., Kodama, H., Higami, Y., Fukai, F. Exposure of the cryptic de-adhesive site FNIII14 in fibronectin molecule and its binding to membrane-type eEF1A induce migration and invasion of cancer cells via β1-integrin inactivation. Am. J. Cancer Res. 10:3990-4004 (2020).
Zhao, J., Nishiumi, S., Tagawa, R., Yano, Y., Inoue, J., Hoshi, N., Yoshida, M., Kodama, Y. Adrenic acid induces oxidative stress in hepatocytes. Biochem. Biophys. Res. Commun. 532:620-625 (2020).
Yamashita, K., Tagawa, R., Higami, Y., Tokunaga, E. Noninvasive and Safe Cell Viability Assay for Breast Cancer MCF-7 Cells Using Natural Food Pigment. Biology (Basel). 9:227 (2020).
Tomonaga, O., Kobayashi, M., Tagawa, R., Higami, Y. The Effects of Teneligliptin on Lipid Profile: A Prospective Study for Comparison of Biomarkers Before and After a Meal, J. Endocrinol. Metab. 10:79-88 (2020).
Kobayashi, M., Uta, S., Otsubo, M., Deguchi, Y., Tagawa, R., Mizunoe, Y., Nakagawa, Y., Shimano, H., Higami, Y. Srebp-1c/Fgf21/Pgc-1α Axis Regulated by Leptin Signaling in Adipocytes-Possible Mechanism of Caloric Restriction-Associated Metabolic Remodeling of White Adipose Tissue. Nutrients. 12:2054 (2020).
Miyano, K., Ohbuchi, K., Sudo, Y., Minami, K., Yokoyama, T., Yamamoto, M., Uzu, M., Nonaka, M., Shiraishi, S., Murata, H., Higami, Y., Uezono, Y. A novel method for evaluating activity of transient receptor potential channels using a cellular dielectric spectroscopy. J. Pharmacol. Sci. 143:320-324 (2020).
Nakane, Y., Kemmochi, Y., Ogawa, N., Sasase, T., Ohta, T., Higami, Y., Fukai, F. Hyperglycemia contributes to the development of Leydig cell hyperplasia in male Spontaneously Diabetic Torii rats. J. Toxicol. Pathol. 33:121-129 (2020).
Kobayashi, M., Ishizaki, Y., Owaki, M., Matsumoto, Y., Kakiyama, Y., Hoshino, S., Tagawa, R., Sudo, Y., Okita, N., Akimoto, K., Higami, Y. Nutlin-3a suppresses poly (ADP-ribose) polymerase 1 by mechanisms different from conventional PARP1 suppressors in a human breast cancer cell line. Oncotarget. 11:1653-1665 (2020).
Koinuma, S., Negishi, R., Nomura, R., Sato, K., Kojima, T., Segi-Nishida, E., Goitsuka, R., Iwakura, Y., Wada, N., Koriyama, Y., Kiryu-Seo, S., Kiyama, H., Nakamura, T. TC10, a Rho family GTPase, is required for efficient axon regeneration in a neuron-autonomous manner. J. Neurochem. doi: 10.1111/jnc.15235 (2020).
Potaczek, D.P., Przytulska-Szczerbik, A., Bazan-Socha, S., Jurczyszyn, A., Okumura, K., Nishiyama, C., Undas, A., and Wypasek, E. Elements of immunoglobulin E network associate with aortic valve area in patients with acquired aortic stenosis. Biomedicines, 9:23 (2020).
Shiromoto, Y*., Sakurai, M., Qu, H., Kossenkov, A.V. , and Nishikura, K. Processing of Alu small RNAs by DICER/ADAR1 complexes and their RNAi targets. RNA. 26: 1801-1814 (2020).
Kishima, H., Kawano, Y., Nakamura, K., Kabasawa, Y., Tabata, Y., Furuya, J., Hanawa, T., Application of a Gelatin Nonwoven Fabric as a Novel Oral Care Product, Jpn. J. Dental Equipment, 25: 41-46 (2020).
Kawano Y.i, Jordan, O., Hanawa, T., Borchard, G., Patrulea, V., Are Antimicrobial Peptide Dendrimers an Escape from ESKAPE?, Adv. Wound Care, 9: 378-95(2020).
Goto, K., Sato, T., Shikamura, Y., Nomura, K., Negishi, K., Hanawa, T., Examining the association between the “My Pharmacist” model and the service quality of community pharmacies, Research Social Administrative Pharmacy,16: 958-966 (2020).
Kawano Y., Chen, S., Hanawa, T., Adsorption of a Poorly Water-Soluble Drug onto Porous Calcium Silicate by the Sealed Heating Method, Int. J. Pharm. 587:119637 (2020).
Otsuka. Y., Utsunomiya, Y., Umeda D., Yonemochi E., Kawano, Y., Hanawa, T., Effect of Polymers and Storage Relative Humidity on Amorphous Rebamipide and Its Solid Dispersion Transformation: Multiple Spectra Chemometrics of Powder X-Ray Diffraction and Near-Infrared Spectroscopy, Pharmaceuticals, 13: 147-165(2020).
Teshima R., Kawano, Y., Hanawa, T., Kikiuchi, A, Preparation and evaluation of physicochemical properties of novel alkaline calcium alginate hydrogels with carbonated water, Polymers for Advanced Technologies, 31: 3032-3038(2020).
Yoshizawa, K., Arai, N., Suzuki, Y., Fujita, A., Takahashi, Y., Kawano, Y., Hanawa, T., Synergistic Antinociceptive Activity of Tramadol/Acetaminophen Combination Mediated by μ-Opioid Receptors, Biol. Pharm. Bull., 43: 1128-1134 (2020).
Hirose, K., Kawano, Y., Shigeno, N., Mizutani, Y., Onishi, H., Hanawa, T., Preliminary Investigation of the Usability Characteristics Required for Wound Management Products by Semi-Structural Interview of Medical Staff, Pharmacy, 8:152 (2020).
Kawano, Y., Utsunomiya, Y., Yokoyama, F., Ishii, N., Hanawa, T., Preparation and Evaluation of Rebamipide Colloidal Nanoparticles Obtained by Cogrinding in Ternary Ground Mixtures, Colloids and Interfaces, 4: 1-20 (2020).
Goto, K., Kawachi, F., Nakano, S., Yoshimura, K., Negishi, K., Hanawa, T., Mizukami, K., An Evaluation of Community Pharmacistsʼ Knowledge and Experience Regarding Dementia with Lewy Bodies: A Cross-Sectional Study in Japan, Japanese Journal of Drug Informatics, 22: 153-161(2020).
Mai, N., N., S.,, Otsuka, Y., Kawano, Y., Hanawa, T., Preparation and Characterization of Solid Dispersions Composed of Curcumin, Hydroxypropyl Cellulose and/or Sodium Dodecyl Sulfate by Grinding with Vibrational Ball Milling, Pharmaceuticals, 13: 383 (2020).
Mai, N.N.S., Nakai, R., Kawano, Y., Hanawa, T., Enhancing the Solubility of Curcumin Using a Solid Dispersion System with Hydroxypropyl-β-Cyclodextrin Prepared by Grinding, Freeze-Drying, and Common Solvent Evaporation Methods, Pharmacy, 8: 203(2020).
Kemmochi, A., Tamura, T., Shimizu, Y., Owada, Y., Ozawa, Y., Oda, T., Kawano, Y., Hanawa, T., Ohkohchi, N. A novel hydrogel sheet prevents postoperative pancreatic fistula in a rat model Journal of Hepato-Biliary-Pancreatic Sciences, 28: 192-201 (2020).
Satoh, M., Shiraishi, T., Sekikawa, K., Motohashi, M., Tanaka, H., Kawano, Y., Hanawa, T., Healing Effects of Rebamipide on Acetic Acid-Induces Oral Stomatitis in 5-Fluorouracil-Treated and -Untreated Golden Syrian Hamsters, Pharmacometrics, 99: 65-70 (2020).
Shu, Z., Ota, A., Takayama, Y., Katsurada, Y., Kusamori, K., Abe, N., Nakamoto, K., Tomoike, F., Tada, S., Ito, Y., Nishikawa, M., Kimura, Y., Abe, H. Intracellular delivery of atisense DNA and siRNA with amino groups masked with disulfide units. Chem. Pharm. Bull. 68, 129-132 (2020).
Seino, N., Omori, E., Kusamori, K., Miyamoto, S., Nagasaki, Y., Higashi, K., Yamase, Y., Nishikawa, M. Application of a sodium alginate hydrogel for clear preoperative endoscopic marking using India ink. Polym. J. 52, 977-983 (2020).
Punzalan, L. L., Jiang, L., Mao, D., Mahapatra, A., D., Sato, S., Takemoto, Y., Tsujimura, M., Kusamori, K., Nishikawa, M., Zhou, L., Uesugi, M. Chemoproteomic profiling of a pharmacophore-focused chemical library. Cell. Chem. Biol. 27, 708-718.e10 (2020).
Liao, W., Akahira, S., Hara, R. I. Wada, T., Kusamori, K., Takakura, Y., Nishikawa, M. Enhanced Immunostimulatory Activity of CpG Oligonucleotide by the Combination of Mannose Modification and Incorporation into Nanostructured DNA. Biol. Pharm. Bull. 43:11881-1195 (2020).
Irie, A., Sato, K., Hara, R. I., Wada, T., Shibasaki, F. An artificial cationic oligosaccharide combined with phosphorothioate linkages strongly improves siRNA stability. Sci. Rep. 10:14845(2020)
Hara, R. I., Yoshino, R., Nukaga, Y., Maeda, Y., Sato, K., Wada, T. Synthesis and properties of DNA oligomers containing stereopure phosphorothioate linkages and C-5 modified deoxyuridine derivatives. RSC Adv. 10, 34006-34013 (2020)
Mizukami, Y., Moriya, A., Takahashi, Y., Shimizu, K., Konishi, S., Takakura, Y., Nishikawa, M. Incorporation of gelatin microspheres into HepG2 human hepatocyte spheroids for functional improvement through improved oxygen supply to spheroid core. Biol. Pharm. Bull. 43, 1220-1225 (2020).
Liao, W., Tan, M., Kusamori, K., Takakura, Y., Nishikawa M. Construction of monomeric and dimeric G-Quadruplex-structured cytosine-phosphate-guanine oligodeoxynucleotides for enhanced uptake and activation in Toll-like receptor 9-positive macrophages. Nucleic Acid Ther. in press.
Liu, W., Takahashi, Y., Morishita, M., Nishikawa, M., Takakura Y. Development of CD40L-modified tumor small extracellular vesicles for the effective induction of anti-tumor immune response. Nanomedicine 15, 1641-1652 (2020).
Maezawa, T., Ohtsuki, S., Hidaka, K., Sugiyama, H., Endo, M., Takahashi, Y., Takakura, Y., Nishikawa, M. DNA density-dependent uptake of DNA origami-based two-or three-dimensional nanostructures by immune cells. Nanoscale 12, 14818-14824 (2020).
Mohri, K., Hayashia, E., Nishinoa, M., Matsushita, N., Tanishita, S., Nishikawa, M., Sakuma, S. Polypod-like structured guanine-rich oligonucleotide aptamer as a selective and cytotoxic nanostructured DNA to cancer cells. J. Drug Target. in press.
Sakurai, M., Okada, S., Ueda, H., and Yang, Y. Discovering A-to-I RNA Editing Through Chemical Methodology "ICE-seq". Methods Mol. Biol. 2181:113-148 (2020)
Shiromoto, Y., Sakurai, M., Qu, H., Kossenkov, A.V. , and Nishikura, K. Processing of Alu small RNAs by DICER/ADAR1 complexes and their RNAi targets. RNA. in press & online (2020)
Yang, Y., Okada, S., and Sakurai, M. Adenosine-to-inosine RNA editing in neurological development and disease. RNA Biology. in press (2020)
Shiromoto, Y.*, Sakurai, M.*, Minakuchi, M.*, Ariyoshi, K., and Nishikura, K. ADAR1 RNA editing enzyme regulates R-loop formation and genome stability at telomeres. Nat. Commun. Revising (2020)
*; Equal contribution as a 1st author.
Yashiro, T., Yura, S., Tobita, A., Toyoda, Y., Kasakura, K., and Nishiyama, C. Pterostilbene reduces colonic inflammation by suppressing dendritic cell activation and promoting regulatory T cell development. FASEB J. 34:14810-14819 (2020).
Potaczek, D.P., Przytulska-Szczerbik, A., Bazan-Socha, S., Nastalek, M., Wojas-Pelc, A., Okumura, K., Nishiyama, C., Jurczyszyn, A., Undas, A., and Wypasek, E. Interaction between functional polymorphisms in FCER1A and TLR2 and the severity of atopic dermatitis. Human Immunol. 81:709-713 (2020).
Inaba, K.*, Yashiro, T.*, Hiroki, I., Watanabe, R., Kasakura, K., and Nishiyama, C. Dual roles of PU.1 in the expression of PD-L2: Direct transactivation with IRF4 and indirect epigenetic regulation. J. Immunol. 205:822-829. (2020).
*; Equal contribution as a 1st author
Hagiwara, S., Nagata, K., Kasakura, K., Sakata, F., Kishino, S., Ogawa, J., Yashiro, T., and Nishiyama, C. The anti-inflammatory effect of the gut lactic acid bacteria-generated metabolite 10-oxo-cis-6,trans-11-octadecadienoic acid on monocytes. Biochem. Biophys. Res. Commun. 530:342-347 (2020).
Yashiro, T., Takeuchi, H., Kasakura, K., and Nishiyama, C. PU.1 regulates Ccr7 gene expression by binding to its promoter in naïve CD4+ T cells. FEBS Open Bio. 10:1115-1121 (2020).
Uemura, T., Hachisu, M., Desaki, Y., Ito, A., Hoshino, R., Sano, Y., Nozawa, A., Mujiono, K., Galis, I., Yoshida, A., Nemoto, K., Miura, S., Nishiyama, M., Nishiyama, C., Horito, S., Sawasaki, T., and Arimura, G. Soy and Arabidopsis receptor-like kinases respond to polysaccharide signals from Spodoptera species and mediate hervivore resistance. Commun. Biol. 3: 224 (2020).
Nagata, K., Kasakura, K., Miura, R., Yashiro, T., and Nishiyama, C. Suppressive role of PPARgannma in the IgE-dependent activation of mast cells. Int. Immunol. 32:143-15 (2020).
Tan, M., Takahashi, N., Fujii, S., Sakurai, K., Kusamori, K., Takahashi, Y., Takakura, Y., Nishikawa, M. Analysis of tertiary structural features of branched DNA nanostructures with partially common sequences using small-angle X-ray scattering. ACS App. Bio Mater. in press.
Komura, F., Okuzumi, K., Takahashi, Y., Takakura, Y., Nishikawa, M. Development of RNA/DNA hydrogel targeting Toll-like receptor 7/8 for sustained RNA release and potent immune activation. Molecules 25, E728 (2020).
Motomura, H., Nozaki, Y., Onaga, Chotaro., Ozakli,A., Tamori, S.homa T., Shiina, T., Kanai, S., Ohira, C., Hara, Y., Harada,Y., Takasawa, R., Hanawa, T., Tanuma, S., Mano, Y., Sato, T., Sato, K., Akimoto, K., High Expression of c-Met , PKCλ and ALDH1A3 Predicts a Poor Prognosis in Late-stage Breast Cancer, ANTICANCER RESEARCH, 40, (1), 35-52(2020).
Sato, K., Tahata, K., Akimoto, K. Five genes associated with survival in patients with lower -grade gliomas were identified by information-theoretical analysis, Anticancer Res. 40: 2777-2785 (2020).
Nozaki, Y., Motomura, H., Tamori, S., Kimura, Y., Onaga, C., Kanai, S., Ishihara, Y., Ozaki, A., Hara, Y., Harada, Y., Mano, Y., Sato, T., Sato, K., Sasaki, K., Ishiguro, H., Ohno, S., Akimoto, K. High PKCλ expression is required for ALDH1-positive cancer stem cell function and indicates a poor clinical outcome in late-stage breast cancer patients, PLOS ONE 15: e0235747 (2020).
Ishii, A., Kusakabe, K., Kato, N., Sasaki, S., Tsujikawa, K., Wada, T. Studies on the phase I metabolites of the new designer drug 1-(2,3-dihydro-1H-inden-5-yl)-2- (pyrrolidine-1-yl)butan-1-one (5-PPDI) in human urine, Forensic Sci Int. 310: 110214 (2020).
Shu, Z., Ota, A., Takayama, Y., Katsurada, Y., Kusamori, K., Abe, N., Nakamoto, K., Tomoike, F., Tada, S., Ito, Y., Nishikawa, M., Kimura, Y., Abe, H. Intracellular delivery of atisense DNA and siRNA with amino groups masked with disulfide units. Chem. Pharm. Bull. 68: 129-132 (2020).
Tan, M., Takahashi, N., Fujii, S., Sakurai, K. Kusamori, K. Takahashi, Y., Takakura, Y., Nishikawa, M. Analysis of tertiary structural features of branched DNA nanostructures with partially common sequences using small-angle X-ray scattering. ACS Appl. Bio Mater. 3: 308-314 (2020).
Seino, N., Omori, E., Kusamori, K. Miyamoto, S., Nagasaki, Y., Higashi, K., Yamase, Y., Nishikawa, M. Application of a sodium alginate hydrogel for clear preoperative endoscopic marking using India ink. Polym. J. in press (2020)
Funai, T., Aotani, M., Kiriu, R., Nakamura, J., Miyazaki, Y., Nakagawa, O., Wada, S., Torigoe, H., Ono, A., Urata, H. Silver(I)-Ion-Mediated Cytosine- Containing Base Pairs: Metal Ion Specificity for Duplex Stabilization and Susceptibility toward DNA Polymerases, ChembioChem 21(4): 517-522 (2020).
Matsuno, Y., Atsumi, Y., Alauddin, M., Rana, M. M., Fujimori, H., Hyodo, M., Shimizu, A., Ikuta, T., Tani, H., Torigoe, H., Nakatsu, Y., Tsuzuki, T., Komai, M., Shirakawa, H., Yoshioka, K. Resveratrol and Its Related Polyphenols Contribute to the Maintenance of Genome Stability, Sci. Rep. 10(1): 5388 (2020).
Takahashi, R, Higami, Y. Multidisciplinary Approach to Aging: Future Trends. Yakugaku Zasshi 140(3): 377-378 (2020)
Hoshino, S., Kobayashi, M., Tagawa, R., Konno, R., Abe, T., Furuya, K., Miura, K., Wakasawa, H., Okita, N., Sudo, Y., Mizunoe, Y., Nakagawa, Y., Nakamura, T., Kawabe, H., Higami, Y. WWP1 knockout in mice exacerbates obesity-related phenotypes in white adipose tissue but improves whole-body glucose metabolism. FEBS Open Bio. 10(3): 06-315 (2020).
Kurokawa, Y., Fujii, G., Tomono, S., Miyamoto, S., Hamoya, T., Takahashi, M., Narita, T., Komiya, M., Kobayashi, M., Higami, Y. Mutoh, M. The Radical Scavenger NZ-419 Suppresses Intestinal Polyp Development in Apc-Mutant Mice. J. Clin. Med. 9(1): 270 (2020).
Mizunoe, Y., Kobayashi, M., Hoshino, S., Tagawa, R., Itagawa, R., Hoshino, A., Okita, N., Sudo, Y., Nakagawa, Y., Shimano, H. Higami, Y. Cathepsin B overexpression induces degradation of perilipin 1 to cause lipid metabolism dysfunction in adipocytes. Sci. Rep. 10(1): 634 (2020).
Miyano K, Eto M, Hitomi S, Matsumoto T, Hasegawa S, Hirano A, Nagabuchi K, Asai N, Uzu M, Nonaka M, Omiya Y, Kaneko A, Ono K, Fujii H, Higami Y, Kono T, Uezono Y. The Japanese herbal medicine Hangeshashinto enhances oral keratinocyte migration to facilitate healing of chemotherapy-induced oral ulcerative mucositis. Sci. Rep. 10(1): 625 (2020).
Miyano, K., Ohshima, K., Suzuki, N., Furuya, S., Yoshida, Y., Nonaka, M., Higami, Y., Yoshizawa, K., Fujii, H., Uezono, Y. Japanese Herbal Medicine Ninjinyoeito Mediates Its Orexigenic Properties Partially by Activating Orexin 1 Receptors. Front. Nutr. 7: 5 (2020).
Kobayashi, M., Higami, Y. Metabolic Alteration in Aging Process: Metabolic Remodeling in White Adipose Tissue by Caloric Restriction. Yakugaku Zasshi 140(3): 383-389 (2020).
Takeda, W., Nishina, T.*, Deguchi, Y., Kawauchi, M., Mikami, T., Yagita, H., Nishiyama, C. Nakano, H. Stromal fibroblasts produce interleukin 11 in the colon of TNBS-treated mice. Toho J. Med. in press (2020).
Shindo, R., Katagiri, T., Komazawa-Sakon, S., Ohmuraya, M., Takeda, W., Nakagawa, Y., Nakagata, N., Sakuma, T., Yamamoto, T., Nishiyama, C., Nishina, T., Yamazaki, S., Kameda, H., Nakano, H. Regenerating islet-derived protein (Reg)3beta plays a crucial role in attenuation of ileitis and colitis in mice. Biochem. Biophys. Rep. in press (2020).
Kasakura, K., Nagata, K., Miura, R., Iida, M., Nakaya, H., Okada, H., Arai, T., Arai, T., Kawakami, Y., Kawakami, T., Yashiro, T., Nishiyama, C. Cooperative regulation of the mucosal mast cell-specific protease genes Mcpt1 and Mcpt2 by GATA and Smad transcription factors. J. Immunol. 204: 1641-1649 (2020).
Kondo, Y., Miyazaki, S. Gene Expression Level and Gene Set Enrichment Analysis of Host Genes, J. Data Mining Genomics & Proteomics 11(1): 1-4 (2020).
Ishikawa, S., Iijima, K., Matsukuma, D., Iijima, M., Osawa, S., Otsuka, H., Enhanced function of chondrocytes in a chitosan‐based hydrogel to regenerate cartilage tissues by accelerating degradability of the hydrogel via a hydrolysable crosslinker, J. Appl. Polym. Sci., 137(19): 48893 (2020).
Ishikawa, S., Iijima, K., Sasaki, K., Kawabe, M., Osawa, S., Otsuka, H., Silica-Based Nonwoven Fiber Fabricated by Electrospinning to Promote Fibroblast Functions, Bull. Chem. Soc. Jpn., 93(4): 477–481 (2020).
Ishikawa, S., Iijima, K., Matsukuma, D., Asawa, Y., Hoshi, K., Osawa, S., Otsuka, H., Interpenetrating Polymer Network Hydrogels via a One-Pot and in Situ Gelation System Based on Peptide Self-Assembly and Orthogonal Cross-Linking for Tissue Regeneration, Chem. Mater., 32(6): 2353–2364 (2020).
Osawa, S., Kashiwakura, M., Yamaguchi, H., Otsuka, H., Influence of anchoring segments on methacrylate-based comb-type hydrophilic polymer segments coated on silica surfaces using the grafting-to method, Colloid Interface Sci. Commun., 36: 100258 (2020).
Osawa, S., Matsumoto, A., Maejima, Y., Suzuki, T., Miyahara, Y., Otsuka H., Direct Observation of Cell Surface Sialylation by Atomic Force Microscopy Employing Boronic Acid–Sialic Acid Reversible Interaction, Anal. Chem., 92(17): 11714–11720 (2020).
Iijima, K., Otsuka, H., Cell Scaffolds for Bone Tissue Engineering, Bioengineering, 7(4): 119 (2020).
Ishikawa, S., Osawa, S., Ostuka, H., One-Pot Design of Injectable Interpenetrating Polymer Network Hydrogel through Time-Sequentially, In Situ Network Formation, J. Jpn. Soc. Biomater., 38(4): 266–267 (2020).
Matsumoto, A., Osawa, S., Arai, T., Maejima, Y., Otsuka, H., Miyahara, Y., Potentiometric Determination of Circulating Glycoproteins by Boronic Acid End-Functionalized Poly(ethylene glycol)-Modified Electrode, Bioconjugate Chem. , 32(2): 239–244 (2020).
2019年の業績
Arima Y, Liu W, Takahashi Y, Nishikawa M., Takakura Y. Effects of localization of antigen proteins in antigen-loaded exosomes on efficiency of antigen presentation. Mol. Pharm. in press.
Yashiro, T.*, Sakata, F.*, Sekimoto, T.*, Shirai, T., Hasebe, F., Matsuda, K., Kurosawa, S., Suzuki, S., Nagata, K., Kasakura, K., Nishiyama, M., Nishiyama, C. Immunosuppressive effect of a non-proteinogenic amino acid from Streptomyce through inhibiting allogeneic T cell proliferation. Biosci. Biotechnol. Biochem., in press. *; contribute equal first authors.
Takashima, I., Kusamori, K., Hakariya, H., Takashima, M., Vu, T.H., Mizukami, Y., Noda, N., Takayama, Y., Katsuda, Y., Sato, S.I., Takakura, Y., Nishikawa, M., Uesugi, M. Multi-functionalization of Cells with a Self-assembling Molecule to Enhance Cell Engraftment. ACS Chem Biol. in press.
Sugiyama, A., Yamada, M., Furuie, H., Goto, L., Saitoh, A., Nagase, H., Oka, J-I., Yamada, M, Systemic administration of the delta opioid receptor agonist KNT-127 facilitates extinction of fear memory in rats, Journal of Pharmacological Sciences, in press.
Sasaki-Hamada, S., Nakamura, Y., Koizumi, K., Nabeta, R., Oka, J-I., Pharmacological evidence for the relationship between the NMDA receptor and nitric oxide pathway and the antidepressant-like effects of glucagon-like peptide-2 in the mouse forced-swim test, Behavioural Brain Research, 364:162-166 (2019).
Yashiro, T., Nakano, S., Nomura, K., Uchida, Y., Kasakura, K., Nishiyama, C.
PU.1 is a critical transcription factor for Ccl22 gene expression in dendritic cells and macrophages. Sci. Rep. in press.
Takayama Y, Kusamori K, Nishikawa M. Click Chemistry as a Tool for Cell Engineering and Drug Delivery. Molecules.24(1):e172. (2019)
Nishikawa, M., Tan, M., Liao, W., Kusamori, K. Nanostructured DNA for the delivery of therapeutic agents. Adv. Drug Deliv. Rev. 147, 29-36 (2019).
Komura, F., Takahashi, Y., Inoue, T., Takakura, Y., Nishikawa, M. Development of a nanostructured RNA/DNA assembly as an adjuvant targeting Toll-like receptor 7/8. Nucleic Acid Ther. 29, 335-342 (2019).
Matsumoto, A., Takahashi, Y., Ariizumi, R., Nishikawa, M., Takakura, Y. Development of DNA-anchored assembly of small extracellular vesicle for efficient antigen delivery to antigen presenting cells. Biomaterials 225, 119518 (2019).
Ohtsuki, S., Shiba, Y., Maezawa, T., Hidaka, K., Sugiyama, H., Endo, M., Takahashi, Y., Takakura, Y., Nishikawa, M. Folding of single-stranded circular DNA into rigid rectangular DNA accelerates its cellular uptake. Nanoscale 11, 23416-23422 (2019).
Piao, X., Miura, R., Miyake, S., Komazawa-Sakon, S., Koike, M., Shindo, R., Takeda, J., Hasegawa, A., Abe, R., Nishiyama, C., Mikami, R., Yagita, H., Uchida, Y., and Nakano, H. Blockade of TNFR1-dependent and –independent cell death is crucial for normal epidermal differentiation. J. Allergy Clin. Immunol. 143:213-228.e10 (2019).
Yashiro, T., Nakano, S., Nomura, K., Uchida, Y., Kasakura, K., and Nishiyama, C. A transcription factor PU.1 is critical for Ccl22 gene expression in dendritic cells and macrophages. Sci. Rep. 9:1161 (2019).
Yashiro, T., Sakata, F., Sekimoto, T., Shirai, T., Hasebe, F., Matsuda, K., Kurosawa, S., Suzuki, S., Nagata, K., Kasakura, K., Nishiyama, M., and Nishiyama, C. Immunosuppressive effect of a non-proteinogenic amino acid from Streptomyces through inhibiting allogeneic T cell proliferation. Biosci. Biotechnol. Biochem. 83:1111-1116 (2019).
Yashiro, T., Takeuchi, H., Nakamura, S., Tanabe, A., Hara, M., Uchida, K., Okumura, K., Kasakura, K., and Nishiyama, C. PU.1 plays a pivotal role in dendritic cell migration from the periphery to secondary lymphoid organs via regulating CCR7 expression. FASEB J. 33:11481-11491 (2019).
Ito, T., Egusa, C., Maeda, T., Numata, T., Nakano, N., Nishiyama, C., and Tsuboi, R. Stem cell factor suppressed IL-33-induced MHC class II expression in murine bone marrow-derived mast cells. Allergol. Int. 68:254-257 (2019).
Hara, R. I., Saito, T., Kogure, T., Hamamura, Y., Uchiyama, N., Nukaga, Y., Iwamoto, N., Wada, T. Stereocontrolled synthesis of boranophosphate DNA by an oxazaphospholidine approach and evaluation of its properties. J. Org. Chem. 84, 7971–7938 (2019).
Sato, K., Imai, H., Shuto, T., Hara, R. I., Wada, T. Solid-phase synthesis of phosphate/boranophosphate chimeric DNAs using the H-phosphate–H-boranophosphonate method. J. Org. Chem. 84: 15032–15041 (2019).
Mizunoe, Y., Kobayashi, M., Tagawa, R., Nakagawa, Y., Shimano, H., Higami, Y. Association between Lysosomal Dysfunction and Obesity-Related Pathology: A Key Knowledge to Prevent Metabolic Syndrome. Int. J. Mol. Sci. 20(15): 3688 (2019).
Miyano, K., Shiraishi, S., Minami, K., Sudo, Y., Suzuki, M., Yokoyama, T., Terawaki, K., Nonaka, M., Murata, H., Higami, Y., Uezono, Y. Carboplatin Enhances the Activity of Human Transient Receptor Potential Ankyrin 1 through the Cyclic AMP-Protein Kinase A-A-Kinase Anchoring Protein (AKAP) Pathways. Int. J. Mol. Sci. 20(13): 3271 (2019).
Hashimoto, Y., Tsuchiya, T., Doi, R., Matsumoto, K., Higami, Y., Kobayashi, E., Nagayasu, T. Alteration of the extracellular matrix and alpha-gal antigens in the rat lung scaffold reseeded using human vascular and adipogenic stromal cells. J. Tissue Eng. Regen. Med. 13(11): 2067-2076 (2019).
Otsuka, K., Sasada, M., Hirano, Y. U., Nohara, Y., Iyoda, T., Higami, Y., Kodama, H., Fukai, F. Acyclic Retinoid Combined With Tenascin-C-derived Peptide Reduces the Malignant Phenotype of Neuroblastoma Cells Through N-Myc Degradation. Anticancer Res. 39(7): 3487-3492 (2019).
Torres, O., Yamada, A., Rigby, N. M., Hanawa, T., Kawano, Y. Gellan gum: A new member in the dysphagia thickener family, Biotribology 17: 8-18 (2019).
Hanawa, T., Kawano, Y. Preparation and characterization of hydrogels by electron beam cross-linking, Proceedings of International Conference on Nuclear Capacity building, Education, Research and Applications, (2019).
Tokinaga-Uchiyama, A., Mizushima, T., Akimoto, K. Nagashima, Y., Sasaki, K., Nakaya, M., Ohashi, K., Kubota, K., Maruyama, Y., Kato, H., Hirahara, F., Miyagi, E., Ohno, S., Asai-Sato, M. Aberrant nuclear localization of aPKCλ/ι is associated with poorer prognosis in uterine cervical cancer, Int. J. Gynecol. Pathol.. 38: 301-309 (2019).
Furuya, K., Zheng, Y.-W. Sako, D., Iwasaki, K., Zheng, D.-X., Ge, J.-Y., Liu, L.-P., Furuta, T., Akimoto, K., Yagi, H., Hamada, H., Isoda, H., Oda, T., Ohkohchi, N. Enhanced hepatic differentiation in the subpopulation of human amniotic stem cells under 3D multicellular microenvironment, World J. Stem Cells 11: 705-721 (2019).
iscovering RNA editing by chemical methods Sakurai, M., Okada, S., Ueda, H., Y. Yang. Methods Mol. Biol. in press (2019).
Ishikawa, S., Matsukuma, D., Iijima, K., Iijima, M., Osawa, S., Otsuka H., N-Hydroxysuccinimide Bifunctionalized Triblock Cross-Linker Having Hydrolysis Property for a Biodegradable and Injectable Hydrogel System, ACS Biomater. Sic. Eng., 5(11): 5759–5769 (2019).
Iijima, K., Ichikawa, S., Ishikawa, S., Matsukuma, D., Yataka, Y., Otsuka, H., Hashizume, M., Preparation of Cell-Paved and -Incorporated Polysaccharide Hollow Fibers Using a Microfluidic Device, ACS Biomater. Sic. Eng., 5(11): 5688–5697 (2019).
Osawa, S., Takahashi, R., Watanabe, R., Kubo, S., Otsuka, H., Increase in the apparent intercalation ability of a platinum complex via multivalency by installation into the sidechain of a graft copolymer and observation of structural changes in the intercalated DNA, RSC Adv., 9(45): 26429–26434 (2019).
Ishikawa, S., Iijima, K., Sasaki, K., Kawabe, M., Otsuka, H., Improvement of Hepatic Functions by Spheroids Coculture with Fibroblasts in 3D Silica Nonwoven Fabrics, J. Nanosci. Nanotechnol., 19(6): 3326–3333 (2019).
2018年の業績
Tokinaga-Uchiyama, A., Mizushima, T., Akimoto, K., Nagashima, Y., Sasaki, K., Nakaya, M., Ohashi, K., Kubota, K., Maruyama, Y., Kato, H., Hirahara, F., Miyagi, E., Ohno, S., Asai-Sato, M. Aberrant nuclear localization of aPKCλ/ι is associated with poorer prognosis in uterine cervical cancer International Journal of Gynecological Pathology in press.
Tamori, S., Nozaki, Y., Motomura, H., Nakane, H., Katayama, R., Onaga, C., Kikuchi, E., Shimada, N., Suzuki, Y., Noike, M., Hara, Y., Sato, K., Sato, T., Yamamoto, K., Hanawa, T., Imai, M., Abe, R., Yoshimori, A., Takasawa, R., Tanuma, S., and Akimoto, K. Glyoxalase 1 gene is highly expressed in basal-like human breast cancers and contributes to survival of ALDH1-positive breast cancer stem cells
Oncotarget, 9: 36515–36529 (2018).
Baba, J., Kioi, M., Akimoto, K., Nagashima, Y., Taguri, M., Inayama, Y., Aoki, I., Ohno, S., Mitsudo, K., and Tohnai, I. Atypical Protein Kinase C λ/ι Expression is Associated with Malignancy of Oral Squamous Cell Carcinoma Anticancer Research, 38: 6291–6297 (2018).
岡淳一郎, ペプチド薬の中枢機能障害改善作用と経鼻投与による中枢移行法の開発, YAKUGAKU ZASSHI, in press.
Ishikawa, S., Iijima, K., Sasaki, K., Kawabe, M., Otsuka, H. Improvement of Hepatic Functions by Spheroids Coculture with Fibroblasts in 3D Silica Nonwoven Fabrics. J. Nanosci. Nanotechnol., in press.
Saitoh, A., Soda, A., Kayashima, S., Yoshizawa, K., Oka, J-I., Nagase, H., Yamada, M, A delta opioid receptor agonist, KNT-127, in the prelimbic medial prefrontal cortex attenuates glial glutamate transporter blocker-induced anxiety-like behavior in mice. Journal of Pharmacological Sciences, 138:176-183 (2018).
Iijima, K., Ishikawa, S., Sasaki, K., Hashizume, M., Kawabe, M., Otsuka, H. Osteogenic Differentiation of Bone Marrow-Derived Mesenchymal Stem Cells in Three-Dimensional Silica Nonwoven Fabrics. ACS Omega., 3:10180−10187 (2018).
Ishikawa, S., Iijima, K., Sasaki,, K. Hashizume, M., Kawabe, M., Otsuka, H. Cartilage Differentiation of Bone Marrow-Derived Mesenchymal Stem Cells in Three-Dimensional Silica Nonwoven Fabrics. Appl. Sci., 8,1398 (2018).
Sudo, Y., Otsuka, H., Miyakawa, R., Goto, A., Kashiwase, Y., Terawaki, K., Miyano, K., Hirao, Y., Taki, K., Tagawa, R., Kobayashi, M., Okita, N., Uezono, Y., Higami, Y. Differential Metabolic Responses to Adipose Atrophy Associated with Cancer Cachexia and Caloric Restriction in Rats and the Effect of Rikkunshito in Cancer Cachexia Int. J. Mol. Sci. 19(12). pii: E3852. doi: 10.3390/ijms19123852. (2018).
Kobayashi, M., Hoshino, S., Abe, T., Okita, N., Tagawa, R., Nagai, W., Konno, R., Suzuki, Y., Furuya, K., Ishikawa, N., Okado, H., Oku, M., Iwamoto, M., Miura, Y., Sudo, Y., Higami, Y. Identification of WWP1 as an obesity-associated E3 ubiquitin ligase with a protective role against oxidative stress in adipocytes. Biochem. Biophys. Res. Commun. 508:117-122 (2019).
Umeki, Y., Saito, M., Kusamori, K., Tsujimura, M., Nishimura, M., Takahashi, Y., Takakura, Y., Nishikawa, M. Combined encapsulation of a tumor antigen and immune cellsusing a self-assembling immunostimulatory DNA hydrogel to enhance antigen-specific tumor immunity. J. Control Release. 288:189-198 (2018).
Kobayashi, M., Fujii, N., Narita, T., Higami, Y. SREBP-1c-Dependent Metabolic Remodeling of White Adipose Tissue by Caloric Restriction. Int. J. Mol. Sci. 19(11). pii: E3335. doi: 10.3390/ijms19113335. Review. (2018).
Charoenviriyakul, C., Takahashi, Y., Nishikawa, M., Takakura, Y. Preservation of exosomes at room temperature using lyophilization. Int. J. Pharm. 553(1-2):1-7. (2018)
Yashiro, T.*, Yamaguchi, M.*, Watanuki, Y., Kasakura, K., Nishiyama, C. The transcription factors PU.1 and IRF4 determine dendritic cell-specific expression of RALDH2. J. Immunol. in press.
*; contribute equal first authors.
Terawaki, K., Kashiwase, Y., Uzu, M., Nonaka, M., Sawada, Y., Miyano, K., Higami, Y., Yanagihara, K., Yamamoto, M., Uezono, Y. Leukemia inhibitory factor via the Toll-like receptor 5 signaling pathway involves aggravation of cachexia induced by human gastric cancer-derived 85As2 cells in rats. Oncotarget. 9:34748-34764 (2018).
Hoshino, S., Kobayashi, M., Higami, Y. Mechanisms of the anti-aging and prolongevity effects of caloric restriction: evidence from studies of genetically modified animals. Aging 10:2243-2251 (2018).
Ito, T., Egusa, C., Maeda, T., Numata, T. Nakano, N., Nishiyama, C., Tsuboi, R. Stem cell factor suppressed IL-33-induced MHC class II expression in murine bone marrow-derived mast cells. Allergol. Int. in press.
Kusamori, K., Takayama, Y., Nishikawa, M. Stable Surface Modification of Mesenchymal Stem Cells Using the Avidin-Biotin Complex Technique. Curr. Protoc. Stem Cell Biol. 47(1):e66(2018)
Mizukami, Y., Takahashi, Y., Shimizu, K., Konishi, S., Takakura, Y., Nishikawa, M. Regulation of the distribution of cells in mixed multicellular spheroids by altering their migration direction. Tissue Eng. A in press.
Nomura, D., Saito, M., Takahashi, Y., Takahashi, Y., Takakura, Y., Nishikawa, M. Development of orally-deliverable DNA hydrogel by microemulsification and chitosan coating. Int. J. Pharm. 547:556-562 (2018).
Sugiyama, A., Yamada, M., Saitoh, A., Nagase, H., Oka, J-I., Yamada, M., Administration of a delta opioid receptor agonist KNT-127 to the basolateral amygdala has potent anxiolytic-like effects in rats, Psychopharmacology, 235:2947-2955 (2018).
Iwai,T., Obara, K., Ito, C., Furukawa H., Oka, J-I., Hydroxyobutustyrene protects neuronal cells from chemical hypoxia-induced cell death, Journal of Natural Medicines, 72:915-921 (2018).
Ohno, H., Matsuzaka, T., Tang, N., Sharma, R., Motomura, K., Shimura, T., Satoh, A., Han, S.I., Takeuchi, Y., Aita, Y., Iwasaki, H., Yatoh, S., Suzuki, H., Sekiya, M., Nakagawa, Y., Sone, H., Yahagi, N., Yamada, N., Higami, Y., Shimano, H.
Transgenic Mice Overexpressing SREBP-1a in Male ob/ob Mice Exhibit Lipodystrophy and Exacerbate Insulin Resistance. Endocrinology. 159:2308-2323 (2018).
Oda, A., Tezuka, T., Ueno, Y., Hosoda, S., Amemiya, Y., Notsu, C., Kasahara, T., Nishiyama, C., Goitsuka, R.
Niche-induced extramedullary hematopoiesis in the spleen is regulated by the transcription factor Tlx1. Sci. Rep. 8:8308 (2018).
Charoenviriyakul, C., Takahashi, Y., Morishita, M., Nishikawa, M., Takakura, Y. Role of Extracellular Vesicle Surface Proteins in the Pharmacokinetics of Extracellular Vesicles. Mol. Pharm. 15:1073-1080 (2018).
Fujiwara, H., Ohtake, H., Oka, J-I., Matsumoto, K., Kimura, K., Endogenous acetylcholine regulates neuronal and astrocytic vascular endothelial growth factor expression levels via different acetylcholine receptor mechanisms, Neurochemistry International, 118:42-51 (2018).
Sasaki-Hamada, S., Narusawa, K., Nakamura, R., Ishibashi, H., Oka, J-I., Effects of centrally administered glucagon-like peptide-2 on blood pressure and barosensitive neurons in spontaneously hypertensive rats, Neuropeptides, 69:66-75 (2018).
Matsushita, J., Okamura, K., Nakabayashi, K., Suzuki, T., Horibe, Y., Kawai, T., Sakurai, T., Yamashita, S., Higami, Y., Ichihara, G., Hata, K., Nohara, K.
The DNA methylation profile of liver tumors in C3H mice and identification of differentially methylated regions involved in the regulation of tumorigenic genes. BMC Cancer. 18:317 (2018).
Hamana, H., Takahashi, Y., Tanioka, A., Nishikawa, M., Takakura, Y. Safe and effective interferon-beta gene therapy for the treatment of multiple sclerosis by regulating biological activity through the design of interferon-beta-galectin-9 fusion proteins. Int. J. Pharm. 536:310-317 (2018).
Uemura, T.*, Yashiro, T.*, Oda, R.*, Shioya, N., Nakajima, T., Hashisu, M., Kobayashi, S., Nishiyama, C., Arimura, G. Intestinal anti-inflammatory activity of Perillaldehyde. J. Agric. Food Chem. in press.
*; contribute equal first authors.
Kaneko, H., Kobayashi, M., Mizunoe, Y., Yoshida, M., Yasukawa, H., Hoshino, S., Itagawa, R., Furuichi, T., Okita, N., Sudo, Y., Imae, M., Higami, Y. Taurine is an amino acid with the ability to activate autophagy in adipocytes. Amino Acids in press.
Piao, X.*, Miura, R.*, Miyake, S., Komazawa-Sakon, S., Koike, M., Shindo, R., Takeda, J., Hasegawa, A., Abe, R., Nishiyama, C., Mikami, R., Yagita, H., Uchida, Y., Nakano, H. Blockade of TNFR1-dependent and –independent cell death is crucial for normal epidermal differentiation. J. Allergy Clin. Immunol. in press.
*; contribute equal first authors.
Araie, Y., Takahashi, Y., Takahashi, Y., Takakura, Y., Nishikawa, M. Enhanced activity of immunosuppressive oligodeoxynucleotides by incorporating them into hexapod-like nanostructured DNA. Biol Pharm Bull in press.
Tsujimura, M., Kusamori, K., Oda, C., Miyazaki, A., Katsumi, H., Sakane, T., Nishikawa, M., Yamamoto, A. Regulation of proliferation and functioning of transplanted cells by using herpes simplex virus thymidine kinase gene in mice. J Control Release 275:78-84 (2018).
Tanaka, Y., Nishikawa, M., Mizukami, Y., Kusamori, K., Ogino, Y., Nishimura, S., Shimizu, K., Konishi, S., Takahashi, Y., Takakura, Y. Control of polarization and tumoricidal activity of macrophages by multicellular spheroid formation. J Control Release 270:177-183 (2018).
Takahashi, Y., Araie, Y., Nomura, D., Takahashi, Y., Sano, K., Saji, H., Takakura, Y., Nishikawa, M. Construction of nanostructured DNA harbouring phosphorodiamidate morpholino oligonucleotide for controlled tissue distribution in mice. J Drug Target 26: 373-381 (2018).
Oda, Y.*, Kasakura, K.*, Fujigaki, I., Kageyama, A., Okumura, K., Ogawa, H., Yashiro, T., Nishiyama, C. The effect of PU.1 knockdown on gene expression and function of mast cells. Sci. Rep. in press.
*; contribute equal first authors.
Narita, N., Kobayashi, M., Itakura, K., Itagawa, R., Kabaya, R., Sudo, Y., Okita, N., Higami, Y.
Differential response to caloric restriction of retroperitoneal, epididymal, and subcutaneous adipose tissue depots in rats, Exp. Gerontol. in press.
Takebe T, Sakamoto K, Higami Y, Harada Y. A novel mouse model for tracking the fate of CXCR5-expressing T cells. Biochem Biophys Res Commun. 495:1642-1647 (2018).
Akagi, K., Yamada, M., Saitoh, A., Oka, J-I., Yamada, M., Post-reexposure administration of riluzole attenuates the reconsolidation of conditioned fear memory in rats, Neuropharmacology, 131: 1-10 (2018).
Sasaki-Hamada, S., Funane, T., Nakao, Y., Sasaki, R., Nagai, M., Ueta, U., Yoshizawa, K., Horiguchi, M., Yamashita, C., Oka, J-I., Intranasal administration of neuromedin U derivatives containing cell-penetrating peptides and a penetration-accelerating sequence induced memory improvements in mice, Peptides, 99:241-246 (2018).
Saitoh, A., Suzuki, S., Soda, A., Ohashi, M., Yamada, M., Oka, J-I., Nagase, H., Yamada, M., The delta opioid receptor agonist KNT-127 in the prelimbic medial prefrontal cortex attenuates veratrine-induced anxiety-like behaviors in mice, Behavioural Brain Research, 336:77-84 (2018).
Sugiyama, A., Yamada, M., Saitoh, A., Oka, J-I., Yamada, M., Administration of riluzole into the basolateral amygdala facilitates the extinction of fear memory in rats, Behavioural Brain Research, 336:8-14 (2018).
2017年の業績
Nishikawa, T., Tanaka, Y., Kusamori, K., Mizuno, N., Mizukami, Y., Ogino, Y., Shimizu, K., Konishi, S., Takahashi, Y., Takakura, Y., Nishikawa, M. Using size-controlled multicellular spheroids of murine adenocarcinoma cells to efficiently establish pulmonary tumors in mice. Biotechnol J in press.
Takahashi, Y., Maezawa, T., Araie, Y., Takahashi, Y., Takakura, Y., Nishikawa, M. In vitro and in vivo stimulation of Toll-like receptor 9 by CpG oligodeoxynucleotides incorporated into polypod-like DNA nanostructures. J Pharm Sci 106: 2457-2462 (2017).
Umeki, Y., Saito, M., Takahashi, Y., Takakura, Y., Nishikawa, M. Retardation of antigen release from DNA hydrogel using cholesterol-modified DNA for increased antigen-specific immune response. Adv Healthc Mater 6: 1700355 (2017).
Ohtsuki, S., Takahashi, Y., Inoue, T., Takakura, Y., Nishikawa, M. Reconstruction of Toll-like receptor 9-mediated responses in HEK-Blue hTLR9 cells by transfection of human macrophage scavenger receptor 1 gene. Sci Rep 7: 13661 (2017).
Mohri, K., Nagata, K., Ohtsuki, S., Toyama, S., Nonomura, M., Takahashi, Y., Takakura, Y., Nishikawa, M., Sakuma, S. Elucidation of the mechanism of increased activity of immunostimulatory DNA by the formation of polypod-like structure. Pharm Res 34: 2362-2370 (2017).
Yata, T., Takahashi, Y., Tan, M., Nakatsuji, H., Ohtsuki, S., Murakami, T., Imahori, H., Umeki, Y., Shiomi, T., Takakura, Y., Nishikawa, M. DNA nanotechnology-based composite-type gold nanoparticle-immunostimulatory DNA hydrogel for tumor photothermal immunotherapy. Biomaterials 146: 136-145 (2017).
Takayama, Y., Kusamori, K., Hayashi, M., Tanabe, N., Matsuura, S., Tsujimura, M., Katsumi, H., Sakane, T., Nishikawa, M., Yamamoto, A. Long-term drug modification to the surface of mesenchymal stem cells by the avidin-biotin complex method. Sci Rep 7: 16953 (2017).
Kobayashi M, Takeda K, Narita T, Nagai K, Okita N, Sudo Y, Miura Y, Tsumoto H, Nakagawa Y, Shimano H, Higami Y. Mitochondrial intermediate peptidase is a novel regulator of sirtuin-3 activation by caloric restriction. FEBS Lett. 591:4067-4073 (2017).
Kobayashi, M., Higami, Y. A novel caloric restriction mediator, Aging (Albany NY) 9:2012-2013 (2017).
Sasaki-Hamada, S., Suzuki, A., Sanai, E., Matsumoto, K., Oka, J-I., Neuroprotection by chotosan, a Kampo formula, against glutamate excitotoxicity involves the inhibition of GluN2B-, but not GluN2A-containing NMDA receptor-mediated responses in primary cultured cortical neurons, Journal of Pharmacological Sciences, 135:134-137 (2017).
Mizunoe, Y., Kobayashi, M., Sudo, Y., Watanabe S, Yasukawa H, Natori D, Hoshino A, Negishi A, Okita, N., Komatsu, M., Higami, Y., Trehalose protects against oxidative stress by regulating the Keap1–Nrf2 and autophagy pathways, Redox Biology, 15:115-124 (2017).
Nagaoka, M.*, Yashiro, T.*, Uchida, Y., Ando, T., Hara, M., Arai, H., Ogawa, H., Kasakura, K., and Nishiyama, C. The nuclear orphan receptor NR4A3 is involved in the function of dendritic cells. J. Immunol. 199:2958-2967 (2017).
*; contribute equal first authors.
Nozaki, Y., Tamori, S., Inada, M., Katayama, R., Nakane, H., Minamishima, O., Onodera, Y., Abe, M., Shiina, S., Tamura, K., Kodama, D., Sato, K., Hara, Y., Abe, R., Takasawa, R., Yoshimori, A., Shinomiya, N., Tanuma, S., Akimoto, K. Correlation between c-Met and ALDH1 contributes to the survival and tumor-sphere formation of ALDH1 positive breast cancer stem cells and predicts poor clinical outcome in breast cancer. Genes & Cancer, in press.
Sugiyama, A., Saitoh, A., Yamada, M., Oka, J-I., Yamada, M., Administration of riluzole into the basolateral amygdala has an anxiolytic-like effect and enhances recognition memory in the rat, Behavioural Brain Research, 327:98-102 (2017).
Saitoh, A., Akagi, K., Oka, J-I., Yamada, M., Post-reexposure administration of D-cycloserine facilitates reconsolidation of contextual conditioned fear memory in rats, Journal of Neural Transmission, 124:583-587 (2017).
Umazume, A., Kezuka, T., Matsuda, R., Usui, Y., Takahashi, H., Yamanaka, N., Yashiro, T., Nishiyama, C., Goto, H. Role of PU.1 expression as an inflammatory marker in experimental autoimmune uveoretinitis. Ocular Immunology and Inflammation, in press
Terawaki, K., Kashiwase, Y., Sawada, Y., Hashimoto, H., Yoshimura, M., Ohbuchi, K., Sudo, Y., Suzuki, M., Miyano, K., Shiraishi, S., Higami, Y., Yanagihara, K., Hattori, T., Kase, Y., Ueta, Y., Uezono, Y. Development of ghrelin resistance in a cancer cachexia rat model using human gastric cancer-derived 85As2 cells and the palliative effects of the Kampo medicine rikkunshito on the model. PLoS One, 12(3):e0173113. (2017).
Hara, R. I., Maeda, Y., Sakamoto, T., Wada, T. Double-stranded RNA-binding artificial cationic oligosaccharides stabilizing siRNAs with a low N/P ratio Organic & Biomolecular Chemistry 15:1710-1717 (2017).
Yashiro, T.*, Kasakura, K.*, Oda, Y., Kitamura, N., Inoue, A., Nakamura, S., Yokoyama, H., Fukuyama, K., Hara, M., Ogawa, H., Okumura, K., Nishiyama, M., Nishiyama, C. The hematopoietic cell-specific transcription factor PU.1 is critical for expression of CD11c. Int. Immunol., 29:87-94 (2017).
*; contribute equal first authors.
Matsukuma, D., Sanbai, T., Otsuka, H. UCST-type Phase Transition driven by Protein-derived Polypeptide Employing Gelatin and Chitosan, Polym. Adv. Technol., 28:1636–1641 (2017).
Fujii, N.*, Narita, T.*, Okita, N.*, Kobayashi, M., Furuta, Y., Chujo, Y., Sakai, M., Yamada, A., Takeda, K., Konishi, T., Sudo, Y., Shimokawa, I., Higami, Y. Sterol Regulatory Element-Binding Protein-1c Orchestrates Metabolic Remodeling of White Adipose Tissue by Caloric Restriction. Aging Cell, 16:508-517 (2017).
*; contribute equal first authors.
Sasaki-Hamada, S., Suzuki, A., Ueda, Y., Matsumoto, K., Oka, J-I., Serotonergic and dopaminergic systems are implicated in the antidepressant-like effects of chotosan, a Kampo formula, in mice, Journal of Pharmacological Sciences, 133:64-70 (2017).
Kawano, Y., Ishii, N., Shimizu, Y., Hanawa, T. Development and Characterization of a Suspension Containing Nanoparticulated Rebamipide for a Mouth Wash for Stomatitis. J. Pharm Sci Tech, Japan, in press.
Sato, K., Akimoto, K. Expression Levels of KMT2C and SLC20A1 Identified by Information-theoretical Analysis Are Powerful Prognostic Biomarkers in Estrogen Receptor-positive Breast Cancer, Clinical Breast Cancer, in press.
Honjo, A., Nakano, N., Yamazaki, S., Hara, M., Uchida, K., Kitaura, J., Nishiyama, C., Yagita, H., Ohtsuka, Y., Ogawa, H., Okumura, K., and Shimizu, T.
Pharmacological inhibition of Notch signaling suppresses food antigen-induced mucosal mast cell hyperplasia. J. Allergy Clin. Immunol. 139:987-996 (2017).
Miyajima, A., Hirota, T., Tashiro, M., Noguchi, W., Kawano, Y., Hanawa, T., Kigure, A., Anata, T., Yamamoto, Y., Yuasa, N., Koshino, M., Shiraishi, Y., Yuzawa, K., Akagi, K., Yoshimasu, T., Makigami, K., Komoda, M. Pharmacokinetics of ivermectin applied topically by whole-body bathing method in healthy volunteers. J. Dermatol. in press.
Sasaki-Hamada, S., Nakamura, R., Nakao, Y., Akimoto, T., Sanai, E., Nagai, M., Horiguchi, M., Yamashita, C., Oka, J-I., Antidepressant-like effects exerted by the intranasal administration of a glucagon-like peptide-2 derivative containing cell-penetrating peptides and a penetration-accelerating sequence in mice, Peptides 87:64-70 (2017).
Iyoda, T., Nagamine, Y., Nakane, Y., Tokita, Y., Hayashi, R., Kodama, H., Fukai, F. Coadministration of the FNIII14 Peptide Synergistically Augments the Anti-Cancer Activity of Chemotherapeutic Drugs by Activating Pro-Apoptotic Bim. PLoS One 11:eo162525 (2017).
Suzuki, H., Sasada, M., Ito, Y., Watanabe, H., Okada, Y., Ishibashi, K., Iyoda, T,, Yanaka, A. and Fukai, F. The Promoting Effect of the Extracellular Matrix peptide TNIIIA2 Derived from Tenascin-C in Colon Cancer Cell Infiltration. Int. Mol. Sci. 18: 181 (2017).
Okita, N., Higami, Y., Fukai, F., Kobayashi, M., Mitarai, M., Sekiya, T., Sasaki, T. Modified Western blotting for insulin and other diabetes-associated peptide hormones. Sci. Rep. 7:6949 (2017).
Yoshizawa, K., Okumura, A., Nakashima, K., Sato, T. Higashi, T. Role of allopregnanolone biosynthesis in acute stress-induced anxiety-like behaviors in mice. Synapse, in press.
Mizunoe, Y., Sudo, Y., Okita, N., Hiraoka, H., Mikami, K., Narahara, T., Negishi, A., Yoshida, M., Higashibata, R., Watanabe, S., Kaneko, H., Natori, D., Furuichi, T., Yasukawa, H., Kobayashi, M., Higami, Y. Involvement of lysosomal dysfunction in autophagosome accumulation and early pathologies in adipose tissue of obese mice. Autophagy, 13:642-653 (2017).
2016年の業績
Sato, K., Wada, T. One-pot conversion reactions of glycosyl boranophosphates into glycosyl phosphate derivatives via acyl phosphite intermediates Organic & Biomolecular Chemistry 14:11092-11095 (2016).
Nukaga, Y., Oka, N., Wada, T. Stereocontrolled Solid-Phase Synthesis of Phosphate/Phosphorothioate (PO/PS) Chimeric Oligodeoxyribonucleotides on an Automated Synthesizer Using an Oxazaphospholidine-Phosphoramidite Method Journal of Organic Chemistry 81:2753-2762 (2016)
Kawano, Y., Imamura, A., Nakamura, T., Akaishi, M., Satoh, M., Hanawa, T. Development and characterization of oral spray for stomatitis containing irsogladine maleate. Chem. Pharm. Bull. 64:1659-1665 (2016).
Satoh, M., Kamada, A., Saito, M., Akaishi, M., Imamura, A., Kawano, Y., Hanawa, T. Healing Effects of Irsogladine Maleate on Acetic Acid- induced Oral Stomatitis in 5-Fluorouracil-treated and -untreated Syrian Golden Hamsters. Research & Reviews in Pharmacy and Pharmaceutical Sciences, 5:18-22 (2016).
Yashiro, T., Hara, M., Ogawa, H., Okumura, K., Nishiyama, C. Critical role of transcription factor PU.1 in the function of the OX40L/TNFSF4 promoter in dendritic cells. Sci. Rep. 6:34825 (2016).
Nakao, Y., Horiguchi, M., Nakamura, R., Sasaki-Hamada, S., Ozawa, C., Funane, T., Ozawa, R., Oka, J-I., Yamashita, C. LARETH-25 and β-CD improve central transitivity and central pharmacological effect of the GLP-2 peptide. International Journal of Pharmaceutics, 515:37-45 (2016).
Iijima, M., Ulkoski, D. Sakuma, S., Matsukuma, D., Nishiyama, N., Otsuka, H., Scholz, C. Synthesis of PEGylated poly(amino acid) pentablock copolymers and their self-assembly. Polym. Int. 65: 1132?1141 (2016).
Sasaki-Hamada, S., Hoshi, M., Niwa, Y., Ueda, Y., Kokaji, A., Kamisuki, S., Kuramochi, K., Sugawara, F., Oka, J-I. Neoechinulin A induced memory improvements and antidepressant-like effects in mice. Progress in Neuro-Psychopharmacology & Biological Psychiatry 71:155-161 (2016).
Suzuki, S., Saitoh, A., Ohashi, M., Yamada, M., Oka, J-I., Yamada, M. The infralimbic and prelimbic medial prefrontal cortices have differential functions in the expression of anxiety-like behaviors in mice. Behavioural. Brain Research 304:120-124 (2016).
Nagasawa, H., Hamada, C., Wakabayashi, M., Nakagawa, Y., Nomura, S., Kohno, Y. Time to spontaneous ductus arteriosus closure in full-term neonates. Open Heart 3:e000413 (2016).
Sato, H., Hirakawa, A., Hamada, C. An adaptive dose-finding method using a change-point model for molecularly targeted agents in phase I trials. Stat Med. 35:4093-109 (2016).
Hamada, C., Yamada, Y., Azuma, M., Nishikawa, K., Gotoh, M., Bando, H., Sugimoto, N., Nishina, T., Amagai, K., Chin, K., Niwa, Y., Tsuji, A., Imamura, H., Tsuda, M., Yasui, H., Fujii, H., Yamaguchi, K., Yasui, H., Hironaka, S., Shimada, K., Miwa, H., Hyodo, I. Meta-analysis supporting noninferiority of oxaliplatin plus S-1 to cisplatin plus S-1 in first-line treatment of advanced gastric cancer (G-SOX study): indirect comparison with S-1 alone. Int J Clin Oncol. 21:668-75 (2016).
Bando, H., Yamada, Y., Tanabe, S., Nishikawa, K., Gotoh, M., Sugimoto, N., Nishina, T., Amagai, K., Chin, K., Niwa, Y., Tsuji, A., Imamura, H., Tsuda, M., Yasui, H., Fujii, H., Yamaguchi, K., Yasui, H., Hironaka, S., Shimada, K., Miwa, H., Hamada, C., Hyodo, I. Efficacy and safety of S-1 and oxaliplatin combination therapy in elderly patients withadvanced gastric cancer. Gastric Cancer 19:919-26 (2016).
Miura, R., Kasakura, K., Nakano, N., Hara, M., Maeda, K., Okumura, K., Ogawa, H., Yashiro, T., Nishiyama, C. Role of PU.1 in MHC class II expression via CIITA transcription in plasmacytoid dendritic cells. PLoS One 11:e0154094 (2016).
Ishii, N., Kawano, Y., Suzuki, M., Komoda, M., Makino, K., Hanawa, T. Effects of camostat mesilate gargle on stomatitis caused by molecular target therapy: a case report. Jpn. J. Pharm. Palliat. Care Sci. 9, 87-91 (2016).
Miyajima, A., Hirota, T., Sugioka, A., Fukuzawa, M., Sekine, Y., Yamamoto, Y., Yoshimasu, T., Kigure, A., Anata, T., Noguchi, W., Akagi, K., Komoda, M. Effect of high-fat meal intake on the pharmacokinetic profile of ivermectin in Japanese patients with scabies, J. Dermatol., 43, 1030-1036 (2016).
Okita, N., Tsuchiya, T., Fukushima, M., Itakura, K., Yuguchi, K., Narita, T., Hashizume, Y., Sudo, Y., Chiba, T., Shimokawa, I., Higami, Y., Chronological analysis of caloric restriction-induced alteration of fatty acid biosynthesis in white adipose tissue of rats. Exp. Gerontol. 63:59-66 (2015).
Mizunuma, T., Iyoda, T., Fukai, F., Cell adhesion-mediated drug resistance (CAM-DR) in acute myelogenous leukemia cells and its abrogation by the antiadhesive peptide FNIII14. Peptide Science 2014, 261-264 (2015).
Iyoda, T., Kazama, M., Takeda, K., Fukai, F., Role of the tenascin-C-derived peptide TNIIIA2 in the formation of atherosclerotic foam cell. Peptide Science 2014, 61-64 (2015).
Yashiro, T., Kubo, M., Ogawa, H., Okumura, K., Nishiyama, C. PU.1 suppresses Th2 cytokine expression via silencing of GATA3 transcription in dendritic cells. PLoS One 10.e0137699 (2015).
Yamazaki, S., Nakano, N., Honjo, A., Hara, M., Maeda, K., Nishiyama, C., Kitamura, J., Ohtsuka, Y., Okumura, K., Ogawa, H., Shimizu, T. The transcription factor Ehf is involved in TGF-β-induced suppression of FcεRI and c-Kit expression and FεcRI-mediated activation of mast cells. J. Immunol. 195, 3427-3435 (2015).
Ito, T., Egusa, C., Maeda, T., Numata, T., Nakano, N., Nishiyama, C., Tsuboi, R., IL-33 promotes MHC class II expression in murine mast cells. Immun. Inflamm. Dis. 3, 196-208 (2015).
Ishiyama, K., Yashiro, T., Nakano, N., Kasakura, K., Miura, R., Hara, M., Kawai, F., Maeda, K., Tamura, N., Okumura, K., Ogawa, H., Takasaki, Y., Nishiyama, C., Involvement of PU.1 in NFATc1 promoter function in osteoclast development. Allergol. Int. 64, 241-247 (2015).
Nakano, N., Nishiyama, C., Yagita, H., Hara, M., Motomura, Y., Kubo, M., Okumura, K., Ogawa, H., Notch signaling enhances FcεRI-mediated cytokine production by mast cells through direct and indirect mechanisms. J. Immunol. 194, 4535-4544 (2015).
Metz, P. J., Arsenio, J., Kakaradov, B., Kim, S. H., Remedios, K. A., Oakley, K., Akimoto, K., Ohno, S., Yeo, G. W., Chang, J. T., Regulation of Asymmetric Division and CD8+ T Lymphocyte Fate Specification by PKCζ and PKCλ/ι. J. Immunol. 194, 2249-2259 (2015).
Iwata, R., Nakayama, F., Hirochi, S., Sato, K., Piao,W., Nishina, K., Yokota, T., Wada, T., Synthesis and properties of vitamin E analog-conjugated neomycin for delivery of RNAi drugs to liver cells. Bioorg. Med. Chem. Lett. 25 (4), 815-819 (2015).
Nishina, T., Numata, J., Nishina,K., Yoshida-Tanaka, K., Nitta, K., Piao, W., Iwata, R., Ito, S., Kuwahara, H., Wada, T., Mizusawa, H., Yokota, T., Chimeric Antisense Oligonucleotide Conjugated to α-Tocopherol. Mol. Ther. Nucleic Acids 4, e220 (2015).
Nukaga, Y., Takemura, T., Iwamoto, N., Okad, N., Wada, T., Enhancement of affinity of 2'-O-Me-oligonucleotides for complementary RNA by incorporating a stereoregulated boranophosphate backbone. RSC Adv. 5, 2392-2395 (2015).
Otsuka, H., Muramatsu, Y., Matsukuma, D., Gold Nanorod Functionalized with Self-assembled Glycopolymers for Ultrasensitive Detection of Proteins. Chem. Lett. 44(2), 132-134 (2015).
Matsukuma, D., Otsuka, H., Thermo-responsive Reversible Phase-transition of Alginate Based Semi-IPN Gel through Self-assembly of Interpenetrated Elastin-Like Polypeptide. Chem. Lett. 44(1), 26-28 (2015).
Goto K., Shinozaki I., Ishihara T., Kaiho F., Hanawa T.，Evaluation of Community Pharmacist Training on Patients'Non-Verbal Communication. Jpn. J. Pharm. Health Care Sci., 41, 66-79(2015).
Sasaki-Hamada S., Yuri, Y., Hoshi, M., Oka, J-I. Immunohistochemical determination of the site of antidepressant-like effects of glucagon-like peptide-2 in ACTH-treated mice. Neuroscience 294, 156-165 (2015).
Sasaki-Hamada, S., Hojo, Y., Koyama, H., Otsuka, H., Oka, J-I. Changes in hippocampal synaptic functions and protein expression in monosodium glutamate-treated obese mice during development of glucose intolerance. Eur. J. Neurosci. 41, 1393-1401 (2015).
Sugiyama, A., Saitoh, A., Inagaki, M., Oka, J-I., Yamada, M. Systemic administration of riluzole enhances recognition memory and facilitates extinction of fear memory in rats. Neuropharmacology 97, 322-328 (2015).
Yamada, M., Saitoh, A., Ohashi, M., Suzuki, S., Oka, J-I., Yamada, M. Induction of c-Fos immunoreactivity in the amygdala of mice expressing anxiety-like behavior after local perfusion of veratrine in the prelimbic medial prefrontal cortex. J. Neural Transm. 122, 1203-1207 (2015).
Saitoh, A., Makino, Y., Hashimoto, T., Yamada, M., Goto, L., Sugiyama, A., Ohashi, M., Tsukagoshi, M., Oka, J-I., Yamada, M. The voltage-gated sodium channel activator veratrine induces anxiogenic-like behaviors in rats. Behav. Brain Res. 292, 316-322 (2015).
Niu, Y., Li, F., Inada, C., Tanaka, K., Watanabe, S., Fujiwara, H., Sasaki-Hamada, S., Oka, J-I., Matsumoto, K., Chemical profiling with HPLC-FTMS of exogenous and endogenous chemicals susceptible to the administration of chotosan in an animal model of type 2 diabetes-induced dementia. J. Pharmaceut. Biomed. Anal. 104, 21-30 (2015).
Ohashi, M., Saitoh, A., Yamada, M., Oka, J-I., Yamada, M., Riluzole in the prelimbic medial prefrontal cortex attenuated veratrine-induced anxiety-like behaviors in mice. Psychopharmacol. 232, 391-398 (2015).
Iwai, T., Jin, K., Ohnuki, T., Sasaki-Hamada, S., Nakamura, M., Saitoh, A., Sugiyama, A., Ikeda, M., Tanabe, M., Oka, J-I., Glucagon-like peptide-2-induced memory improvement and anxiolytic effects in mice. Neuropeptides 49, 7-14 (2015).
Yamada, M., Tsukagoshi, M., Hashimoto, T., Oka, J-I., Saitoh, A., Yamada, M., Lysophosphatidic acid induces anxiety-like behavior via its receptors in mice. J. Neural Transm. 122, 487-494 (2015).
Kato, M., Sasaki, M., Ueyama, Y., Koga, A., Sano, A., Higashi, T., Santa, T., Comparison of the Migration Behavior of the Polyethylene Glycol- and the Silica-Based Nanoparticles Using Micellar Electrokinetic Chromatography. J. Sep. Sci. 38, 468-474 (2015).
Miyajima, A., Komoda, M., Akagi, K., Yuzawa, K., Yoshimasu, T., Yamamoto, Y., Hirota, T., Experimental study of pharmacokinetics of external, whole body bathing application of ivermectin. J. Dermatol. 42(1), 87-89(2015).
Kakurai, Y., Hirakawa, A., and Hamada, C., A Dose-Finding Method Based on Multiple Dosing in Two-Agent Combination Phase I Trials. J. Biopharm. Stat. [Epub ahead of print] PubMed PMID: 25369852.(2015).
Kubota, K., Kamijima, Y., Sato, T., Ooba, N., Koide, D., Iizuka, H., and Nakagawa, H., Epidemiology of psoriasis and palmoplantar pustulosis: a nationwide study using the Japanese national claims database. BMJ Open 5, e006450 (2015).
Terawaki, K., Sawada, Y., Kashiwase, Y., Hashimoto, H., Yoshimura, M., Suzuki, M., Miyano, K., Sudo, Y., Shiraishi, S., Higami, Y., Yanagihara, K., Kase, Y., Ueta, Y., Uezono, Y., New cancer cachexia rat model generated by implantation of a peritoneal dissemination-derived human stomach cancer cell line. Am. J. Physiol. Endocrinol. Metab. 306(4), E373-87 (2014).
Okita, N., Ishikawa, N., Mizunoe, Y., Oku, M., Nagai, W., Suzuki, Y., Matsushima, S., Mikami, K., Okado, H., Sasaki, T., Higami, Y., Inhibitory effect of p53 on mitochondrial content and function during adipogenesis. Biochem. Biophys. Res. Commun. 446(1), 91-97 (2014).
Hatachi, G., Tsuchiya, T., Miyazaki, T., Matsumoto, K., Yamasaki, N., Okita, N., Nanashima, A., Higami, Y., Nagayasu, T., The poly(adenosine diphosphate-ribose) polymerase inhibitor PJ34 reduces pulmonary ischemia-reperfusion injury in rats. Transplantation. 98(6), 618-624 (2014).
Miyano, K., Sudo, Y., Yokoyama, A., Hisaoka-Nakashima, K., Morioka, N., Takebayashi, M., Nakata, Y., Higami, Y., Uezono, Y., History of the G protein-coupled receptor (GPCR) assays from traditional to a state-of-the-art biosensor assay. J. Pharmacol. Sci. 126(4), 302-9 (2014).
Tanaka, R., Seki, Y., Saito, Y., Kamiya, S., Fujita, M., Okutsu, H., Iyoda, T., Takai, T., Owaki, T., Yajima, H., Taira, J., Hayashi, R., Kodama, H., Matsunaga, T., and Fukai, F., Tenascin-C-derived peptide TNIIIA2 highly enhances cell survival and platelet-derived growth factor (PDGF)-dependent cell proliferation through potentiated and sustained activation of integrin a5b1. J. Biol. Chem. 289(25), 17699-17708 (2014).
Iyoda, T., Takada, M., Fukatsu, K., Kumokoshi, S., Fujisawa, T., Shimada, T.,Shimokawa, N., Matsunaga, T., Makino, K., Doi, N., Terada, H., and Fukai, F., A novel mechanism underlying the basic defensive response of macrophages against Mycobacterium infection. J. Immnunol. 192(9), 4254-4262 (2014).
Yoshida, A., Tomita, T., Fujimura, T., Nishiyama, C., Kuzuyama, T., Nishiyama, M., Structure insight into amino group-carrier protein-mediated lysine biosynthesis: crystal structure of the LysZ-LysW complex from Thermus thermophilus. J. Biol. Chem. 290, 435-447 (2014).
Kasakura, K., Takahashi, K., Ito, T., Hosono, A., Nunomura, S., Ra, C., Momose, Y., Ito, K., Nishiyama, C., Kaminogawa, S., C/EBPα controls functions of mast cells. FEBS Lett. 588, 4645-4653 (2014).
Kasakura, K., Takahashi, K., Ito, T., Hosono, A., Momose, Y., Ito, K., Nishiyama, C., Kaminogawa, S., Commensal bacteria directly suppress in vitro degranulation of mast cells in a MyD88-independent manner. Biosci. Biotechnol. Biochem. 78, 1669-1676 (2014).
Inage, E., Kasakura, K., Yashiro, T., Suzuki, R., Baba, Y., Nakano, N., Hara, M., Tanabe, A., Oboki, K., Matsumoto, K., Saito, H., Niyonsaba, F., Ohtsuka, Y., Ogawa, H., Okumura, K., Shimizu, T., Nishiyama, C., Critical roles for PU.1, GATA1 and GATA2 in the expression of human FcεRI on mast cells: PU.1 and GATA1 transactivate FCER1A, and GATA2 transactivates FCER1A and MS4A2. J. Immunol. 192, 3936-3946 (2014).
Nakamura, Y., Nakano, N., Ishimaru, K., Hara, M., Ikegami, T., Tahara, Y., Katoh, R., Ogawa, H., Okumura, K., Shibata, S., Nishiyama, C., Nakao, A., Circadian regulation of allergic reaction by the mast cell clock. J. Allergy Clin. Immunol. 133, 568-575 (2014).
Schendzielorz, G., Dippong, M., Grunberger, A., Kohlheyer, D., Yoshida, A., Binder, S., Nishiyama, C., Nishiyama, M., Bott, M., Eggeling, L., Taking control over control: Use of product sensing in single cells to remove flux control at key enzymes in biosynthesis pathways. ACS Synth. Biol. 3, 21-29 (2014).
Ichikawa, Y., Nagashima, Y., Morioka, K., Akimoto, K., Kojima, Y., Ishikawa, T., Goto, A., Kobayashi, N., Watanabe, K., Ota, M., Fujii, S., Kawamata, M., Takagawa, R., Kunizaki, C., Takahashi, H., Nakajima, A., Maeda, S., Shimada, H., Inayama, Y., Ohno, S., Endo, I., Colorectal laterally spreading tumors show characteristic expression of cell polarity factors, including atypical protein kinase C λ/ι, E-cadherin, β-catenin and basement membrane component. Oncol. Lett. 8, 977-984 (2014).
Okayama, A., Miyagi, Y., Oshita, F., Nishi, M., Nakamura, Y., Nagashima, Y., Akimoto, K., Ryo, A., Hirano, H.,Proteomic analysis of proteins related to prognosis of lung adenocarcinoma. J. Proteosome Res. 13, 4686-4694 (2014).
Otsuka, H., Matsukuma, D., Sanbai, T., and Ikenaga, Y., Self-Assembly of Poly(ethylene glycol)-block-Polypyridine Copolymer into Micelles and at Silica Surface: Effect of molecular architecture on Silica Dispersion. Colloid Polym. Sci., 292, 291?300 (2014). (DOI 10.1007:s00396-013-3062-2)
Matsukuma, D., Maejima, Y, Ikenaga, Y., Sanbai, T., Ueno, K., and Otsuka, H., Amphiphilic Copolymer of Poly(ethylene glycol)-block-Polypyridine; Synthesis, Physicochemical Characterization, and Adsorption onto Silica Nanoparticle. J. Nanosci. Nanotechnol., 14(9), 6774-6780 (2014).
Kutsuzawa, K., Suzuki, T., Kishimoto, H., Murakami, A., Azuma, T., Abe, R., Otsuka, H. Highly Robust Protein Production by Coculture of CHO Spheroids Layered on Feeder Cells in Serum-Free Medium. Colloid Polym. Sci., 292, 839-848 (2014). (DOI: 10.1007:s00396-013-3093-8)
Otsuka, H., Sasaki, K., Okimura, S., Nagamura, M., Watanabe, R., Kawabe, M., Contribution of Fibroblasts Cultured on 3D Silica Nonwoven Fabrics to the Co-cultured Hepatocytes Function. Chem. Lett., 43, 343?345 (2014).
Otsuka, H., Hagiwara, T., Yamamoto, S., Carbohydrate-Based Amphiphilic Diblock Copolymers With Pyridine for the Sensitive Detection of Protein Binding. J. Nanosci. Nanotechnol. 14(9), 6764-6773 (2014).
Kuriyama, M., Haruta, K., Dairaku, T., Kawamura, T., Kikkawa, S., Inamoto, K., Tsukamoto, H., Kondo, Y., Torigoe, H., Okamoto, I., Ono, A., Morita, E. H., Tanaka, Y., Hg2+-Trapping Beads: Hg2+-Specific Recognition through Thymine-Hg(II)-Thymine Base Pairing. Chem. Pharm. Bull. 62(7), 709-712 (2014).
Iwai, T., Sawabe, T., Tanimitsu, K., Suzuki, M., Sasaki-Hamada, S., Oka, J-I., Glucagon-like peptide-1 protects synaptic and learning functions from neuroinflammation in rodents. J. Neurosci. Res. 92, 446-454 (2014).
Sasaki-Hamada, S., Tamaki, K., Otsuka, H., Ueno, T., Sacai, H., Niu, Y., Matsumoto, K., Oka, J-I., Chotosan, a Kampo formula, ameliorates hippocampal LTD and cognitive deficits in juvenile-onset diabetes rats. J. Pharmacol. Sci. 124, 192-200 (2014).
Sugiyama, A., Nagase, H., Oka, J-I., Yamada, M., Saitoh, A., DOR2-selective but not DOR1-selective antagonist abolishes anxiolytic-like effects of the d opioid receptor agonist KNT-127. Neuropharmacol. 79, 314-320 (2014).
Sacai1, H., Sasaki-Hamada1, S., Sugiyama, A., Saitoh, A., Mori, K., Yamada, M., Oka, J-I., The impairment in spatial learning and hippocampal LTD through the PKA pathway in juvenile-onset diabetes rats are rescued by modulating NMDA receptor function. Neurosci. Res. 81-82, 55-63 (2014). 1These authors contributed equally to this work.
Saitoh, A., Ohashi, M., Suzuki, S., Tsukagoshi, M., Sugiyama, A., Yamada, M., Oka, J-I., Inagaki, M., Yamada, M., Activation of the prelimbic medial prefrontal cortex induces anxiety-like behaviors via N-methyl-D-aspartate receptor-mediated glutamatergic neurotransmission in mice. J. Neurosci. Res. 92, 1044-1053 (2014).
Ogawa, S., Tadokoro, H., Sato, M., Higashi, T., Enantioselective Determination of Ibuprofen in Saliva by Liquid Chromatography/Tandem Mass Spectrometry with Chiral Electrospray Ionization-Enhancing and Stable Isotope-Coded Derivatization. J. Pharm. Biomed. Anal. 98, 387-392 (2014).
Higashi, T., Goto, A., Morohashi, M., Ogawa, S., Komatsu, K., Sugiura, T., Fukuoka, T., and Mitamura, K., Development and Validation of a Method for Determination of Plasma 25-Hydroxyvitamin D3 3-Sulfate Using Liquid Chromatography/Tandem Mass Spectrometry. J. Chromatogr. B 969, 230-234 (2014).
Ogawa, S., Ooki, S., Shinoda, K., Higashi, T., Analysis of Urinary Vitamin D3 Metabolites by Liquid Chromatography/Tandem Mass Spectrometry with ESI-Enhancing and Stable Isotope-Coded Derivatization. Anal. Bioanal. Chem. 406, 6647-6654 (2014).
Saito, M., Sugiyama, N., Komoda, M., Faculty Development of Oncology Expects. Juntendo Medical Journal. 60(3), 220-223(2014).
Shikamura, Y., Kikuchi, Y., Takahashi, J., Negishi, K., Komoda, M., Mochizuki, M., Terada, H., Medical Economic Research on Pharmaceutical Inquiries Made by Hospital Pharmacists about Prescriptions for Inpatients. 医薬品情報学. 16(2), 41-52(2014).
Abe, K., Itoyama, Y., Sobue, G., Tsuji, S., Aoki, M., Doyu, M., Hamada, C., Kondo, K., Yoneoka, T., Akimoto, M., Yoshino, H., Edaravone ALS Study Group. Confirmatory double-blind, parallel-group, placebo-controlled study of efficacy and safety of edaravone (MCI-186) in amyotrophic lateral sclerosis patients. Amyotroph. Lateral Scler. Frontotemporal Degener. 15(7-8), 610-7(2014).
Asano, J., Hirakawa, A., Hamada, C., Assessing the prediction accuracy of cure in the Cox proportional hazards cure model: an application to breast cancer data. Pharm. Stat. 13(6), 357-63(2014).
Uchiyama, S., Shinohara, Y., Katayama, Y., Yamaguchi, T., Handa, S., Matsuoka, K., Ohashi, Y., Tanahashi, N., Yamamoto, H., Genka, C., Kitagawa, Y., Kusuoka, H., Nishimaru, K., Tsushima, M., Koretsune, Y., Sawada, T., Hamada, C., Benefit of cilostazol in patients with high risk of bleeding: subanalysis of cilostazol stroke prevention study 2. Cerebrovasc. Dis. 37(4), 296-303(2014).
Tsuchiya, T., Sadahiro, S., Sasaki, K., Kondo, K., Katsumata, K., Nishimura, G., Kakeji, Y., Baba, H., Morita, T., Koda, K., Sato, S., Matsuoka, J., Yamaguchi, Y., Usuki, H., Hamada, C., Kodaira, S., Saji, S., Safety analysis of two different regimens of uracil-tegafur plus leucovorin as adjuvant chemotherapy for high-risk stage II and III colon cancer in a phase III trial comparing 6 with 18 months of treatment: JFMC33-0502 trial. Cancer Chemother. Pharmacol. 73(6), 1253-61(2014).
Asakawa, T., Hirakawa, A., Hamada, C., Bayesian model averaging continual reassessment method for bivariate binary efficacy and toxicity outcomes in phase I oncology trials. J. Biopharm. Stat. 24(2), 310-25(2014).
Nakamura, M., Nanto, S., Hirayama, A., Takayama, T., Nishikawa, M., Kimura, K., Morita, S., Aizawa, T., Asano, R., Matsumaru, Y., Hamada, C., Isshiki, T, OPERA Steering Committee and Investigators. Optimal duration of dual antiplatelet therapy following treatment with the endeavor zotarolimus-eluting stent in real-world Japanese patients with coronary artery disease (OPERA): study design and rationale. Catheter. Cardiovasc. Interv. 84(3), 368-74(2014).
Ishihara, M., Asakura, M., Kimura, K., Nakao, K., Hamada, C., Hirayama, A., Trial design and rationale of TY-51924 as a novel Na+/H+ exchanger inhibitor in patients with ST-elevation acute myocardial infarction undergoing percutaneous coronary intervention. J. Cardiol. 63(1), 82-7 (2014).
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