著書
著書:新田 剛「コウモリはウイルスを抱いて空を翔ぶ – 生き物たちのネオ免疫学」
ブックマン社(2023/5/9)
論文
① 英文(原著・総説・著書)
- Muro R, Nitta T. It's Time to Unite: Diversity and Coordination of Thymic Stromal Cells for T Cell Selection and Organ Integrity. Immunol Rev, 332(1):e70040. 2025 Jul doi: 10.1111/imr.70040
- Kakeya H, Nitta T, Kamijima Y, Miyazawa T. Significant Increase in Excess Deaths after Repeated COVID-19 Vaccination in Japan. JMA Journal 2025. doi: 10.31662/jmaj.2024-0298
- Muro R, Nitta T, Nitta S, Tsukasaki M, Asano T, Nakano K, Okamura T, Nakashima T, Okamoto K, Takayanagi H. Transcript splicing optimizes the thymic self-antigen repertoire to suppress autoimmunity. J Clin Invest, 134(20):e179612, 2024 Oct 15,doi: 10.1172/JCI179612.
- Ota A, Iguchi T, Nitta S, Muro R, Mino N, Tsukasaki M, Penninger JM, Nitta T, Takayanagi H. Synchronized development of thymic eosinophils and thymocytes. Int Immunol, dxae037, 2024. doi: 10.1093/intimm/dxae037.
- Yan M, Tsukasaki M, Muro R, Ando Y, Nakamura K, Komatsu N, Nitta T, Okamura T, Okamoto K, Takayanagi H. Identification of an intronic enhancer regulating RANKL expression in osteocytic cells. Bone Res 11, 43, 2023. doi: 10.1038/s41413-023-00277-6.
- Kimura A, Takagi T, Thamamongood T, Sakamoto S, Ito T, Seki I, Okamoto M, Aono H, Serada S, Naka T, Imataka H, Miyake K, Ueda T, Miyanokoshi M, Wakasugi K, Iwamoto N, Ohmagari N, Iguchi T, Nitta T, Takayanagi H, Yamashita H, Kaneko H, Tsuchiya H, Fujio K, Handa H, Suzuki H. Extracellular aaRSs drive autoimmune and inflammatory responses in rheumatoid arthritis via the release of cytokines and PAD4. Ann Rheum Dis 11, 1153-1161, 2023. doi: 10.1136/ard-2023-224055.
- Muro R, Narita T, #Nitta T, Takayanagi H. Spleen tyrosine kinase mediates the γδTCR signaling required for γδT cell commitment and γδT17 differentiation. Front Immunol 13, 1045881, 2023. doi: 10.3389/fimmu.2022.1045881. (#, corresponding author)
- #Nitta T. Mesenchymal stromal cells in the thymus. Inflamm Regen, 42, 33, 2022. doi: 10.1186/s41232-022-00219-5. (#, corresponding author)
- Yan M, Komatsu N, Muro R, Huynh NC, Tomofuji Y, Okada Y, Suzuki HI, Takaba H, Kitazawa R, Kitazawa S, Pluemsakunthai W, Mitsui Y, Satoh T, Okamura T, Nitta T, Im SH, Kim CJ, Kollias G, Tanaka S, Okamoto K, Tsukasaki M, Takayanagi H. ETS1 governs pathological tissue-remodeling programs in disease-associated fibroblasts. Nat Immunol, 23, 1330-1341, 2022. doi: 10.1038/s41590-022-01285-0.
- Tsukasaki M, Komatsu N, Negishi-Koga T, Huynh NC, Muro R, Ando Y, Seki Y, Terashima A, Pluemsakunthai W, Nitta T, Nakamura T, Nakashima T, Ohba S, Akiyama H, Okamoto K, Baron R, Takayanagi H. Periosteal stem cells control growth plate stem cells during postnatal skeletal growth. Nat Commun, 13, 4166, 2022. doi: 10.1038/s41467-022-31592-x.
- Mino N, Muro R, Ota A, Nitta S, Lefebvre V, #Nitta T, Fujio K, Takayanagi H. The transcription factor Sox4 is required for thymic tuft cell development. Int Immunol, 34, 45-52, 2022. doi: 10.1093/intimm/dxab098. (#, corresponding author)
- #Nitta T, Ota A, Iguchi T, Muro R, Takayanagi H. The fibroblast: an emerging key player in thymic T cell selection. Immunol Rev, 302, 68-85, 2021. doi:10.1111/imr.12985 (#, corresponding author)
- #Nitta T, Takayanagi H. Non-epithelial thymic stromal cells: Unsung heroes in thymus organogenesis and T cell development. Front Immunol, 11, 620894, 2021. doi: 10.3389/fimmu.2020.620894 (#, corresponding author)
- Tsukasaki M, Huynh NCN, Okamoto K, Muro R, Terashima A, Kurikawa Y, Komatsu N, Pluemsakunthai W, Nitta T, Okamura T, Sakai M, Matsukawa T, Matsumoto M, Kobayashi Y, Penninger JM, Takayanagi H. Stepwise cell fate decision pathways during osteoclastogenesis at single-cell resolution. Nat Metab, 2, 1382-1390, 2020. doi: 10.1038/s42255-020-00318-y.
- #Nitta T, Tsutsumi M, Nitta S, Muro R, Suzuki EC, Nakano K, Tomofuji Y, Sawa S, Okamura T, Penninger JM, Takayanagi H. Fibroblasts as a source of self-antigens for central immune tolerance. Nat Immunol, 21, 1172-1180, 2020. doi: 10.1038/s41590-020-0756-8 (#, corresponding author)
- Tsukasaki M, Asano T, Muro R, Huynh NC, Nakano K, Komatsu N, Okamoto K, Okamura T, Nitta T, Takayanagi H. OPG production matters where it happened. Cell Rep, 32, 108124, 2020. doi: 10.1016/j.celrep.2020.108124.
- Jandke A, Melandri D, Monin L, Ushakov DS, Laing AG, Vantourout P, East P, Nitta T, Narita T, Takayanagi H, Feederle R, Hayday A. Butyrophilin-like proteins display combinatorial diversity in selecting and maintaining signature intraepithelial γδ T cell compartments. Nat Commun, 11, 3769, 2020. doi: 10.1038/s41467-020-17557-y
- Muro R, Takayanagi H, #Nitta T. Retroviral gene transduction into T-cell progenitors for analysis of T cell development in the thymus. Methods Mol Biol, 2111, 193-203, 2020. doi: 10.1007/978-1-0716-0266-9_16. (#, corresponding author)
- Asano T, Okamoto K, Nakai Y, Tsutsumi M, Muro R, Suematsu A, Hashimoto K, Okamura T, Ehata S, Nitta T, Takayanagi H. Soluble RANKL is physiologically dispensable but accelerates tumor metastasis to bone. Nat Metab, 1, 868-875, 2019. doi.org/10.1038/s42255-019-0104-1
- Muro R, Takayanagi H, #Nitta T. T cell receptor signaling for γδT cell development. Inflamm Regen, 39,6, 2019. doi.org/10.1186/s41232-019-0095-z. (#, corresponding author)
- Tamehiro N, Nishida K, Sugita Y, Hayakawa K, Oda H, Nitta T, Nakano M, Nishioka A, Yanobu-Takanashi R, Goto M, Okamura T, Adachi R, Kondo K, Morita A, Suzuki H. Ras homolog gene family H (RhoH) deficiency induces psoriasis-like chronic dermatitis by promoting TH17 cell polarization. J Allergy Clin Immunol,143, 1878-1891, 2019. doi: 10.1016/j.jaci.2018.09.032.
- Inoue M, Okamoto K, Terashima A, Nitta T, Muro R, Negishi-Koga T, Kitamura T, Nakashima T, Takayanagi H. Arginine methylation controls the strength of c family cytokine signaling in T cell maintenance. Nat Immunol, 19, 1265-1276, 2018. doi:10.1038/s41590-018-0222-z.
- *Narita T, *Nitta T, Nitta S, Okamura T, Takayanagi H. Mice lacking all of the Skint family genes. Int Immunol, 30, 301-309, 2018. doi:10.1093/intimm/dxy030 (*, co-first author)
- Tsukasaki M, Komatsu N, Nagashima K, Nitta T, Pluemsakunthai W, Shukunami C, Iwakura Y, Nakashima T, Okamoto K, Takayanagi H. Host defense against oral microbiota by bone-damaging T cells. Nat Commun, 9, 701, 2018. doi:10.1038/s41467-018-03147-6
- Muro R, Nitta T, Kitajima M, Okada T, Suzuki H. Rasal3-mediated T cell survival is essential for inflammatory responses. Biochem Biophys Res Commun, 496, 25-30, 2018. doi: 10.1016/j.bbrc.2017.12.159.
- *Muro R, *#Nitta T, Nakano K, Okamura T, #Takayanagi H, #Suzuki H. TCR recruits the Syk/PI3K axis to drive proinflammatory differentiation program. J Clin Invest, 128, 415-426, 2018. doi: 10.1172/JCI95837. (*, co-first author; #, corresponding author)
- Nagashima K, Sawa S, Nitta T, Prados A, Koliaraki V, Kollias G, Nakashima T, Takayanagi H. Targeted deletion of RANKL in M cell inducer cells by the Col6a1-Cre driver. Biochem Biophys Res Commun, 493, 437-443, 2017. Doi: 10.1016/j.bbrc.2017.09.004.
- Nitta T, Kochi Y, Muro R, Tomofuji, Y, Okamura T, Murata S, Suzuki H, Sumida T, Yamamoto K, Takayanagi H. Human thymoproteasome variations influence CD8 T cell selection. Sci Immunol, 2, eaan5165, 2017. Doi: 10.1126/sciimmunol.aan5165.
- Okamoto K, Nakashima T, Shinohara M, Negishi-Koga T, Komatsu N, Terashima A, Sawa S, Nitta T, Takayanagi H. Osteoimmunology: the conceptual framework for unifying the immune and skeletal systems. Physiol Rev, 97, 1295-1349, 2017. Doi: 10.1152/physrev.00036.2016.
- Nagashima K, Sawa S, Nitta T, Tsutsumi M, Okamura T, Penninger JM, Nakashima T, Takayanagi H. Identification of subepithelial mesenchymal cells that induce IgA and diversify gut microbiota. Nat Immunol, 18, 675-682, 2017. doi:10.1038/ni.3732. 表紙(June 2017, Vol.18 No.6)に採用
- Tsukasaki M, Hamada K, Okamoto K, Nagashima K, Terashima A, Komatsu N, Win S, Okamura T, Nitta T, Yasuda H, Penninger JM, Takayanagi H. LOX Fails to Substitute for RANKL in Osteoclastogenesis. J Bone Miner Res, 32, 434-439, 2017. doi: 10.1002/jbmr.2990.
- *Nitta T, *Suzuki H. Thymic stromal cell subsets for T cell development. Cell Mol Life Sci, 73, 1021-1037, 2016. DOI 10.1007/s00018-015-2107-8 (*, corresponding author)
- Ono T, Okamoto K, Nakashima T, Nitta T, Hori S, Iwakura Y, Takayanagi H. IL-17-producing T cells enhance bone regeneration. Nat Commun, 7, 10928, 2016. DOI 10.1038/ncomms10928.
- Nitta T, Muro R, Shimizu Y, Nitta S, Oda H, Ohte Y, Goto M, Yanobu R, Narita T, Takayanagi H, Yasuda H, Okamura T, Murata S, Suzuki H. The thymic cortical epithelium determines the TCR repertoire of IL-17-producing T cells. EMBO Rep, 16, 638-653, 2015.
- Muro R, Nitta T, Okada T, Ideta H, Tsubata T, Suzuki H. The Ras GTPase-activating protein Rasal3 supports survival of naïve T cells. PLoS One, 10, e0119898, 2015.
- Takaba H, Morishita Y, Tomofuji Y, Danks L, Nitta T, Komatsu N, Kodama T, Takayanagi H. Fezf2 orchestrates the thymic program of self-antigen expression for immune tolerance. Cell, 163, 975-987, 2015.
- *Okada T, *Nitta T, Kaji K, Takashima A, Oda H, Tamehiro N, Goto M, Okamura T, Patrick MS, Suzuki H. Differential function of Themis CABIT domains during T cell development. PLoS One, 9, e89115, 2014. (*, equal contribution)
- Yano K, Carter C, Yoshida N, Abe T, Yamada A, Nitta T, Ishimaru N, Takada K, Butcher GW, Takahama Y. Gimap3 and Gimap5 cooperate to maintain T-cell numbers in the mouse. Eur J Immunol, 44, 561-572, 2014.
- Williams JA, Zhang J, Jeon H, Nitta T, Ohigashi I, Klug D, Kruhlak MJ, Choudhury B, Sharrow SO, Granger L, Adams A, Eckhaus MA, Jenkinson SR, Richie ER, Gress RE, Takahama Y, Hodes RJ. Thymic medullary epithelium and thymocyte self-tolerance require cooperation between CD28-CD80/86 and CD40-CD40L costimulatory pathways.
J Immunol, 192, 630-640, 2014.
- Jenkinson SR, Williams JA, Jeon H, Zhang J, Nitta T, Ohigashi I, Kruhlak MJ, Zuklys S, Sharrow SO, Adams A, Granger L, Choi Y, Siebenlist U, Bishop GA, Hollander G, Takahama Y, Hodes RJ. Traf3 enforces the requirement for T cell crosstalk in thymic medullary epithelial development.
Proc Natl Acad Sci USA, 110 21107-21112, 2013.
- Nitta T, Ohigashi I, Takahama Y. The development of T lymphocytes in fetal thymus organ culture. Methods Mol Biol, 946, 85-102, 2013.
- *Nakagawa Y, *Ohigashi I, *Nitta T, *Sakata M, Tanaka K, Murata S, Kanagawa O, Takahama Y. Thymic nurse cells provide microenvironment for secondary TCR rearrangement in cortical thymocytes. Proc Natl Acad Sci USA, 109, 20572-20577, 2012. (*, equal contribution)
- Zuklys S, Mayer CE, Zhanybekova S, Stefanski HE, Nusspaumer G, Gill J, Barthlott T, Chappaz S, Nitta T, Dooley J, Nogales-Cadenas R, Takahama Y, Finke D, Liston A, Blazar BR, Pascual-Montano A, Holländer GA. MicroRNAs Control the Maintenance of Thymic Epithelia and Their Competence for T Lineage Commitment and Thymocyte Selection. J Immunol, 189, 3894-3904, 2012.
- Roberts NA, White AJ, Jenkinson WE, Turchinovich G, Nakamura K, Withers DR, McConnell FM, Desanti GE, Benezech C, Parnell SM, Cunningham AF, Paolino M, Penninger JM, Simon AK, Nitta T, Ohigashi I, Takahama Y, Caamano JH, Hayday AC, Lane PJ, Jenkinson EJ, Anderson G. Rank Signaling Links the Development of Invariant γδ T Cell Progenitors and Aire+ Medullary Epithelium. Immunity, 36, 427-437, 2012.
- Ishimaru N, Yamada A, Nitta T, Arakaki R, Lipp M, Takahama Y, Hayashi Y. CCR7 with S1P1 signaling through AP-1 for migration of Foxp3+ regulatory T-cells controls autoimmune exocrinopathy. Am J Pathol, 180:199-208, 2012.
- *Ohigashi I, *Nitta T, Lkhagvasuren E, Yasuda H, Takahama Y. Effects of RANKL on the thymic medulla. Eur J Immunol 41, 1822-1827, 2011. (*, equal contribution)
- Mat Ripen A, Nitta T, Murata S, Tanaka K, Takahama Y. Ontogeny of thymic cortical epithelial cells expressing thymoproteasome subunit 5t. Eur J Immunol, 41, 1278-1287, 2011.
- Lei Y, Mat Ripen A, Ishimaru N, Ohigashi I, Nagasawa T, Jeker LT, Bösl MR, Holländer GA, Hayashi Y, de Waal Malefyt R, Nitta T, Takahama Y. Aire-dependent production of XCL1 mediates medullary accumulation of thymic dendritic cells and contributes to regulatory T cell development. J Exp Med, 208, 383-394, 2011.
- Yamano T, Watanabe S, Hasegawa H, Suzuki T, Abe R, Tahara H, Nitta T, Ishimaru N, Sprent J, Kishimoto H. Ex-vivo expanded DC induce donor-specific central and peripheral tolerance and prolong the acceptance of donor skin allografts. Blood, 117, 2640-2648, 2011.
- Nitta T, Ohigashi I, Nakagawa Y, Takahama Y. Cytokine crosstalk for thymic medulla formation. Curr Opin Immunol, 23, 190-197, 2011.
- White AJ, Nakamura K, Jenkinson WE, Saini M, Sinclair C, Seddon B, Narendran P, Pfeffer K, Nitta T, Takahama Y, Caamano JH, Lane PJL, Jenkinson EJ, Anderson G. Lymphotoxin signals from positively selected thymocytes regulate the terminal differentiation of medullary thymic epithelial cells. J Immunol, 185, 4769-4776, 2010.
- Hidaka K, Nitta T, Sugawa R, Schwartz RJ, Amagai T, Nitta S, Takahama Y, Morisaki T. Differentiation of Pharyngeal Endoderm from Mouse Embryonic Stem Cells. Stem Cells Dev, 19, 1735-1743, 2010.
- Takahama Y, Nitta T, Mat Ripen A, Nitta S, Murata S, Tanaka K. Role of thymic-cortex-specific self-peptides in positive selection of T cells. Semin Immunol 22, 287-293, 2010.
- Nitta T, Murata S, Sasaki K, Fujii H, Mat Ripen A, Ishimaru N, Koyasu S, Tanaka K, Takahama Y. Thymoproteasome shapes immunocompetent repertoire of CD8+ T cells. Immunity 32, 29-40, 2010.
- Tosa N, Iwai A, Tanaka T, Kumagai T, Nitta T, Chiba S, Maeda M, Takahama Y, Uede T, Miyazaki T. Critical function of death-associated protein 3 in T cell receptor-mediated apoptosis induction. Biochem Biophys Res Commun 395, 356-360, 2010.
- Ishimaru N, Nitta T, Arakaki R, Yamada A, Lipp M, Takahama Y, Hayashi Y. In situ Patrolling of Regulatory T cells is Essential for Protecting Autoimmune Exocrinopathy. PLoS One 5, e8588, 2010.
- Nitta T, Nitta S, Lei Y, Lipp M, Takahama Y. CCR7-mediated migration of developing thymocytes to the medulla is essential for negative selection to tissue-restricted antigens. Proc Natl Acad Sci USA 106, 17129-17133, 2009.
- Nitta T, Takahama Y. Towards understanding how immune system establishes a diverse yet self-tolerant T-cell repertoire: stepwise roles of thymic microenvironments. Systems Biology: Challenge of Complexity. eds. Nakanishi S, Kageyama R, Watanabe D. Springer Tokyo, 71-82, 2009.
- Nitta T, Murata S, Ueno T, Tanaka K, Takahama Y. Thymic microenvironments for T-cell repertoire formation. Adv Immunol 99, 59-94, 2008.
- *Hikosaka Y, *Nitta T, Ohigashi I, Yano K, Ishimaru N, Hayashi Y, Matsumoto M, Matsuo K, Penninger JM, Takayanagi H, Yokota Y, Yamada H, Yoshikai Y, Inoue J, Akiyama T, Takahama Y. The cytokine RANKL produced by positively selected thymocytes fosters medullary thymic epithelial cells that express autoimmune regulator. Immunity 29, 438-450, 2008. (*, equal contribution)
- Akiyama T, Shimo Y, Yanai H, Qin J, Ohshima D, Maruyama Y, Asaumi Y, Kitazawa J, Takayanagi H, Penninger JM, Matsumoto M, Nitta T, Takahama Y, Inoue J. The tumor necrosis factor family receptors RANK and CD40 cooperatively establish the thymic medullary microenvironment and self-tolerance. Immunity 29, 423-437, 2008.
- Irla M, Hugues S, Gill J, Nitta T, Hikosaka Y, Williams IR, Hubert FX, Scott HS, Takahama Y, Hollander GA, Reith W. Autoantigen-specific interactions with CD4+ thymocytes control mature medullary thymic epithelial cell cellularity. Immunity 29, 451-463, 2008.
- Nitta T, Takahama Y. The lymphocyte guard-IANs: regulation of lymphocyte survival by IAN/GIMAP family proteins. Trends Immunol 28, 58-65, 2007.
- Nitta T, Nasreen M, Seike T, Goji A, Ohigashi I, Miyazaki T, Ohta T, Kanno M, Takahama Y. IAN family critically regulates survival and development of T lymphocytes. PLoS Biology 4(4):e103, 2006.
- Ueno T, Liu C, Nitta T, Takahama Y. Development of T-lymphocytes in mouse fetal thymus organ culture. Methods Mol Biol 290, 117-133, 2005.
- Liu C, Ueno T, Kuse S, Saito F, Nitta, T., Piali L, Nakano H, Kakiuchi T, Lipp M, Hollander GA, Takahama Y. The role of CCL21 in recruitment of T-precursor cells to fetal thymi. Blood 105, 31-39, 2005.
- Nitta T, Chiba A, Yamamoto N, Yamaoka S. Lack of cytotoxic property in a variant of Epstein-Barr virus latent membrane protein 1 isolated from nasopharyngeal carcinoma. Cell Signal 16:1071-1081, 2004.
- Nitta T, Chiba A, Yamashita A, Rowe M, Israel A, Reth M, Yamamoto N, Yamaoka, S. NF-B is required for cell death induction by latent membrane protein 1 of Epstein-Barr virus. Cell Signal 15, 423-433, 2003.
- Saito N, Courtois G, Chiba A, Yamamoto N, Nitta T, Hironaka N, Rowe M, Yamamoto N, Yamaoka S. Two carboxyl-terminal activation regions of Epstein-Barr virus latent membrane protein 1 activate NF-B through distinct signaling pathways in fibroblast cell lines. J Biol Chem 278, 46565-46575, 2003.
- Nitta T, Igarashi K, Yamamoto N. Polyamine depletion induces apoptosis through mitochondria-mediated pathway. Exp Cell Res 276, 120-128, 2002.
- Nitta T, Igarashi K, Yamashita A, Yamamoto M, Yamamoto N. Involvement of polyamines in B cell receptor-mediated apoptosis: spermine functions as a negative modulator. Exp Cell Res 265, 174-183, 2001.
- Nitta T, Nagamitsu H, Murata M, Izu H, Yamada M. Function of the sigma(E) regulon in dead-cell lysis in stationary-phase Escherichia coli. J Bacteriol 182, 5231-5237, 2000.
- Yamada M, Talukder AA, Nitta T. Characterization of the ssnA gene, which is involved in the decline of cell viability at the beginning of stationary phase in Escherichia coli. J Bacteriol 181, 1838-1846, 1999.
- Yamada M, Izu H, Nitta T, Kurihara K, Sakurai T. High-temperature, nonradioactive primer extension assay for determination of a transcription-initiation site. Biotechniques 25, 72-74, 1998.
- Talukder AA, Yanai S, Nitta T, Kato A, Yamada M. RpoS-dependent regulation of genes expressed at late stationary phase in Escherichia coli. FEBS Lett 386, 117-180, 1996.
② 和文(総説)
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- Matsui N, Nitta T, Takahama Y. Development of the thymus and immune system. Brain Nerve, 63, 679-684, 2011.
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