新田研究室

室龍之介 業績

    ① 英文（原著・総説・著書）
  1. Muro R, Nitta T. It's Time to Unite: Diversity and Coordination of Thymic Stromal Cells for T Cell Selection and Organ Integrity. Immunol Rev, 332(1):e70040. 2025 Jul doi: 10.1111/imr.70040
  2. Muro R, Nitta T, Nitta S, Tsukasaki M, Asano T, Nakano K, Okamura T, Nakashima T, Okamoto K, Takayanagi H. Transcript splicing optimizes the thymic self-antigen repertoire to suppress autoimmunity. J Clin Invest, 134(20):e179612, 2024 Oct 15,doi: 10.1172/JCI179612.
  3. Nakamura K, Tsukasaki M, Tsunematsu T, Yan M, Ando Y, Nam Huynh CN, Hashimoto K, Gou Q, Muro R, Itabashi A, Iguchi T, Okamoto K, Nakamura T, Nakano K, Okamura T, Ueno T, Ito K, Ishimaru N, Hoshi K, Takayanagi H. The periosteum provides a stromal defence against cancer invasion into the bone. Nature 2024 Oct;634(8033):474-481. doi: 10.1038/s41586-024-07822-1. Epub 2024 Aug 21. PMID: 39169177.
  4. Huynh NC, Ling R, Komagamine M, Shi T, Tsukasaki M, Matsuda K, Okamoto K, Asano T, Muro R, Pluemsakunthai W, Kollias G, Kaneko Y, Takeuchi T, Tanaka S, Komatsu N, Takayanagi H. Oncostatin M-driven macrophage-fibroblast circuits as a drug target in autoimmune arthritis. Inflamm Regen. 44, 36, 2024. doi: 10.1186/s41232-024-00347-0.
  5. Ota A, Iguchi T, Nitta S, Muro R, Mino N, Tsukasaki M, Penninger JM, Nitta T, Takayanagi H. Synchronized development of thymic eosinophils and thymocytes. Int Immunol. dxae037, 2024. doi: 10.1093/intimm/dxae037.
  6. Ando Y, Tsukasaki M, Huynh NC, Zang S, Yan M, Muro R, Nakamura K, Komagamine M, Komatsu N, Okamoto K, Nakano K, Okamura T, Yamaguchi A, Ishihara K, Takayanagi H. The neutrophil-osteogenic cell axis promotes bone destruction in periodontitis. Int J Oral Sci. 16, 18, 2024. doi: 10.1038/s41368-023-00275-8.
  7. Yan M, Tsukasaki M, Muro R, Ando Y, Nakamura K, Komatsu N, Nitta T, Okamura T, Okamoto K, Takayanagi H. Identification of an intronic enhancer regulating RANKL expression in osteocytic cells. Bone Res 11, 43, 2023. doi: 10.1038/s41413-023-00277-6.
  8. Muro R, Narita T, Nitta T, Takayanagi H. Spleen tyrosine kinase mediates the γδTCR signaling required for γδT cell commitment and γδT17 differentiation. Front Immunol 13, 1045881, 2023. doi: 10.3389/fimmu.2022.1045881.
  9. Yan M, Komatsu N, Muro R, Huynh NC, Tomofuji Y, Okada Y, Suzuki HI, Takaba H, Kitazawa R, Kitazawa S, Pluemsakunthai W, Mitsui Y, Satoh T, Okamura T, Nitta T, Im SH, Kim CJ, Kollias G, Tanaka S, Okamoto K, Tsukasaki M, Takayanagi H. ETS1 governs pathological tissue-remodeling programs in disease-associated fibroblasts. Nat Immunol, 23, 1330-1341, 2022. doi: 10.1038/s41590-022-01285-0.
  10. Tsukasaki M, Komatsu N, Negishi-Koga T, Huynh NC, Muro R, Ando Y, Seki Y, Terashima A, Pluemsakunthai W, Nitta T, Nakamura T, Nakashima T, Ohba S, Akiyama H, Okamoto K, Baron R, Takayanagi H. Periosteal stem cells control growth plate stem cells during postnatal skeletal growth. Nat Commun, 13, 4166, 2022. doi: 10.1038/s41467-022-31592-x.
  11. Mino N, Muro R, Ota A, Nitta S, Lefebvre V, Nitta T, Fujio K, Takayanagi H. The transcription factor Sox4 is required for thymic tuft cell development. Int Immunol, 34, 45-52, 2022. doi: 10.1093/intimm/dxab098.
  12. Nitta T, Ota A, Iguchi T, Muro R, Takayanagi H. The fibroblast: An emerging key player in thymic T cell selection. Immunol Rev. 302, 68-85, 2021. doi: 10.1111/imr.12985.
  13. Murata M, Nakamura K, Kosaka T, Ota N, Osawa A, Muro R, Fujiyama K, Oshima T, Mori H, Wanner BL, Yamada M. Cell Lysis Directed by SulA in Response to DNA Damage in Escherichia coli. Int J Mol Sci. 22, 4535, 2021. doi: 10.3390/ijms22094535.
  14. Tsukasaki M, Huynh NC, Okamoto K, Muro R, Terashima A, Kurikawa Y, Komatsu N, Pluemsakunthai W, Nitta T, Abe T, Kiyonari H, Okamura T, Sakai M, Matsukawa T, Matsumoto M, Kobayashi Y, Penninger JM, Takayanagi H. Stepwise cell fate decision pathways during osteoclastogenesis at single-cell resolution. Nat Metab, 2, 1382-1390, 2020. doi: 10.1038/s42255-020-00318-y.
  15. Tsukasaki M, Asano T, Muro R, Huynh NC, Komatsu N, Okamoto K, Nakano K, Okamura T, Nitta T, Takayanagi H. OPG Production Matters Where It Happened. Cell Rep. 32, 108124, 2020. doi: 10.1016/j.celrep.2020.108124.
  16. Nitta T, Tsutsumi M, Nitta S, Muro R, Suzuki EC, Nakano K, Tomofuji Y, Sawa S, Okamura T, Penninger JM, Takayanagi H. Fibroblasts as a source of self-antigens for central immune tolerance. Nat Immunol. 21, 1172-1180, 2020. doi: 10.1038/s41590-020-0756-8.
  17. Muro R, Takayanagi H, Nitta T. Retroviral Gene Transduction into T Cell Progenitors for Analysis of T Cell Development in the Thymus. Methods Mol Biol. 2111, 193-203, 2020. doi: 10.1007/978-1-0716-0266-9_16.
  18. Asano T, Okamoto K, Nakai Y, Tsutsumi M, Muro R, Suematsu A, Hashimoto K, Okamura T, Ehata S, Nitta T, Takayanagi H. Soluble RANKL is physiologically dispensable but accelerates tumour metastasis to bone. Nat Metab. 1, 868-875, 2019. doi: 10.1038/s42255-019-0104-1.
  19. Muro R, Takayanagi H, Nitta T. T cell receptor signaling for γδT cell development. Inflamm Regen. 39, 6, 2019. doi: 10.1186/s41232-019-0095-z.
  20. Inoue M, Okamoto K, Terashima A, Nitta T, Muro R, Negishi-Koga T, Kitamura T, Nakashima T, Takayanagi H. Arginine methylation controls the strength of γc-family cytokine signaling in T cell maintenance. Nat Immunol. 19, 1265-1276, 2018. doi: 10.1038/s41590-018-0222-z.
  21. Muro R, Nitta T, Kitajima M, Okada T, Suzuki H. Rasal3-mediated T cell survival is essential for inflammatory responses. Biochem Biophys Res Commun. 496, 25-30, 2018. doi: 10.1016/j.bbrc.2017.12.159.
  22. Muro R, Nitta T, Nakano K, Okamura T, Takayanagi H, Suzuki H. γδTCR recruits the Syk/PI3K axis to drive proinflammatory differentiation program. J Clin Invest. 128, 415-426, 2018. doi: 10.1172/JCI95837.
  23. Nitta T, Kochi Y, Muro R, Tomofuji Y, Okamura T, Murata S, Suzuki H, Sumida T, Yamamoto K, Takayanagi H. Human thymoproteasome variations influence CD8 T cell selection. Sci Immunol. 2, eaan5165, 2017. doi: 10.1126/sciimmunol.aan5165.
  24. Takikita S, Muro R, Takai T, Otsubo T, Kawamura YI, Dohi T, Oda H, Kitajima M, Oshima K, Hattori M, Endo TA, Toyoda T, Weis J, Shinkai Y, Suzuki H. A Histone Methyltransferase ESET Is Critical for T Cell Development. J Immunol. 197, 2269-79. 2016. doi: 10.4049/jimmunol.1502486.
  25. Muro R, Nitta T, Okada T, Ideta H, Tsubata T, Suzuki H. The Ras GTPase-activating protein Rasal3 supports survival of naive T cells. PLoS One. 10, e0119898, 2015. doi: 10.1371/journal.pone.0119898.
  26. Nitta T, Muro R, Shimizu Y, Nitta S, Oda H, Ohte Y, Goto M, Yanobu-Takanashi R, Narita T, Takayanagi H, Yasuda H, Okamura T, Murata S, Suzuki H. The thymic cortical epithelium determines the TCR repertoire of IL-17-producing γδT cells. EMBO Rep. 16, 638-53. 2015. doi: 10.15252/embr.201540096.
    ② 和文（総説）
  1. 室龍之介、新田　剛「T細胞による自己・非自己認識の相剋 – ゆらぐ自己、曖昧な自己」医学のあゆみ 291(12,13):1142-1146, 2024
  2. 室　龍之介、新田　剛「γδT細胞の分化制御機構」炎症と免疫 80(3): 266-272, 2023
  3. 室　龍之介、美野　名波、高柳　広「中枢性免疫寛容と自己抗原多様化機構」実験医学　40(15): 2408-2415, 2022
  4. 室　龍之介、新田　剛「胸腺ストロマ細胞による中枢性免疫寛容の制御」感染・炎症・免疫 52(2): 25-36, 2022
  5. 室　龍之介、新田　剛「胸腺線維芽細胞と中枢性免疫寛容」臨床免疫・アレルギー科 75 (5): 590-596, 2021
  6. 室　龍之介、新田　剛「γδT細胞の新たな機能」炎症と免疫 29 (4): 26-30, 2021
  7. 室龍之介、新田　剛「胸腺線維芽細胞と中枢性免疫寛容」臨床免疫・アレルギー科 75 (5): 590-596, 2021
  8. 室龍之介、新田　剛「γδT細胞の新たな機能」炎症と免疫 29 (4): 26-30, 2021
  9. 室　龍之介、新田　剛「チロシンキナーゼによるT細胞の分化制御」日本応用酵素協会誌 55, 11-18, 2020
  10. 室　龍之介、高柳　広「骨免疫学：創成から応用へ」医学のあゆみ　275 (2): 215-221, 2020
  11. 室　龍之介、新田　剛「胸腺プロテアソームと自己ペプチド」臨床免疫・アレルギー科 74,1-7,2020
  12. 室龍之介、新田　剛「胸腺プロテアソームの機能と遺伝的多様性」臨床免疫・アレルギー科 72,691-696,2019
  13. 室龍之介、新田　剛「胸腺皮質上皮細胞によるT細胞レパトア制御」臨床免疫・アレルギー科 65,191-194,2016
    ③ 和文（著書）
  1. 室　龍之介、高柳　広「基礎免疫学」臨床基礎研究につながる分子生物学 クリニコ出版 （2024/2/20）ISBN-13: 978-4910396408