Reproductive and Developmental Toxicities of Environmental Chemicals

In 1996, 2-bromopropane, which was introduced to workplaces as an alternative to ozone-depleting solvents, was revealed to induce amenorrhea, oligozoospermia and aplastic anemia in male and female workers. A new alternative, 1-bromopropane, the isomer of 2-bromopropaen was introduced replacing 2-bromopropane, but 1-bromopropane was also revealed to be toxic to reproductive systems, but its mechanism was different from that of 2-bromopropane.