研究業績

研究業績

原著論文

2019年以降

  1. Tai Y., Sakaida Y., Kawasaki R., Kanemaru K., Akimoto K.,Brombacher F., Ogawa S., Nakamura Y., Harada Y. Foxp3 and Bcl6 deficiency synergistically induces spontaneous development of atopic dermatitis-like skin disease. Int. Immunol. 35, 423-435 (2023)
  2. Haan KD., Park SJ., Nakamura Y., Fukami K., Fisher TE.* Osmotically evoked PLCδ1-dependent translocation of ΔN-TRPV1 channels in rat supraoptic neurons. iScience. 26, 106258(2023)
  3. Miyazaki M., Nakabo A., Nagano Y., Nagamura Y., Yanagihara K., Ohki R., Nakamura Y., Fukami K., Kawamoto J., Umayahara K., Sakamoto M., Iwaya K., Yamaguchi H*. Tissue factor-induced fibrinogenesis mediates cancer cell clustering and multiclonal peritoneal metastasis. Cancer Lett. 553, 215983 (2023)
  4. Kanemaru K., Shimozawa M., Kitamata M., Furuishi R., Kayano H., Sukawa Y., Chiba Y., Fukuyama T., Hasegawa J., Nakanishi H., Kishimoto T., Tsujita K., Tanaka K., Itoh T., Sasaki J., Sasaki T., Fukami K*., Nakamura Y*. Plasma membrane phosphatidylinositol (4,5)-bisphosphate is critical for determination of epithelial characteristics. Nat. Commun. 13, 2347 (2022)
  5. Tsujita K*, Satow R, Asada S, Nakamura Y, Arnes L, Sako K, Fujita Y, Fukami K, and Itoh T, Homeostatic membrane tension constrains cancer cell dissemination by counteracting BAR protein assembly. Nat. Commun. 12, 5930 (2021)
  6. Park SJ, Haan K, Nakamura Y, Fukami K, Fisher TE*.PLCδ1 plays central roles in the osmotic activation of ΔN-TRPV1 channels in mouse supraoptic neurons and in murine osmoregulation. J. Neurosci. 41,3579-3587 (2021)
  7. Nakamura Y*, Kanemaru K, Shoji M, Totoki K, Nakamura K, Nakaminami H, Nakase K, Noguchi N, Fukami K*. Phosphatidylinositol-specific phospholipase C enhances epidermal penetration by Staphylococcus aureus Sci. Rep. 10,17845 (2020)
  8. Yoneda A#, Kanemaru K#, Matsubara A, Takai E, Shimozawa M, Satow R, Yamaguchi H, Nakamura Y, Fukami K*. Phosphatidylinositol 4,5-bisphosphate is localized in the plasma membrane outer leaflet and regulates cell adhesion and motility. Biochem. Biophys. Res. Commun.527,1050-1056 (2020)
  9. Kobayashi I*, Kondo M, Yamamori S, Kobayashi-Sun J, Taniguchi M, Kanemaru K, Katakura F, Traver D. Enrichment of hematopoietic stem/progenitor cells in the zebrafish kidney. Sci. Rep. 9,1420 (2019)
  10. Fukuyama T#, Nakamura Y*,#, Kanemaru K, Toyoda C, Jang HJ, Suh PG, Fukami K*. Phospholipase Cγ1 is required for normal irritant contact dermatitis responses and sebaceous gland homeostasis. Exp. Dermatol. 28, 1051-1057 (2019)
  11. Shiratori K#, Kanemaru K#, Ogura T, Nakajima A, Sugizaki Y, Fukuyama T, Iwakura Y, Nakamura Y*, Fukami K*. Epidermal loss of phospholipase Cδ1 attenuates irritant contact dermatitis. Biochem. Biophys. Res. Commun. 511, 330-335 (2019)

2018年以前

  1. Kanemaru K.#, Nakamura Y.#,*, Totoki K., Fukuyama T., Shoji M., Kaneko H., Shiratori K., Yoneda A., Inoue T., Iwakura Y., Kabashima K., Fukami K.* Phospholipase Cδ1 regulates p38 MAPK activity and skin barrier integrity. Cell Death Differ. 24, 1079-1090 (2017)
  2. Kudo K., Uchida T., Sawada M., Nakamura Y., Yoneda A., Fukami K.* Phospholipase C δ1 in macrophages negatively regulates TLR4-induced proinflammatory cytokine production and Fcγ receptor-mediated phagocytosis. Adv. Biol. Regul. 61, 68-79 (2016)
  3. Kanemaru K., Matsuyuki A., Nakamura Y.*, Fukami K. Obesity exacerbates imiquimod-induced psoriasis-like epidermal hyperplasia and interleukin-17 and interleukin-22 production in mice. Exp. Dermatol. 24, 436-442 (2015)
  4. Nakamura Y., Kanemaru K., Kojima R., Hashimoto Y., Marunouchi T., Oka N., Ogura T., Tanonaka K., Fukami K.* Simultaneous loss of phospholipase Cδ1 and phospholipase Cδ3 causes cardiomyocyte apoptosis and cardiomyopathy. Cell Death Dis. 5, e1215 (2014)
  5. Staats KA., Van Helleputte L., Jones AR., Bento-Abreu A., Van Hoecke A., Shatunov A., Simpson CL., Lemmens R., Jaspers T., Fukami K., Nakamura Y., Brown RH Jr., Van Damme P., Liston A., Robberecht W., Al-Chalabi A., Van Den Bosch L*. Genetic ablation of phospholipase C delta 1 increases survival in SOD1G93A mice. Neurobiol. Dis. 60C, 11-17 (2013)
  6. Kanemaru K.#, Nakamura Y.#,*, Sato K., Kojima R., Takahashi S., Yamaguchi M., Ichinohe M., Kiyonari H., Shioi G., Kabashima K., Nakahigashi K., Asagiri M., Jamora C., Yamaguchi H., Fukami K.* Epidermal phospholipase Cδ1 regulates granulocyte counts and systemic interleukin-17 levels in mice. Nat. Commun. 3, 963 (2012)
  7. Yamaguchi H., Yoshida S., Muroi E., Yoshida N., Kawamura M., Kouchi Z., Nakamura Y., Sakai R., and Fukami K. Phosphoinositide 3-kinase signaling pathway mediated by p110a regulates invadopodia formation. J. Cell Biol. 193, 1275-1288 (2011)
  8. Hirata M., Suzuki M., Ishii R., Satow R., Uchida T., Kitazumi T., Sasaki T., Kitamura T., Yamaguchi H., Nakamura Y., and Fukami K. Genetic defect in phospholipase Cd1 protects mice from obesity by regulating thermogenesis and adipogenesis. Diabetes. 60, 1926-1937 (2011)
  9. Kouchi Z., Igarashi T., Shibayama N., Inanobe S., Sakurai K., Yamaguchi H., Fukuda T., Yanagi S., Nakamura Y., and Fukami K. Phospholipase Cdelta3 regulates RhoA/Rho kinase signaling and neurite outgrowth. J. Biol. Chem. 286, 8459-8471 (2011)
  10. Kouchi Z., Fujiwara Y., Yamaguchi H., Nakamura Y., and Fukami K. Phosphatidylinositol 5-phosphate 4-kinase type II beta is required for vitamin D receptor-dependent E-cadherin expression in SW480 cells. Biochem. Biophys. Res. Commun. 408, 523-9 (2011)
  11. Sakurai K., Hirata M., Yamaguchi H., Nakamura Y., and Fukami K. Phospholipase Cd3 is a novel binding partner of Myosin VI and functions as anchoring of Myosin VI on plasma membrane. Advan. Enzyme Regul. 51, 171-81 (2011)
  12. Du F., Nakamura Y. (co-1st), Tan T.L., Lee P., Lee R., Yu B., and Jamora C. Expression of Snail in epidermal keratinocytes promotes cutaneous inflammation and hyperplasia conducive to tumor formation. Cancer Res. 70, 10080-10089 (2010)
  13. Yamaguchi H., Yoshida S., Muroi E., Kawamura M., Kouchi Z., Nakamura Y., Sakai R., and Fukami K. Phosphatidylinositol 4,5-bisphosphate and PIP5-kinase Ia are required for invadopodia formation in human breast cancer cells. Cancer Sci. 101, 1632-8 (2010)
  14. Kanemaru K., Nakahara M., Nakamura Y., Hashiguchi Y., Kouchi Z., Yamaguchi H., Oshima N., Kiyonari H., Fukami K. Phospholipase C-eta2 is highly expressed in the habenula and retina. Gene Expr. Patterns. 10, 119-126 (2010)
  15. Yamaguchi H., Takeo Y., Yoshida S., Kouchi Z., Nakamura Y., and Fukami K. Lipid rafts and caveolin-1 are required for invadopodia formation and extracellular matrix degradation by human breast cancer cells.  Cancer Res. 69, 8594-8602 (2009)
  16. Nakamura Y., Ichinohe M., Hirata M., Matsuura H., Fujiwara T., Igarashi T., Nakahara M., Yamaguchi H., Yasugi S., Takenawa T., and Fukami K. Phospholipase C-d1 is an essential molecule downstream of Foxn1, the gene responsible for the nude mutation, in normal hair development. FASEB J. 22, 841-849 (2008)
  17. Runkel1 F., Aubin I., Bussow H., Fukami K., Nakamura Y., Simon-Chazottes D., Guénet J-L., and Franz T. Alopecia and male infertility in oligotriche mutant mice are caused by a deletion on distal chromosome 9., Mamm. Genome 19, 691-702 (2008)
  18. Ichinohe M., Nakamura Y., Sai K., Nakahara M., Yamaguchi H., and Fukami K. Lack of phospholipase C-delta1 induces skin inflammation. Biochem. Biophys. Res. Commun. 356, 912-918 (2007)
  19. Nakamura Y., Hamada Y., Fujiwara T., Enomoto H., Hiroe T., Tanaka S., Nose M., Nakahara M., Yoshida N., Takenawa T., and Fukami K. Phospholipase Cd1 and d3 Are Essential in Trophoblast for Placental Development. Mol. Cell. Biol. 25, 10979-10988 (2005)
  20. Irino Y., Ichinohe M., Nakamura Y., Nakahara M., and Fukami K. Phospholipase Cd4 associates with glutamate receptor interacting protein1 in testis. J. Biochem. 138, 451-6 (2005)
  21. Nakahara M., Shimozawa M., Nakamura Y., Irino Y., Morita M., Kudo Y., and Fukami K. A novel phospholipase C, PLCh2, is a neuron-specific isozyme. J. Biol. Chem. 280, 29128-34 (2005)
  22. Kouchi Z., Shikano T., Nakamura Y., Shirakawa H., Fukami K., and Miyazaki S. The role of EF-hand domains and C2 domain in regulation of enzymatic activity of phospholipase Czeta. J. Biol. Chem. 280, 21015-21 (2005)
  23. Kouchi Z., Fukami K., Shikano T., Oda S., Nakamura Y., Takenawa T., and Miyazaki S. Recombinant Phospholipase Cz Has High Ca2+ Sensitivity and Induces Ca2+ Oscillations in Mouse Eggs. J. Biol. Chem. 279, 10408-12 (2004)
  24. Irino Y., Cho H., Nakamura Y., Nakahara M., Furutani M., Suh P.G., Takenawa T., and Fukami K. Phospholipase C delta-type consists of three isozymes: bovine PLCdelta2 is a homologue of human/mouse PLCdelta4. Biochem. Biophys. Res. Commun. 320(2), 537-43 (2004)
  25. Takenaka K., Fukami K., Otsuki M., Nakamura Y., Kataoka Y., Wada M., Tsuji K., Nishikawa S., Yoshida N., and Takenawa T. Role of phospholipase C-l2, a novel phospholipase C-like protein that lacks lipase activity, in B-cell receptor signaling. Mol. Cell. Biol. 23, 7329-38 (2003)
  26. Nakamura Y., Fukami K., Yu H., Takenaka K., Kataoka Y., Shirakata Y., Nishikawa S., Hashimoto K., Yoshida N., and Takenawa T. Phospholipase Cd1 is required for skin stem cell lineage commitment. EMBO J. 22, 2981-2991 (2003)

総説等

英文

  1. Kanemaru K., Nakamura Y. Activation Mechanisms and Diverse Functions of Mammalian Phospholipase C. Biomolecules, 13, 915 (2023)
  2. Nakamura Y. Phospholipid signaling, lipase. Plasma Membrane ShapingELSEVIER). Chapter 8 (2022)
  3. Nakamura Y., and Fukami K. Regulation and physiological functions of mammalian phospholipase C. J. Biochem. 161, 315-321 (2017)
  4. Fukami, K., and Nakamura, Y. The role of phospholipase C isozymes in cellular homeostasis. Phospholipases in Health and Disease 10,201-210 (2014)
  5. Nakamura Y., Kanemaru K., and Fukami K. Physiological functions of Phospholipase Cd1 and d3. Adv. Biol. Regul. 53,356-362 (2013)
  6. Fukami K., Inanobe S., Kanemaru K., and Nakamura Y. Phospholipase C is a key enzyme regulating intracellular calcium and modulating balance of phosphoinositides. Prog. Lipid Res. 49, 366-377 (2010)
  7. Nakamura Y., and Fukami, K. Roles of phospholipase C isozymes in organogenesis and embryonic development. Physiology. 24, 332-341 (2009)
  8. Fukami K., Inoue T.,, Kurokawa M., Fissore R.A., Nakao K., Nakamura Y., Takenaka K., Yoshida N., Mikoshiba K., and Takenawa T. Phospholipase Cδ4: from genome structure to physiological function. Advan. Enzyme Regul. 43, 87-106 (2003)

和文

  1. 金丸佳織中村由和「炎症性皮膚疾患とイノシトールリン脂質代謝」〜治療標的がみえてきた脂質疾患学がん、不妊症、免疫・神経・皮膚・代謝性疾患のメカニズムから臨床検体による診断、層別化まで〜、羊土社、41195-201 (2023)
  2. 中村由和「ホスホイノシタイド代謝によるがん化の制御」、The Lipidi いま脂質がおもしろい 〜若手研究者による最新の脂質研究~、31、53-57 (2020)
  3. 中村由和、深見希代子「ホスフォリパーゼ C によるイノシトールリン脂質代謝と疾患の制御」、医学のあゆみ 脂質クオリティ  研究の基礎と臨床、269、1029-1034 (2019)
  4. 中村由和 「総説:ホスホリパーゼCの活性化機構と生理機能」、生化学、日本生化学会 日本生化学会奨励賞受賞総説 189-198 (2017)
  5. 中村由和金丸佳織、深見希代子 「炎症性皮膚疾患とイノシトールリン脂質代謝系」、実験医学増刊 脂質疾患学、羊土社、126-132 (2015)
  6. 中村由和、深見希代子 「ホスホリパーゼC」、疾患モデルの作製と利用-脂質代謝異常と関連疾患、エル・アイ・シー、下巻271-282 (2015)
  7. 金丸佳織中村由和、深見希代子 「ミニレビュー:表皮におけるイノシトールリン脂質代謝の役割」、生化学、日本生化学会、255-258 (2014)
  8. 深見希代子、中村由和 「ホスホリパーゼC (PLC)による恒常性維持機構とその破綻がもたらす疾病」、医学のあゆみ「生命を支える脂質 最新の研究と臨床」、医歯薬出版、1051-1058 (2014)
  9. 中村由和、深見希代子 「遺伝子改変マウスの表現型より示されるホスホリパーゼCの生理的役割」、実験医学増刊 分子から個体へと深化する脂質生物学、羊土社、126-132 (2010)
  10. 中村由和、深見希代子 「ミニレビュー:ホスホリパーゼCdタイプの生理機能」、生化学、 日本生化学会、1431-1435 (2005)
  11. 中村由和、深見希代子 「ホスホリパーゼCの調節機構と生理機能」、実験医学増刊 ダイナミックに新展開する脂質研究、羊土社、933-939 (2005)
  12. 深見希代子、中村由和 「イノシトールリン脂質代謝酵素の生理的重要性」、東京医科大学雑誌、9-18 (2004)