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八代拓也

学位; 博士(農学)  

出身; 埼玉県久喜市 

学歴・職歴
2002〜2006   明治大学 農学部 生命科学科
2006~2008   東京大学大学院 農学生命科学研究科 
                応用生命化学専攻 修士課程
2008~2011   東京大学大学院 農学生命科学研究科 
                応用生命化学専攻 博士課程
(2009~2011   日本学術振興会特別研究員DC2)
2011~2013   順天堂大学大学院 医学研究科 
                アトピー疾患研究センター 博士研究員
2013~2015   東京理科大学 基礎工学部 生物工学科 博士研究員
(2013~2015   日本学術振興会特別研究員PD)
2015~      東京理科大学 基礎工学部 生物工学科 助教

原著論文:
23) Immunosuppressive effect of a non-proteinogenic amino acid from Streptomyces through inhibiting allogeneic T cell proliferation.
Yashiro T*, Sakata F*, Sekimoto T*, Shirai T, Hasebe F, Matsuda K, Kurosawa S, Suzuki S, Nagata K, Kasakura K, Nishiyama M, Nishiyama, C.
(*These authors contributed equally to this work.)
Biosci Biotechnol Biochem, in press.

22) A transcription factor PU.1 is critical for Ccl22 gene expression in dendritic cells and macrophages.
Yashiro T, Nakano S, Nomura K, Uchida Y, Kasakura K, Nishiyama, C.
Sci Rep, in press.

21) The transcription factors PU.1 and IRF4 determine dendritic cell-specific expression of RALDH2.
Yashiro T*, Yamaguchi M*, Watanuki Y, Kasakura K, Nishiyama, C.
(*These authors contributed equally to this work.)
J. Immunol, 201,pp3677-3682, 2018.

20) Intestinal anti-inflammatory activity of Perillaldehyde.
Uemura T*, Yashiro T*, Oda R*, Shioya N, Nakajima T, Hachisu M, Kobayashi S, Nishiyama C, Arimura G.
(*These authors contributed equally to this work.)
J. Agric. Food Chem., 66,pp3443-3448, 2018.

19) The effect of PU.1 knockdown on gene expression and function of mast cells.
Oda Y*, Kasakura K*, Fujigaki I, Kageyama A, Okumura K, Ogawa H, Yashiro T, Nishiyama C.
(*These authors contributed equally to this work.)
Sci. Rep., 8, 2005, 2018.

18) The nuclear orphan receptor NR4A3 is involved in the function of dendritic cells.
Nagaoka M*, Yashiro T*, Uchida Y, Ando T, Hara M, Arai H, Ogawa H, Okumura K, Kasakura K, Nishiyama C.
(*These authors contributed equally to this work.)
J. Immunol., 199,pp2958-2967, 2017.

17) Role of PU.1 expression as an inflammatory marker in experimental autoimmune uveoretinitis.
Umazume A, Kezuka T, Matsuda R, Usui Y, Takahashi H, Yamakawa N, Yashiro T, Nishiyama C, Goto R.
Ocul Immunol Inflamm. 26:pp951-963, 2018.

16) The hematopoietic cell-specific transcription factor PU.1 is critical for expression of CD11c.
Yashiro T*, Kasakura K*, Oda Y, Kitamura N, Inoue A, Nakamura S, Yokoyama H, Fukuyama K, Hara M, Ogawa H, Okumura K, Nishiyama M, Nishiyama C.
(*These authors contributed equally to this work.)
Int. Immunol., 29,pp87-94, 2017

15) Critical role of transcription factor PU.1 in the function of the OX40L/TNFSF4 promoter in dendritic cells..
Yashiro T, Hara M, Ogawa H, Okumura K, Nishiyama C.
Sci. Rep., 6, 34825, 2016

14) Role of PU.1 in MHC class II expression via CIITA transcription in plasmacytoid dendritic cells.
Miura R, Kasakura K, Nakano N, Hara M, Maeda K, Okumura K, Ogawa H, Yashiro T, Nishiyama C.
PLoS One, 11, e0154094, 2016

13) PU.1 suppresses Th2 cytokine expression via silencing GATA3 transcription in dendritic cells.
Yashiro T, Kubo M, Ogawa H, Okumura K, Nishiyama C.
PLoS One., 10, e0137699, 2015

12) Involvement of PU.1 in NFATc1 promoter function in osteoclast development.
Ishiyama K, Yashiro T, Nakano N, Kasakura K, Miura R, Hara M, Kawai F, Maeda K, Tamura N, Okumura K, Ogawa H, Takasaki Y, Nishiyama C.
Allergol. Int., 64,pp241-7, 2015

11) Critical Roles for PU.1, GATA1, and GATA2 in the expression of human FcεRI on mast cells: PU.1 and GATA1 transactivate FCER1A, and GATA2 transactivates FCER1A and MS4A2.
Inage E, Kasakura K, Yashiro T, Suzuki R, Baba Y, Nakano N, Hara M, Tanabe A, Oboki K, Matsumoto K, Saito H, Niyonsaba F, Ohtsuka Y, Ogawa H, Okumura K, Shimizu T, Nishiyama C.
J. Immunol., 192,pp3936-46, 2014

10) 5-Aminoimidazole-4-carboxamide ribonucleoside stabilizes low density lipoprotein receptor mRNA in hepatocytes via ERK-dependent HuR binding to an AU-rich element.
Yashiro T, Nanmoku M, Shimizu M, Inoue J, Sato R.
Atherosclerosis, 226, pp95-101, 2013

9) GATA2 is a critical transactivator for the human IL1RL1/ST2 promoter in mast cells/basophils: opposing roles for GATA2 and GATA1 in human IL1RL1/ST2 gene expression.
Baba Y*, Maeda K*, Yashiro T*, Inage E, Kasakura K, Suzuki R, Niyonsaba F, Hara M, Tanabe A, Ogawa H, Okumura K, Ohtsuka Y, Shimizu T, Nishiyama C. (*These authors contributed equally to this work.)
J. Biol. Chem., 287, pp32689-96, 2012

8) Involvement of PU.1 in mast cell/basophil-specific function of the human IL1RL1/ST2 promoter.
Baba Y, Maeda K, Yashiro T, Inage E, Niyonsaba F, Hara M, Suzuki R, Ohtsuka Y, Shimizu T, Ogawa H, Okumura K, Nishiyama C.
Allergol. Int., 61, pp461-7, 2012

7) Resveratrol increases the expression and activity of the low density lipoprotein receptor in hepatocytes by the proteolytic activation of the sterol regulatory element-binding proteins.
Yashiro T, Nanmoku M, Shimizu M, Inoue J, Sato R.
Atherosclerosis, 220, pp369-74, 2012

6) Role of PU.1 in MHC class II expression through transcriptional regulation of class II transactivator pI in dendritic cells.
Kitamura N, Yokoyama H, Yashiro T, Nakano N, Nishiyama M, Kanada S, Fukai T, Hara M, Ikeda S, Ogawa H, Okumura K, Nishiyama C.
J. Allergy Clin. Immunol., 129, pp814-24, 2012

5) Chenodeoxycholic acid stabilization of LDL receptor mRNA depends on 3'-untranslated region and AU-rich element-binding protein.
Yashiro T, Yokoi Y, Shimizu M, Inoue J, Sato R.
Biochem. Biophys. Res. Commun., 409, pp155-9, 2011

4) Stabilization of small heterodimer partner mRNA by grape seed procyanidins extract in cultured hepatocytes.
Inoue J, Tanaka M, Nanmoku M, Yashiro T, Sato R.
Mol. Nutr. Food Res., 55, pp1052-8, 2011

3) Quercetin enhances VDR activity, leading to stimulation of its target gene expression in Caco-2 cells.
Inoue J, Choi JM, Yoshidomi T, Yashiro T, Sato R.
J. Nutr. Sci. Vitaminol., 56, pp326-30, 2010

2) Effects of coumestrol on lipid and glucose metabolism as a farnesoid X receptor ligand.
Takahashi M, Kanayama T, Yashiro T, Kondo H, Murase T, Hase T, Tokimitsu I, Nishikawa J, Sato R.
Biochem. Biophys. Res. Commun., 372, pp395-9, 2008

1) Non-involvement of the human monocarboxylic acid transporter 1 (MCT1) in the transport of phenolic acid.
Watanabe H, Yashiro T, Tohjo Y, Konishi Y.
Biosci. Biotechnol. Biochem., 70, pp1928-33, 2006

大学HP(教員プロフィール)

http://www.tus.ac.jp/fac_grad/p/index.php?6b1c

Chiharu Nishiyama Laboratory
Department of Biological Science and Technology
Faculty of Industrial Science and Technology
Tokyo University of Science