HOME > PUBLICATIONS

                         2021年9月22日現在
(*; corresponding author)

2021

Nagata, K., Nagase, H., Okuzumi, A., and Nishiyama, C.*
Delta opioid receptor agonists ameliorate colonic inflammation by modulating immune responses.
Front. Immunol. 12:730706. 2021.

Nagata, K., and Nishiyama, C.*
IL-10 in mast cell-mediated immune responses: anti-inflammatory and proinflammatory roles.
Int. J. Mol. Sci. 22:4972. 2021.

Nishina, T., Deguchi, Y., Ohshima, D., Takeda, W., Ohtsuka, M., Shichino, S., Ueha, S., Yamazaki, S., Kawauchi, M., Nakamura, E., Nishiyama, C., Kojima, Y., Adachi-Akahane, S., Hasegawa, M., Nakayama, M., Oshima, M., Yagita, H., Shibuya, K., Mikami, T., Inohara, N., Matsushima, K., Tada, N., and Nakano, H.*
Interleukin-11-expressing fibroblasts have a unique gene signature correlated with poor prognosis of colorectal cancer.
Nat. Commun. 12:2281. 2021.

Yashiro, T.*, Yamamoto, M., Araumi, S., Hara, M., Yogo, K., Uchida, K., Kasakura, K., and Nishiyama, C.
PU.1 and IRF8 modulate activation of NLRP3 inflammasome via regulating its expression in huma macrophages.
Front. Immunol. 12:649572. 2021.

2020

Potaczek, D.P., Przytulska-Szczerbik, A., Bazan-Socha, S., Jurczyszyn, A., Okumura, K., Nishiyama, C., Undas, A., and Wypasek, E.*
(D.P.P. and A.P.-S. are contribute equal first authors.)
Elements of immunoglobulin E network associate with aortic valve area in patients with acquired aortic stenosis.
Biomedicines. 9:23. 2020.

Yashiro, T*, Yura, S., Tobita, A., Toyoda, Y., Kasakura, K., and Nishiyama, C.
Pterostilbene reduces colonic inflammation by suppressing dendritic cell activation and promoting regulatory T cell development.
FASEB J. 34:14810-14819. 2020.

Potaczek, D.P.*, Przytulska-Szczerbik, A., Bazan-Socha, S., Nastalek, M., Wojas-Pelc, A., Okumura, K., Nishiyama, C., Jurczyszyn, A., Undas, A., and Wypasek, E.*
(D.P.P. and A.P.-S. are contribute equal first authors.)
Interaction between functional polymorphisms in FCER1A and TLR2 and the severity of atopic dermetitis.
Human Immunol. 81:709-713. 2020.

Inaba, K., Yashiro, T., Hiroki, I., Watanabe, R., Kasakura, K. and Nishiyama, C.*
(K.I. and T.Y. are contribute equal first authors.)
Dual roles of PU.1 in the expression of PD-L2: Direct transactivation with IRF4 and indirect epigenetic regulation.
J. Immunol. 205:822-829. 2020.

Hagiwara, S., Nagata, K., Kasakura, K., Sakata, F., Kishino, S., Ogawa, J., Yashiro, T. and Nishiyama, C.*
The anti-inflammatory effect of the gut lactic acid bacteria-generated metabolite 10-oxo-cis-6,trans-11-octadecadienoic acid on monocytes.
Biochem. Biophys. Res. Commun. 530:342-347. 2020.

Yashiro, T.*, Takeuchi, H., Kasakura, K., and Nishiyama, C.
PU.1 regulates Ccr7 gene expression by binding to its promoter in naïve CD4+ T cells.
FEBS Open Bio, 10:1115-1121. 2020.

Uemura, T., Hachisu, M., Desaki, Y., Ito, A., Hoshino, R., Sano, Y., Nozawa, A., Mujiono, K., Galis, I., Yoshida, A., Nemoto, K., Miura, S., Nishiyama, M., Nishiyama, C., Horito, S., Sawasaki, T., and Arimura, G.*
Soy and Arabidopsis receptor-like kinases respond to polysaccharide signals from Spodoptera species and mediate hervivore resistance.
Commun. Biol. 3: 224. 2020.

Takeda, W., Nishina, T.*, Deguchi, Y., Kawauchi, M., Mikami, T., Yagita, H., Nishiyama, C., and Nakano, H.
Stromal fibroblasts produce interleukin 11 in the colon of TNBS-treated mice.
Toho J. Med. 6:111-120. 2020.

Shindo, R., Katagiri, T., Komazawa-Sakon, S., Ohmuraya, M., Takeda, W., Nakagawa, Y., Nakagata, N., Sakuma, T., Yamamoto, T., Nishiyama, C., Nishina, T., Yamazaki, S., Kameda, H., and Nakano, H.*
Regenerating islet-derived protein (Reg)3beta plays a crucial role in attenuation of ileitis and colitis in mice.
Biochem. Biophys. Rep. 21:100738. 2020.

Kasakura, K., Nagata, K., Miura, R., Iida, M., Nakaya, H., Okada, H., Arai, T., Arai, T., Kawakami, Y., Kawakami, T., Yashiro, T., and Nishiyama, C.*
Cooperative regulation of the mucosal mast cell-specific protease genes, Mcpt1 and Mcpt2, by GATA and Smad transcription factors.
J. Immunol. 204:1641-1649. 2020.

Nagata, K., Kasakura, K., Miura, R., Yashiro, T., and Nishiyama, C.*
Suppressive role of PPARgamma in the IgE-dependent activation of mast cells.
Int. Immunol. 32:143-150. 2020.

2019

Ueno, Y., Fujisaki, K., Hosoda, S., Amemiya, Y., Okazaki, S., Notsu, C., Nishiyama, C., Mabuchi, Y., Matsuzaki, Y., Oda, A., and Goitsuka, R.*
Transcription factor Tlx1 marks a subset of lymphoid tissue organizer-like mesenchymal progenitor cells in the neonatal spleen.
Sci. Rep. 9:20408. 2019.

Yashiro, T.*, Takeuchi, H., Nakamura, S., Tanabe, A., Hara, M., Uchida, K., Okumura, K., Kasakura, K., and Nishiyama, C.*
PU.1 plays a pivotal role in dendritic cell migration from the periphery to secondary lymphoid organs via regulating CCR7 expression.
FASEB J. 33:11481-11491. 2019.

Yashiro, T., Sakata, F., Sekimoto, T., Shirai, T., Hasebe, F., Matsuda, K., Kurosawa, S., Suzuki, S., Nagata, K., Kasakura, K., Nishiyama, M., and Nishiyama, C.*
(T.Y. F.S. and T.S. are contribute equal first authors.)
Immunosuppressive effect of a non-proteinogenic amino acid from Streptomyces through inhibiting allogeneic T cell proliferation.
Biosci. Biotechnol. Biochem. 83:1111-1116. 2019.

Yashiro, T., Nakano, S., Nomura, K., Uchida, Y., Kasakura, K., and Nishiyama, C.*
A transcription factor PU.1 is critical for Ccl22 gene expression in dendritic cells and macrophages.
Sci. Rep. 9:1161. 2019.

Ito, T., Egusa, C., Maeda, T., Numata, T. Nakano, N., Nishiyama, C., and Tsuboi, R.*
Stem cell factor suppressed IL-33-induced MHC class II expression in murine bone marrow-derived mast cells.
Allergol. Int. 68:254-267. 2019.

Piao, X., Miura, R., Miyake, S., Komazawa-Sakon, S., Koike, M., Shindo, R., Takeda, J., Hasegawa, A., Abe, R., Nishiyama, C., Mikami, R., Yagita, H., Uchida, Y., and Nakano, H.*
(X. P. and R. M. are contribute equal first authors.)
Blockade of TNFR1-dependent and -independent cell death is crucial for normal epidermal differentiation.
J. Allergy Clin. Immunol. 143:213-228.e10. 2019.

2018

Yashiro, T., Yamaguchi, M., Watanuki, Y., Kasakura, K., and Nishiyama, C.*
(T.Y. and M.Y. are contribute equal first authors.)
The transcription factors PU.1 and IRF4 determine dendritic cell-specific expression of RALDH2.
J. Immunol. 201:3677-3682. 2018.

Oda, A., Tezuka, T., Ueno, Y., Hosoda, S., Amemiya, Y., Notsu, C., Kasahara, T., Nishiyama, C., and Goitsuka, R.*
Niche-induced extramedullary hematopoiesis in the spleen is regulated by the transcription factor Tlx1.
Sci. Rep. 8:8308. 2018.

Uemura, T., Yashiro, T., Oda, R., Shioya, N., Nakajima, T., Hachisu, M., Kobayashi, S., Nishiyama, C., and Arimura, G.*
(T. U., T. Y., and R. O. are contribute equal first authors.)
Intestinal anti-inflammatory activity of Perillaldehyde.
J. Agric. Food Chem. 66:3443-3448. 2018.

Oda, Y., Kasakura, K., Fujigaki, I., Kageyama, A., Okumura, K., Ogawa, H., Yashiro, T., and Nishiyama, C.*
(Y. O. and K. K. are contribute equal first authors.)
The effect of PU.1 knockdown on gene expression and function of mast cells.
Sci. Rep. 8:2005. 2018.

Umazume, A., Kezuka, T.*, Matsuda, R., Usui, Y., Takahashi, H., Yamanaka, N., Yashiro, T., Nishiyama, C., and Goto, H.
Role of PU.1 expression as an inflammatory marker in experimental autoimmune uveoretinitis.
Ocul. Immunol. Inflamm. 26:951-963. 2018.

2017

Nagaoka, M., Yashiro, T., Uchida, Y., Ando, T., Hara, M., Arai, H., Ogawa, H., Okumura, K., Kasakura, K., and Nishiyama, C.*
(M. N. and T. Y. are contribute equal first authors.)
The orphan nuclear receptor NR4A3 is involved in the function of dendritic cells.
J. Immunol. 199:2958-2967. 2017.

Yashiro, T., Kasakura, K., Oda, Y., Kitamura, N., Inoue, A., Nakamura, S., Yokoyama, H., Fukuyama, K., Hara, M., Ogawa, H., Okumura, K., Nishiyama, M., and Nishiyama, C.*
(T. Y. and K. K. are contribute equal first authors.)
The hematopoietic cell-specific transcription factor PU.1 is critical for expression of CD11c.
Int. Immunol. 29:87-94. 2017.

Honjo, A., Nakano, N.*, Yamazaki, S., Hara, M., Uchida, K., Kitaura, J., Nishiyama, C., Yagita, H., Ohtsuka, Y., Ogawa, H., Okumura, K., and Shimizu, T.
Pharmacological inhibition of Notch signaling suppresses food antigen-induced mucosal mast cell hyperplasia.
J. Allergy Clin. Immunol. 139:987-996.e10. 2017.

2016

Yashiro, T., Hara, M., Ogawa, H., Okumura, K., and Nishiyama, C.*
Critical role of transcription factor PU.1 in the function of the OX40L/TNFSF4 promoter in dendritic cells.
Sci. Rep. 6:34825. 2016.

Miura, R., Kasakura, K., Nakano, N., Hara, M., Maeda, K., Okumura, K., Ogawa, H., Yashiro, T. and Nishiyama, C.*
Role of PU.1 in MHC class II expression via CIITA transcription in plasmacytoid dendritic cells.
PLoS One 11:e0154094. 2016.

2015

Yashiro, T., Kubo, M., Ogawa, H., Okumura, K., and Nishiyama, C.*
PU.1 suppresses Th2 cytokine expression via silencing of GATA3 transcription in dendritic cells.
PLoS One 10:e0137699. 2015.

Yamazaki, S., Nakano, N.*, Honjo, A., Hara, M., Maeda, K., Nishiyama, C., Kitaura, J., Ohtsuka, Y., Okumura, K., Ogawa, H., and Shimizu, T.
The transcription factor Ehf is involved in TGF-beta-induced suppression of FcepsilonRI and c-Kit expression and FcepsilonRI-mediated activation in mast cells.
J. Immunol. 195:3427-3435. 2015.

Ito, T.*, Egusa, C., Maeda, T., Numata, T., Nakano, N., Nishiyama, C., and Tsuboi, R.
IL-33 promotes MHC class II expression in murine mast cells.
Immun. Inflamm. Dis. 3:196-208. 2015.

Nakano, N.*, Nishiyama, C., Yagita, H., Hara, M., Motomura, Y., Kubo, M., Okumura, K., and Ogawa, H.
Notch signaling enhances FcepsilonRI-mediated cytokine production by mast cells through direct and indirect mechanisms.
J. Immunol. 194:4535-4544. 2015.

Ishiyama, K., Yashiro, T., Nakano, N., Kasakura, K., Miura, R., Hara, M., Kawai, F., Maeda, K., Tamura, N., Okumura, K., Ogawa, H., Takasaki, Y., and Nishiyama, C.*
Involvement of PU.1 in NFATc1 promoter function in osteoclast development.
Allergol. Int. 64:241-247. 2015.

Yoshida, A., Tomita, T., Fujimura, T., Nishiyama, C., Kuzuyama, T., and Nishiyama, M.*
Structural insight into amino group-carrier protein-mediated lysine biosynthesis: crystal structure of the LysZ-LysW complex from Thermus thermophilus.
J. Biol. Chem. 290:435-447. 2015.

2014

Kasakura, K., Takahashi, K.*, Ito, T., Hosono, A., Nunomura, S., Ra, C., Momose, Y., Ito, K., Nishiyama, C., and Kaminogawa, S.
C/EBPalpha controls functions of mast cells.
FEBS Lett. 588:4645-4653. 2014.

Kasakura, K., Takahashi, K.*, Ito, T., Hosono, A., Momose, Y., Ito, K., Nishiyama, C., and Kaminogawa, S.
Commensal bacteria directly suppress in vitro degranulation of mast cells in a MyD88-independent manner.
Biosci. Biotechnol. Biochem. 78:1669-1676. 2014.

Inage, E., Kasakura, K., Yashiro, T., Suzuki, R., Baba, Y., Nakano, N., Hara, M., Tanabe, A., Oboki, K., Matsumoto, K., Saito, H., Niyonsaba, F., Ohtsuka, Y., Ogawa, H., Okumura, K., Shimizu, T., and Nishiyama, C.*
(E. I. and K. K. are contribute equal first authors.)
Critical roles for PU.1, GATA1 and GATA2 in the expression of human FcepsilonRI on mast cells: PU.1 and GATA1 transactivate FCER1A, and GATA2 transactivates FCER1A and MS4A2.
J. Immunol. 192:3936-3946. 2014.

Nakamura, Y., Nakano, N., Ishimaru, K., Hara, M., Ikegami, T., Tahara, Y., Katoh, R., Ogawa, H., Okumura, K., Shibata, S., Nishiyama, C., and Nakao, A.*
Circadian regulation of allergic reaction by the mast cell clock.
J. Allergy Clin. Immunol. 133:568-575. 2014.

Schendzielorz, G., Dippong, M., Grünberger, A., Kohlheyer, D., Yoshida, A., Binder, S., Nishiyama, C., Nishiyama, M., Bott, M., Eggeling, L.
Taking control over control: Use of product sensing in single cells to remove flux control at key enzymes in biosynthesis pathways.
ACS Synth. Biol. 3:21-29. 2014.

2013

Ouchi, T., Tomita, T., Horie, A., Yoshida, A., Takahashi, K., Nishida, H., Lassak, K., Taka, H., Mineki, R., Fujimura, T., Kosono, S., Nishiyama, C., Masui, R., Kiramitsu, S., Albers, S.-V., Kuzuyama, T., and Nishiyama, M.*
Lysine and arginine biosyntheses mediated by a common carrier protein in Sulfolobus.
Nat. Chem. Biol. 9:277-283. 2013.

Hara, M., Yokoyama, H., Fukuyama, K., Kitamura, N., Shimokawa, N., Maeda, K., Kanada, S., Ito, T., Usui, Y., Ogawa, H., Okumura, K., Nishiyama, M., and Nishiyama, C.*
(M. H. and H. Y. are contribute equal first authors.)
Transcriptional regulation of the mouse CD11c promoter by AP-1 complex with JunD and Fra2 in dendritic cells.
Mol. Immunol. 53:295-301. 2013.

2012

Hirota, T., Takahashi, A., Kubo, M., Tsunoda, T., Tomita, K., Sakashita, M., Yamada, T., Fujieda, S., Tanaka, S., Doi, S., Miyatake, A., Enomoto, T., Nishiyama, C., Nakano, N., Maeda, K., Okumura, K., Ogawa, H., Ikeda, S., Noguchi, E., Sakamoto, T., Hizawa, N., Ebe, K., Saeki, H., Sasaki, T., Ebihara, T., Amagai, M., Takeuchi, S., Furue, M., and Tamari, M.*
Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population.
Nat. Genet. 44:1222-1226. 2012.

Matsuda, R., Kezuka, T.*, Nishiyama, C., Usui, Y., Matsunaga, Y., Okunuki, Y., Yamakawa, N., Ogawa, H., Okumura, K., and Goto, H.
Interleukin-10 gene-transfected mature dendritic cells suppress murine experimental autoimmune optic neuritis.
Invest. Ophthalmol. Vis. Sci. 53:7235-7245. 2012.

Baba, Y., Maeda, K., Yashiro, T., Inage, E., Kasakura, K., Suzuki, R., Niyonsaba, F., Hara, M., Tanabe, A., Ogawa, H., Okumura, K., Ohtsuka, Y., Shimizu, T., and Nishiyama, C.*
(Y. B., K. M., and T. Y. are contribute equal first authors.)
GATA2 is critical transactivator for human IL1RL1/ST2 promoter in mast cells/basophils: Opposing roles for GATA2 and GATA1 in human IL1RL1/ST2 gene expression.
J. Biol. Chem. 287:32689-32696. 2012.

Matsuda, R., Kezuka, T.*, Nishiyama, C., Usui, Y., Matsunaga, Y., Okunuki, Y., Yamakawa, N., Ogawa, H., Okumura, K., and Goto, H.
Suppression of murine experimental autoimmune optic neuritis by mature dendritic cells transfected with calcitonin gene-related peptide gene.
Invest. Ophthalmol. Vis. Sci. 53:5475-5485. 2012.

Baba, Y., Maeda, K., Yashiro, T., Inage, E., Niyonsaba, F., Hara, M., Suzuki, R., Ohtsuka, Y., Shimizu, T., Ogawa, H., Okumura, K., and Nishiyama, C.*
Involvement of PU.1 in mast cell/basophil-specific function of the human IL1RL1/ST2 promoter.
Allergol. Int. 61:461-467. 2012.

Undas, A.*, Potaczek, D. P., Nishiyama, C., and Okumura, K.
Nonsevere allergic asthma is associated with elevated plasma protein C and protein S.
Thromb. Haemostasis, 107:1000-1002. 2012.

Kamijo, M., Nishiyama, C.*, Takagi, A., Nakano, N., Hara, M., Ikeda, S., Okumura, K., Ogawa, H. Cyclooxygenase-2 inhibition restores UVB-induced downregulation of ATP2A2/SERCA2 in keratinocytes: Possible therapeutic approach of Cyclooxygenase-2 inhibition for treatment of Darier disease.
Br. J. Dermatol. 166:1017-1022. 2012.

Kitamura, N., Yokoyama, H., Yashiro, T., Nakano, N., Nishiyama, M., Kanada, S., Fukai, T., Hara, M., Ikeda, S., Ogawa, H., Okumura, K., and Nishiyama, C.*
Role of PU.1 in MHC class II expression via transcriptional regulation of class II transactivator pI in dendritic cells.
J. Allergy Clin. Immunol. 129:814-824.e6. 2012.

Potaczek, D. P., Kamijo, M., Hara, M., Okumura, K., Undas, A., and Nishiyama, C.*
A comparative search for human FceRI gene (FCER1A) 3’-UTR polymorphisms in Japanese and Polish populations.
Mol. Biol. Reports 39:3747-3753. 2012.

2011

Nishida, C., Tomita, T., Nishiyama, M., Suzuki, R., Hara, M., Itoh, Y., Ogawa, H., Okumura, K., and Nishiyama, C.*
B-transferase with Pro234Ser substitution acquires AB-transferase activity.
Biosci. Biotechnol. Biochem. 75:1570-1575. 2011.

Nakano, N.*, Nishiyama, C., Yagita, H., Koyanagi, A., Ogawa, H., and Okumura, K.
Notch1-mediated signaling induces MHC class II expression through the activation of class II transactivator promoter III in mast cells.
J. Biol. Chem. 286:12042-12048. 2011.

Potaczek, D. P., Nastalek, M., Okumura, K., Wojas-Pelc, A., Undas, A., and Nishiyama, C.*
An association of TLR2-16934A>T polymorphism and severity/phenotype of atopic dermatitis.
J. Eur. Acad. Deramatol. Venereol. 25:715-721. 2011.

Potaczek, D. P., Nastalek, M., Wajas-Pelc, A., Okumura, K., Undas, A., and Nishiyama, C.*
Naturally occurring FCER1A N222K mutation – its ethnicity-dependent distribution and a role in atopic dermatitis.
Mol. Immunol. 48:979-980. 2011.

Kanada, S., Nishiyama, C.*, Nakano, N., Suzuki, R., Maeda, K., Hara, M., Kitamura, N., Ogawa, H., and Okumura, K.
(S. K. and C. N. are contribute equal first authors.)
Critical role of transcription factor PU.1 in the expression of CD80 and CD86 on dendritic cells.
Blood 117:2211-2222. 2011.

Potaczek, D., Pieculewicz, M., Mazur, M., Branicka, A., Nishiyama, C., Okumura, K., and Undas, A.*
Very rare minor homozygous GG genotype of tissue factor +5466A>G mutation in a patient with two cryptogenic cerebovascular ischemic events.
Int. J. Cardiology 147:e13-15. 2011.

2010

Maeda, K., Nishiyama, C.*, Ogawa, H., and Okumura, K.
GATA2 and Sp1 positively regulate the c-kit promoter in mast cells.
J. Immunol. 185:4252-4260. 2010.

Wang, Q.-h., Nishiyama, C.*, Nakano, N., Kanada, S., Hara, M., Kitamura, N., Shimokawa, N., Lu, C.-l., Ogawa, H., and Okumura, K.
Opposite effects of Trichostatin A on activation of mast cells by different stimulants.
FEBS Lett. 584:2315-2320. 2010.

Nishida, C., Nishiyama, C.*, Satoh, K., Hara, M., Itoh, Y., Ogawa, H., and Okumura, K.
Establishment of a simple detection system for blood group ABO-specific transferase activity in DNA-transfected cells.
Legal Med. 12:172-176. 2010.

Shimokawa, N., Nishiyama, C.*, Nakano, N., Maeda, K., Suzuki, R., Hara, M., Fukai, T., Tokura, T., Miyajima, H., Nakao, A., Ogawa, H., and Okumura, K.
Suppressive effects of transcription factor GATA-1 on cell type-specific gene expression in dendritic cells.
Immunogenetics 62:421-429. 2010.

Potaczek, D., Owczarek, D., Okumura, K., Mach, T., Undas, A., and Nishiyama, C.*
An association between functional FcepsilonRIalpha polymorphisms and total serum IgE levels in patients with inflammatory bowel disease.
Scand. J. Gastroenterology 45:766-767. 2010.

Niwa, Y., Potaczek, D., Kanada, S., Takagi, A., Shimokawa, N., Ito, T., Mitsuishi, K., Okubo, Y., Tajima, M., Hobo, A., Ng, W., Tsuboi, R., Ikeda, S., Ogawa, H., Okumura, K., and Nishiyama, C.*
FcepsilonRIalpha gene (FCER1A) promoter polymorphisms and total serum IgE levels in Japanese atopic dermatitis patients.
Int. J. Immunogenetics 37:139-141. 2010.

Potaczek, D., Owczarek, D., Cibor, D., Nishiyama, C., Okumura, K., Mach, T., and Undas, A.*
Tissue factor -1208D>I polymorphism is associated with D-dimer levels in patients with inflammatory bowel disease.
Inflamm. Bowel. Dis. 16:1095-1096. 2010.

Potaczek, D., Kwasny-Krochin, B., Nishiyama, C., Okumura, K., Gluszko, P., Undas, A.*
Tissue factor +5466A>G and -1208D>I genetic polymorphisms and severity of rheumatoid arthritis.
Clin. Chem. Lab. Med. 48:423-425. 2010.

2009

Potaczek, D. P., Wang, Q.-h., Sanak, M., Tokura, T., Matsuda, H., Dziedzina, S., Nakano, N., Hara, M., Ogawa, H., Szczeklik, A., Okumura, K., and Nishiyama, C.*
Interaction of functional FCER2 promoter polymorphism and phenotype-associated haplotypes.
Tissue Antigens 74:534-538. 2009.

Potaczek, D., Maeda, K., Wang, Q.-h., Nakano, N., Kanada, S., Stepien, E., Branicka, A., Fukai, T., Hara, M., Tokura, T., Ogawa, H., Undas, A., Okumura, K., and Nishiyama, C.*
FcepsilonRIalpha gene -18483 A>C polymorphism affects transcriptional activity through YY1 binding.
Immunogenetics 61:649-655. 2009.

Fukai, T., Nishiyama, C.*, Kanada, S., Nakano, N., Hara, M., Tokura, T., Ikeda, S., Ogawa, H., and Okumura, K.
Involvement of PU.1 in the transcriptional regulation of TNF-alpha.
Biochem. Biophys. Res. Commun. 388:102-106. 2009.

Potaczek, D. P.*, Nishiyama, C., Undas, A., and Okumura, K.
Tissue factor genetic polymorphisms and haplotypes in Japanese population.
Atherosclerosis 207:344-345. 2009.

Horie, A., Tomita, T., Saiki, A., Kono, H., Taka, H., Mineki, R., Fujimura, T., Nishiyama, C., Kuzuyama, T., and Nishiyama, M.*
Discovery of proteinaceous N-modification in lysine biosynthesis of Thermus thermophilus.
Nat. Chem. Biol. 5:673-679. 2009

Ito, T., Nishiyama, C.*, Nakano, N., Nishiyama, M., Usui, Y., Takeda, K., Kanada, S., Fukuyama, K., Akiba, H., Tokura, T., Hara, M., Tsuboi, R., Ogawa, H., and Okumura, K.
Roles of PU.1 in monocyte- and mast cell-specific gene regulation: PU.1 transactivates CIITA pIV in cooperation with IFN-gamma.
Int. Immunol. 21:803-816. 2009

Potaczek, D., Pieculewicz, M., Mazur, M., Branicka, A., Nishiyama, C., Okumura, K., and Undas, A.*
Tissue factor (TF) +5466A>G polymorphism predicts plasma TF levels in subjects with cryptogenic ischemic stroke.
Thromb. Haemost. 102:173-175. 2009

Potaczek, D., Okumura, K., and Nishiyama, C.*
FCER1A genetic variability and serum IgE levels.
Allergy 64:1383. 2009.

Ng, W.*, Nishiyama, C., Mizoguchi, M., Ikeda, S., Okumura, K., and Ogawa, H.
Human umbilical cord epithelial cells express Notch ligands Delta1 and Jagged1.
J. Dermatol. Sci. 54:131-134. 2009.

Shimokawa, N., Nishiyama, C.*, Hirota, T., Tamari, M., Hara, M., Ikeada, S., Okumura, K., and Ogawa, H.
Functional analysis of a polymorphism in the promoter region of the IL-12/23p40 gene.
Clin. Exp. Allergy 39:228-235. 2009.

Potaczek, D., Nishiyama, C.*, Sanak, M., Szczeklik, A., and Okumura, K.
Genetic variability of the high-affinity IgE receptor alpha-subunit (FcepsilonRIalpha).
Immunol. Res. 45:75-84. 2009.

Nakano, N.*, Nishiyama, C., Yagita, H., Koyanagi, A., Akiba, H., Chiba, S., Ogawa, H., and Okumura, K.
Notch signaling confers antigen-presenting cell functions on mast cells.
J. Allergy Clin. Immunol. 123:74-81.e1. 2009.

2008

Sawada, T., Nishiyama, C., Kishi, T., Sasazuki, T., Komazawa-Sakon, S., Xue, X., Piao, J.-H., Ogata, H., Nakayama, J.-i., Taki, T., Hayashi, Y., Watanabe, M., Yagita, H., Okumura, K., and Nakano, H.*
Fusion of One twenty-two to BSAC (Basic, SAP, and coiled-coil domain) results in aberrant upregulation of transcriptional activity.
J. Biol. Chem. 283:26820-26828. 2008.

Niwa, Y., Nishiyama, C.*, Nakano, N., Kamei, A., Kato, H., Kanada, S., Ikeda, S., Ogawa, H., and Okumura, K.
Opposite effects of PU.1 on mast cell stimulation.
Biochem. Biophys. Res. Commun. 375:95-100. 2008.

Potaczek, D., Sanak, M., Nishiyama, C., Okumura, K., Ogawa, H., and Szkzeklik, A.*
FCER1A gene proximal promoter polymorphisms in Caucasians and East Asians.
Int. J. Immunogenetics 35:339-340. 2008.

Wang, Q.-h., Nishiyama, C.*, Nakano, N., Shimokawa, N., Hara, M., Kanada, S., Ogawa, H., and Okumura, K.
Suppressive effect of Elf-1 on FceRI a-chain expression in primary mast cells.
Immunogenetics 60:557-563. 2008.

Kanada, S., Nakano, N., Potaczek, D., Maeda, K., Shimokawa, N., Niwa, Y., Fukai, T., Sanak, M., Szczeklik, A., Yagita, H., Okumura, K., Ogawa, H., and Nishiyama, C.*
Two different transcription factors discriminate the -315C>T-polymorphism of the FceRIa gene: Binding of Sp1 to -315C and of a high mobility group-related molecule to -315T.
J. Immunol. 180:8204-8210. 2008.

Nakano, N., Nishiyama, C.*, Tokura, T., Nagasako-Akazome, Y., Ohtake, Y., Okumura, K., and Ogawa, H.
Procyanidin C1 from apple extracts inhibits FceRI-mediated mast cell activation.
Int. Arch. Allergy Immunol. 147:213-221. 2008.

Potaczek, D., Nishiyama, C.*, Sanak, M., Szczeklik, A., Okumura, K., and Ogawa, H.
FCER1A gene exon 1A polymorphisms in Japanese and Polish subjects - a comparative analysis of haplotypes.
Allergy 63:626-627. 2008.

Ng, W.*, Nishiyama, C., Mizoguchi, M., Nakano, N., Suga, Y., Ikeda, S., Itoh, S., Kinoshita, K., Okumura, K., and Ogawa, H.
Human umbilical cord epithelial cells express Notch1: Implications for its epidermal-like differentiation.
J. Dermatol. Sci. 49:143-152. 2008.

Takagi, A., Nishiyama, C.*, Maeda, K., Tokura, T., Kawada, H., Kanada, S., Niwa, Y., Nakano, N., Mayuzumi, N., Nishiyama, M., Ikeda, S., Okumura, K., and Ogawa, H.
Role of Sp1 in transcription of human ATP2A2 gene promoter in keratinocytes.
J. Invest. Dermatol. 128:96-103. 2008.

2007

Nakano, N., Nishiyama, C.*, Kanada, S., Niwa, Y., Shimokawa, N., Ushio, H., Nishiyama, M., Okumura, K., and Ogawa, H.
Involvement of mast cells in IL-12/23 p40 production is essential for survival from polymicrobial infections.
Blood 109:4846-4855. 2007.

2006

Takagi, A., Nishiyama, C.*, Kanada, S., Niwa, Y., Fukuyama, K., Ikeda, S., Okumura, K., and Ogawa, H.
Prolonged MHC class II expression and CIITA transcription in human keratinocytes.
Biochem. Biophys. Res. Commun. 347: 388-393. 2006.

Maeda, K., Nishiyama, C.*, Tokura, T., Nakano, N., Kanada, S., Nishiyama, M., Okumura, K., and Ogawa, H.
FOG-1 represses GATA-1-dependent FceRI b-chain transcription: transcriptional mechanism of mast cell-specific gene expression in mice.
Blood 108: 262-269. 2006.

Nishiyama, C.*
Molecular mechanism of allergy-related gene regulation and hematopoietic cell development by transcription factors.
Biosci. Biotechnol. Biochem. 70: 1-9. 2006.

2005

Tokura, T., Nakano, N., Ito, T., Matsuda, H., Nagasako-Akazome, Y., Kanda, T., Ikeda, M., Okumura, K., Ogawa, H., and Nishiyama, C.*
Inhibitory effect of polyphenol-enriched apple extracts on mast cell degranulation in vitro targeting the binding between IgE and FceRI.
Biosci. Biotechnol. Biochem. 69: 1974-1977. 2005.

Nishiyama, C.*, Ito, T., Nishiyama, M., Masaki, S., Maeda, K., Nakano, N., Ng, W., Fukuyama, K., Yamamoto, M., Okumura, K., and Ogawa, H.
GATA-1 is required for expression of FceRI on mast cells: analysis of mast cells derived from GATA-1 knockdown mouse bone marrow.
Int. Immunol. 17: 847-856. 2005.

Tsubouchi, T., Mineki, R., Taka, H., Kaga, N., Murayama, K., Nishiyama, C., Yamane, H., Kuzuyama, T., and Nishiyama, M.*
Leader peptide-mediated transcriptional attenuation of lysine biosynthetic gene cluster in Thermus thermopiles.
J. Biol. Chem. 280: 18511-18516. 2005.

Kawada, H., Nishiyama, C.*, Takagi, A., Tokura, T., Nakano, N., Maeda, K., Mayuzumi, N., Ikeda, S., Okumura, K., and Ogawa, H.
Transcriptional regulation of ATP2C1 gene by Sp1 and YY1 and reduced function of its promoter in Hailey-Hailey disease keratinocytes.
J. Invest. Dermatol. 124: 1206-1214. 2005.

Nakano, N., Nishiyama, C.*, Masuoka, N., Nishiyama, M., Yamane, H., Okumura, K., and Ogawa, H.
Analysis of PU.1/ICSBP (IRF-8) complex formation with various PU.1 mutants: Molecular cloning of rat Icsbp (Irf-8) cDNA.
Immunogenetics 56: 871-877. 2005.

Ito, T., Nishiyama, C.*, Nishiyama, M., Matsuda, H., Maeda, K., Akizawa, Y., Tsuboi, R., Okumura, K., and Ogawa, H.
Mast cells acquire monocyte-specific gene expression and monocyte-like morphology by overproduction of PU.1.
J. Immunol. 174: 376-383. 2005.

2004

Nishiyama, C.*, Akizawa, Y., Nishiyama, M., Tokura, T., Kawada, H., Mitsuishi, K., Hasegawa, M., Ito, T., Nakano, N., Okamoto, A., Takagi, A., Yagita, H., Okumura, K., and Ogawa, H.
Polymorphisms in the FceRIb promoter region affecting transcription activity: a possible promoter-dependent mechanism for association between FceRIb and atopy.
J. Immunol. 173: 6458-6464. 2004.

Nishiyama, C.*, Masuoka, N., Nishiyama, M., Ito, T., Yamane, H., Okumura, K., and Ogawa, H.
Evidence against requirement of Ser41 and Ser45 for function of PU.1: Molecular cloning of rat PU.1.
FEBS Lett. 572: 57-64. 2004.

Nishiyama, C.*, Nishiyama, M., Ito, T., Masaki, S., Masuoka, N., Yamane, H., Kitamura, T., Ogawa, H., and Okumura, K.
Functional analysis of PU.1 domains in monocyte-specific gene regulation.
FEBS Lett. 561: 63-68. 2004.

Nishiyama, C.*, Nishiyama, M., Ito, T., Masaki, S., Maeda, K., Masuoka, N., Yamane, H., Kitamura, T., Ogawa, H., and Okumura, K.
Overproduction of PU.1 in mast cell progenitors: its effect on monocyte- and mast cell-specific gene expression.
Biochem. Biophys. Res. Commun. 313: 516-521. 2004.

2003

Takahashi, K., Nishiyama, C., Hasegawa, M., Akizawa, Y., Ra, C.*
Regulation of the human high affinity IgE receptor b-chain gene expression via an intronic element.
J. Immunol. 171: 2478-2484. 2003.

Hasegawa, M., Nishiyama, C.*, Nishiyama, M., Akizawa, Y., Mitsuishi, K., Ito, T., Kawada, H., Furukawa, S., Ra, C., Okumura, K., and Ogawa, H.
A novel –66T/C polymorphism in FceRI a-chain promoter affecting the transcription activity: possible relationship to allergic diseases.
J. Immunol. 171: 1927-1933. 2003.

Akizawa, Y., Nishiyama, C.*, Hasegawa, M., Maeda, K., Nakahata, T., Okumura, K., Ra, C., and Ogawa, H.
Regulation of the human FceRI b-chain gene expression by Oct-1.
Int. Immunol. 15: 549-556. 2003.

Hasegawa, M., Nishiyama, C.*, Nishiyama, M., Akizawa, Y., Takahashi, K., Ito, T., Furukawa, S., Ra, C., Okumura, K., and Ogawa, H.
Regulation of the human FceRI a-chain distal promoter.
J. Immunol. 170: 3732-3738. 2003.

Nishiyama, C.*, Yokota, T., Nishiyama, M., Ra, C., Okumura, K., and Ogawa, H.
Molecular cloning of rat transcription factor YY1.
Biosci. Biotechnol. Biochem. 67: 654-658. 2003.

Maeda, K., Nishiyama, C.*, Tokura, T., Akizawa, Y., Nishiyama, M., Ogawa, H., Okumura, K., and Ra, C.
Regulation of cell type-specific mouse FceRI b-chain gene expression by GATA-1 via four GATA motifs in the promoter.
J. Immunol. 170: 334-340. 2003.

2002

Nishiyama, C., Hasegawa, M., Nishiyama, M., Takahashi, K., Akizawa, Y., Yokota, T., Okumura, K., Ogawa, H., and Ra, C.*
Regulation of human FceRI a-chain gene expression by multiple transcription factors.
J. Immunol. 168: 4546-4552. 2002.

Nishiyama, C.*, Takahashi, K., Ohtake, Y., Yokota, T., Okumura, K., Ogawa, H., and Ra, C.
Analysis of transactivation region of Elf-1 by using a yeast one-hybrid system.
Biosci. Biotechnol. Biochem. 66: 875-877. 2002.

Takahashi, K., Nishiyama, C., and Ra, C.*
Transcriptional regulation of the human high affinity IgE receptor a-chain gene.
Mol. Immunol. 38: 1193-1199. 2002.

2001

Nishiyama, C.*, Hasegawa, M., Nishiyama, M., Takahashi, K., Yokota, T., Okumura, K., and Ra, C.
Cloning of full length genomic DNA encoding human FceRI a-chain and its transcriptional regulation.
Biochem. Biophys. Res. Commun. 284: 1056-1064. 2001.

Takahashi, K.*, Nishiyama, C.*, Nishiyama, M., Okumura, K., Ra, C., Ohtake, Y., and Yokota, T.
A complex composed of USF1 and USF2 activates the human FceRI a chain expression via a CAGCTG element in the first intron.
Eur. J. Immunol. 31: 590-599. 2001

Takahashi, K., Nishiyama, C.*, Okumura, K., Ra, C., Ohtake, Y., and Yokota, T.
Molecular cloning of rat USF2 cDNA and characterization of splicing variants.
Biosci. Biotechnol. Biochem. 65: 56-62. 2001

2000

Nishiyama, C.*, Takahashi, K., Nishiyama, M., Okumura, K., Ra, C., Ohtake, Y., and Yokota, T.
Splice isoforms of transcription factor Elf-1 affecting its regulatory function in transcription. –Molecular cloning of rat Elf-1.
Biosci. Biotechnol. Biochem. 64:2601-2607. 2000

1999

Nishiyama, C., Yokota, T., Okumura, K., and Ra, C.*
The transcription factor Elf-1 and GATA-1 bind to cell-specific enhancer elements of human high-affinity IgE receptor a-chain gene.
J. Immunol. 163: 623-630. 1999

Nishiyama, C.*, Hatanaka, H., Ichikawa, S., Fukada, M., Akagawa-Chihara, M., Yuuki, T., Yokota, T., Inagaki, F., and Okumura, Y.
Analysis of human IgE epitope of Der f 2 with anti-Der f 2 mouse monoclonal antibodies.
Mol. Immunol. 36: 53-60. 1999

1998

Ichikawa, S., Hatanaka, H.*, Yuuki, T., Iwamoto, N., Kojima, S., Nishiyama, C., Ogura, K., Okumura, Y., and Inagaki, F.
Solution structure of Der f 2, the major mite allergen for atopic diseases.
J. Biol. Chem. 273. 356-360. 1998

1997

Takai, T.*, Yokota, T., Yasue, M., Nishiyama, C., Yuuki, T., Mori, A., Okudaira, H., and Okumura, Y.
Engineering of the major house dust mite allergen Der f 2 for allergen-specific immunotherapy.
Nat. Biotech. 15: 754-758. 1997

1996

Noguchi, E., Shibasaki, M., Nishiyama, C., Okumura, Y., and Takita, H.
IgE responsiveness to Dermatophagoides farinae in young asthmatic children: IgE binding study using recombinant allergens of Der f 1, Der f 2 and mutant proteins of Der f 2.
Int. Arch. Allergy Immunol. 110: 380-387. 1996

Iwamoto, N.*, Nishiyama, C., Yasuhara, T., Saito, A., Yuuki, T., Okumura, Y., and Okudaira, H.
Direct expression of Der f 2, a major house dust mite allergen, in Escherichia coli.
Int. Arch. Allergy Immunnol. 109: 356-361. 1996

1995

Nishiyama, C.*, Yasuhara, T., Yuuki, T., and Okumura, Y.
Cloning and expression in Escherichia coli of cDNA encoding house dust mite allergen Der f 3, serine protease from Dermatophagoides farinae.
FEBS Lett. 377: 62-66. 1995

Nishiyama, C.*, Fukada, M., Usui, Y., Iwamoto, N., Yuuki, T., Okumura, Y., and Okudaira, H.
Analysis of the IgE-epitope of Der f 2, a major mite allergen, by in vitro mutagenesis.
Mol. Immunol. 32: 1021-1029. 1995

1994

Nishiyama, C.*, Yuuki, T., Usui, Y., Iwamoto, N., Okumura, Y., and Okudaira, H.
Effects of amino acid variations in recombinant Der f II on its human IgE and mouse IgG recognition.
Int. Arch. Allergy Immunol. 105: 62-69. 1994

1993

Nishiyama, C.*, Yuuki, T., Takai, T., Okumura, Y., and Okudaira, H.
Determination of three disulfide bonds in a major house dust mite allergen, Der f II.
Int. Arch. Allergy Immunol. 101: 159-166. 1993

1992

Nishiyama, C.*, Nagai, T., and Yano, T.
Effects of pH on the in vitro sorption of mutagens to dietary fibers.
Biosci. Biotech. Biochem. 56: 1100-1103. 1992

1991

Nagai, T.*, Nishiyama, C., and Yano, T.
Sorption characteristics of water-vapor and mutagens on calcium alginate.
J. Jpn. Soc. Food Sci. Technol. 38:520-526. 1991.

Nishiyama, C.*, Nagai, T., and Yano, T.
Adsorption of mutagens in distilled water by dietary fibers.
Agric. Biol. Chem. 55:797-802. 1991


Chiharu Nishiyama Laboratory
Department of Biological Science and Technology
Faculty of Advanced Engineering
Tokyo University of Science











img_0107.jpg cimg1521.jpg cimg1229.jpg cimg1237.jpg cimg1213.jpg cimg1245.jpg cimg1274.jpg cimg1277.jpg cimg1286.jpg cimg1289.jpg cimg1428.jpg cimg1366.jpg img_0097.jpg cimg1404.jpg imgp1481.jpg 20140920-dsc_9874.jpg