ACHIEVEMENT

英文原著論文

    2025

  1. Aoyama Y, Yamazaki H, Nishimura K, Nomura M, Shigehiro T, Suzuki T, Zang W, Tatara Y, Ito H, Hayashi Y, Koike Y, Fukumoto M, Tanaka A, Zhang Y, Saika W, Hasegawa C, Kasai S, Kong Y, Minakuchi Y, Itoh K, Yamamoto M, Toyokuni S, Toyoda A, Ikawa T, Takaori-Kondo A, Inoue D. Selenoprotein-mediated redox regulation shapes the cell fate of HSCs and mature lineages. Blood. 145:1149-1163, 2025

    2. 2024

  2. Miyatake Y, Ikawa T, Yanagiya R, Kotaki R, Kameda K, Koyama-Nasu R, Okuyama K, Hirano K, Hosokawa H, Hozumi K, Ohtsuka M, Kishikawa T, Shibata C, Otsuka M, Maruyama R, Ando K, Kurosaki T, Kawamoto H, Kotani A. A single microRNA miR-195 rescues the arrested B cell development induced by EBF1 deficiency. eLife. https://doi.org/10.7554/eLife.101510.1, 2024

  3. Uehata T, Yamada S, Ori D, Vandenbon A, Giladi A, Jelinski A, Murakawa Y, Watanabe H, Takeuchi K, Toratani K, Mino T, Kiryu H, Standley DM, Tsujimura T, Ikawa T, Kondoh G, Landthaler M, Kawamoto H, Rodewald HR, Amit I, Yamamoto R, Miyazaki M and Takeuchi O. Regulation of lymphoid-myeloid lineage bias through Regnase-1/3-mediated control of Nfkbiz. Blood. 143:243-257, 2024

    4. 2023

  4. Xiao M, Kondo S, Nomura M, Kato S, Nishimura K, Zang W, Akashi T, Viny A, Shigehiro T, Ikawa T, Yamazaki H, Fukumoto M, Tanaka A, Hayashi Y, Koike Y, Aoyama Y, Ito H, Nishikawa H, Kitamura T, Kanai A, Yokoyama A, Fujiwara T, Goyama S, Noguchi H, Lee SC, Toyoda A, Hinohara K, Abdel-Wahab O and Inoue D. BRD9 determines the cell fate of hematopoietic stem cells by regulating chromatin state. Nat Commun.. 14: 8372, 2023

  5. Nakajima-Takagi Y, Oshima M, Takano J, Koide S, Itokawa N, Uemura S, Yamashita M, Andoh S, Aoyama K, Isshiki Y, Shinoda D, Saraya A, Arai F, Yamaguchi K, Furukawa Y, Koseki H, Ikawa T, and Iwama A. Polycomb repressive complex 1.1 coodinates homeostatic and emergency myelopoiesis. eLife. 12:e83004, 2023

  6. Jin J, Ogawa T, Hojo N, Kryukov K, Shimiz K, Ikawa T, Imanishi T, Okazaki T, and Shiroguchi K. Robotic data acquisition with deep learning enables cell image-based prediction of transcriptomic phenotypes. PNAS. 120(1):e2210283120, 2023

    7. 2022

  7. Nagahata Y, Masuda K, Nishimura Y, Ikawa T, Kawaoka S, Kitawaki T, Nanya Y, Ogawa S, Suga H, Satou Y, Takaori-Kondo A, and Kawamoto H. Tracing the evolutionary history of blood cells to the unicellular ancestor of animals. Blood. 140(24):2611-2625, 2022

  8. Takano J, Ito S, Dong Y, Sharif J, Nakajima-Takagi Y, Umeyama T, Han YW, Isono K, Kondo T, Iizuka-Y, MIyai T, Koseki Y, Ikegaya M, Sakihara M, Bardwell VJ, Nakayama M, Ohara O, Hasegawa Y, Hashimoto K, Arner E, Klose RJ, Iwama A, Koseki H, and Ikawa T. PCGF1-PRC links chromatin repression with DNA replication during hematopoietic cell lineage commitment. Nat Commun. 13(1):7159, 2022

  9. Ogawa T, Ochiai K, Iwata T, Ikawa T, Tsuzuki T, Shiroguchi K and Takahashi K. Different cell imaging methods did not significantly improve immune cell image classification performance. PLOS ONE. 17(1):e0262397, 2022

    10. 2020

  10. Ochiai K, Yamaoka M, Swaminathan A, Shima H, Hiura H, Matsumoto M, Kurotaki D, Nakabayashi J, Funeyama R, Nakayama K, Arima T, Ikawa T, Tamura T, Sciammas R, Bouvet P, Kundu TK, Igarashi K. Chromatin protein PC4 orchestrates B cell differentiation by collaborating with IKAROS and IRF4. Cell Rep. 33: 108517-108538, 2020

  11. Fischer U, Yang JJ, Ikawa T, Hein D, Vicente-Dueñas, Borkhardt A and Sánchez-García I. Cell fate decisions: The role of transcription factors in early B-cell development and leukemia. Blood Cancer Discov. 1: 224-233, 2020

  12. Watanabe A, Miyake K, Nordlund J, Syvänen AC, van der Weyden L, Honda H, Yamasaki N, Nagamachi A, Inaba T, Ikawa T, Urayama KY, Kiyokawa N, Ohara A, Kimura S, Kubota Y, Takita J, Goto H, Sakaguchi K, Minegishi M, Iwamoto S, Shinohara T, Kagami K, Abe M, Akahane K, Goi K, Sugita K, Inukai T*. Association of aberrant ASNS imprinting with asparaginase sensitivity and chromosomal abnormality in childhood BCP-ALL. Blood. 136: 2319-2333, 2020

    13. 2019

  13. Hashimoto K, Kouno T, Ikawa T, Hayatsu N, Miyajima Y, Yabukami H, Terooatea T, Sasaki T, Suzuki T, Valentine M, Pascarella G, Minoda A, Taniuchi I, Arai Y, Hirose N, Carninci P*. Single-cell transcriptomics reveals expansion of cytotoxic CD4 T cells in supercentenarians. PNAS. 116: 24242-24251, 2019

    14. 2018

  14. Masuda J, Takayama E, Ichinose T, Strober W, Mizuno Kamiya M, Ikawa T, Kitani A, Kawaki H, Fuss I, Kawamoto H, Seno A, Vaidyanath A, Umemura N, Mizutani A, Kasai T, Honjo Y, Satoh A, Murakami H, Katsura Y, Kondoh N and Seno M. Suppression effect on IFN-g of adipose tissue-derived mesenchymal stem cells isolated from b2-microglobin-deficient mice. Experimental and Therapeutic Med. 16: 4277-4282, 2018

  15. Li S, Liu J, Min Q, Ikawa T, Yasuda S, Yang Y, Wang YQ, Tsubata T, Zhao Y, Wang JY. Kelch-like protein 14 promotes B-1a but suppresses B-1b cell development. Int Immunol. 30: 311-318, 2018

  16. Miyai T, Takano J, Endo TA, Kawakami E, Agata Y, Motomura Y, Kubo M, Kashima Y, Suzuki Y, Kawamoto H, Ikawa T*. Three-step transcriptional priming that drives the commitment of multipotent progenitors toward B cells. Genes Dev. 32:112-126, 2018

    17. 2017

  17. Noguchi S, Arakawa T,…, Ikawa T(178人中75番目),…, Kawaji H*, Carninci P, Forrest ARR, Hayashizaki Y. FANTOM5 CAGE profiles of human and mouse samples. Sci Data. 4: 170112, 2017

    18. 2016

  18. Ikawa T*, Masuda K, Endo TA, Endo M, Isono K, Koseki Y, Nakagawa R, Kometani K, Takano J, Agata Y, Katsura Y, Kurosaki T, Vidal M, Koseki H, Kawamoto H*. Conversion of T cells to B cells by inactivation of polycomb-mediated epigenetic suppression of the B-lineage program. Genes Dev. 30: 2475-2485, 2016

  19. Masuda J, Kawamoto H, Strober W, Takayama-E, Mizutani A, Murakami H, Ikawa T, Kitani A, Maeno N, Shigehiro T, Satoh A, Seno A, Arun V, Kasai T, Fuss IJ, Katsura Y, Seno M*. Transient Tcf3 gene repression by TALE-tanscription factor targeting. Appl Biochem Biotechnol. 180: 1559-1573, 2016

    20. 2015

  20. Calés C, Pavón L, Starowicz K, Pérez C, Bravo M, Ikawa T, Koseki H, Vidal M. Role of Polycomb RYBP in maintaining the B-1 to B-2 B-cell lineage switch in adult hematopoiesis. Mol Cell Biol. 36: 900-912, 2015

  21. Ikawa T*, Masuda K, Huijskens MJAJ, Satoh R, Kakugawa K, Agata Y, Miyai T, Germeraad WTV, Katsura Y, Kawamoto H*. Induced developmental arrest of early hematopoietic progenitors leads to the generation of leukocyte stem cells. Stem Cell Reports. 5:716-727, 2015

  22. Inoue T, Morita M, Hijikata A, Fukuda-Yuzawa Y, Adachi S, Isono K, Ikawa T, Kawamoto H, Koseki H, Natsume T, Fukao T, Ohara O, Yamamoto T, Kurosaki T*. CNOT3 contributes to early B cell development by controlling Igh rearrangement and p53 mRNA stability. J Exp Med. 212:1465-1479, 2015

  23. Iguchi T, Aoki K, Ikawa T, Taoka M, Taya C, Yoshitani H, Toma-Hirano M, Koiwai O, Isobe T, Kawamoto H, Masai H, Miyatake S*. BTB-ZF protein Znf131 regulates cell growth of developing and mature T cells. J Immunol. 195:982-993, 2015

  24. Arner E, Daub CO, Vitting-Seerup K, …, Ikawa T (109人中36番目), …, Hayashizaki Y*. Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells. Science. 347:1010-1014, 2015

    25. 2014

  25. Itoh-Nakadai A, Hikota R, Muto A, Kometani K, Watanabe-Matsui M, Sato Y, Kobayashi M, Nakamura A, Miura Y, Yano Y, Tashiro S, Sun J, Ikawa T, Ochiai K, Kurosaki T, Igarashi K*. The transcription repressors Bach2 and Bach1 promote B cell development by repressing the myeloid program. Nat Immunol. 12:1171-1180, 2014

  26. Hojyo S, Miyai T, Fujishiro H, Kawamura M, Yasuda T, Hijikata A, Bin BH, Irié T, Tanaka J, Atsumi T, Murakami M, Nakayama M, Ohara O, Himeno S, Yoshida H, Koseki H, Ikawa T, Mishima K, Fukada T*. Zinc transporter SLC39A

  27. Miyai T, Hojyo S, Ikawa T, Kawamura M, Irié T, Ogura H, Hijikata A, Bin BH, Yasuda T, Kitamura H, Nakayama M, Ohara O, Yoshida H, Koseki H, Mishima K, Fukada T*. Zinc transporter SLC39A10/ZIP10 facilitates antiapoptotic signaling during early B-cell development. Proc Natl Acad Sci U S A. 111(32):11780-5, 2014

  28. Obata Y, Furusawa Y, Endo TA, Sharif J, Takahashi D, Atarashi K, Nakayama M, Onawa S, Fujimura Y, Takahashi M, Ikawa T, Otsubo T, Kawamura YI, Dohi, Tajima S, Matsumoto H, Ohara O, Honda K, Hori S, Ohno H, Koseki H, Hase K*. The epigenetic regulator Uhrf1 facilitates the proliferation and maturation of colonic regulatory T cells. Nat Immunol. 15: 571-579, 2014

  29. FANTOM Consortium and the RIKEN PMI and CLST (DGT), Forrest AR*, Kawaji H,…, Ikawa T (261人中102番目),…, Hayashizaki Y*. A promoter-level mammalian expression atlas. Nature 507: 462-470, 2014

  30. Hoshii T, Kasada A, Hatakeyama T, Ohtani M, Tadokoro Y, Naka K, Ikenoue T, Ikawa T, Kawamoto H, Fehling HJ, Araki K, Yamamura K, Matsuda S, Hirao A*. Loss of mTOR complex 1 induces developmental blockade in early T-lymphopoiesis and eradicates T-cell acute lymphoblastic leukemia cells. Proc. Natl. Acad. Sci. USA. 111: 3805-3810. 2014

    31. 2013

  31. Okuyama K, Ikawa T, Gentner B, Hozumi K, Harnprasopwat R, Lu J, Yamashita R, Ha D, Toyoshima T, Chanda B, Kawamata T, Yokoyama K, Wang S, Ando K, Lodish HF, Tojo A, Kawamoto H, Kotani A*. MicroRNA-126-mediated control of cell fate in B-cell myeloid progenitors as a potential alternative to transcription factors. Proc Natl Acad Sci USA. 110: 13410-13415, 2013

  32. antigen-specific T cells from iPSCs derived from mature CD8(+) T cells. Cell Stem Cell. 12: 31-36, 2013

    33. 2012

  33. Isoda T, Takagi M, Piao-J, Nakagama S, Sato M, Masuda K, Ikawa T, Azuma M, Morio T, Kawamoto H, and Mizutani S*. Process for immune defect and chromosomal translocation during early thymocyte development lacking ATM. Blood 120: 789-799, 2012

  34. Seo W, Ikawa T, Kawamoto H, and Taniuchi I*. Runx1-Cbfb facilitates early B lymphocyte development by regulating expression of Ebf1. J Exp Med. 209 1255-1262, 2012

  35. Sakamoto S, Wakae K, Anzai Y, Murai K, Tamaki N, Miyazaki M, Miyazaki K, Romanow WJ, Ikawa T, Kitamura D, Yanagihara I, Minato N, Murre C, Agata Y*. E2A and CBP/p300 act in synergy to promote chromatin accessibility of the immunoglobulin k locus. J. Immunol. 188: 5547-5560. 2012

    36. 2011

  36. Shibata K*, Yamada H*, Sato T, Dejima T, Nakamura M, Ikawa T, Hara H, Yamasaki S, Kageyama R, Iwakura Y, Kawamoto H, Toh H, Yoshikai Y. Notch-Hes1 pathway is required for the development of IL-17-producing gd T cells. Blood 118: 586-593, 2011

    37. 2010

  37. Ikawa T, Hirose S, Masuda K, Kakugawa K, Satoh R, Shibano-Satoh A, Kominami R,Katsura Y, and Kawamoto H*. An essential developmental checkpoint for production of the T cell lineage. Science 329: 93-96, 2010

  38. Hirose K, Inukai T*, Kikuchi J, Furukawa Y, Ikawa T, Kawamoto H, Oram SH, Gottgen B, Kiyokawa N, Miyagawa Y, Okita H, Akahane K, Zhang X, Kuroda I, Nonna H, Kagami K, Goi K, Kurosawa H, Look AT, Matsui H, Inaba T and Sugita K. Aberrant induction of LMO2 theE2A-HLF chimeric transcription factor and its implication in leukemogenesis of B-precursor ALL with t(17;19). Blood 116: 962-970, 2010

  39. Oguro H, Jin Y, Ichikawa H, Ikawa T, Yamazaki S, Kawamoto H, Nakauchi H, and Iwama A*. Poised lineage specification in multipotent hematopoietic progenitor cells by the polycomb protein Bmi1. Cell Stem Cell 6: 279-286, 2010

  40. Moro K, Yamada T, Tanabe M, Takeuchi T, Ikawa T, Kawamoto H, Fujiwara J-I, Ohtani M, Fujii H, and Koyasu S*. Innate production of Th2 cytokines by adipose tissue-associated c-Kit(+)Sca-1(+) lymphocytes. Nature 463: 540-544, 2010

    41. 2009

  41. Higashi AY, Ikawa T, Muramatsu M, Ecnomides AN, Niwa A, Okuda T, Murphy AJ, Rojas J, Heike T, Nakahata T, Kawamoto H, Kita T, and Yanagita M*. Direct hematological toxicity and illegitimate chromosomal recombination caused by the systemic activation of CreERT2. J. Immunol. 182:5633-5640, 2009

  42. Masuda K, Germeraad WTV, Satoh R, Itoi M, Ikawa T, Minato M, Katsura Y, W. van Ewijk, and Kawamoto H*. Notch activation in thymic epithelial cells induces development of thymic microenvironments. Mol. Immunol. 46: 1756-1767, 2009

  43. Komaniwa S, Hayashi H, Kawamoto H, Ikawa T, Sato SB, Katsura Y, and Udaka K*. Lipid-mediated presentation of MHC class II molecules guides thymocytes to the CD4 lineage. Eur. J. Immunol. 39: 96-122, 2009

    44. 2008

  44. Yano M, Kuroda N, Han H, Horike M, Nishimura Y, Kiyonari H, Maemura K, Yanagawa Y, Obata K, Takahashi S, Ikawa T, Satoh R, Kawamoto H, Muroi Y, and Matsumoto M*. Aire controls the differentiation of thymic epithelial cells in the medulla for the establishment of self-tolerance. J. Exp. Med. 205: 2877-2838, 2008

  45. Minami Y, Stuart SA, Ikawa T, Jiang Y, Banno A, Hunton IC, Young DJ, Naoe T, Murre C, Jamieson CH, and Wang JY*. BCR-ABL-transformed GMP as myeloid leukemic stem cells. Proc Natl Acad Sci USA. 105: 17967-17972, 2008

  46. Muroi S, Naoe Y, Miyamoto C, Akiyama K, Ikawa T, Masuda K, Kawamoto H, and Taniuchi I*. Cascading suppression of transcriptional silencers by ThPOK seals helper T cell fate. Nat Immunol. 9: 1113-1121, 2008

  47. Ko, J, Patel N, Ikawa T, Kawamoto H, Frank O, Rivera R, van Etten RA, and Murre C*. Id2 deficient mice develop myeloproliferative disorder whereas forced Id2 expression interferes with the development of BCR/ABL induced myloid leukemia. Proc Natl Acad Sci USA. 105: 12967-12972, 2008

  48. Wada H, Masuda K, Satoh R, Kakugawa K, Ikawa T, Katsura Y and Kawamoto H*. Adult T cell progenitors retain myeloid potential. Nature 452: 768-772, 2008

    49. 2007

  49. Agata, Y, Tamaki N, Sakamoto S, Ikawa T, Masuda K, Kawamo H, and Murre C*. Regulation of T cell receptor beta gene rearrangements and allelic exclusion by the helix-loop-helix protein, E47. Immunity 27: 871-884, 2007

  50. Fujimoto S*, Ikawa T, Kina T, and Yokota Y. Forced expression of Id2 in fetal thymic T cell progenitors allows some of their progeny to adopt NK cell fate. Int Immunol. 10: 1175-1182, 2007

    51. 2006

  51. Ikawa T, Kawamoto H, Goldrath AW., and Murre C*. E proteins and Notch signaling cooperate to promote T cell lineage specification and commitment. J. Exp. Med. 203: 1329-1342, 2006

    52. 2005

  52. Masuda K, Kubagawa H, Ikawa T, Chen Ching-Cheng, Kubagawa K, Hattori M, Kageyama R, Cooper MD, Minato N, Katsura Y, and Kawamoto H*. Prethymic T-cell development defined by the expression of paired immunoglobulin-like receptors. EMBO J. 24: 4052-4060, 2005

  53. Lu M, Tayu R, Ikawa T, Masuda K, Matsumoto I, Mugishima H, Kawamoto H, Katsura Y. The earliest thymic progenitors in adults are restricted to T, NK, and dendritic cell lineage and have a potential to form more diverse TCRbeta chains that fetal progenitors. J. Immunol. 175:5848-5856, 2005

  54. Kawabata N*, Kishimoto H, T Abe, Ikawa T, Yamanaka K, Ikeuchi H, and Kakimoto C. Control of tomatobacterial wilt without disinfection using a new functional polymer that catures microbial cells alive on the surface and is highly biodegradable. Biosci Biotech Bioch. 69: 326-333, 2005

    55. 2004

  55. Maier H, Ostraat R, Gao H, Fields S, Shinton SA, Medina KL, Ikawa T, Murre C, Singh H, Hardy RR, and Hagman J*. Early B cell factor cooperates with Runx1 and mediates epigenetic changes associated with mb-1 transcription. Nat Immunol. 10:1069-1077, 2004

  56. Ikawa T, Kawamoto H, Wright LYT, and Murre C*. Long-term cultured E2A-deficient hematopoietic progenitor cells are pluripotent. Immunity 20: 349-360, 2004

  57. Ikawa T, Masuda K, Min L, Minato N, Katsura Y, and Kawamoto H*. Identification of the earliest prethymic T-cell progenitors in murine fetal blood. Blood 103: 530-537, 2004

    58. 2003

  58. Kawamoto H., Ohmura K, Fujimoto S, Min L, Ikawa T, and Katsura Y*. Extensive proliferation of T cell lineage-restricted progenitors in the thymus: essential process for clonal expression of diverse T cell receptor b chains. Eur. J. Immunol. 33: 606-615, 2003

  59. Shen HQ, Lu M, Ikawa T, Masuda K, Ohmura K, Minato N, Katsura Y, and Kawamoto H*. T/NK bipotent progenitors in the murine thumus retain the potential to generate dendritic cells. J. Immunol. 171: 3401-3406, 2003

    60. 2002

  60. Lu M, Kawamoto H, Katsube Y, Ikawa T, and Katsura Y*. The common myelolymphoid progenitor: A key intermediate stage in hemopoiesis generating T and B cells. J. Immunol. 169: 3519-3525, 2002

    61. 2001

  61. Ikawa T, Fujimoto S, Kawamoto H, Katsura Y, and Yokota Y*. Commitment to natural killer cells requires the helix-loop-helix inhibitor Id2. Proc Natl Acad Sci USA. 98: 5164-5169, 2001

  62. Ohmura K, Kawamoto H, Min L, Ikawa T, Ozaki S, Nagao K, and Katsura Y*. Immature multipotent hematopoietic progenitors lacking bone marrow repopulating activity in the aorta-gonad-mesonephros region of murine day 10 fetuses. J. Immunol. 166: 3290-3296, 2001

    63. 2000

  63. Kawamoto H, Ikawa T, Ohmura K, Fujimoto S, and Katsura Y*. T cell progenitors emerge earlier than B cell progenitors in the murine fetal liver. Immunity 12: 441-450, 2000

    64. 1999

  64. Ikawa T, Kawamoto H, Fujimoto S, and Katsura Y*. Commitment of T/Natural killer (NK) progenitors to unipotent T and NK progenitors in the murine fetal thumus revealed by a single progenitor assay. J. Exp. Med. 190: 1617-1625, 1999

英文総説：

1. Ikawa T*. Genetic and epigenetic control of early lymphocyte development. Curr Top Microbiol Immunol. 381:1-20, 2014

2. Kawamoto H*, Ikawa T, Masuda K, Wada H and Katsura Y. A map for lineage restriction of progenitors during hematopoiesis: the essence of the myeloid-based model. Immunol Rev. 238: 23-26, 2010

日本語総説：

1. 伊川 友活、平川 真弓. ポリコーム蛋白質によるDNA複製制御と造血. 臨床免疫・アレルギー科, 80(4):495-501, 2023

2. 伊川友活. エピゲノム制御による免疫細胞の分化運命決定機構. 科学フォーラム　東京理科大学　432: 16-20, 2022

3. 伊川友活. 転写因子とマクロファージ分化. 臨床免疫・アレルギー科 75: 699-706, 2021

4. 薬師寺那由他, 伊川友活. B細胞分化を駆動する転写プログラムとクロマチン制御. 臨床免疫・アレルギー科 71:215-222, 2019

5. 宮井智浩, 伊川友活. 多能性前駆細胞からB細胞への分化における段階的転写制御. 臨床免疫・アレルギー科 70:503-513, 2018

6. 伊川友活, 高野淳一朗. T細胞の運命を制御する分子機構. 臨床免疫・アレルギー科 68:203-210, 2017

7. 伊川友活, 宮井智浩. B細胞系列への運命決定を制御する転写因子. 臨床免疫・アレルギー科 61:704-710, 2014

8. 伊川友活, 河本宏. T細胞運命決定マスター遺伝子の同定. 感染・炎症・免疫 41:81-83, 2011

9. 伊川友活, 河本宏. 転写因子Bcl11bによるT細胞分化チェックポイント. 医学のあゆみ 236:864-866, 2011

10. 伊川友活, 河本宏. 転写因子Bcl11bはT細胞系列への運命決定に必須である.実験医学 28:3123-3126, 2010

11. 伊川友活，Cornelis Murre, 河本　宏．B細胞系列への決定とE2A. 免疫2005,41: 30-38,2004

12. 伊川友活，河本宏，桂義元．NK細胞系列決定におけるId2の役割．臨床免疫　37:284-290, 2002

13. 伊川友活，河本宏，桂義元．T/NK共通の前駆細胞からT細胞あるいはNK細胞への系列決定．臨床免疫　33: 282-289. 2000