Disease models and research tools
The following gene manipulated mice are available on request. Please contact Dr. Yoichiro Iwakura.
A: available
B: may be delayed
C: only frozen embryos are available
Knockout mouse
transgenic mouse
Genetic background** | |||||||
---|---|---|---|---|---|---|---|
Strains | 129*B6 | C57BL/6J | BALB/cA | C3H/HeN | NOD | Reference | note |
Human T-cell Leukemia Virus type 1(pX) gene | - | C | C | C | - | Science 253: 1026-8 (1991) | |
c-fms promoter/tax gene | - | - | - | C | - | J Immunol 162: 2956-63 (1999) | |
Human Immunodeficiency Virus (RT-) gene | - | C | - | C | - | AIDS 6: 1069-75 (1992) | |
CD4 promoter/vpr gene | - | - | - | C | - | Virology 285: 181-92 (2001) | |
CD4 promoter/human CD4 gene | - | - | - | C | - | - | |
metallothioneine promoter/Ifnb gene | - | - | - | C | - | EMBO J 7: 3757-62 (1988) | |
SAP promoter/RANKL | - | C | - | - | - | J Bone Miner Metab 20: 337-44 (2002) |
4 |
PGK promoter/neomycin phosphotransferase gene | - | - | - | C | - | - | |
CD34 promoter/Cre recombinase gene | - | C | - | - | - | - |
** mice were backcrossed more than 8 generations except for 129*B6 intercrossed mice
Additional permission from the following developers is required.
1: Dr. M Aguet
2: Dr. M Kopf
3: Dr. K Sekikawa
4: Snow Brand Milk Products Co. Ltd.
5: Yakult Central Institute for Microbiological Research
6: Dr. Y Yamanashi.