８．解析用ツール

ａ）IFN-βトランスジェニックマウス

1) Iwakura, Y., Asano, M., Nishimune, Y., and Kawade, Y. Male sterility of transgenic mice carrying exogenous mouse interferon-b gene under the control of the metallothionein enhancer-promoter. EMBO J., 7, 3757-3762 (1988).

ｂ）IFN-γトランスジェニックマウス

1) Iwakura, Y., Hayashi, M., and Asano, M. Transgenic mice carrying interferon genes. Mol. Reprod. Develop., 36, 245-247 (1993).

c）ヒトHLA-B51トランスジェニックマウス

1) Karaki, S., Kariyone, A., Kato, N., Kano, K., Iwakura, Y., and Takiguchi, M. Lack of production of antibody specific for HLA-C antigens in HLA-B51 transgenic mice. Immunogenetics, 37, 139-142 (1993).

d）ヒトGM-CSFレセプタートランスジェニックマウス

1) Nishijima, I., Nakahata, T., Hirabayashi, Y., Inoue, T., Kurata, H., Miyajima, A., Hayashi, N., Iwakura, Y., Arai, K., and Yokota, T. A human GM-CSF receptor expressed in transgenic mice stimulates proliferation and differentiation of hemopoietic progenitors to all lineages in response to human GM-CSF. Mol. Biol. Cell, 6, 497-508 (1995).

e) CD19-Cre, CD34-Creトランスジェニックマウス

1) Tokoyoda, K., Egawa, T., Sugiyama, T., Choi, B.I., and Nagasawa, T. Cellular niches controlling B lymphocyte behavior within bone marrow during development. Immunity, 20, 707-718 (2004).