Ribs - Iwakura Lab.

IL-1欠損マウス論文リスト
　　IL-1α、IL-1β、IL-1α/β

1) Horai, R., Asano, M., Sudo, K., Kanuka, H., Suzuki, M., Nishihara, M., Takahashi, M., and Iwakura, Y. Production of mice deficient in genes for IL-1a, IL-1b, IL-1a/b, and IL-1 receptor antagonist shows that IL-1b is crucial in turpentine-induced fever development and glucocorticoid secretion. J. Exp. Med., 187, 1463-1475 (1998).

2) Miwa, K., Asano, M., Horai, R., Iwakura, Y., Nagata, S., and Suda, T. Caspase 1-independent IL-1b release and inflammation induced by the apoptosis inducer Fas ligand. Nature Medicine, 4, 1287-1292 (1998).

3)Horai, R., Saijo, S., Tanioka, H., Nakae, S., Sudo, K., Okahara, A., Ikuse, T., Asano, M., and Iwakura, Y. Development of chronic inflammatory arthropathy resembling rheumatoid arthritis in IL-1 receptor antagonist-deficient mice. J. Exp. Med., 191, 313-320 (2000).

4) Yamada, H., Mizumo, S., Horai, R., Iwakura, Y., and Sugawara, I. Protective role of interleukin-1 in mycobacterial infection in IL-1 alpha/beta double-knockout mice. Lab. Invest., 80, 759-67 (2000).

5) Tanaka, J., Ozaki, H., Yasuda, J., Horai, R., Tagawa, Y., Asano, M., Saijo, S., Imai, M., Sekikawa, K., Kopf, M., and Iwakura, Y. Lipopolysaccharide-induced HIV-I expression in transgenic mice is mediated by tumor necrosis factor-a and interleukin-1, but not by interferon-g nor interleukin-6. AIDS, 14, 1299-1307 (2000).

6) Yamaguchi, K., Motegi, K., Iwakura, Y., and Endo, Y. Involvement of interleukin-1 in the inflammatory actions of aminobisphosphonates in mice. Br. J. Pharmacol., 130, 1646-1654 (2000).

7) Yoneto, T., Waki, S., Takai, T., Tagawa, Y., Iwakura, Y., Mizuguchi, J., Nariuchi, H., and Yoshimoto, T. 　A critical role of Fc receptor-mediated antibody-dependent phagocytosis in the host resistance to blood-stage Plasmodium berghei XAT infection. J. Immunol. 166, 6236-6241 (2001).

8) Hayakawa, Y., Takeda, K., Yagita, H., Kakuta, S., Iwakura, Y., Van Kaer, L., Saiki, I., and Okumura, K. Critical contribution of IFN-gamma and NK cells, but not perforin-mediated cytotoxicity, to anti-metastatic effect of alpha-galactosylceramide. Eur J Immunol., 31, 1720-1727 (2001).

9) Boutin, H., LeFeuvre, R. A., Horai, R., Asano, M., Iwakura, Y., and Rothwell, N. Role of IL-1a and IL-1b in ischaemic brain damage. J. Neuroscience, 21, 5528-5534 (2001).

10) Morita, Y., Maravei, D. V., Bergeron, L., Wang, S., Perez, G. I.,　Tsutsumi, O., Taketani, Y., Asano, M., Horai, R., Korsmeyer, S. J., Iwakura, Y., Yuan, J., and Tilly, J. L. Caspase-2 deficiency prevents programmed germ cell death resulting from cytokine insufficiency but not meiotic defects caused by loss of ataxia telangiectasia-mutated (Atm) gene function. Cell Death Differ., 8, 614-620 (2001).

11) Imaizumi, Y., Mizushima, H., Matsumoto, H., Dohi, K., Motsumoto, K., Ohtaki, H., Funahashi, H., Matsunaga, S., Horai, R., Asano, M., Iwakura, Y., and Shioda, S. Increased expression of interleukin-1b in mouse hippocampus after global cerebral ischemia. Acta Histochem. Cytochem., 34, 357-362 (2001).

12) Nakae, S., Naruse-Nakajima, C., Sudo, K., Horai, R., Asano, M., and Iwakura, Y. IL-1a, but not IL-1b, is required for contact-allergen-specific T cell activation during the sensitization phase in contact hypersensitivity. Int. Immunol., 13, 1471-1478 (2001).

13) Moshkin, M. P., Tamagawa, A., Kolosova, I. E., Gerlinskaya, L. A., Iwakura, Y., and Endo, Y. Social behavior in male mice deficient in genes for interleukin-1. Med. Immunol., 3, 449-457 (2001).

14) Le Feuvre, R. A., Brough, D., Iwakura, Y., Takeda. K., Rothwell, N. J. Priming of macrophages with LPS potentiates P2X7 mediated cell death via a caspase-1 dependent mechanism, independently of cytokine production. J. Biol. Chem., 277, 3210-3218 (2002).

15) Brough, D., LeFeuvre, R. A., Iwakura, Y., and Rothwell, N. J. Purinergic (P2X7) receptor activation of microglia induces cell death via an interleukin-1-independent mechanism. Mol. Cell Neurosci., 19, 272-280 (2002).

16) Nakae, S., Asano, M., Horai, R., and Iwakura, Y. Interleukin (IL)-1b, but not IL-1a, is required for T cell-dependent antibody production. Immunology, 104, 402-409 (2002).

17) Saijo, S., Asano, M., Horai, R., Yamamoto, H., and Iwakura, Y. Suppression of autoimmune arthritis in IL-1-deficient mice in which T cell activation is impaired due to low levels of CD40L and OX40 expression on T cells. Arth. Rheum., 46, 533-544 (2002).

18) Furuzawa, M., Kuwahara, M., Ishii, K., Iwakura, Y., and Tsubone, H. Diurnal variation of heart rate, locomotor activity, and body temperature in interleukin-1 alpha/beta doubly deficient mice. Exp. Anim., 51, 49-56 (2002).

19) Oguro, T., Takahashi, Y., Ashino, T., Takaki, A., Shioda, S., Horai, R., Asano, M., Sekikawa, K., Iwakura, Y., and Yoshida, T. Involvement of tumor necrosis factorα、rather than interleukin-1 or nitric oxides in the HEME Oxygenase-1 gene expression by lipopolysaccaride in the mouse liver. FEBS Letters, 516, 63-66 (2002).

20) Mizushima, H., Cheng, J-Z., Dohi, K., Horai, R., Asano, M., Iwakura, Y., Hirabayashi, T., Arata, S., Nakajo, S., Takaki,A., Ohtaki, H., and Shioda, S. Reduced postischemic apoptosis in the hippocampus of mice deficient in interleukin-1. J. comparative Neurol., in press.

21) Oguri, S., Motegi, K., Iwakura, Y. and Endo, Y. Primary role of interleukin-1α and interleukin-1β in lopopolysaccharide-induced hypoglycemia in mice. Clin. Diagn. Lab. Immunol., 9, 1307-1312 (2002).

22) Ikegaya, Y., Delcroix, I., Iwakura, Y., Matsuki, N. and Nishiyama, N. Interleukin-1β abrogates long-term depression of hippocampal CA1 synaptic transmission. Synapse, 47, 54-57 (2003).

23) Nakae, S., Komiyama, Y., Narumi, S., Sudo, K., Horai, R., Tagawa, Y., Sekikawa, K., Matsushima, K., Asano, M. and Iwakura, Y. IL-1-induced TNFα elicits inflammatory cell infiltration in the skin by inducing interferon-γ-inducible protein-10 in the elicitation phase of contact hypersensitivity response. Int. Immunol., 15, 251-260 (2003).

24) Ohtaki, H., Funahashi, H., Dohi, K., Oguro, T., Horai, R., Asano, M., Iwakura, Y., Yin, L., Matsunaga, M., Goto, N. and Shioda, S. Suppression of oxidative neuronal damage after transient middle cerebral artery occlusion in mice lacking interleukin-1. Neuroscience Res., 45, 313-324 (2003).

25) Nakae, S., Komiyama, K., Yokoyama, H., Nambu, A., Umeda, M., Iwase, M., Homma, I., Sudo, K., Horai, R., Asano, M. and Iwakura, Y. Interleukin-1 is required for allergen-specific Th2 cell activation and the development of airway hypersensitivity response. Int. Immunol., 15, 483-490 (2003).

26) Voronov, E., Shouval, D. S., Krelin, Y., Cagnano, E., Benharroch, D., Iwakura, Y., Dinarello, C. A., and Apte, R. N. Interleukin 1 is required for tumor invasiveness and angiogenesis. Rroc. Natl. Sci. USA, 100, 2645-2650 (2003).

27) Kirii, H., Niwa, T., Yamada, Y., Wada, H., Saito, K., Iwakura, Y., Asano, M., Moriwaki, H., and Seshima M. Lack of interleukin-1b decreases the severity of atherosclerosis in apolipoprotein E-deficient mice. Arterioscler. Thromb. Vasc. Biol., 23, 656-660 (2003).

28) Nakae, S., Horai, R., Komiyama, Y., Nambu, A., Asano, M., Nakane, A., and Iwakura, Y. The role of IL-1 in the immune system. Cytokine Knockouts, (Humana Press, Totowa, NJ), in press.

29) Nakae, S., Saijo, S., Horai, R., Sudo, K., Mori, S., and Iwakura, Y. IL-17 production from activated T cells is required for the spontaneous development of destructive arthritis in mice deficient in IL-1 receptor antagonist. Proc. Natl. Acad. Sci. USA, 100, 5986-5990 (2003).

30) Wheeler, R. D., Brough, D., Le Feuvre, R. A., Takeda, K., Iwakura, Y., Luheshi, G. N., and Rothwell, N. J. Interleukin-18 induces expression and release of cytokines from murine glial cells: interactions with interleukin-1β. J. Neurochem., 85, 1412-1420 (2003).

31) Ohtaki, H., Takaki, A., Yin, L., Dohi, K., Nakamachi, T., Matsunaga, M., Horai, R., Asano, M., Iwakura, Y., Shioda, S. Suppression of oxidative stress after transient faocal ischemia in interleukin-1 knocknout mice. Acta Neurochir. Suppl., 86, 191-194 (2003).

32) Timoshanko, J.R., Kitching, A.R., Iwakura, Y., Holdsworth, S.R., and Tipping, P.G. Contributions of IL-1β and IL-1α to Crescentic Glomerulonephritis in Mice. J. Am. Soc. Nephrol., 15, 910-918 (2004).

33) Wu, X., Yoshida, A., Sasano, T., Iwakura, Y., and Endo, Y. Histamine production via mast cell-independent induction of histamine decarboxylase in responece to lipopolysaccharide and interleukin-1. Int. Immunopharmacol., 4, 513-520 (2004).

34) Thimoshanko, J.R., Kitching, A.R., Iwakura, Y., Holdsworth, S.R., and Tipping, P.G. Leukocyte derived interleukin-1β interacts with renal interleukin-1 receptor I to promote renal TNF and glomerular injury in murine crescentic glomerulonephritis. Am. J. Physiol., 164, 1967-1977 (2004).

35) Ashino, T., Oguro, T., Shioda, S., Horai, R., Asano, M., Sekikawa, K., Iwakura, Y., Numazawa, S., and Yoshida, T. Involvement of interleukin-6 and tumor necrosis factor alpha in CYP3A11 and 2C29 down-regulation by Bacillus Calmette-Guerin and lipopolysaccharide in mouse liver. Drug Metab. Dispos., 32, 707-714 (2004).

36) Umemura, M., Kawabe, T., Shudo, K., Kidoya, H., Fukui, M., Asano, M., Iwakura, Y., Matsuzaki, G., Imamura, R., and Suda, T. Involvement of IL-17 in Fas ligand-induced inflammation. Int. Immunol., 16, 1099-1108 (2004).

37) Hata, H., Sakaguchi, N., Yoshitomi, H., Iwakura, Y., Sekikawa, K., Azuma, Y., Kanai, C., Moriizumi, E., Nomura, T., Nakamura, T., and Sakaguchi, S. Distinct contribution of IL-6, TNF-α, IL-1, and IL-10 to T cell-mediated spontaneous autoimmune arthritis in mice. J. Clin. Invest., 114, 582-588 (2004).

38) Joosten, L.A., Smeets, R.L., Koenders, M.I., van den Bersselaar, L.A., Helsen, M.M., Oppers-Walgreen, B., Lubberts, E., Iwakura, Y., van de Loo, F.A., and van den Berg, W.B. Interleukin-18 promotes joint inflammation and induces interleukin-1 driven cartilage destruction. Am. J. Pathol., 165, 959-967 (2004).

39) Kagiwada, K., Chida, D., Sakatani, T., Asano, M., Nambu, A., Kakuta, S., and Iwakura, Y. Interleukin (IL)-6, But Not IL-1, Induction in the Brain Downstream of Cyclooxygenase-2 Is Essential for the Induction of Febrile Response against Peripheral IL-1α. Endocrinology, 145, 5044-5048 (2004).

40) Tanabe, M., Matsumoto, T., Shibuya, K., Tateda, K., Miyazaki, S., Nakane, A., Iwakura , Y., and Yamaguchi, K. Compensatory response of IL-1 gene knockout mice after pulmonary infection with Klebsiella pneumoniae. J. Med. Microbiol., 54, 7-13 (2005).

41) Horino, T., Matsumoto, T., Uramatsu, M., Tanabe, M., Tateda, K., Miyazaki, S., Nakane, A., Iwakura, Y., and Yamaguchi, K. Interleukin-1-deficient mice exhibit high sensitivity to gut-derived sepsis caused by Pseudomonas aeruginosa. Cytokine, 30, 339-346 (2005).

42) Hedtjam, M., Mallard, C., Iwakura, Y., and Hagberg, H. Combined deficiency of IL-1β18, but not IL-1αβ, reduces susceptibility to hypoxia-ischemia in the immature brain. Dev. Neurosci., 27, 143-148 (2005).

43) Chida, D., Imaki, T., Suda, T., and Iwakura, Y. Involvement of CRH- and IL-6-dependent proopiomelanocortin induction in the anterior pituitary during hypothalamic-pituitary-adrenal axis activation by IL-1α. Endocrinology, 146, 5496-5502 (2005).

44) Zhu, Y., Saito, K., Murakami, Y., Asano, M., Iwakura, Y., and Seishima, M. Early increase in mRNA levels of pro-inflammatory cytokines and their interactions in the mouse hippocampus after transient global ischemia. Neurosci. Lett., 393, 122-126 (2006).

45) Honore, P., Wade, CL., Zhong, C., Harris, RR., Wu, C., Ghayur, T., Iwakura, Y., Decker, MW., Faltynek, C., Sullivan, J., and Jarvis, MF. Interleukin-1alphabeta gene-deficient mice show reduced nociceptive sensitivity in models of inflammatory and neuropathic pain but not post-operative pain. Behav. Brain Res., 167, 355-364 (2006).

46) Matsuki, T., Nakae, S., Sudo, K., Horai, R., and Iwakura, Y. Abnormal T cell activation caused by the imbalance of the IL-1/IL-1R antagonist system is responsible for the development of experimental autoimmune encephalomyelitis. Int. Immunol., 18, 399-407 (2006).

47) Chida, D., Osaka, T., Hashimoto, O., and Iwakura, Y. Combined IL-6 and IL-1 deficiency causes obesity in young mice. Diabetes, 55, 971-977 (2006).

48) Vonk, AG., Netea, MG., van Krieken, JH., Iwakura, Y., van der Meer, JWM., and Kullberg, JB. Endogenous Interleukin (IL)-1α and IL-1β Are Crucial for Host Defense against Disseminated Candidiasis. J. Infect. Dis., 193, 1419-1426 (2006).

49) Nambu, A., Nakae, S., and Iwakura, Y. IL-1β, but not IL-1α, is required for antigen-specific T cell activation and the induction of local inflammation in the delayed -type hypersensitivity responses. Int. Immunol., 18, 701-712 (2006).

50) Deng, X., Yu, Z., Funayama, H., Shoji, N., Sasano, T., Iwakura, Y., Sugawara, S., and Endo, Y. Mutual augmentation of the induction of the histamine-forming enzyme, histidine decarboxylase, between alendronate and immuno-stimulants (IL-1, TNF, and LPS), and its prevention by clodronate. Toxicol. Appl. Pharmacol., 213, 64-73 (2006).

51) Tateno, K., Minamino, T., Toko, H., Akazawa, H., Shimizu, N., Takeda, S., Kunieda, T., Miyauchi, H., Oyama, T., Matsuura, K., Nishi, JI., Kobayashi, Y., Nagai, T., Kuwabara, Y., Iwakura, Y., Nomura, F., Saito, Y., and Komuro, I. Critical Roles of Muscle-Secreted Angiogenic Factors in Therapeutic Neovascularization. Circ. Res., 98, 1194-1202 (2006).

52) Voronov, E., Dayan, M., Zinger, H., Gayvoronsky, L., Lin, JP., Iwakura, Y., Apte, RN., and Mozes, E. IL-1β-deficient mice are resistant to induction of experimental SLE. Eur. Cytokine Netw., 17, 109-116 (2006).

53) Furuichi, K., Wada, T., Iwata, Y., Kokubo, S., Hara, A., Yamahana, J., Sugaya, T., Iwakura, Y., Matsushima, K., Asano, M., Yokoyama, H., and Kaneko, S. Interleukin-1-dependent sequential chemokine expression and inflammatory cell infiltration in ischemia-reperfusion injury. Crit. Care Med., 34, 2447-2455 (2006).

54) Maedler, K., Schumann, DM., Sauter, N., Ellingsgaard, H., Bosco, D., Baertschiger, R., Iwakura, Y., Oberholzer, J., Wollheim, CB., Gauthier, BR., Donath, MY. Low Concentration of Interleukin-1β Induces FLICE-Inhibitory Protein-Mediated β-Cell Proliferation in Human Pancreatic Islets. Diabetes, 55, 2713-2722 (2006).

55) Krelin, Y., Voronov, E., Dotan, S., Elkabets, M., Reich, E., Fogel, M., Huszar, M., Iwakura, Y., Segal, S., Dinarello, CA., and Apte, RN. Interleukin-1β-Driven Inflammation Promotes the Development and Invasiveness of Chemical Carcinogen-Induced Tumors. Cancer Res., 67, 1062-1071 (2007).

56) Nigrovic, PA., Binstadt, BA., Monach, PA., Johnsen, A., Gurish, M., Iwakura, Y., Benoist, C., Mathis, D., and Lee, DM. Mast cells contribute to initiation of autoantibody-mediated arthritis via IL-1. Proc. Natl. Acad. Sci. USA., 104, 2325-2330 (2007).

57) Sugihara T, Sekine C, Nakae T, Kohyama K, Harigai M, Iwakura Y, Matsumoto Y, Miyasaka N, Kohsaka H. A new murine model to define the critical pathologic and therapeutic mediators of polymyositis. Arthritis Rheum., 56, 1304-1314 (2007).

58) Sato, N., Kinbara, M., Kuroishi, T., Kimura, K., Iwakura, Y., Ohtsu, H., Sugawara, S., and Endo, Y. Lipopolysaccharide promotes and augments metal allergies in mice, dependent on innate immunity and histidine decarboxylase. Clin Exp Allergy. 37, 743-751 (2007).

59) Ohama, T., Hori, M., Momotani, E., Iwakura, Y., Guo, F., Kishi, H., Kobayashi, S., and Ozaki, H. Intestinal inflammation down-regulates smooth muscle CPI-17 through induction of TNF-α and causes motility disorders. Am. J. Physiol. Gastrointest. Liver Physiol., 292, G1429-1438 (2007).

60) Takagi, K., Matsumura, S., Okuda-Ashitaka, E., Okuda, K., Watanabe, J., Takahashi, H., Iwakura, Y., and Ito, S. Interleukin-1 is not essential for expression of inducible NOS in hepatocytes induced by lipopolysaccharide in vivo. Nitric Oxide, 16, 433-441 (2007).

61) Tamagawa, A., Kolosova, I., Endo, Y., Gerlinskaya, L., Iwakura, Y., and Moshikin, M.? Interleukin-1 deficiency and aggressiveness in male mice.?? In “Psychoneuroendocrinology Research Trends”, M. T. Czerbnska ed., Nova Science Publishers, Inc., pp1-16 (2007).

62) Kamari, Y., Werman-Venkert, R., Shaish, A., Werman, A., Harari, A., Gonen, A., Voronov, E., Grosskopf, I., Sharabi, Y., Grossman, E., Iwakura, Y., Dinarello, CA., Apte, RN., and Harats, D. Differential role and tissue specificity of interleukin-1α gene expression in atherogenesis and lipid metabolism. Atherosclerosis, 195, 31-38 (2007).

63) Miller, LS., Pietras, EM., Uricchio, LH., Hirano, K., Rao, S., Lin, H., O'Connell, RM., Iwakura, Y., Cheung, AL., Cheng, G., and Modlin, RL. Inflammasome-Mediated Production of IL-1 Is Required for Neutrophil Recruitment against Staphylococcus aureus In Vivo. J. Immunol., 179, 6933-6942 (2007).

64) Chida, D., and Iwakura, Y.? Peripheral TNFα, but not peripheral IL-1, requires endogenous IL-1 or TNFα induction in the brain for the febrile response.? Biochem. Biophys. Res. Commun., 364, 765-770 (2007).

65) Honda, A., Abe, R., Makino, T., Norisugi, O., Fujita, Y., Watanabe, H., Nishihira, J., Iwakura, Y., Yamagishi, SI., Shimizu, H., and Shimizu, T. Interleukin-1β and macrophage migration inhibitory factor (MIF) in dermal fibroblasts mediate UVA-induced matrix metalloproteinase-1 expression. J. Dermatol. Sci., 49, 63-72 (2008).