Publications

    • Magnesium Carbenoids in Homologation Chemistry
      Tsutomu Kimura, Koto Sekiguchi
      In Homologation Reactions: Reagents, Applications, and Mechanisms; Wiley, 2023, Vol. 1, 191–216.
      ISBN: 9783527348152
    • Use of 1-Chlorovinyl p-Tolyl Sulfoxides as Alkynylmagnesium Chloride Sources
      Koto Sekiguchi, Tsutomu Kimura
      Tetrahedron 2023, 139, 133439.
      DOI: 10.1016/j.tet.2023.133439
    • Fritsch–Buttenberg–Wiechell Rearrangement of Magnesium Alkylidene Carbenoids Leading to the Formation of Alkynes
      Tsutomu Kimura, Koto Sekiguchi, Akane Ando, Aki Imafuji
      Beilstein Journal of Organic Chemistry 2021, 17, 1352–1359.
      DOI: 10.3762/bjoc.17.94
    • Discovery of a Multipotent Chaperone, 1-(2,6-Difluorobenzylamino)-3-(1,2,3,4-tetrahydrocarbazol-9-yl)-propan-2-ol with the Inhibitory Effects on the Proliferation of Prion, Cancer as Well as Influenza Virus
      Satoshi Yamashita, Ryo Honda, Mayuko Fukuoka, Tsutomu Kimura, Junji Hosokawa-Muto, Kazuo Kuwata
      PRION 2020, 14 (1), 42–46.
      DOI: 10.1080/19336896.2020.1714372
    • Oral Toxicity Study of an Antiprion Compound N,N'-[(Cyclohexylmethylene)di-4,1-phenylene]bis[2-(1-pyrrolidinyl)acetamide] in Rats and Cynomolgus Monkeys
      Tsutomu Kimura, Junji Hosokawa-Muto, Kazuo Kuwata
      Fundamental Toxicological Sciences 2019, 6 (5), 187–195.
      DOI: https://doi.org/10.2131/fts.6.187
    • A Designer Molecular Chaperone Against Transmissible Spongiform Encephalopathy Slows Disease Progression in Mice and Macaques
      Keiichi Yamaguchi, Yuji O. Kamatari, Fumiko Ono, Hiroaki Shibata, Takayuki Fuse, Abdelazim Elsayed Elhelaly, Mayuko Fukuoka, Tsutomu Kimura, Junji Hosokawa-Muto, Takeshi Ishikawa, Minoru Tobiume, Yoshinori Takeuchi, Yutaka Matsuyama, Daisuke Ishibashi, Noriyuki Nishida, Kazuo Kuwata
      Nature Biomedical Engineering 2019, 3 (5), 206–219.
      DOI: 10.1038/s41551-019-0349-8
      Chemical & Engineering News
    • Development of Organic Reactions Utilizing Three Different Types of Reactivity of Magnesium Carbenoids
      Tsutomu Kimura
      Journal of Synthetic Organic Chemistry, Japan 2018, 76 (3), 209–217.
      DOI: 10.5059/yukigoseikyokaishi.76.209
    • Efficient One-Pot Synthesis of 1-Chlorovinyl p-Tolyl Sulfoxides from Aldehydes and Ketones by the Horner–Wadsworth–Emmons Reaction
      Tsutomu Kimura, Gen Kobayashi, Shiori Ijima, Sae Saito, Aki Imafuji, Tsuyoshi Satoh
      Heteroatom Chemistry 2017, 28(5), e21395.
      DOI: 10.1002/hc.21395
    • Recent Advances in Magnesium Carbenoid Chemistry
      Tsutomu Kimura
      Synthesis 2017, 49 (23), 5105–5119.
      DOI: 10.1055/s-0036-1590894
    • Consecutive Reaction of 1-Chlorovinyl p-Tolyl Sulfoxides with [Chloro(p-tolylsulfinyl)methyl]lithium Leading to the Formation of Multi-Functionalized Methylenecyclopropanes
      Tsutomu Kimura, Hitoshi Momochi, Kaho Moriuchi, Tsukasa Katagiri, Tsuyoshi Satoh
      Tetrahedron Letters 2017, 58 (36), 3505–3507.
      DOI: 10.1016/j.tetlet.2017.07.083
    • Synthesis of 2-Azabicyclo[2.1.0]pentanes by the Intramolecular Nucleophilic Substitution of Cyclopropylmagnesium Carbenoids with Magnesium Anilide
      Tsutomu Kimura, Toshiki Nishimura, Natsumi Wada, Tsuyoshi Satoh
      Tetrahedron 2017, 73 (18), 2623–2628.
      DOI: 10.1016/j.tet.2017.03.045
    • N,P- and P,P-Acetals Tsutomu Kimura
      In Science of Synthesis Knowledge Update; Thieme, 2016, Vol. 2, 407–460.
      ISBN: 9783132208711
    • Synthesis of 3-Azabicyclo[3.1.0]hexanes by Insertion of Cyclopropylmagnesium Carbenoids into an Intramolecular C‒H Bond Adjacent to a Nitrogen Atom
      Tsutomu Kimura, Natsumi Wada, Takahiro Tsuru, Taro Sampei, Tsuyoshi Satoh
      Tetrahedron 2015, 71 (35), 5952–5958.
      DOI: 10.1016/j.tet.2015.02.059
    • Mechanism of Magnesium Carbenoid 1,3-C–H Insertion: A DFT Study
      Tsutomu Kimura, Tsuyoshi Satoh
      Journal of Physical Organic Chemistry 2015, 28 (7), 509–512.
      DOI: 10.1002/poc.3440
    • Synthesis of α-Halobutenolides Using the Nucleophilicity of Magnesium Alkylidene Carbenoids
      Tsutomu Kimura, Kazuki Fukuda, Gaku Kashiwamura, Tsuyoshi Satoh
      Heterocycles 2015, 90 (1) , 163–171.
      DOI: 10.3987/COM-14-S(K)60
    • Synthesis of Cyclopropane-Fused α-Chlorolactones Utilizing the Nucleophilicity of Cyclopropylmagnesium Carbenoids
      Tsutomu Kimura, Junichiro Nishida, Gaku Kashiwamura, Gen Kobayashi, Tsuyoshi Satoh
      Tetrahedron Letters 2014, 55 (8), 1428–1430.
      DOI: 10.1016/j.tetlet.2014.01.038
    • New Synthetic Methods by Using the Electrophilic Nature of Magnesium Carbenoids: Recent Progress and Elucidation of the Essence of the Reactivity by DFT Calculation
      Tsuyoshi Satoh, Tsutomu Kimura
      Journal of Synthetic Organic Chemistry, Japan 2013, 71 (10), 1033–1044.
      DOI: 10.5059/yukigoseikyokaishi.71.1033
    • Nucleophilic Substitution at the Alkenyl and Cyclopropyl Carbon Atoms of Magnesium Carbenoids: A DFT Study
      Tsutomu Kimura, Tsuyoshi Satoh
      Tetrahedron Letters 2013, 54 (37), 5072–5074.
      DOI: 10.1016/j.tetlet.2013.07.030
    • Degree of Vinylidene Character of α-Heteroatom-Substituted Vinylmagnesium Chlorides: A DFT Study to Discern the Role of the Halogen Atom in Magnesium Alkylidene Carbenoid Chemistry
      Tsutomu Kimura, Tsuyoshi Satoh
      Tetrahedron 2013, 69 (31), 6371–6374.
      DOI: 10.1016/j.tet.2013.05.108
    • Applications of Density Functional Theory Calculations to Lithium Carbenoids and Magnesium Carbenoids
      Tsutomu Kimura
      In Density Functional Theory: Principles, Applications and Analysis; Nova Science Publishers, Inc. 2013, 59–94.
      ISBN: 978-1-62417-954-9
    • Synthesis of an 11C-Labeled Antiprion GN8 Derivative and Evaluation of Its Brain Uptake by Positron Emission Tomography
      Tsutomu Kimura, Takeo Sako, Siqin, Junji Hosokawa-Muto, Yi Long Cui, Yasuhiro Wada, Yosky Kataoka, Hisashi Doi, Suehiro Sakaguchi, Masaaki Suzuki, Yasuyoshi Watanabe, Kazuo Kuwata
      ChemMedChem 2013, 8 (7), 1035–1039.
      DOI: 10.1002/cmdc.201300167
    • Synthesis of Small Ring-Containing Conjugated Dienes via the Coupling Reaction of Cyclopropyl- and Cyclobutylmagnesium Carbenoids with α-Sulfonylallyllithiums
      Tsutomu Kimura, Mio Inumaru, Takuma Migimatsu, Masashi Ishigaki, Tsuyoshi Satoh
      Tetrahedron 2013, 69 (19), 3961–3970.
      DOI: 10.1016/j.tet.2013.03.019
    • A Novel One-Pot Synthesis of Cyclopropanols Based on the Reaction of Magnesium Carbenoids with Lithium Enolate of Ketones
      Gaku Kashiwamura, Tsutomu Kimura, Tsuyoshi Satoh
      Tetrahedron Letters 2013, 54 (20), 2533–2535.
      DOI: 10.1016/j.tetlet.2013.03.025
    • Alkenylation of 1- and 2-Naphthols by Using Magnesium Alkylidene Carbenoids as Electrophilic Alkenylating Agents
      Tsutomu Kimura, Masaya Watanabe, Gaku Kashiwamura, Jo Sakurada, Tsuyoshi Satoh
      Synthesis 2013, 45 (5), 659–667.

      DOI: 10.1055/s-0032-1318132
    • Efficient Synthesis of Cyclopropanecarboxylic Acid Esters Starting from the Conjugate Addition of Lithium Ester Enolates to 1-Chlorovinyl p-Tolyl Sulfoxides
      Tsutomu Kimura, Yoshiaki Hattori, Hitoshi Momochi, Nobuhito Nakaya, Tsuyoshi Satoh
      Synlett 2013, 24 (4), 483–486.
      DOI: 10.1055/s-0032-1318168
    • Configurational Stability of Optically Active Dichloromethyl p-Tolyl Sulfoxide and Its Anionic Species: Experimental and Theoretical Study
      Tsutomu Kimura, Takahiro Tsuru, Hitoshi Momochi, Tsuyoshi Satoh
      Heteroatom Chemistry 2013, 24 (2), 131–137.
      DOI: 10.1002/hc.21074
      Advances in Engineering
    • A Novel Consecutive Reaction of Lithium Acetylides with 2-Aryl-1-chlorovinyl p-Tolyl Sulfoxides Leading to the Formation of (Z)-Enediynes
      Tsutomu Kimura, Yuka Nishimura, Naoyuki Ishida, Hitoshi Momochi, Hironori Yamashita, Tsuyoshi Satoh
      Tetrahedron Letters 2013, 54 (9), 1049–1051.
      DOI: 10.1016/j.tetlet.2012.11.152
    • Coupling Reaction of Magnesium Alkylidene Carbenoids with α-Sulfonylallyllithiums: An Efficient Route to Multi-Substituted Vinylallenes
      Tsutomu Kimura, Gen Kobayashi, Masashi Ishigaki, Mio Inumaru, Jo Sakurada, Tsuyoshi Satoh
      Synthesis 2012, 44 (23), 3623–3632.
      DOI: 10.1055/s-0032-1317507
    • Respiratory and Cardiovascular Toxicity Studies of a Novel Antiprion Compound, GN8, in Rats and Dogs
      Junji Hosokawa-Muto, Tsutomu Kimura, Kazuo Kuwata
      Drug and Chemical Toxicology 2012, 35 (3), 264–271.
      DOI: 10.3109/01480545.2011.598533
    • Synthesis of Spiro[2.6]nonadienones and Spiro[3.6]decadienones by the Reaction of Cyclopropyl- and Cyclobutylmagnesium Carbenoids with Lithium Phenolates and Naphtholates
      Tsuyoshi Satoh, Tsutomu Kimura, Yuki Sasaki, Shinobu Nagamoto
      Synthesis 2012, 44 (13), 2091–2101.
      DOI: 10.1055/s-0031-1291011
    • Quantum Chemical Characterization of Magnesium Carbenoids
      Tsutomu Kimura, Tsuyoshi Satoh
      Journal of Organometallic Chemistry 2012, 715, 1–4.
      DOI: 10.1016/j.jorganchem.2012.04.028
    • New Synthesis of Multi-substituted α-Chlorocyclobutanones from 1-Chloro-3-cyanoalkyl p-Tolyl Sulfoxides by 4-Exo-Dig Nucleophilic Ring Closure of Magnesium Carbenoids to Nitrile Group as the Key Reaction
      Hideki Saitoh, Taro Sampei, Tsutomu Kimura, Yuichi Kato, Naoyuki Ishida, Tsuyoshi Satoh
      Tetrahedron Letters 2012, 53 (24), 3004–3008.
      DOI: 10.1016/j.tetlet.2012.03.127
    • New Synthesis of Multisubstituted Cyanocyclopropanes by the Intramolecular SN2 Alkylation and 1,3-CC Insertion Reaction of Magnesium Carbenoids as the Key Reactions
      Hideki Saitoh, Tatsuya Watanabe, Tsutomu Kimura, Yuichi Kato, Tsuyoshi Satoh
      Tetrahedron 2012, 68 (11), 2481–2495.
      DOI: 10.1016/j.tet.2012.01.059
    • Synthesis, Including Asymmetric Synthesis, of 3-Oxabicyclo[3.1.0]hexanes and Bicyclo[3.1.0]hexanes by the 1,5-CH Insertion of Cyclopropylmagnesium Carbenoids as the Key Reaction
      Tsuyoshi Satoh, Takahiro Tsuru, Shotaro Ikeda, Toshifumi Miyagawa, Hitoshi Momochi, Tsutomu Kimura
      Tetrahedron 2012, 68 (4), 1071–1084.
      DOI: 10.1016/j.tet.2011.11.085
    • Synthesis of 9-Substituted 2,3,4,9-Tetrahydro-1H-carbazole Derivatives and Evaluation of Their Anti-prion Activity in TSE-infected Cells
      Tsutomu Kimura, Junji Hosokawa-Muto, Kenji Asami, Toshiaki Murai, Kazuo Kuwata
      European Journal of Medicinal Chemistry 2011, 46 (11), 5675–5679.
      DOI: 10.1016/j.ejmech.2011.08.039
    • Aryl(chloro)methyl 4-Tolyl Sulfoxides: Synthesis and Application to the Synthesis of α-Aryl Ketones
      Shigehiko Fukuda, Kazuhito Tsuji, Jun Musashi, Ryo Nonaka, Tsutomu Kimura, Tsuyoshi Satoh
      Synthesis 2011, (22), 3615–3626.
      DOI: 10.1055/s-0031-1260251
    • Synthesis of GN8 Derivatives and Evaluation of Their Antiprion Activity in TSE-infected Cells
      Tsutomu Kimura, Junji Hosokawa-Muto, Yuji O. Kamatari, Kazuo Kuwata
      Bioorganic & Medicinal Chemistry Letters 2011, 21 (5), 1502–1507.
      DOI: 10.1016/j.bmcl.2010.12.132
    • Synthesis of [2,6-Bis(2-oxazolinyl)phenyl]palladium Complexes via the Ligand Introduction Route
      Tsutomu Kimura, Yasuhiro Uozumi
      Organometallics 2008, 27 (19), 5159–5162.
      DOI: 10.1021/om800666x
    • Alkylative Cyclization of 1,6-Enynes in Water with an Amphiphilic Resin-Supported Palladium Catalyst
      Yasushi Nakai, Tsutomu Kimura, Yasuhiro Uozumi
      Synlett 2006, (18), 3065–3068.
      DOI: 10.1055/s-2006-951498
    • PCP Pincer Palladium Complexes and Their Catalytic Properties:  Synthesis via the Electrophilic Ligand Introduction Route
      Tsutomu Kimura, Yasuhiro Uozumi
      Organometallics 2006, 25 (20), 4883–4887.
      DOI: 10.1021/om060506b
    • Synthesis, Structures, and Some Reactions of [(Thioacyl)thio]- and (Acylseleno)antimony and -bismuth Derivatives ((RCSS)xMR13–x and (RCOSe)xMR13–x with M = Sb, Bi and x = 1–3)
      Mitsutoshi Kimura, Akiyuki Iwata, Masahiro Itoh, Kazuki Yamada, Tsutomu Kimura, Noriyuki Sugiura, Masaru Ishida, Shinzi Kato
      Helvetica Chimica Acta 2006, 89 (4), 747–783.
      DOI: 10.1002/hlca.200690070
    • Syntheses and Properties of Phosphinoselenoic Chlorides, Acids, and Their Salts
      Toshiaki Murai, Tsutomu Kimura
      Current Organic Chemistry 2006, 10 (15), 1963–1973.
      DOI: 10.2174/138527206778521231
    • Optically Active P-Chiral Phosphinoselenoic Amides: Stereochemical Outcome at the P-Stereogenic Center in the Synthesis of These Substances and Their Characterization
      Tsutomu Kimura, Toshiaki Murai
      Tetrahedron: Asymmetry 2005, 16 (22), 3703–3710.
      DOI: 10.1016/j.tetasy.2005.09.028
    • Enantiomerically Pure P-Chiral Phosphinoselenoic Chlorides: Inversion of Configuration at the P-Chirogenic Center in the Synthesis and Reaction of These Substances
      Tsutomu Kimura, Toshiaki Murai
      Chemical Communications 2005, (32), 4077–4079.
      DOI: 10.1039/B507755A
    • Phosphinoselenothioic Acids and Their Salts:  Synthesis, Characterization, and Reaction with Electrophiles
      Tsutomu Kimura, Toshiaki Murai, Akihiro Miwa, Daisuke Kurachi, Haruhisa Yoshikawa, Shinzi Kato
      Journal of Organic Chemistry 2005, 70 (14), 5611–5617.
      DOI: 10.1021/jo050576c
    • Selenophilic Reaction of Organolithium and Magnesium Reagents with Phosphinoselenoic Chlorides
      Tsutomu Kimura, Toshiaki Murai, Noriko Mizuhata
      Heteroatom Chemistry 2005, 16 (3), 185–191.
      DOI: 10.1002/hc.20091
    • P-Chiral Phosphinoselenoic Chlorides and Phosphinochalcogenoselenoic Acid Esters:  Synthesis, Characterization, and Conformational Studies
      Tsutomu Kimura, Toshiaki Murai
      Journal of Organic Chemistry 2005, 70 (3), 952–959.
      DOI: 10.1021/jo0484979
    • P-Chiral Phosphinoselenoic Chlorides and Optically Active P-Chiral Phosphinoselenoic Amides: Synthesis and Stereospecific Interconversion with Extrusion and Addition Reactions of the Selenium Atom
      Tsutomu Kimura, Toshiaki Murai
      Chemistry Letters 2004, 33 (7), 878–879.
      DOI: 10.1246/cl.2004.878
    • Iodo-cyclization of N-Homoallyl Thioamides Leading to 2,4-Diaryl-5,6-dihydro-4H-1,3-thiazines
      Toshiaki Murai, Hisayuki Niwa, Tsutomu Kimura, Fumitoshi Shibahara
      Chemistry Letters2004, 33 (5), 508–509.
      DOI: 10.1246/cl.2004.508
    • Heck Reaction in Water with Amphiphilic Resin-Supported Palladium-Phosphine Complexes
      Yasuhiro Uozumi, Tsutomu Kimura
      Synlett 2002, (12), 2045–2048.
      DOI: 10.1055/s-2002-35605
    • Selenothiophosphinic Acid Salts: Efficient Synthesis, Structure and Reactivity
      Toshiaki Murai, Tsutomu Kimura, Akihiro Miwa, Daisuke Kurachi, Shinzi Kato
      Chemistry Letters2002, 31 (9), 914–915.
      DOI: 10.1246/cl.2002.914

    • Presentations

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