論文
- Magnesium Carbenoids in Homologation Chemistry
Tsutomu Kimura, Koto Sekiguchi
In Homologation Reactions: Reagents, Applications, and Mechanisms; Wiley, 2023, Vol. 1, 191–216.
ISBN: 9783527348152
- Use of 1-Chlorovinyl p-Tolyl Sulfoxides as Alkynylmagnesium Chloride Sources
Koto Sekiguchi, Tsutomu Kimura
Tetrahedron 2023, 139, 133439.
DOI: 10.1016/j.tet.2023.133439
- Fritsch–Buttenberg–Wiechell Rearrangement of Magnesium Alkylidene Carbenoids Leading to the Formation of Alkynes
Tsutomu Kimura, Koto Sekiguchi, Akane Ando, Aki Imafuji
Beilstein Journal of Organic Chemistry 2021, 17, 1352–1359.
DOI: 10.3762/bjoc.17.94
- Discovery of a Multipotent Chaperone, 1-(2,6-Difluorobenzylamino)-3-(1,2,3,4-tetrahydrocarbazol-9-yl)-propan-2-ol with the Inhibitory Effects on the Proliferation of Prion, Cancer as Well as Influenza Virus
Satoshi Yamashita, Ryo Honda, Mayuko Fukuoka, Tsutomu Kimura, Junji Hosokawa-Muto, Kazuo Kuwata
PRION 2020, 14 (1), 42–46.
DOI: 10.1080/19336896.2020.1714372
- Oral Toxicity Study of an Antiprion Compound N,N'-[(Cyclohexylmethylene)di-4,1-phenylene]bis[2-(1-pyrrolidinyl)acetamide] in Rats and Cynomolgus Monkeys
Tsutomu Kimura, Junji Hosokawa-Muto, Kazuo Kuwata
Fundamental Toxicological Sciences 2019, 6 (5), 187–195.
DOI: 10.2131/fts.6.187 - A Designer Molecular Chaperone Against Transmissible Spongiform Encephalopathy Slows Disease Progression in Mice and Macaques
Keiichi Yamaguchi, Yuji O. Kamatari, Fumiko Ono, Hiroaki Shibata, Takayuki Fuse, Abdelazim Elsayed Elhelaly, Mayuko Fukuoka, Tsutomu Kimura, Junji Hosokawa-Muto, Takeshi Ishikawa, Minoru Tobiume, Yoshinori Takeuchi, Yutaka Matsuyama, Daisuke Ishibashi, Noriyuki Nishida, Kazuo Kuwata
Nature Biomedical Engineering 2019, 3 (5), 206–219.
DOI: 10.1038/s41551-019-0349-8
Chemical & Engineering Newsで取り上げられました。
- マグネシウムカルベノイドの三面的な反応性を活用する合成反応の開発
木村 力
有機合成化学協会誌 2018, 76 (3), 209–217.
DOI: 10.5059/yukigoseikyokaishi.76.209
- Efficient One-Pot Synthesis of 1-Chlorovinyl p-Tolyl Sulfoxides from Aldehydes and
Ketones by the Horner–Wadsworth–Emmons Reaction
Tsutomu Kimura, Gen Kobayashi, Shiori Ijima, Sae Saito, Aki Imafuji, Tsuyoshi Satoh
Heteroatom Chemistry 2017, 28 (5), e21395.
DOI: 10.1002/hc.21395
- Recent Advances in Magnesium Carbenoid Chemistry
Tsutomu Kimura
Synthesis 2017, 49 (23), 5105–5119.
DOI: 10.1055/s-0036-1590894
Graphical Abstractがカバーピクチャーに採用されました。
- Consecutive Reaction of 1-Chlorovinyl p-Tolyl Sulfoxides with [Chloro(p-tolylsulfinyl)methyl]lithium
Leading to the Formation of Multi-Functionalized Methylenecyclopropanes
Tsutomu Kimura, Hitoshi Momochi,
Kaho Moriuchi, Tsukasa Katagiri, Tsuyoshi Satoh
Tetrahedron Letters 2017, 58 (36), 3505–3507.
DOI: 10.1016/j.tetlet.2017.07.083
- Synthesis of 2-Azabicyclo[2.1.0]pentanes
by the Intramolecular Nucleophilic Substitution of Cyclopropylmagnesium
Carbenoids with Magnesium Anilide
Tsutomu Kimura, Toshiki
Nishimura, Natsumi Wada, Tsuyoshi Satoh
Tetrahedron 2017, 73 (18), 2623–2628.
DOI: 10.1016/j.tet.2017.03.045
Organic Chemistry Portal で紹介されました。
- N,P- and P,P-Acetals
Tsutomu Kimura
In Science of
Synthesis Knowledge Update; Thieme, 2016, Vol. 2,
407–460.
ISBN: 9783132208711
- 理工系の基礎 教養化学(丸善出版株式会社) 9.分子の構造と電子, 2016, 176-192.
河合 英敏,木村 力 他 全26名,教養化学編集委員会 編
ISBN:978-4-621-30041-1
- Synthesis of 3-Azabicyclo[3.1.0]hexanes
by Insertion of Cyclopropylmagnesium Carbenoids into
an Intramolecular C‒H Bond
Adjacent to a Nitrogen Atom
Tsutomu Kimura, Natsumi Wada,
Takahiro Tsuru, Taro Sampei,
Tsuyoshi Satoh
Tetrahedron 2015, 71 (35), 5952–5958.
DOI: 10.1016/j.tet.2015.02.059
Organic Chemistry Portal で紹介されました。
- Mechanism of Magnesium Carbenoid 1,3-C–H Insertion: A DFT Study
Tsutomu Kimura, Tsuyoshi Satoh
Journal of
Physical Organic Chemistry 2015, 28 (7), 509–512.
DOI: 10.1002/poc.3440
- Synthesis of α-Halobutenolides
Using the Nucleophilicity of Magnesium Alkylidene
Carbenoids
Tsutomu Kimura, Kazuki Fukuda,
Gaku Kashiwamura, Tsuyoshi
Satoh
Heterocycles 2015, 90(1), 163–171.
DOI: 10.3987/COM-14-S(K)60
- Synthesis of Cyclopropane-Fused α-Chlorolactones Utilizing the Nucleophilicity of Cyclopropylmagnesium Carbenoids
Tsutomu Kimura, Junichiro Nishida, Gaku
Kashiwamura, Gen Kobayashi, Tsuyoshi Satoh
Tetrahedron
Letters 2014, 55 (8), 1428–1430.
DOI: 10.1016/j.tetlet.2014.01.038
- マグネシウムカルベノイドの求電子的性質を活用する有機合成:最近の展開とDFT計算による反応の本質の解明
佐藤 毅, 木村 力
有機合成化学協会誌 2013, 71 (10), 1033–1044.
DOI: 10.5059/yukigoseikyokaishi.71.1033
- Nucleophilic Substitution at the Alkenyl and Cyclopropyl
Carbon Atoms of Magnesium Carbenoids: A DFT Study
Tsutomu Kimura, Tsuyoshi Satoh
Tetrahedron
Letters 2013, 54 (37), 5072–5074.
DOI: 10.1016/j.tetlet.2013.07.030
- Degree of Vinylidene Character of α-Heteroatom-Substituted
Vinylmagnesium Chlorides: A DFT Study to Discern the
Role of the Halogen Atom in Magnesium Alkylidene
Carbenoid Chemistry
Tsutomu Kimura, Tsuyoshi Satoh
Tetrahedron 2013, 69 (31), 6371–6374.
DOI: 10.1016/j.tet.2013.05.108
- Applications of Density Functional Theory Calculations to
Lithium Carbenoids and Magnesium Carbenoids
Tsutomu Kimura
In Density Functional Theory: Principles, Applications and Analysis; Nova Science Publishers, Inc. 2013,
59–94.
ISBN: 978-1-62417-954-9
- Synthesis of an 11C-Labeled Antiprion
GN8 Derivative and Evaluation of Its Brain Uptake by Positron Emission
Tomography
Tsutomu Kimura, Takeo Sako, Siqin, Junji Hosokawa-Muto, Yi
Long Cui, Yasuhiro Wada, Yosky Kataoka,
Hisashi Doi, Suehiro Sakaguchi, Masaaki
Suzuki, Yasuyoshi Watanabe, Kazuo Kuwata
ChemMedChem 2013, 8 (7), 1035–1039.
DOI: 10.1002/cmdc.201300167
- Synthesis of Small Ring-Containing Conjugated Dienes via the Coupling
Reaction of Cyclopropyl- and Cyclobutylmagnesium
Carbenoids with α-Sulfonylallyllithiums
Tsutomu Kimura, Mio Inumaru, Takuma
Migimatsu, Masashi Ishigaki,
Tsuyoshi Satoh
Tetrahedron 2013, 69 (19), 3961–3970.
DOI: 10.1016/j.tet.2013.03.019
- A Novel One-Pot Synthesis of Cyclopropanols
Based on the Reaction of Magnesium Carbenoids with Lithium Enolate
of Ketones
Gaku Kashiwamura, Tsutomu Kimura, Tsuyoshi Satoh
Tetrahedron
Letters 2013, 54 (20), 2533–2535.
DOI: 10.1016/j.tetlet.2013.03.025
Organic Chemistry Portal で紹介されました。
- Alkenylation of 1-
and 2-Naphthols by Using Magnesium Alkylidene
Carbenoids as Electrophilic Alkenylating Agents
Tsutomu Kimura, Masaya Watanabe, Gaku
Kashiwamura, Jo Sakurada, Tsuyoshi Satoh
Synthesis 2013, 45 (5), 659–667.
DOI: 10.1055/s-0032-1318132
- Efficient Synthesis of Cyclopropanecarboxylic
Acid Esters Starting from the Conjugate Addition of Lithium Ester Enolates to 1-Chlorovinyl p-Tolyl Sulfoxides
Tsutomu Kimura, Yoshiaki Hattori, Hitoshi Momochi, Nobuhito Nakaya, Tsuyoshi Satoh
Synlett 2013, 24 (4), 483–486.
DOI: 10.1055/s-0032-1318168
- Configurational Stability of Optically Active Dichloromethyl p-Tolyl
Sulfoxide and Its Anionic Species: Experimental and Theoretical Study
Tsutomu Kimura, Takahiro Tsuru,
Hitoshi Momochi, Tsuyoshi Satoh
Heteroatom
Chemistry 2013, 24 (2), 131–137.
DOI: 10.1002/hc.21074
Advances in Engineeringで紹介されました。
- A Novel Consecutive Reaction of Lithium Acetylides
with 2-Aryl-1-chlorovinyl p-Tolyl Sulfoxides Leading to the Formation of (Z) -Enediynes
Tsutomu Kimura, Yuka Nishimura, Naoyuki
Ishida, Hitoshi Momochi, Hironori Yamashita, Tsuyoshi
Satoh
Tetrahedron Letters 2013, 54 (9), 1049–1051.
DOI: 10.1016/j.tetlet.2012.11.152
- Coupling Reaction of Magnesium Alkylidene
Carbenoids with α-Sulfonylallyllithiums: An Efficient
Route to Multi-Substituted Vinylallenes
Tsutomu Kimura, Gen Kobayashi, Masashi Ishigaki, Mio Inumaru, Jo
Sakurada, Tsuyoshi Satoh
Synthesis 2012, 44 (23), 3623–3632.
DOI: 10.1055/s-0032-1317507
- Respiratory and Cardiovascular Toxicity Studies of a Novel Antiprion Compound, GN8, in Rats and Dogs
Junji Hosokawa-Muto, Tsutomu
Kimura, Kazuo Kuwata
Drug and Chemical Toxicology 2012, 35 (3), 264–271.
DOI: 10.3109/01480545.2011.598533
- Synthesis of Spiro[2.6]nonadienones and Spiro[3.6]decadienones
by the Reaction of Cyclopropyl- and Cyclobutylmagnesium Carbenoids with Lithium Phenolates and Naphtholates
Tsuyoshi Satoh, Tsutomu Kimura, Yuki Sasaki, Shinobu Nagamoto
Synthesis 2012, 44 (13), 2091–2101.
DOI: 10.1055/s-0031-1291011
- Quantum Chemical Characterization of Magnesium Carbenoids
Tsutomu Kimura, Tsuyoshi Satoh
Journal of Organometallic Chemistry 2012, 715, 1–4.
DOI: 10.1016/j.jorganchem.2012.04.028
- New Synthesis of Multi-substituted α-Chlorocyclobutanones from 1-Chloro-3-cyanoalkyl p-Tolyl
Sulfoxides by 4-Exo-Dig Nucleophilic
Ring Closure of Magnesium Carbenoids to Nitrile Group as the Key Reaction
Hideki Saitoh, Taro Sampei, Tsutomu Kimura, Yuichi Kato, Naoyuki Ishida,
Tsuyoshi Satoh
Tetrahedron Letters 2012, 53 (24), 3004–3008.
DOI: 10.1016/j.tetlet.2012.03.127
- New Synthesis of Multisubstituted Cyanocyclopropanes by the Intramolecular SN2
Alkylation and 1,3-CC Insertion Reaction of Magnesium Carbenoids as the Key
Reactions
Hideki Saitoh, Tatsuya Watanabe, Tsutomu
Kimura, Yuichi Kato, Tsuyoshi Satoh
Tetrahedron 2012, 68 (11), 2481–2495.
DOI: 10.1016/j.tet.2012.01.059
- Synthesis, Including Asymmetric Synthesis, of 3-Oxabicyclo[3.1.0]hexanes
and Bicyclo[3.1.0]hexanes by the 1,5-CH Insertion of Cyclopropylmagnesium Carbenoids as the Key Reaction
Tsuyoshi Satoh, Takahiro Tsuru, Shotaro Ikeda, Toshifumi Miyagawa, Hitoshi Momochi, Tsutomu
Kimura
Tetrahedron 2012, 68 (4), 1071–1084.
DOI: 10.1016/j.tet.2011.11.085
- Synthesis of 9-Substituted 2,3,4,9-Tetrahydro-1H-carbazole Derivatives and Evaluation
of Their Anti-prion Activity in TSE-infected Cells
Tsutomu Kimura, Junji
Hosokawa-Muto, Kenji Asami, Toshiaki Murai, Kazuo Kuwata
European Journal of Medicinal Chemistry 2011, 46 (11), 5675–5679.
DOI: 10.1016/j.ejmech.2011.08.039
- Aryl(chloro)methyl 4-Tolyl Sulfoxides:
Synthesis and Application to the Synthesis of α-Aryl Ketones
Shigehiko Fukuda, Kazuhito Tsuji, Jun Musashi, Ryo
Nonaka, Tsutomu Kimura, Tsuyoshi Satoh
Synthesis 2011, (22), 3615–3626.
DOI: 10.1055/s-0031-1260251
- Synthesis of GN8 Derivatives and Evaluation of Their Antiprion Activity in TSE-infected Cells
Tsutomu Kimura, Junji
Hosokawa-Muto, Yuji O. Kamatari, Kazuo Kuwata
Bioorganic & Medicinal Chemistry Letters 2011, 21 (5), 1502–1507.
DOI: 10.1016/j.bmcl.2010.12.132
- Synthesis of [2,6-Bis(2-oxazolinyl)phenyl]palladium
Complexes via the Ligand Introduction Route
Tsutomu Kimura, Yasuhiro Uozumi
Organometallics 2008, 27 (19), 5159–5162.
DOI: 10.1021/om800666x
- Alkylative Cyclization of
1,6-Enynes in Water with an Amphiphilic Resin-Supported Palladium Catalyst
Yasushi Nakai, Tsutomu Kimura,
Yasuhiro Uozumi
Synlett 2006, (18), 3065–3068.
DOI: 10.1055/s-2006-951498
- PCP Pincer Palladium Complexes and Their Catalytic Properties: Synthesis via the Electrophilic Ligand
Introduction Route
Tsutomu Kimura, Yasuhiro Uozumi
Organometallics 2006, 25 (20), 4883–4887.
DOI: 10.1021/om060506b
- Synthesis, Structures, and Some Reactions of [(Thioacyl)thio]- and (Acylseleno)antimony
and -bismuth Derivatives ((RCSS)xMR13–x and (RCOSe)xMR13–x with M = Sb, Bi and x = 1–3)
Mitsutoshi Kimura, Akiyuki Iwata, Masahiro Itoh, Kazuki
Yamada, Tsutomu Kimura, Noriyuki Sugiura,
Masaru Ishida, Shinzi Kato
Helvetica Chimica Acta 2006, 89 (4), 747–783.
DOI: 10.1002/hlca.200690070
- Syntheses and Properties of Phosphinoselenoic
Chlorides, Acids, and Their Salts
Toshiaki Murai, Tsutomu Kimura
Current Organic Chemistry 2006, 10 (15), 1963–1973.
DOI: 10.2174/138527206778521231
- Optically Active P-Chiral
Phosphinoselenoic Amides: Stereochemical
Outcome at the P-Stereogenic Center in the Synthesis
of These Substances and Their Characterization
Tsutomu Kimura, Toshiaki Murai
Tetrahedron: Asymmetry 2005, 16 (22), 3703–3710.
DOI: 10.1016/j.tetasy.2005.09.028
- Enantiomerically Pure P-Chiral Phosphinoselenoic Chlorides: Inversion of
Configuration at the P-Chirogenic Center in the
Synthesis and Reaction of These Substances
Tsutomu Kimura, Toshiaki Murai
Chemical
Communications 2005, (32), 4077–4079.
DOI: 10.1039/B507755A
- Phosphinoselenothioic Acids
and Their Salts: Synthesis,
Characterization, and Reaction with Electrophiles
Tsutomu Kimura, Toshiaki Murai,
Akihiro Miwa, Daisuke Kurachi, Haruhisa
Yoshikawa, Shinzi Kato
Journal of
Organic Chemistry 2005, 70 (14), 5611–5617.
DOI: 10.1021/jo050576c
- Selenophilic
Reaction of Organolithium and Magnesium Reagents with
Phosphinoselenoic Chlorides
Tsutomu Kimura, Toshiaki Murai,
Noriko Mizuhata
Heteroatom
Chemistry 2005, 16 (3), 185–191.
DOI: 10.1002/hc.20091
- P-Chiral
Phosphinoselenoic Chlorides and Phosphinochalcogenoselenoic
Acid Esters: Synthesis,
Characterization, and Conformational Studies
Tsutomu Kimura, Toshiaki Murai
Journal of
Organic Chemistry 2005, 70 (3), 952–959.
DOI: 10.1021/jo0484979
- P-Chiral Phosphinoselenoic Chlorides and Optically Active P-Chiral Phosphinoselenoic
Amides: Synthesis and Stereospecific Interconversion with Extrusion and
Addition Reactions of the Selenium Atom
Tsutomu Kimura, Toshiaki Murai
Chemistry Letters 2004, 33 (7), 878–879.
DOI: 10.1246/cl.2004.878
- Iodo-cyclization of N-Homoallyl Thioamides Leading to 2,4-Diaryl-5,6-dihydro-4H-1,3-thiazines
Toshiaki Murai, Hisayuki
Niwa, Tsutomu Kimura, Fumitoshi
Shibahara
Chemistry Letters 2004, 33 (5), 508–509.
DOI: 10.1246/cl.2004.508
- Heck Reaction in Water with Amphiphilic Resin-Supported
Palladium-Phosphine Complexes
Yasuhiro Uozumi, Tsutomu Kimura
Synlett 2002, (12), 2045–2048.
DOI: 10.1055/s-2002-35605
- Selenothiophosphinic Acid
Salts: Efficient Synthesis, Structure and Reactivity
Toshiaki Murai, Tsutomu Kimura,
Akihiro Miwa, Daisuke Kurachi, Shinzi
Kato
Chemistry Letters 2002, 31 (9), 914–915.
DOI: 10.1246/cl.2002.914
-
Presentations
https://www.tus.ac.jp/ridai/doc/ji/RIJIA01User.php?act=nam&kin=soc&diu=64d7
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研究室所属学生の受賞
- 第12回CSJ化学フェスタ2022(2022年10月20日) 優秀ポスター発表賞
マグネシウムカルベノイドの求電⼦的な反応性を利⽤したビニル炭素上およびシクロプロパン環上での求核置換
理学研究科 修士1年 小又 凌
https://festa.csj.jp/2022/
- 第10回CSJ化学フェスタ2020(2020年10月22日) 優秀ポスター発表賞
α-ハロ置換ビニル金属のビニリデン特性の解明
理学研究科 修士1年 関口 琴
https://festa.csj.jp/2020/
- 第9回CSJ化学フェスタ2019(2019年10月16日) 優秀ポスター発表賞
Fritsch-Buttenberg-Wiechell転位を利用したマグネシウムアセチリドの生成と利用
理学部第二部化学科 4年 関口 琴
https://festa.csj.jp/2019/
- 第6回CSJ化学フェスタ2016(2016年11月16日) 優秀ポスター発表賞
シクロプロピルマグネシウムカルベノイドの分子内求核置換によるアザビシクロ化合物の合成
総合化学研究科 修士2年 西村 俊樹
https://festa.csj.jp/2016/
- 第70回有機合成化学協会関東支部シンポジウム(2015年11月21日) 若手講演賞
シクロプロピルマグネシウムカルベノイドと求核剤および求電子剤との連続反応による多置換シクロプロパンの合成
総合化学研究科 修士1年 岩佐 崇弘
- 13th
Symposium on Chemical Approaches to Chirality (November 12, 2014) Best Poster Award
Asymmetric
Synthesis of 3-Oxa- and 3-Azabicyclo[3.1.0]hexanes by
the 1,5-C-H Insertion of Cyclopropylmagnesium
Carbenoids
総合化学研究科 修士2年 和田 夏美
- 第4回CSJ化学フェスタ2014(2014年10月15日) 優秀ポスター発表賞
シクロプロピルマグネシウムカルベノイドの多様な反応性を活かした有機分子変換
総合化学研究科 修士2年 西田 潤一郎
- 12th
Symposium on Chemical Approaches to Chirality (November 27, 2013) Best Poster Award
Asymmetric
Synthesis of Cyclopropane-Containing Carboxylic Acid Esters Using Magnesium
Carbenoid Chemistry
総合化学研究科 修士2年 服部 芳明
- 第65回有機合成化学協会関東支部シンポジウム(2013年5月18日) 若手講演賞
シクロプロピルマグネシウムカルベノイドの求核性を利用したビシクロ-γ-ラクトン類の合成
総合化学研究科 修士1年 西田 潤一郎
- 第64回有機合成化学協会関東支部シンポジウム(2012年12月1日) 若手講演賞
マグネシウムアルキリデンカルベノイドのFritsch-Buttenberg-Wiechell転位による共役ジインの合成
理学部第一部応用化学科 4年 武田 光佑
- 第64回有機合成化学協会関東支部シンポジウム(2012年12月1日) 若手講演賞
カルベノイドの求核性を利用した不飽和ラクトンの新規合成法の開発
理学部第一部応用化学科 4年 福田 一生
- 第63回有機合成化学協会関東支部シンポジウム(2012年5月19日) 若手講演賞
3-シアノアルキルマグネシウムカルベノイドの4-Exo-Dig型環化反応によるシクロブタノン類の合成
総合化学研究科 修士1年 三瓶 太朗
-