論文

  • Oral Toxicity Study of an Antiprion Compound N,N'-[(Cyclohexylmethylene)di-4,1-phenylene]bis[2-(1-pyrrolidinyl)acetamide] in Rats and Cynomolgus Monkeys
    Tsutomu Kimura, Junji Hosokawa-Muto, Kazuo Kuwata
    Fundamental Toxicological Sciences 2019, 6 (5), 187–195.
    DOI: https://doi.org/10.2131/fts.6.187
  • A Designer Molecular Chaperone Against Transmissible Spongiform Encephalopathy Slows Disease Progression in Mice and Macaques
    Keiichi Yamaguchi, Yuji O. Kamatari, Fumiko Ono, Hiroaki Shibata, Takayuki Fuse, Abdelazim Elsayed Elhelaly, Mayuko Fukuoka, Tsutomu Kimura, Junji Hosokawa-Muto, Takeshi Ishikawa, Minoru Tobiume, Yoshinori Takeuchi, Yutaka Matsuyama, Daisuke Ishibashi, Noriyuki Nishida, Kazuo Kuwata
    Nature Biomedical Engineering 2019, 3 (5), 206–219.
    DOI: 10.1038/s41551-019-0349-8
    Chemical & Engineering Newsで取り上げられました。
  • マグネシウムカルベノイドの三面的な反応性を活用する合成反応の開発
    木村 力
    有機合成化学協会誌 2018, 76 (3), 209–217.
    DOI: 10.5059/yukigoseikyokaishi.76.209
  • Efficient One-Pot Synthesis of 1-Chlorovinyl p-Tolyl Sulfoxides from Aldehydes and Ketones by the Horner–Wadsworth–Emmons Reaction
    Tsutomu Kimura, Gen Kobayashi, Shiori Ijima, Sae Saito, Aki Imafuji, Tsuyoshi Satoh
    Heteroatom Chemistry 2017, 28 (5), e21395.
    DOI: 10.1002/hc.21395
  • Recent Advances in Magnesium Carbenoid Chemistry
    Tsutomu Kimura
    Synthesis 2017, 49 (23), 5105–5119.
    DOI: 10.1055/s-0036-1590894
    Graphical Abstractがカバーピクチャーに採用されました。
  • Consecutive Reaction of 1-Chlorovinyl p-Tolyl Sulfoxides with [Chloro(p-tolylsulfinyl)methyl]lithium Leading to the Formation of Multi-Functionalized Methylenecyclopropanes
    Tsutomu Kimura, Hitoshi Momochi, Kaho Moriuchi, Tsukasa Katagiri, Tsuyoshi Satoh
    Tetrahedron Letters 2017, 58 (36), 3505–3507.
    DOI: 10.1016/j.tetlet.2017.07.083
  • Synthesis of 2-Azabicyclo[2.1.0]pentanes by the Intramolecular Nucleophilic Substitution of Cyclopropylmagnesium Carbenoids with Magnesium Anilide
    Tsutomu Kimura, Toshiki Nishimura, Natsumi Wada, Tsuyoshi Satoh
    Tetrahedron 2017, 73 (18), 2623–2628.
    DOI: 10.1016/j.tet.2017.03.045
    Organic Chemistry Portal で紹介されました。
  • N,P- and P,P-Acetals
    Tsutomu Kimura
    In Science of Synthesis Knowledge Update; Thieme, 2016, Vol. 2, 407–460.
    ISBN: 9783132208711
  • 理工系の基礎 教養化学(丸善出版株式会社) 9.分子の構造と電子, 2016, 176-192.
    河合 英敏,木村 力 他 全26名,教養化学編集委員会 編
    ISBN:978-4-621-30041-1
  • Synthesis of 3-Azabicyclo[3.1.0]hexanes by Insertion of Cyclopropylmagnesium Carbenoids into an Intramolecular C‒H Bond Adjacent to a Nitrogen Atom
    Tsutomu Kimura, Natsumi Wada, Takahiro Tsuru, Taro Sampei, Tsuyoshi Satoh
    Tetrahedron 2015, 71 (35), 5952–5958.
    DOI: 10.1016/j.tet.2015.02.059
    Organic Chemistry Portal で紹介されました。
  • Mechanism of Magnesium Carbenoid 1,3-C–H Insertion: A DFT Study
    Tsutomu Kimura, Tsuyoshi Satoh
    Journal of Physical Organic Chemistry 2015, 28 (7), 509–512.
    DOI: 10.1002/poc.3440
  • Synthesis of α-Halobutenolides Using the Nucleophilicity of Magnesium Alkylidene Carbenoids
    Tsutomu Kimura, Kazuki Fukuda, Gaku Kashiwamura, Tsuyoshi Satoh
    Heterocycles 2015, 90(1), 163–171.
    DOI: 10.3987/COM-14-S(K)60
  • Synthesis of Cyclopropane-Fused α-Chlorolactones Utilizing the Nucleophilicity of Cyclopropylmagnesium Carbenoids
    Tsutomu Kimura, Junichiro Nishida, Gaku Kashiwamura, Gen Kobayashi, Tsuyoshi Satoh
    Tetrahedron Letters 2014, 55 (8), 1428–1430.
    DOI: 10.1016/j.tetlet.2014.01.038
  • マグネシウムカルベノイドの求電子的性質を活用する有機合成:最近の展開とDFT計算による反応の本質の解明
    佐藤 毅, 木村 力
    有機合成化学協会誌 2013, 71 (10), 1033–1044.
    DOI: 10.5059/yukigoseikyokaishi.71.1033
  • Nucleophilic Substitution at the Alkenyl and Cyclopropyl Carbon Atoms of Magnesium Carbenoids: A DFT Study
    Tsutomu Kimura, Tsuyoshi Satoh
    Tetrahedron Letters 2013, 54 (37), 5072–5074.
    DOI: 10.1016/j.tetlet.2013.07.030
  • Degree of Vinylidene Character of α-Heteroatom-Substituted Vinylmagnesium Chlorides: A DFT Study to Discern the Role of the Halogen Atom in Magnesium Alkylidene Carbenoid Chemistry
    Tsutomu Kimura, Tsuyoshi Satoh
    Tetrahedron 2013, 69 (31), 6371–6374.
    DOI: 10.1016/j.tet.2013.05.108
  • Applications of Density Functional Theory Calculations to Lithium Carbenoids and Magnesium Carbenoids
    Tsutomu Kimura
    In Density Functional Theory: Principles, Applications and Analysis; Nova Science Publishers, Inc. 2013, 59–94.
    ISBN: 978-1-62417-954-9
  • Synthesis of an 11C-Labeled Antiprion GN8 Derivative and Evaluation of Its Brain Uptake by Positron Emission Tomography
    Tsutomu Kimura, Takeo Sako, Siqin, Junji Hosokawa-Muto, Yi Long Cui, Yasuhiro Wada, Yosky Kataoka, Hisashi Doi, Suehiro Sakaguchi, Masaaki Suzuki, Yasuyoshi Watanabe, Kazuo Kuwata
    ChemMedChem 2013, 8 (7), 1035–1039.
    DOI: 10.1002/cmdc.201300167
  • Synthesis of Small Ring-Containing Conjugated Dienes via the Coupling Reaction of Cyclopropyl- and Cyclobutylmagnesium Carbenoids with α-Sulfonylallyllithiums
    Tsutomu Kimura, Mio Inumaru, Takuma Migimatsu, Masashi Ishigaki, Tsuyoshi Satoh
    Tetrahedron 2013, 69 (19), 3961–3970.
    DOI: 10.1016/j.tet.2013.03.019
  • A Novel One-Pot Synthesis of Cyclopropanols Based on the Reaction of Magnesium Carbenoids with Lithium Enolate of Ketones
    Gaku Kashiwamura, Tsutomu Kimura, Tsuyoshi Satoh
    Tetrahedron Letters 2013, 54 (20), 2533–2535.
    DOI: 10.1016/j.tetlet.2013.03.025
    Organic Chemistry Portal で紹介されました。
  • Alkenylation of 1- and 2-Naphthols by Using Magnesium Alkylidene Carbenoids as Electrophilic Alkenylating Agents
    Tsutomu Kimura, Masaya Watanabe, Gaku Kashiwamura, Jo Sakurada, Tsuyoshi Satoh
    Synthesis 2013, 45 (5), 659–667.
    DOI: 10.1055/s-0032-1318132
  • Efficient Synthesis of Cyclopropanecarboxylic Acid Esters Starting from the Conjugate Addition of Lithium Ester Enolates to 1-Chlorovinyl p-Tolyl Sulfoxides
    Tsutomu Kimura, Yoshiaki Hattori, Hitoshi Momochi, Nobuhito Nakaya, Tsuyoshi Satoh
    Synlett 2013, 24 (4), 483–486.
    DOI: 10.1055/s-0032-1318168
  • Configurational Stability of Optically Active Dichloromethyl p-Tolyl Sulfoxide and Its Anionic Species: Experimental and Theoretical Study
    Tsutomu Kimura, Takahiro Tsuru, Hitoshi Momochi, Tsuyoshi Satoh
    Heteroatom Chemistry 2013, 24 (2), 131–137.
    DOI: 10.1002/hc.21074
    Advances in Engineeringで紹介されました。
  • A Novel Consecutive Reaction of Lithium Acetylides with 2-Aryl-1-chlorovinyl p-Tolyl Sulfoxides Leading to the Formation of (Z) -Enediynes
    Tsutomu Kimura, Yuka Nishimura, Naoyuki Ishida, Hitoshi Momochi, Hironori Yamashita, Tsuyoshi Satoh
    Tetrahedron Letters 2013, 54 (9), 1049–1051.
    DOI: 10.1016/j.tetlet.2012.11.152
  • Coupling Reaction of Magnesium Alkylidene Carbenoids with α-Sulfonylallyllithiums: An Efficient Route to Multi-Substituted Vinylallenes
    Tsutomu Kimura, Gen Kobayashi, Masashi Ishigaki, Mio Inumaru, Jo Sakurada, Tsuyoshi Satoh
    Synthesis 2012, 44 (23), 3623–3632.
    DOI: 10.1055/s-0032-1317507
  • Respiratory and Cardiovascular Toxicity Studies of a Novel Antiprion Compound, GN8, in Rats and Dogs
    Junji Hosokawa-Muto, Tsutomu Kimura, Kazuo Kuwata
    Drug and Chemical Toxicology 2012, 35 (3), 264–271.
    DOI: 10.3109/01480545.2011.598533
  • Synthesis of Spiro[2.6]nonadienones and Spiro[3.6]decadienones by the Reaction of Cyclopropyl- and Cyclobutylmagnesium Carbenoids with Lithium Phenolates and Naphtholates
    Tsuyoshi Satoh, Tsutomu Kimura, Yuki Sasaki, Shinobu Nagamoto
    Synthesis 2012, 44 (13), 2091–2101.
    DOI: 10.1055/s-0031-1291011
  • Quantum Chemical Characterization of Magnesium Carbenoids
    Tsutomu Kimura, Tsuyoshi Satoh
    Journal of Organometallic Chemistry 2012, 715, 1–4.
    DOI: 10.1016/j.jorganchem.2012.04.028
  • New Synthesis of Multi-substituted α-Chlorocyclobutanones from 1-Chloro-3-cyanoalkyl p-Tolyl Sulfoxides by 4-Exo-Dig Nucleophilic Ring Closure of Magnesium Carbenoids to Nitrile Group as the Key Reaction
    Hideki Saitoh, Taro Sampei, Tsutomu Kimura, Yuichi Kato, Naoyuki Ishida, Tsuyoshi Satoh
    Tetrahedron Letters 2012, 53 (24), 3004–3008.
    DOI: 10.1016/j.tetlet.2012.03.127
  • New Synthesis of Multisubstituted Cyanocyclopropanes by the Intramolecular SN2 Alkylation and 1,3-CC Insertion Reaction of Magnesium Carbenoids as the Key Reactions
    Hideki Saitoh, Tatsuya Watanabe, Tsutomu Kimura, Yuichi Kato, Tsuyoshi Satoh
    Tetrahedron 2012, 68 (11), 2481–2495.
    DOI: 10.1016/j.tet.2012.01.059
  • Synthesis, Including Asymmetric Synthesis, of 3-Oxabicyclo[3.1.0]hexanes and Bicyclo[3.1.0]hexanes by the 1,5-CH Insertion of Cyclopropylmagnesium Carbenoids as the Key Reaction
    Tsuyoshi Satoh, Takahiro Tsuru, Shotaro Ikeda, Toshifumi Miyagawa, Hitoshi Momochi, Tsutomu Kimura
    Tetrahedron 2012, 68 (4), 1071–1084.
    DOI: 10.1016/j.tet.2011.11.085
  • Synthesis of 9-Substituted 2,3,4,9-Tetrahydro-1H-carbazole Derivatives and Evaluation of Their Anti-prion Activity in TSE-infected Cells
    Tsutomu Kimura, Junji Hosokawa-Muto, Kenji Asami, Toshiaki Murai, Kazuo Kuwata
    European Journal of Medicinal Chemistry 2011, 46 (11), 5675–5679.
    DOI: 10.1016/j.ejmech.2011.08.039
  • Aryl(chloro)methyl 4-Tolyl Sulfoxides: Synthesis and Application to the Synthesis of α-Aryl Ketones
    Shigehiko Fukuda, Kazuhito Tsuji, Jun Musashi, Ryo Nonaka, Tsutomu Kimura, Tsuyoshi Satoh
    Synthesis 2011, (22), 3615–3626.
    DOI: 10.1055/s-0031-1260251
  • Synthesis of GN8 Derivatives and Evaluation of Their Antiprion Activity in TSE-infected Cells
    Tsutomu Kimura, Junji Hosokawa-Muto, Yuji O. Kamatari, Kazuo Kuwata
    Bioorganic & Medicinal Chemistry Letters 2011, 21 (5), 1502–1507.
    DOI: 10.1016/j.bmcl.2010.12.132
  • Synthesis of [2,6-Bis(2-oxazolinyl)phenyl]palladium Complexes via the Ligand Introduction Route
    Tsutomu Kimura, Yasuhiro Uozumi
    Organometallics 2008, 27 (19), 5159–5162.
    DOI: 10.1021/om800666x
  • Alkylative Cyclization of 1,6-Enynes in Water with an Amphiphilic Resin-Supported Palladium Catalyst
    Yasushi Nakai, Tsutomu Kimura, Yasuhiro Uozumi
    Synlett 2006, (18), 3065–3068.
    DOI: 10.1055/s-2006-951498
  • PCP Pincer Palladium Complexes and Their Catalytic Properties:  Synthesis via the Electrophilic Ligand Introduction Route
    Tsutomu Kimura, Yasuhiro Uozumi
    Organometallics 2006, 25 (20), 4883–4887.
    DOI: 10.1021/om060506b
  • Synthesis, Structures, and Some Reactions of [(Thioacyl)thio]- and (Acylseleno)antimony and -bismuth Derivatives ((RCSS)xMR13–x and (RCOSe)xMR13–x with M = Sb, Bi and x = 1–3)
    Mitsutoshi Kimura, Akiyuki Iwata, Masahiro Itoh, Kazuki Yamada, Tsutomu Kimura, Noriyuki Sugiura, Masaru Ishida, Shinzi Kato
    Helvetica Chimica Acta 2006, 89 (4), 747–783.
    DOI: 10.1002/hlca.200690070
  • Syntheses and Properties of Phosphinoselenoic Chlorides, Acids, and Their Salts
    Toshiaki Murai, Tsutomu Kimura
    Current Organic Chemistry 2006, 10 (15), 1963–1973.
    DOI: 10.2174/138527206778521231
  • Optically Active P-Chiral Phosphinoselenoic Amides: Stereochemical Outcome at the P-Stereogenic Center in the Synthesis of These Substances and Their Characterization
    Tsutomu Kimura, Toshiaki Murai
    Tetrahedron: Asymmetry 2005, 16 (22), 3703–3710.
    DOI: 10.1016/j.tetasy.2005.09.028
  • Enantiomerically Pure P-Chiral Phosphinoselenoic Chlorides: Inversion of Configuration at the P-Chirogenic Center in the Synthesis and Reaction of These Substances
    Tsutomu Kimura, Toshiaki Murai
    Chemical Communications 2005, (32), 4077–4079.
    DOI: 10.1039/B507755A
  • Phosphinoselenothioic Acids and Their Salts:  Synthesis, Characterization, and Reaction with Electrophiles
    Tsutomu Kimura, Toshiaki Murai, Akihiro Miwa, Daisuke Kurachi, Haruhisa Yoshikawa, Shinzi Kato
    Journal of Organic Chemistry 2005, 70 (14), 5611–5617.
    DOI: 10.1021/jo050576c
  • Selenophilic Reaction of Organolithium and Magnesium Reagents with Phosphinoselenoic Chlorides
    Tsutomu Kimura, Toshiaki Murai, Noriko Mizuhata
    Heteroatom Chemistry 2005, 16 (3), 185–191.
    DOI: 10.1002/hc.20091
  • P-Chiral Phosphinoselenoic Chlorides and Phosphinochalcogenoselenoic Acid Esters:  Synthesis, Characterization, and Conformational Studies
    Tsutomu Kimura, Toshiaki Murai
    Journal of Organic Chemistry 2005, 70 (3), 952–959.
    DOI: 10.1021/jo0484979
  • P-Chiral Phosphinoselenoic Chlorides and Optically Active P-Chiral Phosphinoselenoic Amides: Synthesis and Stereospecific Interconversion with Extrusion and Addition Reactions of the Selenium Atom
    Tsutomu Kimura, Toshiaki Murai
    Chemistry Letters 2004, 33 (7), 878–879.
    DOI: 10.1246/cl.2004.878
  • Iodo-cyclization of N-Homoallyl Thioamides Leading to 2,4-Diaryl-5,6-dihydro-4H-1,3-thiazines
    Toshiaki Murai, Hisayuki Niwa, Tsutomu Kimura, Fumitoshi Shibahara
    Chemistry Letters 2004, 33 (5), 508–509.
    DOI: 10.1246/cl.2004.508
  • Heck Reaction in Water with Amphiphilic Resin-Supported Palladium-Phosphine Complexes
    Yasuhiro Uozumi, Tsutomu Kimura
    Synlett 2002, (12), 2045–2048.
    DOI: 10.1055/s-2002-35605
  • Selenothiophosphinic Acid Salts: Efficient Synthesis, Structure and Reactivity
    Toshiaki Murai, Tsutomu Kimura, Akihiro Miwa, Daisuke Kurachi, Shinzi Kato
    Chemistry Letters 2002, 31 (9), 914–915.
    DOI: 10.1246/cl.2002.914
  • Presentations

    https://www.tus.ac.jp/ridai/doc/ji/RIJIA01User.php?act=nam&kin=soc&diu=64d7
  • 研究室所属学生の受賞

  • 第9回CSJ化学フェスタ2016(2019年11月20日) 優秀ポスター発表賞
    Fritsch-Buttenberg-Wiechell転位を利用したマグネシウムアセチリドの生成と利用
    理学部第二部化学科 4年 関口 琴
  • 第6回CSJ化学フェスタ2016(2016年11月16日) 優秀ポスター発表賞
    シクロプロピルマグネシウムカルベノイドの分子内求核置換によるアザビシクロ化合物の合成
    総合化学研究科 修士2年 西村 俊樹
  • 第70回有機合成化学協会関東支部シンポジウム(2015年11月21日) 若手講演賞
    シクロプロピルマグネシウムカルベノイドと求核剤および求電子剤との連続反応による多置換シクロプロパンの合成
    総合化学研究科 修士1年 岩佐 崇弘
  • 13th Symposium on Chemical Approaches to Chirality (November 12, 2014) Best Poster Award
    Asymmetric Synthesis of 3-Oxa- and 3-Azabicyclo[3.1.0]hexanes by the 1,5-C-H Insertion of Cyclopropylmagnesium Carbenoids
    総合化学研究科 修士2年 和田 夏美
  • 第4回CSJ化学フェスタ2014(2014年10月15日) 優秀ポスター発表賞
    シクロプロピルマグネシウムカルベノイドの多様な反応性を活かした有機分子変換
    総合化学研究科 修士2年 西田 潤一郎
  • 12th Symposium on Chemical Approaches to Chirality (November 27, 2013) Best Poster Award
    Asymmetric Synthesis of Cyclopropane-Containing Carboxylic Acid Esters Using Magnesium Carbenoid Chemistry
    総合化学研究科 修士2年 服部 芳明
  • 第65回有機合成化学協会関東支部シンポジウム(2013年5月18日) 若手講演賞
    シクロプロピルマグネシウムカルベノイドの求核性を利用したビシクロ-γ-ラクトン類の合成
    総合化学研究科 修士1年 西田 潤一郎
  • 第64回有機合成化学協会関東支部シンポジウム(2012年12月1日) 若手講演賞
    マグネシウムアルキリデンカルベノイドのFritsch-Buttenberg-Wiechell転位による共役ジインの合成
    理学部第一部応用化学科 4年 武田 光佑
  • 第64回有機合成化学協会関東支部シンポジウム(2012年12月1日) 若手講演賞
    カルベノイドの求核性を利用した不飽和ラクトンの新規合成法の開発
    理学部第一部応用化学科 4年 福田 一生
  • 第63回有機合成化学協会関東支部シンポジウム(2012年5月19日) 若手講演賞
    3-シアノアルキルマグネシウムカルベノイドの4-Exo-Dig型環化反応によるシクロブタノン類の合成
    総合化学研究科 修士1年 三瓶 太朗