publications 2

Single-Step Conversion of Electron-Deficient Aldehydes into the Corresponding Esters in Aqueous Alcohols in the Presence of Iodine and Sodium Nitrite.

Kiran, Y. B.; Ikeda, R.; Sakai, N.; Konakahara, T.

Synthesis 2010, 276-282.

An Oxidant-Free Single-Step Synthesis of Tetra- or Disubstituted Symmetrical Pyridine Derivatives by a Hf(OTf)4-Catalyzed Annulation.

Sasada, T.; Kobayashi, F.; Moriuchi, M.; Sakai, N.; Konakahara, T.

Synlett 2011, 2029-2034.

Synthesis of Tri- or Tetrasubstituted Pyrimidine Derivatives through the [5+1] Annulation of Enamidines with either N,N-Dimethylformamide Dialkyl Acetals or Orthoesters and Their Application in a Ring Transformation of Pyrimidines to Pyrido[2,3-d]pyrimidin-5-one Derivatives.

Sasada, T.; Aoki, Y.; Ikeda, R.; Sakai, N.; Konakahara, T.

Chem. Eur. J. 2011, 17, 9385-9394.

Indium-Catalyzed Reductive Esterification of a Carboxylic Acid: Sequential Preparation of an Ester and Symmetrical Ether.

Sakai, N.; Usui, Y.; Ikeda, R.; Konakahara, T.

Adv. Synth. Catal. 2011, 353, 3397-3401.

InBr3-catalyzed reduction of ketones with a hydrosilane: deoxygenation of aromatic ketones and selective synthesis of secondary alcohols and symmetrical ethers from aliphatic ketones.

Sakai, N.; Nagasawa, K.; Ikeda, R.; Nakaike, Y.; Konakahara, T.

Tetrahedron Lett. 2011, 52, 3133-3136.

3価のインジウム塩による活性化を基盤とした新しい有機合成反応の開発

坂井教郎、小中原猛雄

有機合成化学協会誌 2011, 69, 38-47.

InBr3-Catalyzed Deoxygenation of Carboxylic Acids with a Hydrosilane: Reductive Conversion of Aliphatic or Aromatic Carboxylic Acids to Primary Alcohols or Diphenylmethanes.

Sakai, N.; Kawana, K.; Ikeda, R.; Nakaike, Y.; Konakahara, T.

Eur. J. Org. Chem. 2011, 3178-3183.

3-(3-Phenoxybenzyl)amino-β-carboline: a novel antitumor drug targeting α-tubulin.

Ikeda, R.; Kurosawa, M.; Okabayashi, T.; Takee, A.; Yoshiwara, M.; Kumakura, T.; Sakai, N.; Funatsu, O.; Morita, A.; Ikekita, M.; Nakaike, Y.; Konakahara, T.

Bioorg. Med. Chem. Lett. 2011, 21, 4784-4787.

3-Benzylamino-β-carboline derivatives induce apoptosis through G2/M arrest in human carcinoma cells HeLa S-3.

Ikeda, R.; Iwaki, T.; Iida, T.; Okabayashi, T.; Nishi, E.; Kurosawa, M.; Sakai, N.; Konakahara, T.

Eur. J. Med. Chem. 2011, 46, 636-646.

One-Pot Sequential Synthesis of Ethers from an Aliphatic Carboxylic Acid and an Alcohol by Indium-Catalyzed Deoxygenation of an Ester.

Sakai, N.; Usui, Y.; Moriya, T.; Ikeda, R.; Konakahara, T.

Eur. J. Org. Chem. 2012, 4603-4608.

Copper-Catalyzed [5 + 1] Annulation of 2-Ethynylanilines with an N,O-Acetal Leading to Construction of Quinoline Derivatives.

Sakai, N.; Tamura, K.; Shimamura, K.; Ikeda, R.; Konakahara, T.

Org. Lett. 2012, 14, 836-839.

Single-Step Thioetherification by Indium-Catalyzed Reductive Coupling of Carboxylic Acids with Thiols.

Sakai, N.; Miyazaki, T.; Sakamoto, T.; Yatsuda, T.; Moriya, T.; Ikeda, R.; Konakahara, T.

Org. Lett. 2012, 14, 4366-4369.

Indium-Catalyzed Reductive Bromination of Carboxylic Acids Leading to Alkyl Bromides.

Moriya, T.; Yoneda, S.; Kawana, K.; Ikeda, R.; Konakahara, T.; Sakai, N.

Org. Lett. 2012, 14, 4842-4845 (Cited by SYNFACTS 2012, 8, 1317-1317).

Structure-activity relationship in the antitumor activity of 6-, 8- or 6,8-substituted 3-benzylamino-β-carboline derivatives.

Ikeda, R.; Kimura, T.; Tsutsumi, T.; Tamura, S.; Sakai, N.; Konakahara, T.

Bioorg. Med. Chem. Lett. 2012, 22, 3506-3515.

Indium(III)-Catalyzed One-pot Synthesis of Alkyl Cyanides from Carboxylic Acids

Moriya, T.; Shoji, K.; Yoneda, S.; Ikeda, R.; Konakahara, T.; Sakai, N.

Synthesis 2013, 45, 3233-3238.

Indium(III)-Catalyzed Reductive Bromination and Iodination of Carboxylic Acids to Alkyl Bromides and Iodides: Scope, Mechanism, and One-Pot Transformation to Alkyl Halides and Amine Derivatives

Moriya, T.; Yoneda, S.; Kawana, K.; Ikeda, R.; Konakahara, T.; Sakai, N.

J. Org. Chem. 2013, 78, 10642–10650.

Copper-Catalyzed Three-, Five- or Seven-Component Coupling Reactions: The Selective Synthesis of Cyanomethylamines, N,N-Bis(cyanomethyl)amines and

N,N’-Bis(cyanomethyl)methylenediamines Based on a Strecker-Type Synthesis

Sakai, N.; Takahashi, N.: Inoda, D.; Ikeda, R.; Konakahara, T.

Molecules, 2013, 18, 12488-12499 (Open Access).

Cobalt–Catalyzed Oxidative α-Cyanation of Tertiary Aromatic Amines with Trimethylsilyl Cyanide (TMSCN) and tert–Butyl Hydroperoxide (TBHP).

Sakai, N.; Mutsuro, A.; Ikeda, R.; Konakahara, T.

Synlett 2013, 24, 1283-1285.

Zinc-Catalyzed Reduction of Aldehydes with a Hydrosilane Leading to Symmetrical Ethers and Silyl Ethers

Sakai, N.; Nonomura, Y.; Ikeda, R.; Konakahara, T.

Chem. Lett. 2013, 42, 489-491.

Gallium-Catalyzed Reductive Chlorination of Carboxylic Acids with Copper(II) Chloride

Sakai, N.; Nakajima, T.; Yoneda, S.; Konakahara, T.; Ogiwara, Y.

J. Org. Chem. 2014, 79, 10619-10623.

Indium-Catalyzed Hydroamination/Hydrosilylation of Terminal Alkynes and Aromatic Amines via a One-Pot Two-Step Protocol

Sakai, N.; Takahashi, N.; Ogiwara, Y.

Eur. J. Org. Chem. 2014, 5078-5082.

Synthesis and in vitro antitumor activity of novel 2-alkyl-5-methoxycarbonyl-11-methyl-6H-pyrido[4,3-b]carbazol-2-ium and 2-alkylellipticin-2-ium chloride derivatives

Mori, R.; Kato, A.; Komenoi, K.; Kurasaki, H.; Iijima, T.; Kawagoshi, M.; Kiran, Y. B.; Takeda, S.; Sakai, N.; Konakahara, T.

Eur. J. Med. Chem. 2014, 82, 16-35.

Efficient Synthesis of 2-Alkylidene-4H-3,1-benzoxathiin-4-ones and Determination of Their Double Bond Configuration

Shimizu, M.; Yamanaka, M.; Ando, W.; Shimada, S.; Konakahara, T.; Sakai, N.

Heterocycles 2014, 89, 981-993.

One-pot preparation of Azobenzenes from Nitrobenzenes by the Combination of an Indium-Catalyzed Reductive Coupling and a Subsequent Oxidation

Sakai, N.: Asama, S.; Anai, S.; Konakahara, T.

Tetrahedron 2014, 70, 2027-2033.

N-Aminomethylation vs. O-Aminomethylation of Indole and Pyrrole with an N,O-Acetal Controlled by the Hardness of a Counterion of an Iminium Compound

Sakai, N.; Okano, H.; Shimamura, K.; Konakahara, T.

Chem. Lett. 2014, 43, 501-503.