Yb(OTf)3-catalyzed cyclization of an N-silylenamine with 2-methylene-1,3-cyclohexanedione to afford a 7,8-dihydroquinolin-5(6H)-one derivative and its application to the one-pot conversion to a 2,3,5-trisubstituted quinoline derivative.

Sakai, N.; Aoki, D.; Hamajima, T.; Konakahara, T.

Tetrahedron Lett. 2006, 47, 1261-1265.

InBr3-catalyzed intramolecular cyclization of 2-alkynylanilines leading to polysubstituted indole and its application to one-pot synthesis of an amino acid precursor.

Sakai, N.; Annaka, K.; Konakahara, T.

Tetrahedron Lett. 2006, 47, 631-634. (64 citation number by Sep 2020)

Direct Synthesis of Polysubstituted Quinoline Derivatives by InBr3-Promoted Dimerization of 2-Ethynylaniline Derivatives.

Sakai, N.; Annaka, K.; Konakahara, T.

J. Org. Chem. 2006, 71, 3653-3655. (70 citation number by Sep 2020)

Direct Measurement of the Thermodynamics of Vinylarene Hydroamination.

Johns, A. M.; Sakai, N.; Ridder, A.; Hartwig, J. F.

J. Am. Chem. Soc. 2006, 128, 9306-9307. (61 citation number by Sep 2020)

Tropene Derivatives by Sequential Intermolecular and Transannular, Intramolecular Palladium-Catalyzed Hydroamination of Cycloheptatriene.

Sakai, N.; Ridder, A.; Hartwig, J. F.

J. Am. Chem. Soc. 2006, 128, 8134-8135. (55 citation number by Sep 2020)

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Palladium-Catalyzed Coupling Reaction of Terminal Alkynes with Aryl Iodides in the Presence of Indium Tribromide and Its Application to a One-Pot Synthesis of 2-Phenylindole

Sakai, N.; Annaka, K.; Konakahara, T.

Org. Lett. 2004, 6, 1527-1530. (114 citation number by Sep 2020)

Facile and convenient synthesis of functionalized propargylic alcohols and amines: an InBr3-Et3N reagent system promotes the alkynylation of aldehydes and N,O- or N,S-acetals.

Sakai, N.; Kanada, R.; Hirasawa, M.; Konakahara, T.

Tetrahedron 2005, 61, 9298-9304.

Indium Tribromide-Catalyzed Deacetoxylation of Propargylic Acetate with Triethylsilane.

Sakai, N.; Hirasawa, M.; Konakahara, T.

Tetrahedron Lett. 2005, 46, 6407-6409.

New Approach for Synthesis of Non-Benzonoid Aromatic Compounds, Functionalized 1-Azaazulene Derivatives: Cyclization Reaction of 2-Substituted Tropones with N-Silylenamine and Enamines.

Sakai, N.; Hattori, N.; Tomizawa, N.; Abe, N.; Konakahara, T.

Heterocycles 2005, 65, 2799-2807.

New Approach to the Practical Synthesis of Tri- or Tetrasubstituted Pyrimidine Derivatives: A Four-Component Coupling Reaction from a Functionalized Silane, Two Types of Aromatic Nitriles, and Acetals.

Sakai, N.; Aoki, Y.; Sasada, T.; Konakahara, T.

Org. Lett. 2005, 7, 4705-4708.

Novel Synthesis of 7-Fluoro-8-(trifluoromethyl)-1H-1,6-naphthyridin-4-one Derivatives: Intermolecular Cyclization of an N-Silyl-1-azaallyl Anion with Perfluoroalkene and Subsequent Intramolecular Skeletal Transformation of the Resulting Pentasubstituted Pyridines.

Suzuki, H.; Sakai, N.; Iwahara, R.; Fujiwaka, T.; Satoh, M.; Kakehi, A.; Konakahara, T.

J. Org. Chem. 2007, 72, 5878-5881.

An Efficient One-Pot Synthesis of Unsymmetrical Ethers: A Directly Reductive Deoxygenation of Esters Using an InBr3/Et3SiH Catalytic System.

Sakai, N.; Moriya, T.; Konakahara, T.

10. J.Org. Chem. 2007, 72, 5920-5922 (Cited by Synfacts 2007, 1082-1082).
    

                                                           (105 citation number by Sep 2020)

Hf(OTf)4-Doped Me3SiCl System-Catalyzed Aminomethylation of Arenes with N,O-Acetals: Facile Approach to Non-Natural Amino Acid Precursors.

Sakai, N.; Asano, J.; Shimano, Y.; Konakahara, T.

Synlett 2007, 2675.

Computational Analysis of Molecular Recognition in DNA Base-Sequence and Groove by Methidium Chloride Using Molecular Mechanics.

Konakahara, T.; Komatsu, H.; Sakai, N.; Gold, B.

J. Comput. Chem., Jpn. 2007, 6, 27-32.

Me3SiCl-Promoted Three-Component Coupling Reaction of a Functionalized Enamine, an Acetal, and an Alkyne: An Unprecedented Approach to the Synthesis of Tetrasubstituted Pyridines via a [3 + 2 + 1] Intermolecular Cyclization.

Sasada, T.; Sakai, N.; Konakahara, T.

J. Org. Chem. 2008, 73, 6905-6908.

Facile and efficient synthesis of polyfunctionalized benzofurans: three-component coupling reactions from an alkynylsilane, an o-hydroxybenzaldehyde derivative, and a secondary amine by a Cu(I)-Cu(II) cooperative catalytic system.

Sakai, N.; Uchida, N.; Konakahara, T.

Tetrahedron Lett. 2008, 49, 3437-3440. (77 citation number by Sep 2020)

Facile and Selective Synthesis of Propargylic Amines, and 1,6-Diynes: One-pot Three-Component Coupling Reactions of Alkynylsilanes, Aldehydes, and Amines by a Cooperative Catalytic System Comprised of CuCl and Cu(OTf)2.

Sakai, N.; Uchida, N.; Konakahara, T.

Synlett 2008, 1515-1519.

Direct Reduction of Esters to Ethers with an Indium(III) Bromide/Triethylsilane Catalytic System.

Sakai, N.; Moriya, T.; Fujii, K.; Konakahara, T.

Synthesis (Practical Synthetic Procedures) 2008, 3533-3536.

One-step Conversion to Tertiary Amines: InBr3/Et3SiH-Mediated Reductive Deoxygenation of Tertiary Amides.

Sakai, N.; Fujii, K.; Konakahara, T.

Tetrahedron Lett. 2008, 49, 6873-6875. (78 citation number by Sep 2020)

A Practical Approach to Non-Natural or N-Unsubstituted α-Arylglycine Derivatives: Hf(OTf)4-Doped Me3SiCl System-Catalyzed Aminomethylation of Electron-Rich Arenes with a New Type of N,O-Acetal.

Sakai, N.; Asano, J.; Shimano, Y.; Konakahara, T.

Tetrahedron 2008, 64, 9208-9215.

InBr3-Promoted Divergent Approach to Polysubstituted Indoles and Quinolines from 2-Ethynylanilines: Switch from an Intramolecular Cyclization to an Intermolecular Dimerization by a Type of Terminal Substituent Group

Sakai, N.; Annaka, K.; Fujita, A.; Sato, A.; Konakahara, T.

J. Org. Chem. 2008, 73, 4160-4165.  (169 citation number by Sep 2020)

A green reagent for iodination of phenols.

Kiran, Y. B.; Konakahara, T.; Sakai, N.

Synthesis 2008, 2327-2332.

An Unprecedented Approach to the Single-Step Synthesis of 3,4-Fused Pyrimidin-2-one and Pyrimidin-2-thione Derivatives by a [3+2+1] Annulation.

Sasada, T.; Moriuchi, M.; Sakai, N.; Konakahara, T.

Eur. J. Org. Chem. 2009, 5738-5743.

An Unprecedented Approach to 4,5-Disubstituted Pyrimidine Derivatives by a ZnCl2-Catalyzed Three-Component Coupling Reaction.

Sasada, T.; Kobayashi, F.; Sakai, N.; Konakahara, T.

Org. Lett. 2009, 11, 2161-2164. (93 citation number by May Sep 2020)

Practical Synthesis of Natural Amino Acid Derivatives: Hf(OTf)4-Catalyzed Mannich-Type Reaction of Ketene Silyl Acetals or Enol Silyl Ethers with N,O-Acetals as a Glycine Cation Equivalent.

Sakai, N.; Sato, A.; Konakahara, T.

Synlett 2009, 1449-1452.

A Novel Approach to the Practical Synthesis of Sulfides: An InBr3-Et3SiH Catalytic System Promoted the Direct Reductive Sulfidation of Acetals with Disulfides.

Sakai, N.; Moritaka, K.; Konakahara, T.

Eur. J. Org. Chem. 2009, 4123-4127.

Chemoselective Isomerization of Secondary-Type Propargylic Alcohols to Propargylic/Allenic Bromides, and Brominated Dienes with Appel-Type Reaction Conditions.

Sakai, N.; Maruyama, T.; Konakahara, T.

Synlett 2009, 2105-2108.

Facile Approach to Natural or Non-Natural Amino Acid Derivatives: Me3SiCl-Promoted Coupling Reaction of Organozinc Compounds with N,O-Acetals.

Sakai, N.; Asano, J.; Kawada, Y.; Konakahara, T.

Eur. J. Org. Chem. 2009, 917-922.

Synthesis of novel silyl enol ethers from chlorodimethyl(naphthylphenylmethyl) silanes having a chiral centre and a ketone and their chirality transfer effects in crossed-aldol reactions.

Miyakawa, K.; Konakahara, T.; Sakai, N.; Kozawa, K.; Gunji, T.; Nagao, Y.

J. Chem. Res. 2009, 46-51.

Tetrahedron Letters Most Cited Paper 2006-2009 Award

InBr3-Et3N Promoted Alkynylation of Aldehydes and N,O-acetals under Mild Conditions: Facile and Simple Preparation of Propargylic Alcohols and Amines

Sakai, N.; Hirasawa, M.; Konakahara, T.

Tetrahedron Lett. 2003, 44, 4171-4174. (57 citation number by Sep 2020)

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