Publications（研究業績）

2017年

1. Yoshida, E., Kurita, M., Eto, K., Kumagai, Y. and Kaji, T. Methylmercury promotes prostacyclin release from cultured human brain microvascular endothelial cells via induction of cyclooxygenase-2 through activation of the EGFR-p38 MAPK pathway by inhibiting protein tyrosine phosphatase 1B activity. Toxicology, 392, 40-46, 2017.
2. Nakamura, T., Yoshida, E., Fujie, T., Ogata, F., Yamamoto, C., Kawasaki, N. and Kaji, T. Synergistic cytotoxicity caused by forming a complex of copper and 2,9-dimethyl-1,10-phenanthroline in cultured vascular endothelial cells. J. Toxic. Sci., 42, 683-687, 2017.
3. Fujie, T., Okino, S., Yoshida, E., Yamamoto, C., Naka, H. and Kaji, T. Copper diethyldithiocarbamate as an inhibitor of tissue plasminogen activator synthesis in cultured human coronary endothelial cells. J. Toxicol. Sci., 42, 553-558, 2017.
4. Hara, T., Yoshida, E., Fujiwara, Y., Yamamoto, C. and Kaji, T. Transforming growth factor-β1 modulates the expression of syndecan-4 in cultured vascular endothelial cells in a biphasic manner. J. Cell. Biochem., 118, 2009-2017, 2017.
5. Hara, T., Yoshida, E., Shinkai, Y., Yamamoto, C., Fujiwara, Y., Kumagai, Y. and Kaji, T. Biglycan intensifies ALK5-Smad2/3 signaling by TGF-β₁ and downregulates syndecan-4 in cultured vascular endothelial cells. J. Cell. Biochem., 118, 1087-1096, 2017.
6. Hara, T., Kojima, T., Matsuzaki, H., Nakamura, T., Yoshida, E., Fujiwara, Y., Yamamoto, C., Saito, S. and Kaji, T. Induction of syndecan-4 by organic-inorganic hybrid molecules with a 1,10-phenanthroline structure in cultured vascular endothelial cells. Int. J. Mol. Sci., 18, 352, 2017.
7. Hirooka, T., Yoshida, E., Eto, K. and Kaji, T. Methylmercury induces hyaluronan synthesis in cultured human brain microvascular endothelial cells and pericytes via different mechanisms. J. Toxic. Sci., 42, 329-333, 2017

2016年

1. Fujie, T., Hara, T. and Kaji, T. Toxicology of organic-inorganic hybrid molecules: Bio-organometallics and its toxicology. J. Toxicol. Sci., 41, SP81-SP88, 2016.
2. Lee, E., Park, JE., Iida, M., Fujie, T., Kaji, T., Ichihara. G., Weon, YC. and Kim, Y., Magnetic resonance imaging of leukoencephalopathy in amnestic workers exposed to organotin. Neurotoxicology, 57, 128-135, 2016.
3. Fujie, T., Murakami, M., Yoshida, E., Yasuike, S., Kimura, T., Fujiwara, Y., Yamamoto, C. and Kaji, T. Transcriptional induction of metallothionein by tris(pentafluorophenyl)stibane in cultured bovine aortic endothelial cells. Int. J. Mol. Sci., 17: 1381, 2016.
4. Unoki, T., Abiko, Y., Toyama, T., Uehara, T., Tsuboi, K., Nishida, M., Kaji, T., and Kumagai Y. Methylmercury, an environmental electrophile capable of activation and disruption of the Akt/CREB/Bcl-2 signal transduction pathway in SH-SY5Y cells. Scientific Reports, 30: 28944, 2016.
5. Fujie, T., Murakami, M., Yoshida, E., Tachinami, T., Shinkai, Y., Fujiwara, Y., Yamamoto, C., Kumagai, Y., Naka, H. and Kaji, T. Copper diethyldithiocarbamate as an activator of Nrf2 in cultured vascular endothelial cells. J. Biol. Inorg. Chem., 21, 263-273, 2016.
6. Fujie T, Segawa Y, Uehara A, Nakamura T, Kimura T, Yoshida E, Yamamoto C, Uchiyama M, Naka H, Kaji T. Zinc diethyldithiocarbamate as an inducer of metallothionein in cultured vascular endothelial cells. J. Toxicol. Sci., 41, 217-224, 2016.
7. Fujie T, Segawa Y, Yoshida E, Kimura T, Fujiwara Y, Yamamoto C, Satoh M, Naka H, Kaji T. Induction of metallothionein isoforms by copper diethyldithiocarbamate in cultured vascular endothelial cells. J. Toxicol. Sci., 41, 225-232, 2016.
8. Fujiwara, Y., Yamamoto, C., Yoshida, E., Kumagai, Y., Kaji, T., Heparan sulfate chains potentiate cadmium cytotoxicity in cultured vascular endothelial cells, Arch. Toxicol., 90, 259-267, 2016
9. Shinkai, Y., Kimura, T., Itagaki, A., Yamamoto, C., Taguchi, K., Yamamoto, M., Kumagai, Y. and Kaji, T. Partial contribution of the Keap1–Nrf2 system to cadmium-mediated metallothionein expression in vascular endothelial cells. Toxicol. Appl. Pharmacol. 295, 37-46, 2016.
10. Katsura, M., Cyou-Nakamine, H., Zen, Q., Zen, Y., Kansai, H., Amagasa, S., Kanki,Y., Inoue, T, Kaneki, K., Taguchi, A., Kobayashi, M., Kaji, T., Kodama, T., Miyagawa, K., Wada, Y., Akimitsu, N., and Sone, H. Effects of chronic low-dose radiation on human neural progenitor cells. Scientific Reports, 6: 20027, 2016.
11. Hara T., Matsuzaki, H., Nakamura, T., Yoshida, E., Ohkubo, T., Maruyama, H., Yamamoto, C., Saito, S. and Kaji, T. Cytotoxicity of zinc, copper and rhodium complexes with 1,10-phenanthroline or 2,9-dimethyl-1,10-phenanthroline in cultured vascular endothelial cells. Fundam. Toxicol. Sci., 3, 109-113, 2016.

2015年

1. Toyama, T., Abiko, Y., Katayama, Y., Kaji, T., and Kumagai, Y., S-Mercuration of ubiquitin carboxyl-terminal hydrolase L1 through Cys152 by methylmercury causes inhibition of its catalytic activity and reduction of monoubiquitin levels in SH-SY5Y cells. J. Toxic. Sci., 40, 887-893, 2015.
2. Kohri, K., Yoshida, E., Yasuike, S., Fujie, T., Yamamoto, C., Kaji, T., The cytotoxicity of organobismuth compounds with certain molecular structures can be diminished by replacing the bismuth atom with an antimony atom in the molecules, J. Toxicol. Sci., 40, 321-327, 2015
3. Murakami, M., Fujie, T., Matsumura, M., Yoshida, E., Yamamoto, C., Fujiwara, Y., Yasuike, S., Kaji, T., Comparative cytotoxicity of triphenylstibane and fluorine-substituted triarylpnictogens in cultured vascular endothelial cells, Fandam. Toxicol. Sci., 2, 61-66, 2015

2014年

1. Naka, H., Takita, R., Kaji, T., Uchiyama, M., 内皮細胞のパールカンの発現を誘導する有機アンチモン化合物の設計・合成・機能解析と構造活性相関研究, YAKUGAKU ZASSHI, 134, 789-791, 2014
2. Takahashi, S., Yamamoto, C., Kaji, T., カドミウムに曝露した血管内皮細胞におけるZIP8の発現, YAKUGAKU ZASSHI, 134, 805-807, 2014
3. Fujie, T., Naka, H., Yamamoto, C., Shinkai, Y., Kumagai, Y., Kaji, T., 有機−無機ハイブリッド分子による生体防御系の活性化, YAKUGAKU ZASSHI, 134, 813-815, 2014
4. Toyama, T., Shinkai, Y., Yazawa, A., Kakehashi, H., Kaji, T., Kumagai, Y., Glutathione-mediated reversibility of covalent modification of ubiquitin carboxyl-terminal hydrolase L1 by 1,2-naphthoquinone through Cys152, but not Lys4, Chem. Biol. Int., 214, 41-48, 2014

2013年

1. Hirooka, T., Yamamoto, C., Yasutake, A., Eto, K., Kaji, T., Expression of VEGF-related proteins in cultured human brain microvascular endothelial cells and pericytes after exposure to methylmercury, J. Toxicol. Sci., 38, 837-845, 2013
2. Toyama, T., Shinkai, Y., Kaji, T., Kumagai, Y., A convenient method to assess chemical modification of protein thiols by electrophilic metals, J. Toxicol. Sci., 38, 477-484, 2013
3. Nsimba, M.M., Lami, J.M., Hayakawa, Y., Yamamoto, C., Kaji, T., Decreased thrombin activity by a Congolese herbal medicine used in sicklecellanemia, J. Ethnopharmacol., 148, 895-900, 2013
4. Nsimba, M.M., Yamamoto, C., Lami, J.M., Hayakawa, Y., Kaji, T., Effect of a Congolese herbal medicine used in sickle cell anemia on the expression of plasminogen activators in human coronary aortic endothelial cell culture, J. Ethnopharmacol., 146, 594-599, 2013

2012年

1. Shinai, Y., and Kaji, T., Cellular defense mechanisms against lead toxicity in the vascular system. Biol. Pharm. Bull., 35, 1885-1891, 2012.
2. Kimura, T., Yoshida, K.,Yamamoto, C., Suzuki, M., Uno, T., Isobe, M.,Naka, H., Yasuike, S.Satho, M., Kaji, T., and Uchiyama, M., Bis (L-cysteinato) zincate (II) as a coordination compound that induces metalloothionein gene transcription without inducing cell-stress-related gene transcription. J. Inorg. Biochem., 117, 140-146, 2012.
3. Kanda, H., Toyama, T., Shinohara-Kanda, A., Iwamatsu, A., Shinkai, Y., Kaji, T., Kikushima, M., and Kumagai, Y., S-Mercuration of rat sorbitol dehydrogenase bymethylmercury causes its aggregation and the release of the zinc ion from the active site. Arch. Toxicol., 86, 1693-1702, 2012.
4. Nsimba, M.M., Lami, J.M.,Yamamoto, C., Kaji, T., Mukengeshaie, M., and Lufuluabo, M., In vitro reversal of deformity and inhibition of aggregation of scikle red blood cells by two Congolese herbalmedicines. J. Med. Plants Res., 6, 4801-4808, 2012.
5. Fujiwara, Y.,Yamamoto, C., Inagaki, T., Satoh, M., and Kaji, T., Bismuth protects against arsenite-induced inhibition of proteoglycan synthesis in cultured vascular endothelial cells. J. Toxicol. Sci., 37, 837-843, 2012.
6. Hirooka, T., and Kaji, T., The Cytotoxicity of methylmercury in human microvascular endothelial cells and pericytes in culture. Biol. Pharm. Bull., 35, 1201-1205, 2012.

2011年

1. Fujiwara, Y., Banno, H., Shinkai, Y., Yamamoto, C., Kaji, T., and Satoh, M., Protective effect of pretreatment with cilostazol on cytotoxicity of cadmium and arsenite in cultured vascular endothelial cells. J. Toxicol. Sci., 36, 155-161, 2011.
2. Fujiwara, Y., Honda, A.,Yamamoto, C., Kaji, T., and Satoh, M., DNA microarray analysis of human coronary artery endothelial cells exposed to cadmium. J. Toxicol. Sci., 36, 141-143, 2011.

2010年

1. Shinkai, Y.,Yamamoto, C., and Kaji, T., Lead induces the expression of endoplasmic reticulum chaperones GRP78 and GRP94 in vascular endothelial cells via the JNK-AP-1 pathway. Toxicol. Sci., 114, 378-386, 2010.
2. Hirooka, T., Fujiwara, Y., Minami, Y., Ishii, A., Ishigooka, M., Shinkai, Y., Yamamoto, C.,Satoh, M., Yasutake ,A., Eto, K., and Kaji, T., Cell-density-dependent methylmercury susceptibility of cultured humanbrain microvascular pericytes. Toxicol. in Vitro, 24, 835-841, 2010.
3. Hirooka, T., Fujiwara, Y., Shinkai, Y., Yamamoto, C., Yasutake, A.,Satoh, M., Eto, K., and Kaji, T., Resistance of human brain microvascular endothelial cells in culture to methylmercury: cell-density-dependent defense mechanisms. J. Toxicol. Sci., 24, 835-841, 2010.

2009年

• Hirooka T., Fujiwara, Y., Inoue S., Shinkai Y., Yamamoto C., Satoh, M., Yasutake, A., Eto, K., and Kaji, T., Suppression of fibroblast growth factor-2 expression: Possible mechanism underlying methylmercury-induced inhibiton of the repair of wounded monolayers of cultured human brain microvascular endothelial cells. J. Toxicol. Sci., 34, 433-439, 2009.
• Fujiwara, Y., Kitagawa, T., Shinkai, Y., Kaji, T., and Satoh, M., Cilostazole induces metallothionein expression in vascular cells. Yakugaku Zasshi, 129, 1415-1422, 2009.
• Shinkai, Y., Sumi, D., Toyama, T., Kaji, T., and Kumagai, Y., Role of aquaporin 9 in cellular accumulation of arsenic and its cytotoxicity in primary mouse hepatocytes. Toxicol. Appl. Pharmacol., 237, 232-236, 2009.
• Fujiwara, Y., Mikami, C., Nagai, M., Yamamoto, C., Hirooka, T., Satoh, M. and Kaji, T., Homocysteine inhibits proteoglycan synthesis in cultured bovine aortic smooth muscle cells. J. Health Sci., 54, 56-65, 2009.

2008年

• Yamamoto, C., Urano, A., Fujiwara, Y., and Kaji, T., Adiponectin as an inducer of decorin synthesis in cultured vascular smooth muscle cells. Life Sci., 83, 447-452, 2008.
• Fujiwara, Y., Yamamoto, C., Hirooka, T., Terada, N., Satoh, M., and Kaji, T., Arsenite but not arsenate Inhibits general proteoglycan synthesis in cultured arterial smooth muscle cells.  J. Health Sci., 33, 487-492, 2008.
• Sato, T., Yamamoto, C., Fujiwara, Y., and Kaji, T., Biological activities of exogenous polysaccharides via controlling endogenous proteoglycan metabolism in vascular endothelial cells. Yakugaku Zasshi, 128, 717-723, 2008.
• Urano, A., Yamamoto, C., Fujiwara, Y., Kaji, T., Proteoglycan as a key molecule in atherosclerosis progression: characteristics of the structure and regulation of the synthesis. Yakugaku Zasshi, 128, 365-375, 2008.
  

2007年

• Hirooka, T., Fujiwara, Y., Yamamoto, C., Yasutake, A., and Kaji, T., Methylmercury retards the repair of wounded monolayer of human brain microvascular endothelial cells by inhibiting their proliferation without nonspecific cell damage. J. Health, Sci., 53, 450-456, 2007.
• Shuo, T., Aono, S., Nakanishi, K., Tokita, Y., Kuroda, Y., Ida, M., Matsui, F., Maruyama, H., Kaji, T., and Oohira, A., Ectodomain shedding of neuroglycan C, a brain-specific chondroitin sulfate proteoglycan, by TIMP-2- and TIMP-3-sensitive proteolysis. J. Neurochem., 102, 1561-1568, 2007.

2006年

• Miura, N., Kanayama, Y., Nagai, W., Hasegawa, T., Seko, Y., Kaji, T., and Naganuma, A., Characterization of an immortalized hepatic stellate cell line established from metallothionein-null mice. J.Toxicol. Sci., 31, 391-398, 2006.
• Kaji, T., Yamamoto, C., Oh-i, M., Fujiwara, Y., Yamazaki, Y., Morita, T., Plaas, A., H., and Wight, T., N., The vascular endothelial growth factor VEGF165 induces perlecan synthesis via VEGF receptor-2 in cultured human brain microvascular endothelial cells. Biochim. Biophys. Acta., 1760, 1465-1474, 2006.
• Yamamoto, C., Morita, Y., Yamaguchi, S., Hayashi, T., and Kaji, T., Colominic acid inhibits the proliferation of cultured bovine aortic endothelial cells and injures their monolayers: cell density-dependent effects prevented by sulfation. Life Sci., 78, 844-850, 2006.
• Ida, M., Shuo, T., Hirano, K., Tokita, Y., Nakanishi, K., Matui, F., Aono, S., Fujita, H., Fujiwara, Y., Kaji, T., and Oohira, A., Identification and functions of chondroitin sulfate in the milieu of neural stem cells. J. Biol. Chem., 281, 5982-5991, 2006.
• Yamamoto, C., Fujiwara, Y., and Kaji, T., The biological effects of depolymerized sodium spirulan and sulfated colominic acid on vascular cells are beneficial in preventing atherosclerosis. J.Health Sci., 52, 205-210, 2006.
• Yasuike, S., Nakata, K., Qin, W., Kaji, T., and Kurita, J., A novel transmetallation of triarylstibanes into arylboronate: Boro-induced ipso-deantimonation and its theoretical calculation. Chem. Let., 35, 1402-1403, 2006.
• Watanabe, K., Itokawa, Y., Yamaori, S., Funahashi, T., Kimura, T., Kaji, T., Usami, N., and Yamamoto, I., Conversion of cannabidiol to Δ9-tetrahydrocannabiol and related cannabinoids in artificial gastric juice, and their pharmacological effects in mice. Forensic Toxicology, 25, 16-21, 2006.

2005年

• Fujiwara, Y., Plaas, A., and Kaji, T., Proteoglycan synthesis is not influenced by zinc in proliferating bovine aortic endothelial cells in culture. J. Health Sci., 51, 720-727, 2005.
• Yamamoto, C., Deng, X., Fujiwara, Y., and Kaji, T., Proteoglycans predominantly synthesized by human brain microvascular endothelial cells in culture are perlecan and biglycan. J. Health Sci., 51, 576-583, 2005.
• Fujiwara, Y., Nakase Y., and Kaji, T., Sodium Arsenite inhibits proteoglycan synthesis by vascular endothelial cells in culture. J. Health Sci., 51, 461-468, 2005.
• Fujiwara, Y., Mitani, M., Yasuike, S., Kurita, J., and Kaji, T., An organobismuth compound that exhibits cytotoxicity selectively to vascular endothelial cells in vitro. J. Health Sci., 51, 333-340, 2005.
• Yamamoto, C., Yamaguchi, S., Hayashi, T., and Kaji, T., Inhibition of cultured bovine aortic smooth muscle cell proliferation by colominic acid. Biol. Pharm. Bull., 28, 994-997, 2005.
• Yamamoto, C., Wakata, T., Fujiwara, Y., and Kaji, T., Induction of synthesis of a large heparan sulfate proteoglycan, perlecan, by thrombin in cultured human coronary smooth muscle cells. Biochim. Biophys. Acta., 1722, 92-102, 2005.
• Yamamoto, C., Sugato, M., Fujiwara, Y. and Kaji, T., Selective promotion of plasminogen activator inhibitor-1 secretion by activation of proteinase-activated receptor-1 in cultured human brain microvascular pericytes: comparison with endothelial cells. Biol. Pharm. Bull., 28, 208-211, 2005.
• Yamamoto, C., Shimada, S., Fujiwara, Y., Lee, J-B*., Hayashi, T., and Kaji, T., Proteoglycans released from cultured bovine aortic endothelial cell layers by sodium spirulan are both perlecan and biglycan. Biol. Pharm. Bull., 28, 32-36, 2005.

2004年

• Fujiwara, Y., Kaji, T., and Plass, A., H., Disaccharide composition of glycosaminoglycan chains in growing vascular endothelial cells in culture after exposure to lead. J. Health Sci., 50, 660-665, 2004.
• Kaji, T., Sakurai, S., Yamamoto, C., Fujiwara, Y., Yamagishi, S., Yamamoto, H., Kinsella, M., J., and Wight, T., N., Characterization of chondroitin/dermatan sulfate proteoglycans synthesized by bovine retinal pericytes in culture. Biol. Pharm. Bull., 27, 1763-1768, 2004.
• Kaji, T., Yamamoto, C., Oh-i, M., Nishida, T., and Takigawa, M., Differential regulation of biglycan and decorin synthesis by connective tissue growth factor in cultured vascular endothelial cells. Biochem. Biophys. Res. Commun., 322, 22-28, 2004.
• Kaji, T., Okabe, M., Shimada, S., Yamamoto, C., Fujiwara, Y., Lee, J-B., and Hayashi, T., Sodium spirulan as a potent inhibitor of arterial smooth muscle cell proliferation in vitro. Life Sci., 79, 2431-2439, 2004.
• Kaji, T., Cell biology of heavy metal toxicity in vascular tissue. Yakugaku Zasshi, 124, 113-120, 2004.

2003年

• Katsuda, S. and Kaji, T., Atherosclerosis and extracellular matrix. J Atheroscler. Thromb., 10, 267-274, 2003.
• Fujiwara, Y., Yamamoto, C., Kaji, T. and Plass, A., H., Analysis of chondroitin/dermatan sulfate microstructure in cultured vascular smooth muscle cells after exposure to lead and cadmium. J. Health Sci., 49, 534-540,2003.
• Yamamoto, C., Nakamura, A., Shimada, S., Kaji, T., Lee, J-B. and Hayashi, T., Differential effects of sodium spirulan on the secretion of fibrinolytic proteins from vascular endothelial cells: enhancement of plasminogen activator activity. J. health Sci., 49, 405-409, 2003
• Kaji, T., Hiraga, S., Yamamoto, C., Fujiwara, Y., Ueda, Y, Zisaki, F., Iwata, K., Katsuda, S., and Nakanishi, I., Vascular smooth muscle cells in culture express tumor necrosis factor-α that suppresses collagen synthesis depending on cell density. J. health Sci., 49, 115-122,203.
• 佐藤雅彦，鍜冶利幸，遠山千春, 低用量カドミウム曝露と健康影響．（3）実験動物および培養細胞における毒性, 日本衛生学雑誌, 57, 615-623, 2003

2002年

• Fujiwara, Y. and Kaji, T., Suppression of proteoglycan synthesis by calcium ionophore A23187 in cultured vascular endothelial cells: Implication of intracellular calcium accumulation in lead inhibition of endothelial proteoglycan synthesis. J.Health Sci., 48, 460-466, 2002.
• Kaji, T., Hiraga, S., Yamamoto, C., Fujiwara, Y., Ueda, Y., Zisaki, F, Iwata, K., Okada, Y., and Katsuda, S., Effects of tumor necrosis factor-α on the synthesis of DNA, the secretion of matrix metalloproteinases/tissue inhibitors of metalloproteinases, and the activity of invasive migration in cultured vascular smooth muscle cells. J. Health Sci., 48, 354-358, 2002.
• Kaji, T., Shimada, S., Yamamoto, C., Fujiwara, Y., Lee, J-B., and Hayashi, T., Inhibition of the association of proteoglycans with cultured vascular endothelial cell layers by calcium and sodium spirulan. J.Health Sci., 48, 250-255, 2002.
• Yamamoto, C. and Kaji, T., Induction of plasminogen activator inhibitor type 1 synthesis by cadmium in human vascular endothelial cells in culture. J. Health Sci., 48, 55-61, 2002.
• Kaji, T., Fujiwara, Y., Hamada, C., Yamamoto, C., Shimada, S., Lee, J-B., and Hayashi, T., Inhibition of cultured bovine aortic endothelial cell proliferation by sodium spirulan, a novel sulfated polysaccharide isolated from Spirulina platensis. Planta Med., 68, 505-509, 2002.
• Kaji, T., Fujiwara, Y., Inomata, Y., Hamada, C., Yamamoto, C., Shimada, S., Lee J-B., and Hayashi, T., Repair of wounded monolayers of cultured bovine aortic endothelial cells is inhibited by calcium spirulan, a novel sulfated polysaccharide isolated from Spirulina platensis. Life Sci., 70, 1841-1848, 2002.
• Fujiwara, Y., Tsumura, N., Yamamoto, C., and Kaji, T., Differential effects of cadmium on proteoglycan synthesis of arterial smooth muscle cells: increase in small dermatan sulfate proteoglycans, biglycan and decorin, in the extracellular matrix at low cell density. Toxicology, 170, 89-101, 2002.
• 鍜冶利幸，小山 洋，佐藤雅彦，遠山千春．低用量カドミウム曝露と健康影響．（2）生活習慣病と生殖毒性．日本衛生学雑誌, 57, 556-563, 2002.
• Satoh, M., Koyama, H., Kaji, T., Kito, H., and Tohyama, C., Perspectives on cadmium toxicity research. Tohoku J. Exp. Med., 196, 23-32,2002.

2001年

• Kaji, T.,  Regulation of proteoglycan synthesis in vascular endothelial cells by transforming growth factor-β1 is cell density-dependent. Connective Tissue, 33, 1-7, 2001.

2000年

• Kaji, T., Miyajima, S., Yamamoto, C., Fujiwara, Y., Sakurai, S., Yamagishi, S., Sueishi, K., and Yamamoto, H., Selective increase in decorin core mRNA level in cultured vascular smooth muscle cells after exposure to advanced glycation endproducts. J. Health Sci., 46, 223-227, 2000.
• Fujiwara, Y., Yamamoto, C., and Kaji, T., Proteoglycans synthesized by cultured bovine aortic smooth muscle cells after exposure to lead: lead selectively inhibits the synthesis of versican, a large chondroitin sulfate proteoglycan. Toxicologhy, 154, 9-19, 2000.
• Kaji, T., Yamada, A., Miyajima, S., Yamamoto, C., Fujiwara, Y., Wight, T. N., and Kinsella, M. G., Cell density-dependent regulation of proteoglycan synthesis by transforming growth factor-β1 in cultured bovine aortic endothelial cells. J. Biol. chem., 275, 1463-1470, 2000.
• Hiraga, S., Kaji, T., Ueda, Y., Zisaki, F., Iwata, K., Koizumi, F., Okada, Y., Katsuda, S., and Nakanishi, I., Modulation of collagen synthesis by tumor necrosis factor alpha in cultured vascular smooth muscle cells. Life Sci., 66, 235-244, 2000.
• Fujiwara, Y. and Kaji, T., Inhibition of the repair of wounded endothelial cell monolayers and its possible mechanisms. J.Health Sci., 46, 1-4, 2000.

1999年

• Yokozawa, T., Kim, D. W., Hattori, M., and Kaji, T., Effect of Luobuma leaves against oxidation of low-density lipoprotein: a cell culture assay. J. Traditional.Med., 16, 141-147, 1999.
• Yamamoto, C. and Kaji, T., Effect of lead on the synthesis of tissue plasminogen activator by vascular endothelial cells in culture. J. Health Sci., 45, 119-125,1999.
• Fujiwara, Y. and Kaji, T., Lead inhibits the core protein synthesis of a large heparan sulfate proteoglycan perlecan by proliferating vascular endothelial cells in culture. Toxicology, 133, 159-169, 1999.
• Fujiwara, Y. and Kaji, T., Possible mechanism for lead inhibition of vascular endothelial cell proliferation: a lower response to basic fibroblast growth factor through inhibition of heparan sulfate synthesis. Toxicology, 133, 147-157, 1999.

1998年

• Fujiwara, Y., Watanabe, S., Sakamoto, M., and Kaji, T., Repair of wounded monolayers of cultured vascular endothelial cells after simultaneous exposure to lead and zinc. Toxicol. Lett., 94, 181-188, 1998.
• Fujiwara, Y., Watanabe, S., and Kaji, T., Promotion of cultured vascular smooth muscle cell proliferation by low levels of cadmium. Toxicol. Lett., 94, 175-180, 1998.

1997年

• Ohkawara, S., Yamamoto, C., Fujiwara, Y., Sakamoto, M., and Kaji, T., Cadmium induces the production of high molecular weight heparan sulfate proteoglycan molecules in cultured vascular endothelial cells. Environ. Toxicol. Pharm., 3, 187-194, 1997.
• Fujii, N., Kaji, T., Akai, T., and Koizumi, F., Thrombin reduces large heparan sulfate proteoglycan molecules in cultured vascular endothelial cell layers through inhibition of core protein synthesis. Thromb. Res., 88, 299-307, 1997.
• Fujiwara, Y. and Kaji, T., Zinc potentiates the stimulation by basic and acidic fibroblast growth factors on the proliferation of cultured vascular smooth muscle cells. Res. Commun. Mol. Pathol. Pharmacol., 97, 95-106, 1997.
• Mishima, A., Yamamoto, C., Fujiwara, Y., and Kaji, T., Tolerance to cadmium cytotoxicity is induced by zinc through non-metallothionein mechanisms as well as metallothionein induction in cultured cells. Toxicology, 118, 85-92, 1997.
• Kaji, T., Ohkawara, S., Nakajima, M., Yamamoto, C., Fujiwara, Y., Miyajima, S., and Koizumi, F., Lead-induced alteration of heparan sulfate proteoglycans in cultured vascular endothelial cells. Toxicology, 118, 1-10, 1997.
• Fujiwara, Y., Kaji, T., Sakurai, S., Sakamoto, M., and Kozuka, H., Inhibitory effect of lead on the repair of wounded monolayers of cultured vascular endothelial cells. Toxicology, 117, 193-198, 1997.
• Yamamoto, C., Miyamoto, A., Sakamoto, M., and Kaji, T., Lead perturbs the regulation of spontaneous release of tissue plasminogen activator and plasminogen activator inhibitor-1 from vascular smooth muscle cells and fibroblasts in culture. Toxicology, 117, 153-161, 1997.
• Kaji, T., Miyamoto, A., Yamamoto, C., Fujiwara, Y., Miyajima, S., and Koizumi, F., Basic fibroblast growth factor-induced glycosaminoglycan production in cultured vascular endothelial cells results from enhanced protein synthesis mediated by the lipoxygenase pathway. Life Sci., 60, 873-881, 1997.

1996年

• Yokozawa, T., Tsuji, A., Hattori, M., Oura, H., Kaji, T., Fujiwara Y., Wakaki, K., Koizumi, F., and Shimizu, M., Effect of a Chinese medical preparation, Hokoei-to, on lipids in blood and involvement of cells of vascular origin. Phytother. Res. 10, 224-227, 1996.
• Mishima, A., Yamamoto, C., Fujiwara, Y., and Kaji, T., Metallothionein-independent protection by low levels of zinc against cadmium cytotoxicity in cultured cells. Res. Commun. Pharmacol. Toxicol., 1, 199-210, 1996.
• Kaji, T., Suzuki, M., Yamamoto, C., Imaki, Y., Miyajima, S., Fujiwara, Y., Sakamoto, M., and Kozuka, H., Sensitive response of cultured vascular smooth-muscle cells to cadmium cytotoxicity: comparison with cultured vascular endothelial cells and kidney epithelial LLC-PK1 cells. Toxicol. Lett., 89, 131-137, 1996.
• Kaji, T., Inada, M., Yamamoto, C., Fujiwara, Y. and Koizumi, F., Cyclic AMP-dependent pathway that mediates suppressive regulation of glycosaminoglycan production in cultured vascular endothelial cells. Thromb. Res., 82, 389-397, 1996.
• Fujii, N., Kaji, T., Yamamoto, C., Fujiwara, Y., and Koizumi, F., Phorbol 12-myristate 13-acetate stimulates the release of glycosaminoglycans from cultured vascular endothelial cells: Possible involvement of protein kinase C activation. Thromb. Res., 82, 379-387, 1996.
• Kaji, T., Mishima, A., Yamamoto, C., Fujiwara, Y., Sakamoto, M., Kozuka, H., and Koizumi, F., Bismuth induces metallothionein but does not protect against cadmium cytotoxicity in cultured vascular endothelial cells. Bull. Environ. Contam. Toxicol., 56, 630-634, 1996.
• Ohkawara, S., Kaji, T., Yamamoto, C., Fujiwara, Y., Sakamoto, M., and Kozuka, H., Interaction between cadmium and zinc on the production and the sulfation of glycosaminoglycans in cultured vascular endothelial cells. 47, 183-193, 1996.
• Yamamoto, C., Kaji, T., Sakamoto, M., and Kozuka, H., Effects of cadmium on the release of tissue plasminogen activator and plasminogen activator inhibitor type 1 from cultured human vascular smooth muscle cells and fibroblasts. Toxicology, 106, 179-185, 1996.

1995年

• Kaji, T., Fujiwara, Y., Sakurai, S., Yamamoto, C., Kozuka, H., and Koizumi, F., Zinc promotes the repair of wounded monolayer of cultured vascular endothelial cells. Res. Commun. Mol. Pathol. Rhamacol., 89, 189-198, 1995.
• Kaji, T., Yamamoto, C., Miyajima, S., Suzuki, M., Fujiwara, Y., Sakamoto, M., and Koizumi, F., Vascular smooth muscle cells in culture are highly sensitive to cadmium cytotoxicity without species-related differences: Comparison with Chang liver cells. Biol. Pharmacol. Bull., 18, 1392-1395, 1995.
• Kaji, T., Yamamoto, C., Suzuki, M., Miyajima, S., Fujiwara, Y., Sakamoto, M., and Koizumi, F., Induction of metallothionein by thrombin in cultured vascular endothelial and smooth muscle cells. Biol. Pharmacol. Bull., 18, 1272-1274,1995.
• Kaji, T., Fujiwara, Y., Yamamoto, C., Sakamoto, M., and Kozuka, H., Stimulation of cultured vascular smooth muscle cell proliferation by thrombospondin is potentiated by zinc. Biol. Pharmacol. Bull., 18, 1264-1266, 1995.
• Kaji, T., Hiraga, S., Ohkawara, S., Inada, M., Yamamoto, C., Kozuka, H., and Koizumi, F., Regulation by basic fibroblast growth factor of glycosaminoglycan biosynthesis in cultured vascular endothelial cells. Microvascular Res., 49, 268-276, 1995.
• Fujiwara, Y., Kaji, T., Yamamoto, C., Sakamoto, M., and Kozuka, H., Stimulatory effect of lead on the proliferation of cultured vascular smooth-muscle cells. Toxicology, 98, 105-110, 1995.
• Kaji, T., Mishima, A., Machida, M., Yabusaki, K., Suzuki, M., Yamamoto, C., Fujiwara, Y., Sakamoto, M., and Kozuka, H., Comparative cytotoxicity of exogenous cadmium-metallothionein and cadmium ion in cultured vascular endothelial cells. Bull. Environ. Contam. Toxicol., 54, 501-506, 1995.
• Kaji, T., Suzuki, M., Yamamoto, C., Mishima, A., Sakamoto, M., and Kozuka, H., Severe damage of cultured vascular endothelial cell monolayer after simultaneous exposure to cadmium and lead. Bull. Environ. Contam. Toxicol., 28, 168-172, 1995.
• Kaji, T., Fujiwara, Y., Hoshino, M., Yamamoto, C., Sakamoto, M., and Kozuka, H., Inhibitory effect of lead on the proliferation of cultured vascular endothelial cells. Toxicology, 95, 87-92, 1995.
• Mishima, A., Kaji, T., Yamamoto, C., Sakamoto, M., and Kozuka, H., Zinc-induced tolerance to cadmium cytotoxicity without metallothionein induction in cultured bovine aortic endothelial cells. Toxicol. Lett., 75, 85-92, 1995.

1994年

• Sakai, T., Kawaguchi, M., Ishizawa, S., Kaji, T., Kitagawa, K., and Koizumi F., Histological features of palatine tonsils in pustulosis palmaris et plantaris: a morphometric study. Pathol. int., 44, 186-193, 1994.
• Kaji, T., Yamamoto, C., Sakamoto, M., Kozuka, H., and Koizumi, F., Suppression of plasminogen activator inhibitor type 1 release from cultured human umbilical vein endothelial cells by basic fibroblast growth factor. Life Sci., 54, 1563-1569, 1994.
• Yamamoto, C., Kaji, T., Sakamoto, M., Kozuka, H., and Koizumi, F., Calcium regulation of tissue plasminogen activator and plasminogen activator inhibitor-1 release from cultured human vascular endothelial cells. Thromb. Res., 74, 163-168, 1994.
• Kaji, T., Hiraga, S., Fujii, N., Yamamoto, C., Sakamoto, M., Kozuka, H., and Koizumi, F., Plasmin-induced reduction of heparan sulfate in cultured vascular endothelial cell layer. Thromb. Res., 74, 85-93, 1994.
• Yamamoto, C., Kaji, T., Furuya, M., Sakamoto, M., and Kozuka, H., Basic fibroblast growth factor suppresses tissue plasminogen activator release from cultured human umbilical vein endothelial cells but enhances that from cultured human aortic endothelial cells. Thromb. Res., 73, 255-263, 1994.
• Kaji, T., Suzuki, M., Yamamoto, C., Imaki, Y., Mishima, A., Fujiwara, Y., Sakamoto, M., and Kozuka, H., Induction of metallothionein synthesis by bismuth in cultured vascular endothelial cells. Res. Commun. Mol. Pathol. Rhamacol., 86, 25-35, 1994.
• Kaji, T., Fujiwara, Y., Yamamoto, C., Sakamoto, M., and Kozuka, H., Stimulation by zinc of cultured vascular endothelial cell proliferation: Possible involvement of endogenous basic fibroblast growth factor. Life Sci., 55, 1781-1787, 1994.
• Kaji, T., Ohkawara, S., Yamamoto, C., Sakamoto, M., and Kozuka, H., Cadmium-induced alteration of glycosaminoglycans with an enhancement of heparin-like activity in cultured vascular endothelial cells. Toxicology, 94, 161-171, 1994.
• Kaji, T., Ohkawara, S., Inada, M., Yamamoto, C., Sakamoto, M., and Kozuka, H., Alteration of glycosaminoglycans induced by cadmium in cultured vasculatr smooth muscle cells. Arch. Toxicol., 68, 560-565, 1994.
• Kaji, T., Ohkawara, S., Inada, M., Yamamoto, C., Sakamoto, M., and Kozuka, H., Cadmium stimulation of glycosaminoglycan synthesis by cultured vascular endothelial cells: Comparison of various cell types. Biol. Pharm. Bull., 17, 454-457, 1994.
• Kaji, T., Ohkawara, S., Yamamoto, C., Sakamoto, M., and Kozuka, H., Transforming growth factor beta-induced tolerance to cadmium cytotoxicity in cultured vascular endothelial cells. Toxicology, 88, 69-79, 1994.

1993年

• Yamamoto, C., Kaji, T., Sakamoto, M., and Koizumi, F., Effect of endothelin on the release of tissue plasminogen activator and plasminogen activator inhibitor-1 from human endothelial cells and interaction with thrombin. Focus on Endothelium and Vascular Diseases, 3, 85-87, 1993.
• Kaji, T., Hiraga, S., Yamamoto, C., Okoshi, T., Sakamoto, M., Kozuka, H., and Koizumi, F., Characterization of tumor necrosis factor alpha-induced alteration of glycosaminoglycans in cultured cells: Comparison among vascular smooth-muscle cells, vascular endothelial cells. Chang liver cells and LLC-PK1 cells. Biol. Pharm. Bull., 16, 834-839, 1993.
• Yamamoto, C., Kaji, T., Sakamoto, M., and Kozuka, H., Modulation by endothelin-1 of tissue plasminogen activator and plasminogen activator inhibitor-1 release from cultured human vascular endothelial cells: Interaction of endothelin-1 with cytokines. Biol. Pharm. Bull., 16, 714-715, 1993.
• Kaji, T., Hiraga, S., Yamamoto, C., Sakamoto, M., Nakashima, Y., Sueishi, K., and Koizumi, F., Tumor necrosis factor alpha-induced alteration of glycosaminoglycans in cultured vascular smooth-muscle cells. Biochim. Biophys. Acta., 1176, 20-26, 1993.
• Kaji, T., Yamamoto, C., Tsubaki, S., Ohkawara, S., Sakamoto, M., Sato, M., and Kozuka, H., Metallothionein induction by cadmium, cytokines, thrombin and endothelin-1 in cultured vascular endothelial cells. Life Sci., 53, 1185-1191, 1993.
• Yamamoto, C., Kaji, T., Sakamoto, M., and Kozuka, H., Cadmium stimulation of plasminogen activator inhibitor-1 release from human vascular endothelial cells in culture. Toxicology, 83, 215-223, 1993.
• Kaji, T., Mishima, A., Yamamoto, C., Sakamoto, M., and Kozuka, H., Zinc protection against cadmium-induced destruction of the monolayer of cultured vascular endothelial cells. Toxicol. Lett., 66, 247-255, 1993.

1992年

• Kaji, T., Hiraga, S., Mishima, A., Yamamoto, C., Sakamoto, M., and Koizumi, F., Plasmin stimulates the release of dermatan sulfate from vascular smooth muscle cells in culture. Thromb. Res., 67, 791-799, 1992.
• Yamamoto, C., Kaji, T., Sakamoto, M., and Koizumi, F., Effect of endothelin on the release of tissue plasminogen activator and plasminogen activator inhibitor-1 from cultured human endothelial cells and interaction with thrombin. Thromb. Res., 67, 619-624, 1992.
• Kaji, T., Yamamoto, C., Sakamoto, M., and Koizumi, F., Endothelin modulation of tissue plasminogen activator release from human vascular endothelial cells in culture. Blood Coagulat. Fibrinol., 3, 5-10, 1992.
• Kaji, T., Mishima, A., Koyanagi, E., Yamamoto, C., Sakamoto, M., and Kozuka, H., Possible mechanism for zinc protection against cadmium cytotoxicity in cultured vascular endothelial cells. Toxicology, 76, 257-270, 1992.
• Kaji, T., Yamamoto, C., Sakamoto, M., and Kozuka, H., Inhibitory effect of lead on the release of tissue plasminogen activator from human vascular endothelial cells in culture. Toxicology, 73, 219-227, 1992.
• Kaji, T., Fujiwara, Y., Koyznagi, E., Yamamoto, C., Mishima, A., Sakamoto, M., and Kozuka, H., Protective effect of copper against cadmium cytotoxicity on cultured vascular endothelial cells. Toxicology, 63, 13-20, 1992.
• Kaji, T., Mishima, A., Yamamoto, C., Sakamoto, M., and Koizumi, F., Effect of cadmium on the monolayer maintenance of vascular endothelial cells in culture. Toxicology, 71, 267-276, 1992.
• Hayashi, T., Kaji, T., Takebayashi, M., Soejima, R., Morita, N., Sakamoto, M., and Sakuragawa, N., Stimulants from Gardenia Fructus for endothelial cell proliferation. Chem. Pharm. Bull., 40, 942-945, 1992.
• Kaji, T., Kawashima, T., Yamamoto, C., Sakamoto, M., Kurashige, Y., and Koizumi, F., Reversibility of the inhibitory effect of rhodamine B on the proliferation of cultured human lip fibroblasts. Toxicol. Lett., 60, 69-74, 1992.
• Kaji, T., Kawashima, T., Yamamoto, C., and Sakamoto, M., Rhodamine B inhibits collagen synthesis by human lip fibroblasts in culture. Toxicol. Lett., 61, 81-87, 1992.
• Kawaguchi, M., Sakai, T., Ishizawa, S., Shimoda, F., Kitagawa, K., Kaji, T., and Koizumi F., Immunohistochemical comparison between multinucleated giant cells which appear frequently in the tonsils of patients with pustulosis palmaris et plantaris and in other granulomatous inflammatory lesions. Advances in Oto-Rhino-Laryngology, 47, 213-221, 1992.