論文発表

2024年

1. "Structure-activity relationship analysis of fluoxetine for suppression of inflammatory cytokine production." Yohei Takenaka, Ryu Tanaka, Kazuki Kitabatake, Fumiaki Uchiumi, Shin Aoki, Kouji Kuramochi, Mitsutoshi Tsukimoto*. Biological and Pharmaceutical Bulletin 2024, 47, in press. NEW

2023年

1. "Fine-tuning of nitrogen-containing bisphosphonate esters that potently induce degradation of HMG-CoA reductase." Kota Kawamura, Hiromasa Yoshioka, Chikako Sato, Tomoko Yajima, Yuuki Furuyama, Kouji Kuramochi, Kenji Ohgane* Bioorganic & Medicinal Chemistry 2023, 78, 117145.
2. "Methylthioacetic acid, a derivative of aroma compounds from Cucumis melo var. conomon dose-dependently triggers differentiation and apoptosis of RCM-1 human colorectal cancer cells." Miyu Kamimura, Azusa Sasaki, Yui Otani, Yasushi Nakamura, Takako Nakamura, Kouji Kuramochi, Toshio Imai, Nakao Kubo, Shigehisa Okamoto* The Journal of Toxicological Sciences 2023, 48, 25-35.
3. "Isolation, structural determination, and antiviral activities of metabolites from vanitaracin A-producing Talaromyces sp." Shinji Kamisuki*, Hisanobu Shibasaki, Hironobu Murakami, Kan Fujino, Senko Tsukuda, Ikumi Kojima, Koudai Ashikawa, Kazuki Kanno, Tomohiro Ishikawa, Tatsuo Saito, Fumio Sugawara, Koichi Watashi, Kouji Kuramochi. The Journal of Antibiotics 2023, 76, 75–82.
4. "Synthesis and Structure-activity Relationship of Violaceoid D, a Cytotoxic Alkylated Phenol Isolated from Aspergillus violaceofuscus Gasperini." Atsushi Shoji, Yuka Arai, Ryuki Asakawa, Tatsuo Saito, Kouji Kuramochi, Arata Yajima*. Bioscience, Biotechnology, and Biochemistry 2023, 87, 363-370.
5. "Selective inhibition of hepatitis B virus internalization by oxysterol derivatives" Mizuki Oshima, Frank Stappenbeck, Hirofumi Ohashi, Masashi Iwamoto, Kento Fukano, Atsuto Kusunoki, Xin Zheng, Feng Wang, Ryo Morishita , Hideki Aizaki, Ryosuke Suzuki, Masamichi Muramatsu, Kouji Kuramochi, Camille Sureau, Farhad Parhami, Koichi Watashi*. Biochemical and Biophysical Research Communications 2023, 675, 139-145.
6. "Anti-Hepatitis C Virus Activity of Juglorubin Derivatives." Hirofumi Ohashi, Kazane Nishioka, Tomoki Kurihara, Kou Nakamura, Masako Yamasaki, Yuuka Ibayashi, Kanta Fuchiyama, Shogo Kamo, Yuuki Furuyama, Kenji Ohgane, Maiko Okada, Shinji Kamisuki, Koichi Watashi,* and Kouji Kuramochi.* Chemical and Pharmaceutical Bulletin 2023, 71, 843-845.

2022年

1. "Determining the absolute configuration of vanitaracin A, an anti-hepatitis B virus agent." Shinji Kamisuki, Hisanobu Shibasaki, Koudai Ashikawa, Kazuki Kanno, Koichi Watashi, Fumio Sugawara, and Kouji Kuramochi. The Journal of Antibiotics 2022, 75, 92-95.
2. "Synthesis and Antiviral Activities of Neoechinulin B and Its Derivatives." Kota Nishiuchi, Hirofumi Ohashi, Kazane Nishioka, Masako Yamasaki, Masateru Furuta, Takumi Mashiko, Shusuke Tomoshige, Kenji Ohgane, Shinji Kamisuki, Koichi Watashi, Kouji Kuramochi*. Journal of Natural Products 2022, 85, 284-291. C型肝炎ウイルスと新型コロナウイルスの増殖を抑制する化合物の開発に関する論文
3. "Characterization and structural analyses of a novel glycosyltransferase acting on the β-1,2-glucosidic linkages." Kaito Kobayashi, Hisaka Shimizu, Nobukiyo Tanaka, Kouji Kuramochi, Hiroyuki Nakai, Masahiro Nakajima*, Hayao Taguchi. Journal of Biological Chemistry 2022, 298, 101606.
4. "Classification of Southeast Asian mints (Mentha spp.) based on simple sequence repeat markers." Yuri Fukui, Moeko Saito, Natsuno Nakamura, Taichi Mizuno, Shuichi Sato, Mayu Tsukuda, Saori Nakaoka, Keita Tsuboi, Azusa Sasaki, Kouji Kuramochi, Panida Boonyaritthongchai, Nichapat Kaewmanee, Krit Thirapanmethee, Mullika Traidej Chomnawang, Bhanubong Bongcheewin, Thuy Linh Nguyen, Huong Lan Thi Nguyen, Huong Thi Le, Shigehisa Okamoto, Takako Nakamura, Yasushi Nakamura, Nakao Kubo. Breeding Science 2022, 72, 181-187.
5. "Fungal secondary metabolite exophillic acid selectively inhibits the entry of hepatitis B and D viruses." Chisa Kobayashi, Yoshihiro Watanabe, Mizuki Oshima Tomoyasu Hirose, Masako Yamasaki, Masashi Iwamoto, Masato Iwatsuki, Yukihiro Asami, Kouji Kuramochi, Kousho Wakae, Hideki Aizaki, Masamichi Muramatsu, Camille Sureau, Toshiaki Sunazuka, Koichi Watashi* Virues 2022, 14, 764. https://doi.org/10.3390/v14040764.
6. "Profiling differential effects of five selective serotonin reuptake inhibitors on TLRs-dependent and -independent IL-6 production in immune cells identifies fluoxetine as preferred anti-inflammatory drug candidate." Yohei Takenaka, Ryu Tanaka, Kazuki Kitabatake, Kouji Kuramochi, Shin Aoki, Mitsutoshi Tsukimoto* Frontiers in Pharmacology 2022, 13, 874375. https://doi.org/10.3389/fphar.2022.874375
7. "Synthesis and Cytotoxic Activities of 8- and 6-Demethyleucalyptins." Ryuki Asakawa,† Kanta Fuchiyama,† Yunosuke Ishii,† Keisuke Hosaka,† Atsushi Kobayashi, Kei Shimazaki, Junki Nagasawa, Sayaka Tsuchida, Kazunari Ushida, Makoto Matsubayashi, Yuuki Furuyama, Kenji Ohgane, Kouji Kuramochi,*. †These authors equally contributed. Bioscience, Biotechnology, and Biochemistry 2022, 86, 1200-1206. NEW ニホンライチョウの餌植物の化学成分に関する論文です。餌植物の採取・同定、成分の構造決定、化学合成、活性評価という幅広い研究内容です。この論文は、私たちが理想としている「化学と生物」の二刀流の研究です。
8. "Cyclic phthalate esters as liver X receptor antagonists with anti-hepatitis C virus and anti-severe acute respiratory syndrome coronavirus 2 properties." Shiki Saito, Hirofumi Ohashi, Kou Nakamura, Junichiro Otagaki, Kazane Nishioka, Kota Nishiuchi, Ayaka Nakamura, Yukine Tsurukawa, Hisanobu Shibasaki, Hironobu Murakami, Masaki Nagane, Maiko Okada, Kouji Kuramochi, Koichi Watashi, Shinji Kamisuki* Chemical and Pharmaceutical Bulletin 2022, 70, 679-683.
9. "C型肝炎ウイルスや新型コロナウイルスの増殖を抑制する化合物の創製" 西内宏太、大橋啓史、山崎雅子、西岡華実、紙透伸治、渡士幸一、倉持幸司* BIOINDUSTRY 2022, 39, 26-31.

2021年

1. "SQAP, an acyl sulfoquinovosyl derivative, suppresses expression of histone deacetylase and induces cell death of cancer cells under hypoxic conditions." Hirofumi Kawakubo, Shinji Kamisuki, Kei Suzuki, Jesus Izaguirre-Carbonell, Shiki Saito, Hiroshi Murata, Atsushi Tanabe, Ayumi Hongo, Hironobu Murakami, Sachihiro Matsunaga, Kengo Sakaguchi, Hiroeki Sahara, Fumio Sugawara, Kouji Kuramochi. Bioscience, Biotechnology, and Biochemistry. 2021, 85, 85-91.
2. "An Alternative Approach to The Development of Near-Infrared Fluorescent Dyes Based on Fluorescein." Akane Katori, Akari Yamagami, Sae Wakabayashi, Kouji Kuramochi, Ayumi Imayoshi, Kazunori Tsubaki*.Heterocycles 2021, 103, 103, 365-378.
3. "Identification of anti-severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) oxysterol derivatives in vitro." Hirofumi Ohashi, Feng Wang, Frank Stappenbeck, Kana Tsuchimoto, Chisa Kobayashi, Wakana Saso, Michiyo Kataoka, Kouji Kuramochi, Masamichi Muramatsu, Tadaki Suzuki, Camille Sureau, Makoto Takeda, Takaji Wakita, Farhad Parhami*, Koichi Watashi*. International Journal of Molecular Sciences 2021, 22, 3163. doi: https://doi.org/10.1101/2021.01.31.429001 新型コロナウイルスの増殖を抑制する酸化ステロールに関す論文
4. "Synthesis, Photochemical Properties, and Cytotoxicity of 10-Alkylphenazin-2(10H)-ones." Haruki Kohatsu, Shogo Kamo, Takuya Hosokai, Shinji Kamisuki, Yutaro Machida, Ryota Kobayashi, Tsuneomi Kawasaki, Kenji Ohgane, Kouji Kuramochi*. Heterocycles 2021, 103, 871-885. 　
5. "Potential anti-COVID-19 agents, cepharanthine and nelfinavir, and their usage for combination treatment." Hirofumi Ohashi, Koichi Watashi*, Wakana Saso, Kaho Shionoya, Shoya Iwanami, Takatsugu Hirokawa, Tsuyoshi Shirai, Shigehiko Kanaya, Yusuke Ito, Kwang Su Kim, Takao Nomura, Tateki Suzuki, Kazane Nishioka, Shuji Ando, Keisuke Ejima, Yoshiki Koizumi, Tomohiro Tanaka, Shin Aoki, Kouji Kuramochi, Tadaki Suzuki, Takao Hashiguchi, Katsumi Maenaka, Tetsuro Matano, Masamichi Muramatsu, Masayuki Saijo, Kazuyuki Aihara, Shingo Iwami, Makoto Takeda, Jane A. McKeating, Takaji Wakita. iScience 2021, 24, 102367. doi; https://doi.org/10.1016/j.isci.2021.102367 新型コロナウイルスの増殖に対するネルフィナビルとセファランチンの併用効果 　
6. "Mefloquine, a Potent anti-Severe Acute Respiratory Syndrome-related Coronavirus 2 (SARS-CoV-2) drug as an entry inhibitor in vitro." Kaho Shionoya, Masako Yamasaki, Shoya Iwanami, Yusuke Ito,Shuetsu Fukushi, Hirofumi Ohashi, Wakana Saso, Tomohiro Tanaka, Shin Aoki, Kouji Kuramochi, Shingo Iwami, Yoshimasa Takahashi, Tadaki Suzuki, Masamichi Muramatsu, Makoto Takeda, Takaji Wakita, Koichi Watashi*.Frontiers Microbiology 2021, 12, 651403. doi; https://doi.org/10.3389/fmicb.2021.651403 メフロキンの新型コロナウイルスの増殖活性 　
7. "Epo-C12 inhibits peroxiredoxin 1 peroxidase activity." Tomoka Yoda, Masateru Furuta, Tomohiko Tsutsumi, Seiki Ikeda,　Shunsuke Yukizawa, Satoshi Arai, Akinori Morita, Kenji Yamatoya, Kazuya Nakata, Shusuke Tomoshige, Kenji Ohgane, Yuuki Furuyama, Kengo Sakaguchi, Fumio Sugawara, Susumu Kobayashi, Masahiko Ikekita, Kouji Kuramochi*. Bioorganic & Medicinal Chemistry 2021, 40, 116203.
8. "Deoxygenation of tertiary and secondary alcohols with sodium borohydride, trimethylsilyl chloride, and potassium iodide in acetonitrile." Yuichi Kato(co-first author), Tomoka Inoue (co-first author), Yuuki Furuyama, Kenji Ohgane, Mahito Sadaie, Kouji Kuramochi*. Tetrahedron Letters 2021, 86, 153519.

2020年

1. "Isolation, synthesis, and biological activities of a bibenzyl from Empetrum nigrum var. japonicum." Sayuki Oka,* Ryo Kuniba,* Nozomi Tsuboi,* Sayaka Tsuchida, Kazunari Ushida, Shusuke Tomoshige, Kouji Kuramochi. *These authors equally contributed. Bioscience, Biotechnology, and Biochemistry 2020, 84, 31-36. BBB論文賞受賞（2020）
2. "Synthesis of nucleotide analogues, EFdA, EdA and EdAP, and the effect of EdAP on hepatitis B virus replication." Mai Kamata, Toshifumi Takeuchi, Ei Hayashi, Kazane Nishioka, Mizuki Oshima, Masashi Iwamoto, Kota Nishiuchi, Shogo Kamo, Shusuke Tomoshige, Koichi Watashi, Shinji Kamisuki, Hiroshi Ohrui, Fumio Sugawara, Kouji Kuramochi*.Bioscience, Biotechnology, and Biochemistry 2020, 84, 217-227.
3. "Synthesis and Optical Properties of L-Shaped Dinaphthofluoresceins with two Peripheral Hydroxy Groups." Hikari Yamashita, Chihiro Minari, Eriko Azuma, Kouji Kuramochi, Ayumi Imayoshi, Kazunori Tsubaki*.Heterocycles 2020, 101, 536-546.
4. "Synthesis and structural revision of an indanone isolated from Triphyophyllum peltatum." Yunosuke Ishii, Motohiro Ota, Shogo Kamo, Shusuke Tomoshige, Kazunori Tsubaki, Kouji Kuramochi. Tetrahedron Letters 2020, 61, 151494.
5. "Dimerizations of 2-bromo-3-methyl-1,4-naphthoquinone and 2-methyl-1,4-naphthoquinone in tetra-n-butylammonium bromide." Mai Onuki, Motohiro Ota, Shoya Otokozawa, Shogo Kamo, Shusuke Tomoshige, Kazunori Tsubaki, Kouji Kuramochi*. Tetrahedron 2020, 76, 130899.
6. "Investigation on the Epoxidation of Piperitenone, and Structure–activity Relationships of Piperitenone Oxide for Differentiation-inducing Activity." Ryohei Sato, Azusa Sasaki, Yuko Mori, Mio Komai, Shogo Kamo, Mai Onuki, Takafumi Seki, Zen Kawabe, Shu Miyajima, Shusuke Tomoshige, Tsuneomi Kawasaki, Shuichi Sato, Takako Nakamura, Nakao Kubo, Seiji Takeda, Shuichi Date, Shigehisa Okamoto, Panida Boonyaritthongchai, Krit Thirapanmethee, Mullika Traidej Chomnawang, Bhanubong Bongcheewin, Thuy Linh Nguyen, Huong Lan Thi Nguyen, Huong Thi Le, Yasushi Nakamura,* Kouji Kuramochi*. Journal of Oleo Science. 2020, 69, 951-958.
7. "Nucleophilic Addition Reactions of Benzoxanthone Derivatives with Collapse of Aromaticity." Hirotaka Sasaki, Takashi Hosoya*, Naoki Egami, Hina Ishimura, Akane Katori, Hisashi Miyafuji, Kouji Kuramochi, Ayumi Imayoshi, Kazunori Tsubaki*. Tetrahedron 2020, 76, 131472.
8. "Chemical and molecular bases of dome formation in human colorectal cancer cells mediated by the sulfur compounds from Cucumis melo var. conomon." Miyu Kamimura, Azusa Sasaki, Shimpei Watanabe, Shiho Tanaka, Akiko Fukukawa, Kazuya Takeda, Yasushi Nakamura, Takako Nakamura, Kouji Kuramochi, Yui Otani, Fumio Hashimoto, Kanji Ishimaru, Tomoaki Matsuo, Shigehisa Okamoto*. FEBS Open Bio 2020, 10, 2640-2655.
9. "Synthesis and Cytotoxic Evaluation of N-Alkyl-2-halophenazin-1-ones." Haruki Kohatsu, Shogo Kamo, Masateru Furuta, Shusuke Tomoshige, Kouji Kuramochi*. ACS Omega 2020, 5, 27667-27674.　 Supplementary Cover に選出されました。

2019年

1. 【書籍】"天然物化学" 菅原二三男、浅見忠男、葛山智久、倉持幸司、新家一男、永田晋治 著. コロナ社 2019.　
2. "Distribution and metabolism of ¹⁴C-Sulfoquinovosylacylpropanediol (¹⁴C-SQAP) after a single intravenous administration in tumor-bearing mice." Tatsushi Ruike, Yoshihiro Kanai, Kazuki Iwabata, Yuki Matsumoto, Hiroshi Murata, Masahiro Ishima, Keisuke Ohta, Masahiko Oshige, Shinji Katsura, Koji Kuramochi, Shinji Kamisuki, Hiroeki Sahara, Masahiko Miura, Fumio Sugawara*, Kengo Sakaguchi*.Xenobiotica 2019, 49, 346-362.
3. "Synthesis, antibacterial and cytotoxic evaluation of flavipucine and its derivatives." Yasuha Kusakabe, Shoma Mizutani, Shogo Kamo, Tatsuki Yoshimoto, Shusuke Tomoshige, Tsuneomi Kawasaki, Ryoko Takasawa, Kazunori Tsubaki, Kouji Kuramochi*. Bioorganic and Medicinal Chemistry Letters 2019, 29, 1390-1394.
4. "Novel neuroprotective hydroquinones with a vinyl alkyne from the fungus, Pestalotiopsis microspora." Kazuki Kanno, Yukine Tsurukawa, Shinji Kamisuki*, Hisanobu Shibasaki, Keita Iguchi, Hironobu Murakami, Jumpei Uchiyama, Kouji Kuramochi. The Journal of Antibiotics 2019, 72, 793-799.
5. "A Unified Approach towards Syntheses of Juglomycins and Their Derivatives." Kai Yoshioka, Shogo Kamo, Keisuke Hosaka, Ryohei Sato, Yuma Miikeda, Yuri Manabe, Shusuke Tomoshige, Kazunori Tsubaki, Kouji Kuramochi*. ACS Omega 2019, 4, 11737-11748.
6. "Monooxygenase-catalyzed regioselective hydroxylation for the synthesis of hydroxyequols." Takafumi Hashimoto, Daiki Nozawa, Katsuyuki Mukai, Akinobu Matsuyama,Kouji Kuramochi, Toshiki Furuya*. RSC Advances 2019, 9, 21826-21830.
7. "Total Syntheses of Pyocyanin, Lavanducyanin, and Marinocyanins A and B." Haruki Kohatsu, Shogo Kamo, Shusuke Tomoshige, Kouji Kuramochi*.Organic Letters 2019, 21, 7311-7314.
8. "Synthetic and Biological Studies of Juglorubin and Related Naphthoquinones." Shogo Kamo, Tatsuo Saito, Yasuha Kusakabe, Shusuke Tomoshige, Masanobu Uchiyama, Kazunori Tsubaki, Kouji Kuramochi*.The Journal of Organic Chemistry 2019, 84, 13957-13966.